|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 2 | Light-Weight Design of CRH Wind Deflector Panels based on Woven Textile Sandwich Composites显示文摘The woven textile sandwich composite(WTSC) is a promising lightweight composite.In bending,two competing core shearing failure modes reduce the strength;deflection induced by the core shearing deformation reduces the flexural rigidity.To replace a solid composite laminate,the span of WTSC panel must be greater than a critical value,which was deduced on the condition that the load capacity and flexural rigidity of the WTSC panel are equal to those of the composite laminate.Three WTSC panels were tested in bending,so that the failure modes were observed,and the critical spans were determined.Using the alternative design method,the WTSC based wind deflector with reduced weight has been fabricated and mounted on the CRH(China Railway High-speed). | Hualin Fan Jianfeng Ouyang Fangfang Sun Peishi Yu Ning Kuang Yang Hu | 2016 | Acta Mechanica Solida Sinica2016，29，2： | 4 |
| 3 | The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),a member of the Phlebovirus genus from the Bunyaviridae family endemic to China,is the causative agent of life-threatening severe fever with thrombocyto-penia syndrome(SFTS),which features high fever and hemorrhage.Similar to other negative-sense RNA viruses,SFTSV encodes a nucleocapsid protein(NP)that is essen-tial for viral replication.NP facilitates viral RNA encapsida-tion and is responsible for the formation of ribonucleopro-tein complex.However,recent studies have indicated that NP from Phlebovirus members behaves in inhomogene-ous oligomerization states.In the present study,we report the crystal structure of SFTSV NP at 2.8Åresolution and demonstrate the mechanism by which it processes a ring-shaped hexameric form to accomplish RNA encapsida-tion.Key residues essential for oligomerization are identi-fi ed through mutational analysis and identifi ed to have a signifi cant impact on RNA binding,which suggests that correct formation of highly ordered oligomers is a criti-cal step in RNA encapsidation.The fi ndings of this work provide new insights into the discovery of new antiviral reagents for Phlebovirus infection. | Honggang Zhou Yuna Sun Ying Wang Min Liu Chao Liu Wenming Wang Xiang Liu Le Li Fei Deng Hualin Wang Yu Guo Zhiyong Lou | 2013 | Protein & Cell2013，4，6： | 4 |
| 4 | Electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in the injured spinal cord of adult rats显示文摘A contusive model of spinal cord injury at spinal segment T8-9 was established in rats. Huantiao (GB30) and Huatuojiaji (Ex-B05) were punctured with needles, and endogenous neural stem cells were labeled with 5-bromo-2'-deoxyuridine (BrdU) and NG2. Double immunofluorescence staining showed that electroacupuncture markedly increased the numbers of BrdU+/NG2+ cells at spinal cord tissue 15 mm away from the injury center in the rostral and caudal directions. The results suggest that electroacupuncture promotes the proliferation of endogenous neural stem cells and oligodendrocytes in rats with spinal cord injury. | Haiying Wu Min HU Dekai Yuan Yunhui Wang Jing Wang Tao Li Chuanyun Qian Hualin YU | 2012 | Neural Regeneration Research2012，7，15： | 4 |
| 5 | A Comparative Study of the Seismic Performances and Failure Mechanisms of Slopes Using Dynamic Centrifuge Modeling显示文摘In this study, dynamic centrifuge model tests were performed for sand slopes under different earthquake ground motions and slope angle to characterize the seismic performance of slopes. Four groups of tests under varying seismic input amplitude were conducted. Under the action of increasing earthquake intensity, the rigidity of the soil decreases and the damping ratio increases, both of the dynamic response and the predominant period of slopes are increased. Three types of seismic waves with the same seismic intensity were applied in the model tests. It shows that the variability in the ground motion leads to the acceleration response spectra of the slopes being completely different and the Northridge seismic wave with low-frequency component is closest to the predominant period of the slope model. In addition, the effect of slope angle on the seismic performance of slopes were also clarified. The results reveal how the slope angle affects the acceleration recorded on the ground surface of the slope, both in terms of the peak ground-motion acceleration(PGA) amplification factor and the predominant period. Finally, the permanent displacement of the model slopes under different earthquake intensities were further analyzed. Based on the nonlinear growth of the permanent displacement of the slope, the test results demonstrated the failure process of the slope, which can further provide a basis for theperformance-based seismic design of slopes. | Hualin Cheng Jiamin Zhou Zhiyi Chen Yu Huang | 2021 | Journal of Earth Science2021，32，5： | 3 |
| 6 | Combined action of MK-801 and ceftriaxone impairs the acquisition and reinstatement of morphine-induced conditioned place preference,and delays morphine extinction in rats显示文摘Objective It is well established that glutamate and its receptors, particularly the N-methyl-D-aspartate receptor (NMDAR), play a significant role in addiction and that the inhibition of glutamatergic hyperfunction reduces addictive behaviors in experimental animals. Specifically, NMDAR antagonists such as MK-801, and an inducer of the expression of glutamate transporter subtype-1 (GLT-1) (ceftriaxone) are known to inhibit addictive behavior. The purpose of this study was to determine whether the combined action of a low dose of MK-801 and a low dose of ceftriaxone provides better inhibition of the acquisition, extinction, and reinstatement of morphine-induced conditioned place preference (CPP) than either compound alone. Methods A morphine-paired CPP experiment was used to study the effects of low doses of MK-801, ceftriaxone and a combination of both on reward-related memory (acquisition, extinction, and reinstatement of morphine preference) in rats. Results A low dose of neither MK-801 (0.05 mg/kg, i.p.) nor ceftriaxone (25 mg/kg, i.p.) alone effectively impaired CPP behaviors. However, when applied in combination, they reduced the acquisition of morphine-induced CPP and completely prevented morphine reinstatement. Their combination also notably impaired the extinction of morphine-induced CPP. Conclusion The combined action of a low dose of an NMDAR antagonist (MK-801) and GLT-1 activation by ceftriaxone effectively changed different phases of CPP behavior. | Yaodong Fan Haichen Niu Joshua D. Rizak Ling Li Guimei Wang Liqi Xu He Ren Hao Lei Hualin Yu | 2012 | Neuroscience Bulletin2012，28，5： | 2 |
| 7 | The first discovery of eclogite and Palaeoproterozoic granitoids in the Beishan area,northwestern Gansu Province,China显示文摘The eclogite, discovered in Liuyuan, occurs as lenticular enclave within granitic gneiss. It has typical features of eclogite in petrology and mineralogy. The eclogite provides an important wirdow to reconstruct the tectonic border of the Tarim block. The granitoids, located in Baihu area, yield U-Pb zircon ages of 1 660—2 000 Ma (Palaeoproterozoic), which irrplies an early Precambrian basement in the area. | Hualin Mei Haifeng Yu Quan Li Songnian Lu Huimin Li Yicheng Zuo Guochao Zuo Dejin Ye Jincheng Liu | 1999 | Chinese Science Bulletin1999，44，4： | 1 |
| 8 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 9 | Monomial Hopf algebras 显示文摘 | CHEN Xiaowu HUANG Hualin YE Yu | 2004 | J Algebra2004，275，1： | 1 |
| 10 | Mechanical property of lattice truss material in sandwich panel including strut flexural deformation显示文摘 | Hailong Chen Qing Zheng Long Zhao Yu Zhang Hualin Fan | 2012 | Composite Structures2012，，12： | 1 |
| 11 | Influences of graphite anode area on electrolysis of solid metal oxides in molten salts显示文摘 | Hualin Chen Xianbo Jin Linpo Yu George Z. Chen | 2014 | Journal of Solid State Electrochemistry2014，，12： | 1 |
| 12 | Monomial Hopf algebras 显示文摘 | CHEN Xiaowu HUANG Hualin YE Yu | 2004 | J Algebra2004，275，1： | 1 |
| 13 | The impact of climate change on coastal geological disasters in southeastern China显示文摘 | Huang Yu Cheng Hualin | | 0，，： | 1 |
| 14 | Effects of Ketamine on Basal Gamma Band Oscillation and Sensory Gating in Prefrontal Cortex of Awake Rats显示文摘Gamma band oscillation(GBO) and sensory gating(SG) are associated with many cognitive functions.Ketamine induces deficits of GBO and SG in the prefrontal cortex(PFC). However, the time-courses of the effects of different doses of ketamine on GBO power and SG are poorly understood. Studies have indicated that GBO power and SG have a common substrate for their generation and abnormalities. In this study, we found that(1) ketamine administration increased GBO power in the PFC in rats differently in the low-and high-dose groups;(2) auditory SG was significantly lower than baseline in the 30 mg/kg and 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and(3) changes in SG and basal GBO power were significantly correlated in awake rats. These results indicate a relationship between mechanisms underlying auditory SG and GBO power. | Renli Qi Jinghui Li Xujun Wu Xin Geng Nanhui Chen Hualin Yu | 2018 | Neuroscience Bulletin2018，34，3： | 1 |
| 15 | Quality control work group focusing onpractical guidelines for improving safety of critically ill patienttransportation in the emergency department 显示文摘 | Yu Nuchang Li Hualin | 2010 | Journal of E-mergency Nursing2010，36，2： | 1 |
| 16 | Carotid atherosclerosis,intima media thickness and risk factors-an analysis of 1781 asymptomatic subjects in TaiWan显示文摘 | Yu Sun Cheng HuaLin Chen JunLu | 2002 | Atherosclerosis2002，164，： | 1 |
| 17 | Discovery and Significance of Eclogite-Granitoid Belts in Northwest China显示文摘 | Lu Songnian Zhao Fengqing Mei Hualin Yu Haifeng Li Huaikun Zheng Jiankang | 1999 | Gondwana Research1999，，1： | 1 |
| 18 | 3D numerical modeling u- sing smoothed particle hydrodynamics of flow - like landslide propaga- tion triggered by the 2008 Wenchuan earthquake 显示文摘 | Zili Dai Yu Huang Hualin Cheng | 2014 | Engineering Geology2014，180，： | 1 |
| 19 | Per1/Per2 double knockout transcriptome analysis reveals circadian regulation of hepatic lipid metabolism显示文摘Scope: Circadian disorder and high-fat diet(HFD)can disturb lipid metabolism homeostasis and may promote the development of various metabolic diseases. The relationship between them is of great concern. This study aimed to explore the effects of Per1/Per2 double knockout(DKO)on hepatic lipid metabolism in mice under HFD and HFD with docosahexaenoic acid(DHA)substitution. Methods and results: Both wild type(WT)and DKO male C57BL/6 mice were fed with normal chow diet(CON), HFD, or HFD with DHA substitution(AO)for 15 weeks. At the end of the experiment, mice were sacrificed at zeitgeber time(ZT)0(7:00 am)or ZT12(7:00 pm). Pathological indicators were determined using histological and biochemical methods. Hepatic transcriptome sequencing analysis showed that DKO mice exhibited multiple dysfunctions in diurnal rhythm, drug metabolism, cell cycle, cancer pathways, and lipid metabolism. HFD had greater effects on fatty acid oxidation and cholesterol synthesis and metabolism in Per1-/-Per2-/-mice, which was improved by DHA substitution. Conclusions: Per1/Per2 played an important role in the circadian regulation of hepatic lipid metabolism, and DKO mice were more sensitive to HFD. DHA can improve circadian-related lipid metabolism disruption induced by HFD in mice. | Yiran Bu Si Chen Mengcheng Ruan Libang Wu Hualin Wang Na Li Xiuju Zhao Xiaoli Yu Zhiguo Liu | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 20 | Layered metastructure containing freely-designed local resonators for wave attenuation显示文摘Combining periodic layered structure with three-dimensional cylindrical local resonators,a hybrid metastructure with improved wave isolation ability was designed and investigated through theoretical and numerical approaches.The metastructure is composed of periodic rubber layers and concrete layers embedded with three-dimensional resonators,which can be freely designed with multi local resonant frequencies to attenuate vibrations at required frequencies and widen the attenuation bandgap.The metastructure can also effectively attenuate seismic responses.Compared with layered rubber-based structures,the metastructure has more excellent wave attenuation effects with greater attenuation and wider bandgap. | Yu Li Huguang He Jiang Feng Hailong Chen Fengnian Jin Hualin Fan | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员