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| 1 | Structure and governance model of rural social space quality:A case study of Longxi County in the Loess Hilly Area of China显示文摘The rural social space quality is an important indicator to measure the living standard and thinking ideas and so forth of rural residents in a certain region.In this paper,213 administrative villages in Longxi County of the Loess Hilly Area,China are taken as evaluation units to construct the evaluation model of the rural social space quality.This paper deeply analyzed the variation patterns and their formation mechanism of the rural social space quality at a village scale,and proposed a governance model based on the rural social space quality.The results show that:(1)the social space quality levels of individual administrative villages show a gradually decreasing trend from the township seats to outward.The eastern part of Longxi County has a relatively high education level and living standard,and the western part has a relatively high population stability level and income level.(2)The rural social space quality is mainly in a ring structure,supplemented by the interlaced structure.The core area is the towns and their surrounding areas,while the transition area,marginal area,and other areas are expanded around the core area.(3)Social forces and spatial effects jointly shape the variation of the rural social space quality.Social organizations provide a driving force for the allocation of elements,and interweaving with the spatial effects lead to the differences in the social space quality.(4)The governance models of the rural social space quality are constructed based on the principles of retaining the rural“people”,optimizing the rural“land”,and developing the rural“industry”,so as to improve the rural centripetal force,core force,inner thrust,and source power. | WU Shanshan MA Libang TAO Tianmin DOU Haojian | 2022 | Journal of Geographical Sciences2022，32，7： | 2 |
| 2 | Fibers reinforced composite hydrogels with improved lubrication and load-bearing capacity显示文摘Hydrogels as one kind of soft materials with a typical three-dimensional(3D)hydrophilic network have been getting great attention in the field of biolubrication.However,traditional hydrogels commonly show poor tribology performance under high-load conditions because of their poor mechanical strength and toughness.Herein,pure chemical-crosslinking hydrogels mixed with different types of the micron-scale fibers can meet the requirements of strength and toughness for biolubrication materials,meanwhile the corresponding tribology performance improves significantly.In a typical case,three kinds of reinforcement matrix including needle-punched fibers,alginate fibers,and cottons are separately combined with Poly(n-vinyl pyrrolidone)-poly 2-hydroxyethyl methacrylate(PVP-PHEMA)hydrogels to prepare fibers reinforced composite hydrogels.The experimental results show that the mechanical properties of fibers reinforced composite hydrogels improve greatly comparable with pure PVP-PHEMA hydrogels.Among three kinds of fibers reinforced composite hydrogel,the as-prepared composite hydrogels reinforced with needle-punched fibers possess the best strength,modulus,and anti-tearing properties.Friction tests indicate that the fibers reinforced composite hydrogels demonstrate stable water-lubrication performance comparable with pure PVP-PHEMA hydrogels.Besides,the hydrogel-spunlace fiber samples show the best load-bearing and anti-wear capacities.The improved tribology performance of the composite hydrogels is highly related to mechanical property and the interaction between the fibers and hydrogel network.Finally,spunlace fibers reinforced hydrogel materials with high load-bearing and low friction properties are expected to be used as novel biomimetic lubrication materials. | Jiawei LI Luyao GAO Rongnian XU Shuanhong MA Zhengfeng MA Yanhua LIU Yang WU Libang FENG Meirong CAI Feng ZHOU | 2022 | Friction2022，10，1： | 1 |
| 3 | Per1/Per2 double knockout transcriptome analysis reveals circadian regulation of hepatic lipid metabolism显示文摘Scope: Circadian disorder and high-fat diet(HFD)can disturb lipid metabolism homeostasis and may promote the development of various metabolic diseases. The relationship between them is of great concern. This study aimed to explore the effects of Per1/Per2 double knockout(DKO)on hepatic lipid metabolism in mice under HFD and HFD with docosahexaenoic acid(DHA)substitution. Methods and results: Both wild type(WT)and DKO male C57BL/6 mice were fed with normal chow diet(CON), HFD, or HFD with DHA substitution(AO)for 15 weeks. At the end of the experiment, mice were sacrificed at zeitgeber time(ZT)0(7:00 am)or ZT12(7:00 pm). Pathological indicators were determined using histological and biochemical methods. Hepatic transcriptome sequencing analysis showed that DKO mice exhibited multiple dysfunctions in diurnal rhythm, drug metabolism, cell cycle, cancer pathways, and lipid metabolism. HFD had greater effects on fatty acid oxidation and cholesterol synthesis and metabolism in Per1-/-Per2-/-mice, which was improved by DHA substitution. Conclusions: Per1/Per2 played an important role in the circadian regulation of hepatic lipid metabolism, and DKO mice were more sensitive to HFD. DHA can improve circadian-related lipid metabolism disruption induced by HFD in mice. | Yiran Bu Si Chen Mengcheng Ruan Libang Wu Hualin Wang Na Li Xiuju Zhao Xiaoli Yu Zhiguo Liu | 2023 | Food Science and Human Wellness2023，12，5： | 0 |
| 4 | Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage显示文摘Unrestrained inflammation is harmful to tissue repair and regeneration.Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation.Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function,but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions.In this study,we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation(early pulpitis as the model)with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo.Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide(E.coli LPS)with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways.Moreover,nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects,attenuating inflammatory conditions in the early stage.Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage,which widens the potential cell types for inflammation regulation. | Lizhong Sun Libang He Wei Wu Li Luo Mingyue Han Yifang Liu Shijie Shi Kaijing Zhong Jiaojiao Yang Jiyao Li | 2021 | International Journal of Oral Science2021，13，4： | 0 |
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