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| 1 | Switched adaptive active disturbance rejection control of variable structure near space vehicles based on adaptive dynamic programming显示文摘Based on the switched nonlinear system, a switched adaptive Active Disturbance Rejection Control(ADRC) law is proposed for the Variable Structure Near Space Vehicle(VSNSV) with unknown uncertainties and external disturbances. The reduced-order Extended State Observers(ESOs) are constructed for the attitude angle system and the angular rate system to estimate the total disturbance in real time. With the extended state introduced to counteract the effects of uncertainties and disturbances, a systematic procedure is presented for the synthesis of the switched adaptive ADRC strategy. Rigorous proof shows that the estimation errors of the reduced-order ESOs would converge to a small neighborhood of zero in finite time, and that the output of the closedloop system can track a given signal stably for a class of switching signals with average dwell time via the proposed approach. The variable gain control strategy based on Adaptive Dynamic Programming(ADP) with the actor-critic structure is also designed to improve the dynamic performance of the system. Simulation results verify the effectiveness and advantage of the proposed control scheme. | Chaoyang DONG Chen LIU Qing WANG Ligang GONG | 2019 | Chinese Journal of Aeronautics2019，32，7： | 10 |
| 2 | Association of renal function with cardiac reverse remodeling and long-term outcome in heart failure patients following cardiac resynchronization therapy显示文摘 | Cai Chi Hua Wei Ding Ligang Wang Jing Chen Keping Yang Xinwei Liu Zhimin Zhang Shu | 2014 | Chinese Medical Journal2014，，23： | 8 |
| 3 | Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell resistance to cisplatin by regulating miR-34b-5p/ABCB1 axis显示文摘Cisplatin resistance is a major challenge for bladder cancer(BC).Evidence indicates that exosome derived from cancer-associated fibroblasts(CAF-Exo)can promote chemotherapy resistance in various human tumors by delivering bioactive molecules.We have previously demonstrated that CAF-derived exosomal LINC00355 promotes BC cell proliferation and invasion.However,the underlying mechanisms are still unclear.In this study,we aimed to investigate the role and mechanisms of CAF-derived exosomal LINC00355 in BC cell resistance to cisplatin.Exosomes were isolated from normal fibroblasts(NFs)and BC tumor-derived CAFs,namely,NF-Exo and CAF-Exo.CAFs were transfected with si-Ctrl or si-LINC00355 and then different exosomes were isolated,namely,CAF^(si-Ctrl)-Exo and CAF^(si-LINC00355)-Exo.The human BC cell lines(T24 and 5367)were incubated with NF-Exo,CAF-Exo,CAF^(si-Ctrl)-Exo,and CAF^(si-LINC00355)-Exo in the presence of cisplatin.MTT proliferation assay and flow cytometric analysis showed that CAF-Exo promoted BC cell resistance to cisplatin and upregulated ABCB1 expression in BC cells by transferring LINC00355 to BC cells.Luciferase activity assay confirmed the interaction between miR-34b-5p and LINC00355 or ABCB1.qRT-PCR and western blot analysis further showed that LINC00355 sponged miR-34b-5p to upregulate ABCB1 expression.However,the promoting effects of CAF-Exo on BC cell resistance to cisplatin were abolished by miR-34b-5p overexpression and ABCB1 silencing.In conclusion,exosomal LINC00355 derived from CAFs promotes BC cell resistance to cisplatin by regulating the miR-34b-5p/ABCB1 axis. | Guangyue Luo Yangyang Zhang Zhonghui Wu Ligang Zhang Chaozhao Liang Xianguo Chen | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 6 |
| 4 | Bifurcation and chaos of the bladed overhang rotor system with squeeze film dampers显示文摘To study the nonlinear dynamic behavior of the bladed overhang rotor system with squeeze film damper (SFD), a blade-overhang rotor-SFD model is formulated using the lumped mass method and the Lagrange approach. The cavitated short bearing model is employed to describe the nonlinear oil force of the SFD. To reduce the scale of the nonlinear coupling system, a set of orthogonal transformations is employed to decouple the one nodal diameter equations of blades, which are coupled with the dy- namical equations of the rotor, with other equations of blades. In this way, the original system with 16+4n (n≥3) degrees of freedom (DoF) is reduced to a system with 24 DoF only. Then the parametric excitation terms in the blade-overhang rotor-SFD model are simplified in terms of periodic transforma- tions. The coupling equations are numerically solved and the solutions are used to analyze the dy- namic behavior of the system in terms of the bifurcation diagram, whirl orbit, Poincaré map and spec- trum plot. A variety of motion types are found such as multi-periodic, quasi-periodic, and chaotic mo- tions. Moreover, the typical nonlinear dynamic evolutions including the periodic-doubling bifurcation and reverse bifurcation are noted. It is noticed that there exist apparent differences in the dynamic behavior between the blade-overhang rotor-SFD models without and with considering the effect of blades. | CAO DengQing WANG LiGang CHEN YuShu HUANG WenHu | 2009 | Science China(Technological Sciences)2009，52，3： | 5 |
| 5 | Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell proliferation and invasion by regulating miR-15a-5p/HMGA2 axis显示文摘We have previously demonstrated that exosomes derived from cancer-associated fibroblasts(CAFs)promote bladder cancer(BC)cell proliferation and invasion by transferring LINC00355.In this study,the molecular mechanisms underlying the pro-bladder cancer action of exosomal LINC00355 were explored.CAFs were obtained from BC tumor tissues,and normal fibroblasts(NFs)were obtained from adjacent normal tissues.Human BC cell lines(T24 and 5367)were incubated with NF-Exo(exosomes from NFs),CAF-Exo(exosomes from CAFs),CAFsi-Ctrl-Exo(exosomes from si-Ctrl-transfected CAFs),and CAFsi-LINC00355-Exo(exosomes from si-LINC00355-transfected CAFs).BC cell proliferation and invasion were evaluated by MTT and Transwell assays,respectively.The interaction between miR-15a-5p and LINC00355 or HMGA2 was examined by online bioinformatics analysis and luciferase activity assay.Results showed that HMGA2 is a direct target of miR-15a-5p,and LINC00355 functions as a sponge of miR-15a-5p to upregulate HMGA2 expression.The promoting effects of CAF-Exo on HMGA2 expression,cell proliferation,and cell invasion were hindered when LINC00355 expression was inhibited in BC cells.These promoting effects were also hindered when miR-15a-5p was overexpressed or HMGA2 was silenced in BC cells.In conclusion,exosomal LINC00355 derived from CAFs promotes BC cell proliferation and invasion by regulating miR-15a-5p/HMGA2 axis. | Yangyang Zhang Guangyue Luo Shinian You Ligang Zhang Chaozhao Liang Xianguo Chen | 2021 | Acta Biochimica et Biophysica Sinica2021，53，6： | 4 |
| 6 | DICER1 regulates antibacterial function of epididymis by modulating transcription of p-defensins显示文摘DICER1 is a key enzyme responsible for the maturation of microRNAs. Recent evidences suggested that DICER1 and microRNAs expressed in epididymis were involved in the control of male fertility. However, the exact mechanism remains to be elucidated. Here, we created a mouse line by targeted disruption of Dicerl gene in the principal cells of distal caput epididymis. Our data indicated that a set of β-defensin genes were downregulated by DICER1 rather than by microRNAs. Moreover, DICER1 was significantly enriched in the promoter of β-defensin gene and controlled transcription. Besides, the antibacterial ability of the adult epididymis significantly declined upon Dicerl deletion both in vitro and in vivo. And a higher incidence of reproductive defect was observed in middle-aged Dicerl^-|- males. These results suggest that DICER1 plays an important role in transcription of β-defensin genes, which are associated with the natural antibacterial properties in a microRNA-independent manner, and further impacts the male fertility. | Chunhua Tang Minjie Ni Shengsong Xie Yao Zhang Chaobao Zhang Zimei Ni Chen Chu Ligang Wu Yuchuan Zhou Yonglian Zhang | 2019 | Journal of Molecular Cell Biology2019，11，5： | 3 |
| 7 | Generalization of the linguistic aggregation operator and its application in decision making显示文摘A generalization of the linguistic aggregation functions (or operators) is presented by using generalized and quasiarithmetic means.Firstly,the linguistic weighted generalized mean (LWGM) and the linguistic generalized ordered weighted averaging (LGOWA) operator are introduced.These aggregation functions use linguistic information and generalized means in the weighted average (WA) and in the ordered weighted averaging (OWA) function.They are very useful for uncertain situations where the available information cannot be assessed with numerical values but it is possible to use linguistic assessments.These aggregation operators generalize a wide range of aggregation operators that use linguistic information such as the linguistic generalized mean (LGM),the linguistic OWA (LOWA) operator and the linguistic ordered weighted quadratic averaging (LOWQA) operator.We also introduce a further generalization by using quasi-arithmetic means instead of generalized means obtaining the quasi-LWA and the quasi-LOWA operator.Finally,we develop an application of the new approach where we analyze a decision making problem regarding the selection of strategies. | Jose M. Merigo Anna M. Gil-Lafuente Ligang Zhou Huayou Chen | 2011 | Journal of Systems Engineering and Electronics2011，22，4： | 3 |
| 8 | SUPPRESSION OF BENDING WAVES IN A PERIODIC BEAM WITH TIMOSHENKO BEAM THEORY显示文摘Active control of bending waves in a periodic beam by the Timoshenko beam theory is concerned. A discussion about the possible wave solutions for periodic beams and their control by forces is presented. Wave propagation in a periodic beam is studied. The transfer matrix between two consecutive unit cells is obtained based on the continuity conditions. Wave amplitudes are derived by employing the Bloch-Floquet theorem and the transfer matrix. The influences of the propagating constant on the wave amplitudes are considered. It is shown that vibrations are still needed to be suppressed in the pass-band regions. Wave-suppression strategy described in this paper is employed to eliminate the propagating disturbance of an infinite periodic beam. A minimum wave-suppression strategy is compared with the classical wave-suppression strategy. | Tao Chen Ligang Wang | 2013 | Acta Mechanica Solida Sinica2013，26，2： | 3 |
| 9 | Co_9S_8 nanowires@NiCo LDH nanosheets arrays on nickel foams towards efficient overall water splitting显示文摘Water electrolysis is considered to be an effective way to fabricate hydrogen, and it is desirable to find the highly efficient, inexpensive and good durability bifunctional electrocatalysts for overall water splitting.In this paper, we synthesis a unique structured catalyst that was composed by Co_9S_8 nanowires and nickel cobalt layered double hydroxide(NiCo-LDH) nanosheets. The ultrathin nanosheets decorated on the Co_9S_8 nanoarrays offer large specific surface area, numerous active edge sites and excellent electrical conductivity for fast electron transfer. Benefiting from this heterogeneous structure, the catalyst presents excellent catalytic performance in alkaline media. It requires 168 mV to reach current density of 10 mA/cm^2 for HER and 278 m V to reach current density of 30 mA/cm^2 for OER. When used as electrode in a homemade two-electrode system, it only needs t a voltage of 1.63 V to achieve current densities of 10 mA/cm^2, which proves Co_9S_8@NiCo LDH/NF as a superior bifunctional catalyst for water splitting. | Jingan Yan Ligang Chen Xin Liang | 2019 | Science Bulletin2019，64，3： | 3 |
| 10 | Selective Introduction of Carbazole and Diphenylamine into Spirofluorenexanthene Core for Different Phosphorescent Hosts显示文摘Built on the spiro[fluorene-9,9'-xanthene] (SFX) core and two frequently-used hole-transporting groups such ascarbazole and diphenylamine, two SFX derivatives, namely SFXCz and SFXDPA, have been synthesized byone-step reaction for red, green and blue phosphorescent organic light-emitting devices (PHOLEDs). Though theproperties of these two groups are very similar, the devices based on SFXCz and SFXDPA exhibit distinct perfor-mances. In blue PHOLEDs, the device based on SFXCz exhibited much better performances than that based onSFXDPA. However, the latter was superior to the former in green and red PHOLEDs. And the red PHOLED basedon SFXDPA exhibited maximum current efficiency (CE) of 27.1 cdoA^-l, power efficiency (PE) of 25.01m·W^-1, andexternal quantum efficiency (EQE) of 15.0%. The results show that the introduction of diphenylamine group issuitable for constructing green and red host materials, whereas the introduction of carbazole group is suitable forconstructing blue host materials. | Mingli Sun Shouzhen Yue Hongtao Cao Changjin Ou Yan Qian Ting Wang Ligang Chen Yi Zhao Wei Huang | 2016 | Chinese Journal of Chemistry2016，34，8： | 3 |
| 11 | Heavy Metal Pollution and Ecological Risk Assessment of Cultivated Land Soil in the Farming Areas of Coastal China:A Case Study of Donghai County,Jiangsu Province显示文摘Classical statistics,Inverse Distance Weighted and Hakasnson potential ecological index were used to study the distribution characteristics of 8 kinds of heavy metals( Cr,Ni,Cu,Zn,As,Cd,Pb and Hg) as well as their potential ecological risks in the topsoil( 0-20 cm) of cultivated land in Donghai County,a typical agricultural area along the Southeast Coast of China.The results showed that the average content of heavy metals in the cultivated soil of Donghai County was not over the risk screening values set in the Environmental Quality Standard for Soils.However,it was worth noting that in some of the sampling points,the content of Cr exceeded the risk screening value,and the standard exceeding points accounted for 24.74% of the total.In addition,the average content of Cr,Ni,As,Cd,Pb and Hg exceeded the soil background values of Jiangsu Province,and values for Cd,Cr and Pb were more than 1.5 times of the soil background value of Jiangsu Province.The heavy metals were at the medium integrated potential ecological risk level,and the potential ecological risk indices were high in the east and low in the west,and distributed in interlaced island shape.The potential ecological risk indices of the plains in the east were higher than those of the central gentle slope area and the western hillock area.The potential ecological risk was at a high level in Niushan Town which was situated the county center and in some regions with high urbanization levels. | Ligang LYU Xiaorui WANG Xueyan SUI Zhenyu LIU Yong YUAN Chen LIN | 2018 | Agricultural Biotechnology2018，7，6： | 2 |
| 12 | Determination of Chlorpyrifos in Rice Based on Magnetic Molecularly Imprinted Polymers Coupled with High-Performance Liquid Chromatography显示文摘 | Guifu Ma Ligang Chen | 2014 | Food Analytical Methods2014，，2： | 2 |
| 13 | ERF1 delays flowering through direct inhibition of FLOWERING LOCUS T expression in Arabidopsis显示文摘ETHYLENE RESPONSE FACTOR1(ERF1)is a key component in ethylene signaling,playing crucial roles in both biotic and abiotic stress responses.Here,we demonstrate that ERF1 also has an important role during floral initiation in Arabidopsis thaliana.Knockdown or knockout of ERF1 accelerated floral initiation,whereas overexpression of ERF1 dramatically delayed floral transition.These contrasting phenotypes were correlated with opposite transcript levels of FLOWERING LOCUS T(FT).Chromatin immunoprecipitation(ChIP)assays revealed that ERF1 associates with genomic regions of the FT gene to repress its transcription.ft-10/ERF1RNAi plants showed a similar flowering phenotype to the ft-10 mutant,whereas the flowering of FTox/ERF1ox mimicked that of FTox plants,suggesting that ERF1 acts upstream of FT during floral initiation.Similarly,altered floral transition in ethylene-related mutants was also correlated with FT expression.Further analysis suggested that ERF1 also participates in delay in flowering-time control mediated by the ethylene precursor 1-aminocyclopropane-1-carboxylic acid.Thus,ERF1 may act as a negative modulator of flowering-time control by repressing FT transcription in Arabidopsis. | Yanli Chen Liping Zhang Haiyan Zhang Ligang Chen Diqiu Yu | 2021 | Journal of Integrative Plant Biology2021，63，10： | 2 |
| 14 | The determination of organochlorine pesticides based on dynamic microwave-assisted extraction coupled with online solid-phase extraction of high-performance liquid chromatography显示文摘 | Ligang Chen Lan Ding Haiyan Jin | 2007 | Analytica Chimica Acta2007，589，： | 1 |
| 15 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 16 | Determination of fluoroquinolone antibiotics in environmental water samples based on magnetic molecularly imprinted polymer extraction followed by liquid chromatography- tandem mass spectrometry 显示文摘 | Ligang Chen Xiaopan Zhang ]fang Xu | 2010 | Analytica Chimiea Aeta2010，662，： | 1 |
| 17 | Determination of Pyrethroids in Environmental Waters Using Magnetic Chitosan Extraction Coupled with High Performance Liquid Chromatography Detection显示文摘 | Jia Tong Ligang Chen | 2013 | Analytical Letters2013，，8： | 1 |
| 18 | Phase lenses and mirrors created by laser micronanofabrication via two photon photopolymerization显示文摘 | Chen Qidai Wu Dong Niu Ligang | 2007 | Appl Phys Lett2007，91，17： | 1 |
| 19 | On-line coupling of solid-phase extraction to liquid chromatography: a review显示文摘 | CHEN Ligang WANG Hui ZENG Qinglei | 2009 | J Chromatogr Sci2009，47，8： | 1 |
| 20 | Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein显示文摘 | Guifang Chen Chien-Hung Liu Ligang Zhou Robert M. Krug | 2014 | Cell Host & Microbe2014，，： | 1 |
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