|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | A neural networks of carrot tip classification显示文摘 | Brandon J R Howarth M S Searcy S W | 1990 | Trans of the ASAE1990，，： | 1 |
| 3 | Accounting for the value of ecosystem services显示文摘 | Howarth R B Farber S | 2002 | Ecological Economics2002，41，3： | 1 |
| 4 | Effects on male rats of di-(2-ethylhexyl) phthalate and di-n-hexylphthalate administered alone or in combination显示文摘 | Howarth J A Price S C Dobrota M | 2001 | Toxicol Lett2001，121，1： | 1 |
| 5 | Correlation of carotid atheromatous plaque inflammation with biomechanical stress: utility of USPIO echanced MR imaging and finite element analy- sis显示文摘 | Tang T Y Howarth S P Li Z Y | 2008 | Atherosclerosis2008，196，2： | 1 |
| 6 | Accounting for the Value of Ecosystem Servic- es显示文摘 | Howarth R B Father S | 2002 | Ecol Econ2002，，41： | 1 |
| 7 | How critical is fibrous cap thickness to carotid plaque stability A flow-plaque interaction model显示文摘 | Li Z Y Howarth S P Tang T | 2006 | Stroke2006，37，10： | 1 |
| 8 | Texture analysis of delicious fruit: Towards multiple measurements on individual fruit显示文摘 | Ioannides Y Howarth M S Raithatha C | 2007 | Food Quality and Preference2007，18，6： | 1 |
| 9 | Eutrophication of freshwater and marine ecosystems 显示文摘 | SMITH V H JOYE S B HOWARTH R W | 2006 | Limnology and Oceanography2006，51，1： | 1 |
| 10 | Airway remodelling in asthma and novel therapy 显示文摘 | Manuyakorn W Howarth P H Holgate S T | 2013 | Asian Pac J Allergy Immunol2013，31，1： | 1 |
| 11 | Accounting for the value of ecosystem services 显示文摘 | Howarth R B Farber S | 2002 | Ecological Economics2002，41，3： | 1 |
| 12 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 13 | Relationships between dynamic response characteristics and physical descriptors of catchments in England and Wales显示文摘 | SEFTON C E M HOWARTH S M | 1998 | Journal of Hydrology1998，211，： | 1 |
| 14 | Effects of epidermal growth factor administration on repair of acetic acid-induced colonic ulcerations in rats显示文摘 | Ribbons K A Howarth G S Ford W D | 1997 | Growth Factors1997，14，23： | 1 |
| 15 | Management of major depression in the primary care setting显示文摘 | Mischoulon D McColl-Vuolo R Howarth S | 2001 | Psychother Psychosom2001，70，： | 1 |
| 16 | Effects of insulin-like growth factor-Ⅰ administration on radiation enteritis in rats显示文摘 | Howarth G S Fraser R Frisby C L e al | 1997 | Scand J Gastroenterol1997，32，11： | 1 |
| 17 | Eutrophication of freshwater andmarine ecosystems显示文摘 | Smith V H Joye S B Howarth R W | 2006 | Limnol Oceanogr2006，51，12： | 1 |
| 18 | Application of a generalized power transformation to geochemical data显示文摘 | Howarth R J Earle S | 1979 | Journal of the Internation Association for Mathematical Geology1979，11，1： | 1 |
| 19 | Estimation of tip shape for carrot classification by machine vision显示文摘 | Howarth M S Brandon J R Searcy S W | 1992 | Journal of Agricultural Engineering Research1992，53，： | 1 |
| 20 | A radio-sensitive primary osteosarcoma in the lung显示文摘 | Wajstaub S Bezjak A Howarth D | 2011 | Int J Clin Oncol2011，16，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员