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| 1 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 2 | Effect of dexamethasone on development of in vitro –produced bovine embryos显示文摘 | Priscila P.B. Santana Carla M.F. Carvalho Nathália N. da Costa Thiago V.G. Silva Priscilla C.A. Ramos Marcela S. Cordeiro Simone S.D. Santos André S. Khayat Otávio M. Ohashi Moysés S. Miranda | 2014 | Theriogenology2014，，： | 1 |
| 3 | Biostimulation of anaerobic BTEX biodegradation under fermentative methanogenic conditions at source-zone groundwater contaminated with a biodiesel blend (B20)显示文摘 | Débora Toledo Ramos Márcio Luis Busi Silva Helen Simone Chiaranda Pedro J. J. Alvarez Henry Xavier Corseuil | 2013 | Biodegradation2013，，3： | 1 |
| 4 | The Path to Information in the Public Domain: Offical Publications in Spain显示文摘 | Luis Fernando Ramos Simon Iuliana Botezan | 2010 | Government Information Quarterly2010，27，1： | 1 |
| 5 | Hypertonic Saline Solution Reduces Mesenteric Microcirculatory Dysfunctions and Bacterial Translocation in a Rat Model of Strangulated Small Bowel Obstruction显示文摘 | Fernando Luiz Zanoni José Walber Miranda Costa Cruz Joilson Oliveira Martins Simon Benabou Karin Vicente Greco Ana Carolina Ramos Moreno Marina Baquerizo Martinez Franco Ferraro Calderaro Mauricio Rocha e Silva Paulina Sannomiya | 2013 | Shock2013，，1： | 1 |
| 6 | Activation of matrix metalloproteinase-9 (MMP-9) via a converging plasmin/stromelysin-1 cascade enhances tumor cell invasion显示文摘 | Hahn Dantona E Sipley J | 1999 | J Biol Chem1999，274，13： | 1 |
| 7 | Interleukin 28B-related polymorphisms: A pathway for understanding hepatitis C virus infection?显示文摘AIM:To analyze the role of rs12979860 and rs8099917polymorphisms in hepatitis C virus(HCV)genotype 1infection of Brazilians.METHODS:A total of 145 adult patients diagnosed with genotype 1 chronic hepatitis C(CHC)who had completed a 48-wk regimen of pegylated-interferonα-2a or-2b plus ribavirin combination therapy were recruited from six large urban healthcare centers and199 healthy blood donors(controls)from a single site between January 2010 and January 2012.Data on the patients’response to treatment was collected.Polymerase chain reaction-restriction fragment length polymorphism genotyping of the interleukin(IL)28B gene fragment encompassing the single nucleotide polymorphisms(SNPs)rs12979860(C/T)and rs8099917(T/G)was carried out for 79 of the CHC patients and 199 of the controls.Bi-directional amplicon sequencing of the two SNPs was carried out for the remaining 66 CHC patients.RESULTS:SNP rs12979860 genotyping was successful in 99.5%of the controls and 97.2%of the CHC patients,whereas the SNP rs8099917 genotyping was successful in 95.5%of the controls and 100%of the CHC patients.The genotype and allele distributions for both rs12979860 and rs8099917 were significantly different between the control and CHC patient groups,with significantly higher genotype frequencies of CC and TT in the controls(P=0.037 and 0.046,respectively)and of TT and GG in the CHC patients(P=0.0009and 0.0001,respectively).Analysis of the CHC patients who achieved sustained virological response(SVR)to treatment(n=55)indicated that the rs12979860 C allele and CC genotype were predictors of SVR(P=0.02).No significant correlation was found between rs8099917 genotypes and treatment response,but carriers of the T allele showed significantly higher rates of SVR(P=0.02).Linkage disequilibrium analysis of the group that achieved SVR showed a significant association between rs12979860 and rs8099917(P=0.07).CONCLUSION:The higher allele frequency of rs12979860 C and rs8099917 T observed in non-HCVinfected individuals may indicate a potential protective role for these IL28B-related polymorphisms. | Raquel Francine Liermann Garcia Simone Moreira Ana Lucia de Araújo Ramos Leslie Ecker Ferreira Angelo Alves de Mattos Cristiane Valle Tovo Lysandro Alsina Nader Juliene Antonio Ramos Edson Rondinelli Arnaldo de Jesus Dominici Christian Evangelista Garcia Mauro de Souza Leite Pinho Carlos Eduardo Brando-Mello Cristiane Alves Villela-Nogueira Paulo Henrique Condeixa de Frana | 2013 | World Journal of Gastroenterology2013，19，42： | 0 |
| 8 | Motor Profile of Students With Dyslexia显示文摘 | Paola Matiko MartinsOkuda Fabiana Garcia Ramos Lara Cristina Antunes dos Santos Niura Aparecida de Moura Ribeiro Padula Amanda Kirby Simone Aparecida Capellini | 2014 | Psychology Research2014，4，1： | 0 |
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