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| 1 | Visceral hypersensitive rats share common dysbiosis features with irritable bowel syndrome patients显示文摘AIM: To evaluate gut microbial dysbiosis in two visceral hypersensitive models in comparison with irritable bowel syndrome(IBS) patients and to explore the extent to which these models capture the dysbiosis of IBS patients. METHODS: Visceral hypersensitivity was developed using the maternal separation(MS) rat model and post-inflammatory rat model. The visceral sensitivity of the model groups and control group was evaluated using the abdominal withdraw reflex score and electromyography in response to graded colorectal distention. The 16 S ribosomal RNA gene from fecal samples was pyrosequenced and analyzed. The correlation between dysbiosis in the microbiota and visceral hypersensitivity was calculated. Positive findings were compared to sequencing data from a published human IBS cohort.RESULTS: Dysbiosis triggered by neonatal maternal separation was lasting but not static. Both MS and postinflammatory rat fecal microbiota deviated from that of the control rats to an extent that was larger than the co-housing effect. Two short chain fatty acid producing genera, Fusobacterium and Clostridium XI, were shared by the human IBS cohort and by the maternal separation rats and post-inflammatory rats, respectively, to different extents. Fusobacterium was significantly increased in the MS group, and its abundance positively correlated with the degree of visceral hypersensitivity. Porphyromonadaceae was a protective biomarker for both the rat control group and healthy human controls. CONCLUSION: The dysbiosis MS rat model and the post-inflammatory rat model captured some of the dysbiosis features of IBS patients. Fusobacterium, Clostridium XI and Porphyromonadaceae were identified as targets for future mechanistic research. | Xiao-Yan Zhou Ming Li Xia Li Xin Long Xiu-Li Zuo Xiao-Hua Hou Ying-Zi Cong Yan-Qing Li | 2016 | World Journal of Gastroenterology2016，22，22： | 10 |
| 2 | 肠道生态营养对肿瘤治疗的影响显示文摘人体内存在大量微生物,主要分布在肠道内,构成肠道微生态(也称为肠道菌群、肠道微生物组)。肠道微生态中的细菌种类繁多、数量巨大。据推测,肠道内的细菌数量是人体细胞总数的10倍,达到1014个。肠道菌群中绝大多数(99%以上)与宿主细胞是共生关系,参与食物分解、防御反应、免疫调节和新陈代谢等重要生理过程。共生菌一般都是专性厌氧菌,主要包括双歧杆菌、乳酸菌和拟杆菌等。 | 黄岚 | 2015 | 肿瘤代谢与营养电子杂志2015，2，4： | 1 |
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