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您的检索式：作者名="Simon Hooper"
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| 1 | Clinical hematological and biochemical parameters in Swiss,BALB/c,C57BL/6 and B6D2F1 Mus musculus显示文摘Background:Animal models are widely used in scientific research in order to obtain information from a whole organism under a specific set of experimental conditions.Various lineages of mice have been used to investigate diseases and new therapeutic strategies,and,consequently,hematological and biochemical tests in these laboratory animals are essential to validate scientific studies.Our study seeks to establish reference values for hematological and biochemical parameters of four lineages of mice.Methods:We evaluated the hematological and biochemical profiles of 20 males and 20 females from the lineages Swiss(heterogeneous),BALB/c and C57BL/6(isogenic),and B6D2F1(hybrid),totaling 160 mice.Analysis were standardized using the systems pocH-100iV Diff™for 19 hematological parameters and VITROS®350 for 12 biochemical parameters.Results:Results are shown as means and standard deviation,grouped by lineage and genre.Comparing the values obtained in this study with the values from previous studies,some variations were detected,which could be explained by differences in methodologies or individual variability.Conclusion:Thus our study shows that knowledge and disclosure of the values of physiological parameters of laboratory animals is necessary,and emphasises the importance of considering variations influenced by gender,lineage and genotype in the choice of the best experimental model. | Giorgio Silva-Santana Juliet Cunha Bax Débora Cristina Silva Fernandes Daniela Tendler Leibel Bacellar Cleber Hooper Alexandre Alves Souza Oliveira Dias Cristina Barbosa Silva Aline Moreira de Souza Simone Ramos Ricardo Alexandre Santos Thainara Ramos Pinto Mariana Antunes Ramão Ana Luíza Mattos-Guaraldi | 2020 | Animal Models and Experimental Medicine2020，3，4： | 2 |
| 2 | 面向教学设计的教学方法新分类显示文摘依据问题的呈方式现、复杂性程度和来源,本文提出了面向教学设计的教学方法分类学。这一富有启发性的理论框架将教学方法分为五个层次:接受、运用、扩展、创见和质疑,从而有希望改变教学仅仅限于传递信息的状况,为培养高层次思维能力和问题解决能力服务。 | Brad Hokanson Simon Hooper 王耐 盛群力 | 2005 | 远程教育杂志2005，23，2： | 2 |
| 3 | Computer-assisted foreign language learning: Effects of text, context, and gender on listening comprehension and motivation显示文摘 | Solveig Jakobsdóttir Simon Hooper | 1995 | Educational Technology Research and Development1995，，4： | 1 |
| 4 | The GSK3 hypothesis of Alzheimer's disease显示文摘 | CLAUDIE HOOPER RICHARD KILLICK SIMON LOVESTONE | 2008 | J Neurochem2008，104，： | 1 |
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