|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The PI3K/AKT Pathway and Renal Cell Carcinoma显示文摘The phosphatidylinositol 3 kinase(PI3K)/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway,and thus is frequently activated as a cancer driver.More importantly,the PI3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades,providing many potential targets for cancer therapy.Renal cell carcinoma(RCC) is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies.The PI3K/AKT pathway is modestly mutated but highly activated in RCC,representing a promising drug target.Indeed,PI3 K pathway inhibitors of the rapalog family are approved for use in RCC.Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC,reiterating the critical role of the PI3K/AKT pathway in this cancer.In this review,we summarize the genetic alterations of the PI3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data,as well as treatments for RCC that target the aberrant activated PI3K/AKT pathway. | Huifang Guo Peter German Shanshan Bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch Gordon B.Mills Zhiyong Ding | 2015 | Journal of Genetics and Genomics2015，42，7： | 39 |
| 2 | Design,modeling and experimental investigation of a magnetically modulated rotational energy harvester for low frequency and irregular vibration显示文摘Vibration energy harvesting is a promising approach for sustainable energy generation from ambience to meet the development of self-powered systems.Here,we propose a novel compact non-resonant magnetically modulated rotational energy harvester(MMR-EH)for low frequency and irregular vibration.Through the rational arrangement of multiple magnetic fields in space,a ring route with low potential energy is established.A movable magnet can be non-contact modulated by the magnetic force to move along the ring route under irregular vibration,which is instrumental in electromechanical energy conversion.A dynamic model of the MMR-EH is developed based on the energy method and verified experimentally.The effects of key parameters on the magnetically modulated route are analysed.The simulation and experimental results demonstrate that the MMR-EH can effectively harvest the energy from ultra-low frequency(3 Hz)and irregular vibration.At a reciprocating vibration frequency of 10 Hz and an amplitude of 20 mm,the harvester can produce an average power of 0.29 mW. | ZHAO LinChuan ZOU HongXiang GAO QiuHua YAN Ge WU ZhiYuan LIU FengRui WEI KeXiang YANG Bin ZHANG WenMing | 2020 | Science China(Technological Sciences)2020，63，10： | 5 |
| 3 | High-average-power, high-repetition-rate tunable terahertz difference frequency generation with GaSe crystal pumped by 2 μm dual-wavelength intracavity KTP optical parametric oscillator显示文摘We have demonstrated a high-average-power,high-repetition-rate optical terahertz(THz)source based on difference frequency generation(DFG)in the GaSe crystal by using a near-degenerate 2μm intracavity KTP optical parametric oscillator as the pump source.The power of the 2μm dual-wavelength laser was up to 12.33 W with continuous tuning ranges of 1988.0–2196.2 nm/2278.4–2065.6 nm for two waves.Different GaSe cystal lengths have been experimentally investigated for the DFG THz source in order to optimize the THz output power,which was in good agreement with the theoretical analysis.Based on an 8 mm long GaSe crystal,the THz wave was continuously tuned from 0.21 to 3 THz.The maximum THz average power of 1.66μW was obtained at repetition rate of 10 kHz under 1.48 THz.The single pulse energy amounted to 166 pJ and the conversion efficiency from 2 μm laser to THz output was 1.68×10^(-6).The signal-to-noise ratio of the detected THz voltage was 23 dB.The acceptance angle of DFG in the GaSe crystal was measured to be 0.16°. | DEXIAN YAN YUYE WANG DEGANG XU PENGXIANG LIU CHAO YAN JIA SHI HONGXIANG LIU YIXIN HE LONGHUANG TANG JIANCHEN FENG JIANQIN GUO WEI SHI KAI ZHONG YUEN H.TSANG JIANQUAN YAO | 2017 | Photonics Research2017，5，2： | 5 |
| 4 | Materials Experiment on Tiangong-2 Space Laboratory显示文摘During the China's Tiangong-2(TG-2) flight mission, the experiments of 18 kinds of material samples were conducted in space by using a Multiple Materials Processing Furnace(MMPF) mounted in the orbital module of the TG-2 space laboratory. After the experiments of 12 kinds of samples of the first and second batches were completed successfully, astronauts packed and brought them back to the ground by ShenzhouII spacecraft. By studying processing and formation on semiconductor and optoelectronics materials, metal alloys and metastable materials, functional single-crystal, micro-and nano-composite materials encapsulated in sample ampoules both in space and on Earth, we expect to explore some physical and chemical processes and mechanism of the materials formation that are normally obscured and therefore are difficult to study quantitatively on the ground due to the gravity-induced convection, to obtain the processing and synthesis technology for preparing high quality materials, and lead to the improvement and development of materials processing techniques on Earth, and also develop the experiment device and comprehensive ability for materials experiment in microgravity environment. This report briefly introduces the main points of each research work and preliminary comparative analysis results of 12 samples carried out by scientists undertaking research task. | LI Xiangyang LU Ye MENG Xiangjian WANG Jianlu WANG Reng CHEN Lidong HUA Zile LI Xiaoya SHI Jianlin LIU Jinfeng XU Guisheng WEI Bingbo XIE Wenjun YIN Zhigang ZHANG Xingwang JIANG Hongxiang LI Hong LUO Xinghong ZHANG Haifeng ZHAO Jiuzhou WANG Binbin PAN Mingxiang | 2018 | 空间科学学报2018，38，5： | 4 |
| 5 | Why 90%of clinical drug development fails and how to improve it?显示文摘Ninety percent of clinical drug development fails despite implementation of many successful strategies,which raised the question whether certain aspects in target validation and drug optimization are overlooked?Current drug optimization overly emphasizes potency/specificity using structure-activityrelationship(SAR)but overlooks tissue exposure/selectivity in disease/normal tissues using structure-tissue exposure/selectivity—relationship(STR),which may mislead the drug candidate selection and impact the balance of clinical dose/efficacy/toxicity.We propose structure-tissue exposure/selectivity—activity relationship(STAR)to improve drug optimization,which classifies drug candidates based on drug’s potency/selectivity,tissue exposure/selectivity,and required dose for balancing clinical efficacy/toxicity.ClassⅠdrugs have high specificity/potency and high tissue exposure/selectivity,which needs low dose to achieve superior clinical efficacy/safety with high success rate.ClassⅡdrugs have high specificity/potency and low tissue exposure/selectivity,which requires high dose to achieve clinical efficacy with high toxicity and needs to be cautiously evaluated.ClassⅢdrugs have relatively low(adequate)specificity/potency but high tissue exposure/selectivity,which requires low dose to achieve clinical efficacy with manageable toxicity but are often overlooked.ClassⅣdrugs have low specificity/potency and low tissue exposure/selectivity,which achieves inadequate efficacy/safety,and should be terminated early.STAR may improve drug optimization and clinical studies for the success of clinical drug development. | Duxin Sun Wei Gao Hongxiang Hu Simon Zhou | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 3 |
| 6 | WATER CONSERVATION CONSTRUCTION AND OPERATION MANAGEMENT TECHNOLOGY SYSTEM FOR GREEN CAMPUS显示文摘 | HongXiang Chai YingHua Wei HaiYan Xu Qiang He | | 0，，07： | 1 |
| 7 | Tribological behaviors and mechanisms of Ti 3 AlC 2显示文摘 | Zhenying Huang Hongxiang Zhai Wei Zhou Xin Liu Mingxing Ai | 2007 | Tribology Letters2007，，： | 1 |
| 8 | Water conserva- tion: construction and operation of management and technology systems for green campus 显示文摘 | Chai HongXiang Wei YingHua Xu HaiYan | 2011 | Environmental Engineering and Management Journal2011，10，7： | 1 |
| 9 | Air-stable ambipolar field-effect transistors based on copper phthalocyanine and tetracyanoquinodimethane显示文摘 | Liqiang Li Hongxiang Li Yabin Song Wei Xu Wenping Hu Daoben Zhu | 2008 | Research on Chemical Intermediates2008，，2： | 1 |
| 10 | Impact toughness of a gradient hardened layer of Cr5Mo1V steel treated by laser shock peening显示文摘Laser shock peening(LSP) is a widely used surface treatment technique that can effectively improve the fatigue life and impact toughness of metal parts.Cr5Mo1 V steel exhibits a gradient hardened layer after a LSP process.A new method is proposed to estimate the impact toughness that considers the changing mechanical properties in the gradient hardened layer.Assuming a linearly gradient distribution of impact toughness,the parameters controlling the impact toughness of the gradient hardened layer were given.The influence of laser power densities and the number of laser shots on the impact toughness were investigated.The impact toughness of the laser peened layer improves compared with an untreated specimen,and the impact toughness increases with the laser power densities and decreases with the number of laser shots.Through the fracture morphology analysis by a scanning electron microscope,we established that the Cr5Mo1 V steel was fractured by the cleavage fracture mechanism combined with a few dimples.The increase in the impact toughness of the material after LSP is observed because of the decreased dimension and increased fraction of the cleavage fracture in the gradient hardened layer. | Weiguang Xia Lei Li Yanpeng Wei Aimin Zhao Yacong Guo Chenguang Huang Hongxiang Yin Lingchen Zhang | 2016 | Acta Mechanica Sinica2016，32，2： | 1 |
| 11 | Manipulations of micro/nanoparticles using gigahertz acoustic streaming tweezers显示文摘Contactless acoustic manipulation of micro/nanoscale particles has attracted considerable attention owing to its near independence of the physical and chemical properties of the targets,making it universally applicable to almost all biological systems.Thin-film bulk acoustic wave(BAW)resonators operating at gigahertz(GHz)frequencies have been demonstrated to generate localized high-speed microvortices through acoustic streaming effects.Benefitting from the strong drag forces of the high-speed vortices,BAW-enabled GHz acoustic streaming tweezers(AST)have been applied to the trapping and enrichment of particles ranging in size from micrometers to less than 100 nm.However,the behavior of particles in such 3D microvortex systems is still largely unknown.In this work,the particle behavior(trapping,enrichment,and separation)in GHz AST is studied by theoretical analyses,3D simulations,and microparticle tracking experiments.It is found that the particle motion in the vortices is determined mainly by the balance between the acoustic streaming drag force and the acoustic radiation force.This work can provide basic design principles for AST-based lab-on-a-chip systems for a variety of applications. | Hang Wu Zifan Tang Rui You Shuting Pan Wenpeng Liu Hongxiang Zhang Tiechuan Li Yang Yang Chongling Sun Wei Pang Xuexin Duan | 2022 | Nanotechnology and Precision Engineering2022，5，2： | 1 |
| 12 | Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury显示文摘 | Xu Jing Dongmei Ren Xinbing Wei Huanying Shi Xiumei Zhang Ruth G. Perez Haiyan Lou Hongxiang Lou | 2013 | Toxicology and Applied Pharmacology2013，，3： | 1 |
| 13 | Removal of strontium(II) ions by potassium tetratitanate whisker and sodium trititanate whisker from aqueous solution: Equilibrium, kinetics and thermodynamics显示文摘 | Wei Guan Jianming Pan Hongxiang Ou Xue Wang Xiaohua Zou Wei Hu Chunxiang Li Xiangyang Wu | 2010 | Chemical Engineering Journal2010，，1： | 1 |
| 14 | Structure-tissue exposure/selectivity relationship(STR) correlates with clinical efficacy/safety显示文摘Drug optimization, which improves drug potency/specificity by structure-activity relationship(SAR) and drug-like properties, is rigorously performed to select drug candidates for clinical trials. However,the current drug optimization may overlook the structure-tissue exposure/selectivity-relationship(STR) in disease-targeted tissues vs. normal tissues, which may mislead the drug candidate selection and impact the balance of clinical efficacy/toxicity. In this study, we investigated the STR in correlation with observed clinical efficacy/toxicity using seven selective estrogen receptor modulators(SERMs) that have similar structures, same molecular target, and similar/different pharmacokinetics. The results showed that drug’s plasma exposure was not correlated with drug’s exposures in the target tissues(tumor, fat pad, bone, uterus),while tissue exposure/selectivity of SERMs was correlated with clinical efficacy/safety. Slight structure modifications of four SERMs did not change drug’s plasma exposure but altered drug’s tissue exposure/selectivity.Seven SERMs with high protein binding showed higher accumulation in tumors compared to surrounding normal tissues, which is likely due to tumor EPR effect of protein-bound drugs. These suggest that STR alters drug’s tissue exposure/selectivity in disease-targeted tissues vs. normal tissues impacting clinical efficacy/toxicity. Drug optimization needs to balance the SAR and STR in selecting drug candidate for clinical trial to improve success of clinical drug development. | Wei Gao Hongxiang Hu Lipeng Dai Miao He Hebao Yuan Huixia Zhang Jinhui Liao Bo Wen Yan Li Maria Palmisano Mohamed Dit Mady Traore Simon Zhou Duxin Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 15 | Removal of strontium(Ⅱ) ions by potassium tetratitanate whisker and sodium trititanate whisker from aqueous solution:equilibrium,kinetics and thermodynamics显示文摘 | Guan Wei Pan Jianming Ou Hongxiang | | 0，，01： | 1 |
| 16 | Stattic sensitizes osteosarcoma cells to epidermal growth factor receptor inhibitors via blocking the interleukin 6-induced STAT3 pathway显示文摘Osteosarcoma(OS),the most common malignant bone tumor with high metastatic potential,frequently affects children and adolescents.Epidermal growth factor receptor(EGFR)-targeted tyrosine kinase inhibitors exhibit encouraging anti-tumor activity for patients with solid tumors,whereas their effects on OS remain controversial.In the present study,we aimed to elucidate the anti-tumor activity of gefitinib for OS,as well as to explore the underlying mechanisms.Gefitinib inhibits cell viability,tumor growth,cell migration,and invasion and promotes cell apoptosis and G1 cycle arrest in OS at a relatively high concentration via suppressing the PI3K/Akt and ERK pathways.However,gefitinib treatment results in the feedback activation of signal transducer and activator of transcription 3(STAT3)induced by interleukin 6(IL-6)secretion.Combined treatment with gefitinib and stattic,an inhibitor for STAT3 phosphorylation,engenders more evident inhibitory effects on cell proliferation,migration,and invasion and promotive effects on cell apoptosis and G1 phase arrest in OS,compared with the single exposure to gefitinib or stattic.Western blot analysis demonstrates that stattic treatment in gefitinib-treated OS abrogates the IL-6-induced STAT3 activation and subsequently further restrains the activities of EGFR,Akt,and ERK pathways in tumor cells.This study confirms that the EGFR inhibitor of gefitinib has moderate anti-tumor effects on OS through IL-6 secretion-mediated STAT3 activation.Additional administration of stattic in EGFR-targeted therapies may contribute to improve the efficacy for OS. | Shenglin Wang Yunqing Wang Zhen Huang Hongxiang Wei Xinwen Wang Rongkai Shen Wenbin Lan Guangxian Zhong Jianhua Lin | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 1 |
| 17 | All-fiber generation of arbitrary cylindrical vector beams on the first-order Poincare sphere显示文摘We propose a linear mapping relationship between the polarization of the fundamental mode and the cylindrical vector(CV)modes on the first-order Poincaresphere(FOPS)in fiber.The new method is based on the fourdimensional complex Jones matrices in terms of the linearly polarized mode bases.With our theoretical model,an all-fiber approach to generate arbitrary CV beams on the FOPS is proposed theoretically and verified experimentally.In the experiment,through the combination of a mode converter and a two-segment cascaded few-mode fiber with fixed stresses,it is possible to generate all CV modes on the FOPS by only adjusting the polarization of the fundamental mode.The Stokes parameters of the output light are measured to verify our scheme,which shows good agreement with the theoretical prediction.The method may provide a convenient way to generate CV beams and evolve the polarization states in any path on the FOPS,which is expected to have potential applications in encoding information and quantum computation. | LIPENG FENG YAN LI SIHAN WU XUN GUAN CHEN YANG WEIJUN TONG WEI LI JIFANG QIU XIAOBIN HONG YONG ZUO HONGXIANG GUO ERHU CHEN JIAN WU | 2020 | Photonics Research2020，8，8： | 1 |
| 18 | Enhanced galloping energy harvester with cooperative mode of vibration and collision显示文摘The low power and narrow speed range remain bottlenecks that constrain the application of small-scale wind energy harvesting.This paper proposes a simple,lowcost,and reliable method to address these critical issues.A galloping energy harvester with the cooperative mode of vibration and collision(GEH-VC)is presented.A pair of curved boundaries attached with functional materials are introduced,which not only improve the performance of the vibration energy harvesting system,but also convert more mechanical energy into electrical energy during collision.The beam deforms and the piezoelectric energy harvester(PEH)generates electricity during the flow-induced vibration.In addition,the beam contacts and separates from the boundaries,and the triboelectric nanogenerator(TENG)generates electricity during the collision.In order to reduce the influence of the boundaries on the aerodynamic performance and the feasibility of increasing the working area of the TENG,a vertical structure is designed.When the wind speed is high,the curved boundaries maintain a stable amplitude of the vibration system and increase the frequency of the vibration system,thereby avoiding damage to the piezoelectric sheet and improving the electromechanical conversion efficiency,and the TENG works with the PEH to generate electricity.Since the boundaries can protect the PEH at high wind speeds,its stiffness can be designed to be low to start working at low wind speeds.The electromechanical coupling dynamic model is established according to the GEH-VC operating principle and is verified experimentally.The results show that the GEH-VC has a wide range of operating wind speeds,and the average power can be increased by 180%compared with the traditional galloping PEH.The GEH-VC prototype is demonstrated to power a commercial temperature sensor.This study provides a novel perspective on the design of hybrid electromechanical conversion mechanisms,that is,to combine and collaborate based on their respective characteristics. | Qiong WANG Zewen CHEN Linchuan ZHAO Meng LI Hongxiang ZOU Kexiang WEI Xizheng ZHANG Wenming ZHANG | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，7： | 0 |
| 19 | 走向我们的小康生活显示文摘Deji Tibetan Family Relocation Area for Poverty Alleviation and Resettlement in Pomona Village,Doilungdeqen District,Lhasa City,Tibet Autonomous Region Photo. | He Guanxin Hu Huhu Wei Shunjiang Chao Yiming Yang Wenbin Yang Ying Liang Zhiqiang Mou Quan Fan Peikun Wu Gang Zhang Hongxiang Chen Bin Zeng Xianghui Jiang Hongjing | 2020 | China's Ethnic Groups2020，，3： | 0 |
| 20 | Suppressing the lattice oxygen diffusion via high-entropy oxide construction towards stabilized acidic water oxidation显示文摘The scale-up deployment of ruthenium(Ru)-based oxygen evolution reaction(OER)electrocatalysts in proton exchange membrane water electrolysis(PEMWE)is greatly restricted by the poor stability.As the lattice-oxygen-mediated mechanism(LOM)has been identified as the major contributor to the fast performance degradation,impeding lattice oxygen diffusion to inhibit lattice oxygen participation is imperative,yet remains challenging due to the lack of efficient approaches.Herein,we strategically regulate the bonding nature of Ru–O towards suppressed LOM via Ru-based high-entropy oxide(HEO)construction.The lattice disorder in HEOs is believed to increase migration energy barrier of lattice oxygen.As a result,the screened Ti_(23)Nb_(9)Hf_(13)W_(12)Ru_(43)O_(x) exhibits 11.7 times slower lattice oxygen diffusion rate,84%reduction in LOM ratio,and 29 times lifespan extension compared with the state-of-the-art RuO_(2) catalyst.Our work opens up a feasible avenue to constructing stabilized Ru-based OER catalysts towards scalable application. | Jing Ni Zhaoping Shi Yibo Wang Jiahao Yang Hongxiang Wu Pengbo Wang Kai Li Meiling Xiao Changpeng Liu Wei Xing | 2024 | Nano Research2024，17，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员