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| 1 | MiR-122-5p suppresses the proliferation, migration, and invasion of gastric cancer cells by targeting LYN显示文摘Gastric cancer(GC)is one of malignant tumors with high mortality and morbidity in the world.MicroRNA-122(miR-122)acts as a tumor suppressor in a variety of cancers and has been found to be dominant in gastric adenocarcinoma.However,the specific biological function of miR-122-5p in GC is not completely clear.In this study,we found that miR-122-5p was low-expressed in GC tissues and cell lines by using qRT-PCR.Overexpression of miR-122-5p inhibited the proliferation,migration,and invasion of GC cells by using CCK-8 and transwell assays.On the contrary,downregulation of miR-122-5p promoted the proliferation,migration,and invasion of GC cells.In addition,we found that the expression of LYN,an Src family tyrosine kinase,was inversely correlated with miR-122-5p expression in GC tissues by using western blot analysis,immunohistochemistry,and qRT-PCR assays.Meanwhile,luciferase assay results indicated that LYN is a direct target of miR-122-5p in GC cells.Moreover,silencing LYN expression by its siRNA inhibited the proliferation,migration,and invasion of GC cells.Importantly,overexpression of LYN restored miR-122-5p-mediated inhibition of the proliferation,migration,and invasion of GC cells.Taken together,our results indicated miR-122-5p inhibited the proliferation,migration,and invasion by targeting LYN in GC. | Lei Meng Zhangming Chen Zhe Jiang Ting Huang Jie Hu Panquan Luo Hongli Zhang Mengqi Huang Lei Huang Yu Chen Ming Lu A-man Xu Songcheng Ying | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 12 |
| 2 | Do vehicular emissions dominate the source of C6–C8 aromatics in the megacity Shanghai of eastern China?显示文摘The characteristic ratios of volatile organic compounds(VOCs) to i-pentane, the indicator of vehicular emissions, were employed to apportion the vehicular and non-vehicular contributions to reactive species in urban Shanghai. Two kinds of tunnel experiments, one tunnel with more than 90% light duty gasoline vehicles and the other with more than 60% light duty diesel vehicles, were carried out to study the characteristic ratios of vehicle-related emissions from December 2009 to January 2010. Based on the experiments, the characteristic ratios of C6–C8aromatics to i-pentane of vehicular emissions were 0.53 ± 0.08(benzene), 0.70 ± 0.12(toluene),0.41 ± 0.09(m,p-xylenes), 0.16 ± 0.04(o-xylene), 0.023 ± 0.011(styrene), and 0.15 ± 0.02(ethylbenzene), respectively. The source apportionment results showed that around 23.3% of C6–C8 aromatics in urban Shanghai were from vehicular emissions, which meant that the non-vehicular emissions had more importance. These findings suggested that emission control of non-vehicular sources, i.e. industrial emissions, should also receive attention in addition to the control of vehicle-related emissions in Shanghai. The chemical removal of VOCs during the transport from emissions to the receptor site had a large impact on the apportionment results. Generally, the overestimation of vehicular contributions would occur when the VOC reaction rate constant with OH radicals(k OH) was larger than that of the vehicular indicator, while for species with smaller k OH than the vehicular indicator, the vehicular contribution would be underestimated by the method of characteristic ratios. | Hongli Wang Qian Wang Jianmin Chen Changhong Chen Cheng Huang Liping Qiao Shengrong Lou Jun Lu | 2015 | Journal of Environmental Sciences2015，27，1： | 7 |
| 3 | Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling显示文摘室的肥大是心血管的疾病的事件的一个强大、独立的预言者。低剂量的乙酰水杨酸酸(阿司匹林) 的脉管的性质通过血小板 cyclooxygenase 的不可逆的抑制提供心血管的好处 1;然而,可能的 anti-hypertrophic 性质和阿司匹林的潜在的机制没详细被调查。在这研究,健康野类型的雄的老鼠随机被划分成三个组并且使遭到了到横向的大动脉的收缩(TAC ) 或假冒的操作。操作 TAC 的老鼠与低剂量的阿司匹林的人的等价物被对待(10 mg 吗? | Samuel Chege Gitau Xuelian Li Dandan Zhao Zhenfeng Guo Haihai Liang Ming Qian Lifang Lv Tianshi Li Bozhi Xu Zhiguo Wang Yong Zhang Chaoqian Xu Yanjie Lu Zhiming Du Hongli Shan Baofeng Yang | 2015 | Frontiers of Medicine2015，9，4： | 6 |
| 4 | Predictive functional control based on fuzzy T-S model for HVAC systems temperature control显示文摘In heating,ventilating and air-conditioning(HVAC)systems,there exist severe nonlinearity,time-varying nature,disturbances and uncertainties.A new predictive functional control based on Takagi-Sugeno(T-S)fuzzy model was proposed to control HVAC systems.The T-S fuzzy model of stabilized controlled process was obtained using the least squares method,then on the basis of global linear predictive model from T-S fuzzy model,the process was controlled by the predictive functional controller.Especially the feedback regulation part was developed to compensate uncertainties of fuzzy predictive model.Finally simulation test results in HVAC systems control applications showed that the proposed fuzzy model predictive functional control improves tracking effect and robustness.Compared with the conventional PID controller,this control strategy has the advantages of less overshoot and shorter setting time,etc. | Hongli LU Lei JIA Shulan KONG Zhaosheng ZHANG | 2007 | 控制理论与应用(英文版)2007，5，1： | 6 |
| 5 | HOSVD-based LPV modeling and mixed robust H_2/H_∞ control design for air-breathing hypersonic vehicle显示文摘This paper focuses on synthesizing a mixed robust H_2/H_∞ linear parameter varying(LPV) controller for the longitudinal motion of an air-breathing hypersonic vehicle via a high order singular value decomposition(HOSVD) approach.The design of hypersonic flight control systems is highly challenging due to the enormous complexity of the vehicle dynamics and the presence of significant uncertainties.Motivated by recent results on both LPV control and tensor-product(TP) model transformation approach,the velocity and altitude tracking control problems for the air-breathing hypersonic vehicle is reduced to that of a state feedback stabilizing controller design for a polytopic LPV system with guaranteed performances.The controller implementation is converted into a convex optimization problem with parameterdependent linear matrix inequalities(LMIs) constraints,which is intuitively tractable using LMI control toolbox.Finally,numerical simulation results demonstrate the effectiveness of the proposed approach. | Wei Jiang Hongli Wang Jinghui Lu Zheng Xie | 2016 | Journal of Systems Engineering and Electronics2016，27，1： | 5 |
| 6 | AlphaLISA detection of alpha-synuclein in the cerebrospinal fluid and its potential application in Parkinson's disease diagnosis显示文摘 | Zhao, Hongli Zhao, Jue Hou, Jiapeng Wang, Siqing Ding, Yu Lu, Boxun Wang, Jian | 2017 | Protein & Cell2017，8，9： | 2 |
| 7 | Unexpected fast radical production emerges in cool seasons:implications for ozone pollution control显示文摘Ozone is a crucial air pollutant that damages human health and vegetation.As it is related to the photo-oxidation of the nitrogen oxides and volatile organic compounds,the summertime reduction of these precursors is the primary focus of current ozone mitigation strategies.During ozone pollution episodes in eastern China,an observed accumulation of daily total oxidants(O_(x)=NO_(2)+O_(3))in cool seasons(spring and autumn:60 ppb and winter 40 ppb)is comparable to that in summer(60 ppb),indicating fast photochemical production of secondary pollutants including ozone over the year.Unrecognized fast radical primary productions are found to counteract the increased termination of hydroxyl radical and unfavorable meteorological conditions to maintain the rapid total oxidant formations in cool seasons.Elucidating and regulating the primary radical sources may be critical for the secondary air pollution control in cool seasons. | Hongli Wang Yanhui Liu Xiaorui Chen Yaqin Gao Wanyi Qiu Shengao Jing Qian Wang Shengrong Lou Peter MEdwards Cheng Huang Keding Lu | 2022 | National Science Open2022，1，2： | 2 |
| 8 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 9 | Circulating microRNA-1 as a potential novel biomarker for acute myocardial infarction显示文摘 | Jing Ai Rong Zhang Yue Li Jielin Pu Yanjie Lu Jundong Jiao Kang Li Bo Yu Zhuqin Li Rongrong Wang Lihong Wang Qiang Li Ning Wang Hongli Shan Zhongyu Li Baofeng Yang | 2009 | Biochemical and Biophysical Research Communications2009，，： | 2 |
| 10 | Construction and biological characterisation of recombinant porcine circovirus type 2 expressing the V5 epitope tag显示文摘 | Liping Huang Yuehua Lu Yanwu Wei Longjun Guo Hongli Wu Feiyan Zhang Yujie Fu Changming Liu | 2011 | Virus Research2011，，2： | 2 |
| 11 | MicroRNA-101 Inhibited Postinfarct Cardiac Fibrosis and Improved Left Ventricular Compliance via the FBJ Osteosarcoma Oncogene/Transforming Growth Factor-β1 Pathway显示文摘 | Zhenwei Pan Xuelin Sun Hongli Shan Ning Wang Jinghao Wang Jinshuai Ren Shuya Feng Liangjun Xie Chunying Lu Ye Yuan Yang Zhang Ying Wang Yanjie Lu Baofeng Yang | 2012 | Circulation2012，，7： | 2 |
| 12 | Cocoon Silk-Derived, Hierarchically Porous Carbon as Anode for Highly Robust Potassium-Ion Hybrid Capacitors显示文摘Potassium-ion hybrid capacitors(KIHCs) have attracted increasing research interest because of the virtues of potassium-ion batteries and supercapacitors.The development of KIHCs is subject to the investigation of applicable K+storage materials which are able to accommodate the relatively large size and high activity of potassium.Here,we report a cocoon silk chemistry strategy to synthesize a hierarchically porous nitrogen-doped carbon(SHPNC).The as-prepared SHPNC with high surface area and rich N-doping not only offers highly efficient channels for the fast transport of electrons and K ions during cycling,but also provides sufficient void space to relieve volume expansion of electrode and improves its stability.Therefore,KIHCs with SHPNC anode and activated carbon cathode afford high energy of 135 Wh kg-1(calculated based on the total mass of anode and cathode),long lifespan,and ultrafast charge/slow discharge performance.This study defines that the KIHCs show great application prospect in the field of high-performance energy storage devices. | Haiyan Luo Maoxin Chen Jinhui Cao Meng Zhang Shan Tan Lei Wang Jiang Zhong Hongli Deng Jian Zhu Bingan Lu | 2020 | Nano-Micro Letters2020，12，9： | 2 |
| 13 | N/S co-doped carbon nanosheet bundles as high-capacity anode for potassium-ion battery显示文摘Potassium-ion batteries(PIBs)are of academic and economic significance,but still limited by the lack of highly active electrode materials for de-/intercalation of large-radius K ions.Herein,an interconnected nitrogen/sulfur co-doped carbon nanosheep bundle(N/S-CSB)was proposed as the potassium ions storage material.The rich co-doping of nitrogen/sulfur of N/S-CNB with three-dimensional hierarchical bundled array structure yields distensible interlayer spaces to buffer the volume expansion during K+insertion/extraction,offers more electrochemical active sites to obtain a high specific capacity,and provides efficient channels for fast ion/electron transports.Therefore,the N/S-CSB anode achieved high reversible specific capacity of 365 mAh/g obtained at 50 mA/g after 200 cycles with a coulombic efficiency(CE)close to 100%,high rate performance and long cycle stability.Moreover,the in-situ Raman spectra indicated outstanding reaction kinetics of as-prepared N/S-CSB anode. | Jinhui Cao Jiang Zhong Hanjiao Xu Shengyang Li Hongli Deng Tao Wang Ling Fan Xinghui Wang Lei Wang Jian Zhu Bingan Lu Xidong Duan | 2022 | Nano Research2022，15，3： | 1 |
| 14 | A variational successive corrections approach for the sea ice concentration analysis显示文摘The sea ice concentration observation from satellite remote sensing includes the spatial multi-scale information.However,traditional data assimilation methods cannot better extract the valuable information due to the complicated variability of the sea ice concentration in the marginal ice zone.A successive corrections analysis using variational optimization method,called spatial multi-scale recursive filter(SMRF),has been designed in this paper to extract multi-scale information resolved by sea ice observations.It is a combination of successive correction methods(SCM)and minimization algorithms,in which various observational scales,from longer to shorter wavelengths,can be extracted successively.As a variational objective analysis scheme,it gains the advantage over the conventional approaches that analyze all scales resolved by observations at one time,and also,the specification of parameters is more convenient.Results of single-observation experiment demonstrate that the SMRF scheme possesses a good ability in propagating observational signals.Further,it shows a superior performance in extracting multi-scale information in a two-dimensional sea ice concentration(SIC)experiment with the real observations from Special Sensor Microwave/Imager SIC(SSMI). | Xuefeng Zhang Lu Yang Hongli Fu Dong Li Zheqi Shen Lianxin Zhang Xuhui Hu | 2020 | Acta Oceanologica Sinica2020，39，9： | 1 |
| 15 | Vertical Profiles of Volatile Organic Compounds in Suburban Shanghai显示文摘As Volatile Organic Compounds(VOCs)are one of the precursors of ozone,their distribution and variable concentrations are highly related to local ozone pollution control.In this study,we obtained vertical profiles of VOCs in Shanghai’s Jinshan district on 8 September and 9 September in 2016 to investigate their distribution and impact on local atmospheric oxidation in the near surface layer.Vertical samples were collected from heights between 50 m and 400 m by summa canisters using an unmanned aerial vehicle(UAV).Concentrations of VOCs(VOCs refers to the 52 species measured in this study)varied minimally below 200 m,and decreased by 21.2%from 100 m to 400 m.The concentrations of VOCs above 200 m decreased significantly in comparison to those below 200 m.The proportions of alkanes and aromatics increased from 55.2%and 30.5%to 57.3%and 33.0%,respectively.Additionally,the proportion of alkenes decreased from 13.2%to 8.4%.Toluene and m/p-xylene were the key species in the formation of SOA and ozone.Principal component analysis(PCA)revealed that the VOCs measured in this study mainly originated from industrial emissions. | Yuhan LIU Hongli WANG Shengao JING Ming ZHOU Shenrong LOU Kun QU Wanyi QIU Qian WANG Shule LI Yaqin GAO Yusi LIU Xiaobing LI Zhong-Ren PENG Junhui CHEN Keding LU | 2021 | Advances in Atmospheric Sciences2021，38，7： | 1 |
| 16 | Parallel induction of cell proliferation and inhibition of cell differentiationin hepatic progenitor cells by hepatitis B virus X gene显示文摘 | Jiayi Huang Lihong Shen Yongliang Lu Hongli Li Xifeng Zhang Daixi Hu Tao Feng Fangzhou Song | 2012 | International Journal of Molecular Medicine2012，，4： | 1 |
| 17 | Semen Analysis and Fecundity Association Among Women with Polycystic Ovary Syndrome Experiencing Ovulatory Dysfunction Treated by Ovulation Induction显示文摘In this study,normal values of semen analysis were set for a general infertile population of couples among which most women had normal ovulation.The predictive capacity values of sperm quality,including concentration,motile count,progressive motile count,and morphology,are unclear for women with polycystic ovary syndrome(PCOS).A secondary analysis was conducted based on a randomized controlled trial investigating infertility among women with PCOS experiencing ovulatory disorder between 2011 and 2016 in China.A total of 1000 women received ovulation induction(acupuncture and clomiphene).We randomized the women with PCOS in 27 hospitals in China who received one of four interventions(acupuncture plus clomiphene,sham acupuncture plus clomiphene,acupuncture plus placebo,or sham acupuncture plus placebo).Semen analysis was performed for every male partner according to the World Health Organization(WHO)criteria.The outcomes included conception,clinical pregnancy,and live birth.Logistic regression was used to evaluate the predictive value of semen analysis among ovulatory women for conception,clinical pregnancy,and live birth.Among the 1000 couples,the number of couples who attained ovulation,conception,clinical pregnancy,and live birth were 780,320,235,and 205,respectively.Semen volume and motility were applied and used as prediction parameters for conception(area under the curve(AUC)of 0.62(95%confidence interval(CI),0.55–0.69)),clinical pregnancy(AUC of 0.67(95%CI:0.61–0.73)),and live birth(AUC of 0.57(95%CI:0.50–0.64)).No poor calibration was shown for these models in Hosmer–Lemeshow tests.The predictive capacity of semen analysis for treatment outcome in PCOS women with PCOS experiencing with ovulatory dysfunction is limited. | Jingshu Gao Yu Wang Mubai Li Mengyi Zhu Xuekui Liu Hongli Ma Yijuan Cao Lu Li Xinming Yang Xiaoke Wu | 2021 | Engineering2021，7，11： | 1 |
| 18 | A FPGA-based discretization algorithm of continuous attributes inrough set显示文摘 | Sun Guoqiang Wang Hongli Lu Jinghui | 2013 | Applied Mechanics and Materials2013，1167，： | 1 |
| 19 | MicroRNA-1 down regulation by propranolol in a rat model of myocardial infarction:A new mechanism for ischaemic cardioprotection显示文摘 | Yanjie Lu Yong Zhang Hongli Shan | 2009 | Cardiovascular Research2009，84，： | 1 |
| 20 | Enhanced Th1-biased immune efficacy of porcine circovirus type 2 Cap-protein-based subunit vaccine when coadministered with recombinant porcine IL-2 or GM-CSF in mice显示文摘 | Yiping Wang Yuehua Lu Dan Liu Yanwu Wei Longjun Guo Hongli Wu Liping Huang Jianbo Liu Changming Liu | 2015 | Applied Microbiology and Biotechnology2015，，3： | 1 |
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