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| 1 | An in vivo study with an MRI tracer method reveals the biophysical properties of interstitial fluid in the rat brain显示文摘The nature of brain interstitial fluid (ISF) has long been a subject of controversy. Most of the previous studies on brain ISF were carried out in vitro. In the present study, a novel method was developed to characterize ISF in the living rat brain by magnetic resonance (MR) imaging using gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) as a tracer. Sprague Dawley rats (n=8) were subjected to MR scanning before and after the introduction of Gd-DTPA into the caudate nucleus. A one-way drainage of brain ISF was demonstrated on the dynamic MR images. According to the traditional diffusion model, the diffusion and clearance rate constants of the tracer within brain extracellular space (ECS) were derived as (3.38±1.07)×10-4 mm 2 s-1 and (7.60±4.18)×10-5 s-1 . Both diffusion and bulk flow contributed to the drainage of ISF from the caudate nucleus, which demonstrated an ISF-cerebrospinal fluid confluence in the subarachnoid space at the lateral and ventral surface of the brain cortex at 3 h after the injection. By using this newly developed method, the brain ECS and ISF can be quantitatively measured simultaneously in the living brain, which will enhance the understanding of ISF and improve the efficiency of drug therapy via the brain interstitium. | HAN HongBin LI Kai YAN JunHao ZHU Kai FU Yu | 2012 | Science China(Life Sciences)2012，55，9： | 25 |
| 2 | Discovery and Analysis of Shale Gas in a Carboniferous Reservoir and its Enrichment Characteristics in the Northern Nanpanjiang Depression, Guizhou Province, China显示文摘Shale gas resources are considered to be extremely abundant in southern China,which has dedicated considerable attention to shale gas exploration in recent years.Exploration of shale gas has considerably progressed and several breakthroughs have been made in China.However,shale gas explorations are still scarce.Summary and detailed analysis studies on black shale reservoirs are still to be performed for many areas.This lack of information slows the progress of shale gas explorations and results in low quantities of stored black shale.The Carboniferous Dawuba Formation,which is widely distributed and considerably thick,is one of the black shale formations targeted for shale gas exploration in southern China in the recent years.The acquisition and analysis of total organic carbon,vitrinite reflectance,types of organic matter,mineral composition,porosity,and permeability are basic but important processes.In addition,we analyzed the microscopic pores present in the shale.This study also showesd the good gas content of the Dawuba Formation,as well as the geological factors affecting its gas content and other characteristics.To understand the prospect of exploration,we compared this with other shale reservoirs which have been already successfully explored for gas.Our comparison showesd that those shale reservoirs have similar but not identical geological characteristics. | LU Shufan LUO Xiangjian DU Shengjiang HE Ben FU Hongbin LIU Kuiyong | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 5 |
| 3 | Origin of strong solid solution strengthening in the CrCoNi-W medium entropy alloy显示文摘Solid solution strengthening is one of the most conventional strategies for optimizing alloys strength,while the corresponding mechanisms can be more complicated than we traditionally thought specifically as heterogeneity of microstructure is involved.In this work,by comparing the change of chemical distribution,dislocation behaviors and mechanical properties after doping equivalent amount of tungsten(W)atoms in CrCoNi alloy and pure Ni,respectively,it is found that the alloying element W in CrCoNi alloy resulted in much stronger strengthening effect due to the significant increase of heterogeneity in chemical distribution after doping trace amount of W.The large atomic scale concentration fluctuation of all elements in CrCoNi-3W causes dislocation motion via strong nanoscale segment detrapping and severe dislocation pile up which is not the case in Ni-3W.The results revealed the high sensitivity of elements distribution in multi-principle element alloys to composition and the significant consequent influence in tuning the mechanical properties,giving insight for complex alloy design. | Yujie Chen Yan Fang Xiaoqian Fu Yiping Lu Sijing Chen Hongbin Bei Qian Yu | 2021 | Journal of Materials Science & Technology2021，，14： | 5 |
| 4 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 5 | Security Analysis of a Park-level Agricultural Energy Network Considering Agrometeorology and Energy Meteorology显示文摘China’s industrial manufacturing industry is well developed,but its agriculture is primitive.The only way to solve this problem is to improve through modern agriculture.The cross integration of new energy development and modern agriculture is becoming more and more critical.However,the research on the interaction between the meteorological disaster of facility agriculture and the power supply security of the integrated energy supply system has not formed a systematic theoretical system,which challenges the collaborative security of the facility agriculture and energy system.In this paper,energy meteorology and agrometeorology are considered and modeled,and the static security of a park-level agricultural energy network is simulated and analyzed under different weather conditions. | Xueqian Fu Dechang Yang Qinglai Guo Hongbin Sun | 2020 | CSEE Journal of Power and Energy Systems2020，6，3： | 5 |
| 6 | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model显示文摘Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained elusive.Here,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of AD.The glial cells,including microglia and astrocytes,play important roles in Aβclearance.Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice.The 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD mice.Moreover,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβclearance.Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. | Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 7 | Isolation and Identification of Photobacterium damselae subsp.damselae(PDD) from Tongue Sole显示文摘In May 2016,an epizootic occured among cultured tongue soles caused mass deaths in a fish farm in Qinhuangdao,China.In order to find out the etiological agent,a bacterial strain was isolated from ascites and other tissues of sick tongue sole aseptically collected.The isolate was identified as Photobacterium damselae subsp.damsela(PDD) by isolation culture,Gram staining,physiological identification,morohological observation,biochemical identification and 16S rDNA sequence analysis.The results showed that the isolate shared 99.6% homology with the reference strain in GenBank.The animal regression test displayed that the isolate had very strong pathogenicity to tongue sole.The LD_(50) was 3.1 × 10~4 CFU/mL,and it showed pathogenicity to mammals.The antimicrobial susceptibility test showed the isolate was highly sensitive to nrofloxacin,Norfloxacin,Ciprofloxacin,Mequindox;moderately sensitive to Cefradine,Doxycycline;and insensitive to Gentamicin,Ceftriaxone,Tilmicosin,etc.. | Yang Nan Zhang Zhiqiang Wu Tonglei Zhu Jianxin Fu Yanfang Han Hongsheng Wang Hongbin Shi Qiumei Gao Guisheng | 2018 | Animal Husbandry and Feed Science2018，10，2： | 2 |
| 8 | Preparation of continuous alumina gel fibres by aqueous sol–gel process显示文摘 | HONGBIN TAN XIAOLING MA MINGXING FU | 2013 | Bulletin of Materials Science2013，，1： | 1 |
| 9 | On the origin of oil-field water in the Biyang depression of China显示文摘 | FU Yong ZHAN Hongbin | 2009 | Environmental Geology2009，58，： | 1 |
| 10 | Characterizations of GaN film growth by ECR plasma chemical vapor deposition 显示文摘 | Silie Fu Junfang Chen Hongbin Zhang | 2009 | Journal of Crystal Growth2009，311，12： | 1 |
| 11 | Dermabrasion with steel wool in the extensive partial burns during shock stage:a case report and review显示文摘 | Yongqiang Feng Ran Huo Hongbin Fu | 2007 | Burns2007，33，4： | 1 |
| 12 | Preparation of PCL/silk fibroin/collagen electrospun fiber for urethral reconstruction显示文摘 | Gaijie Wei Chao Li Qiang Fu Yuemin Xu Hongbin Li | 2015 | International Urology and Nephrology2015，，1： | 1 |
| 13 | Therapeutic Effect and Mechanism of New Maixian Powder on DSS-induced UC Rats显示文摘[Objectives] To study the therapeutic effect and mechanism of New Maixian Powder on ulcerative colitis( UC) rats through observing its regulatory effect on the protein kinase R-like endoplasmic reticulum kinase( PERK)/eukaryotic translation initiation factor-2α( e IF-2α)/nuclear transcription factor-kappa B( NF-κB) signaling pathway. [Methods]First,60 SD rats were randomly divided into normal group,model group,mesalazine group,and New Maixian Powder low,medium and high dose groups,10 rats each group. Then,dextran sulfate sodium( DSS) was used to induce UC rats. The mesalazine group was given 0. 42 g/( kg·d) of mesalazine sustained-release granule suspension,New Maixian Powder low,medium and high dose groups were given 1. 5,3,and 6 g/( kg·d) of New Maixian Powder suspension,respectively,and other groups were given an equal volume of physiological saline,continuous intragastric administration for 14 d. Next,the disease activity index( DAI) of UC rats was evaluated; the expression of NF-κB in serum was measured by enzyme-linked immunosorbent assay( ELISA); the expression of PERK and e IF-2α protein and m RNA in colon tissue was detected by Western blot and real-time quantitative polymerase chain reaction( RT q-PCR). [Results] Compared with the normal group,the DAI score and serum NF-κB level in the model group were significantly higher( P < 0. 05),and PERK and e IF-2α protein and m RNA levels in the colon tissue were increased( P < 0. 05); compared with the model group,the DAI score decreased and serum NF-κB level declined in the New Maixian Powder group,and the expression of PERK and e IF-2α protein and m RNA in New Maixian Powder medium dose and high dose groups declined( P < 0. 05). [Conclusions]New Maixian Powder has good therapeutic effect on UC rats,and its mechanism may be connected with the inhibition of the activation of PERK/e IF-2α/NF-κB signaling pathway. | Minjun FU Rongzhen SHI Jianjun SHEN Meixia YANG Hongbin ZHENG | 2018 | Medicinal Plant2018，9，3： | 1 |
| 14 | Preparation and Characterization of Ca_3Co_4O_9 Thin Films on Polycrystalline Al_2O_3 Substrates by Chemical Solution Deposition显示文摘Ca3Co4O9 thin films have been first prepared on polycrystalline Al2O3 substrates using chemical solution deposition method by multiple annealing processing. It is observed that the derived thin films are c-axis oriented although the substrates are polycrystalline Al2O3 substrates, suggesting the self-assembled c-axis orientation. The annealing temperature effects on the properties are investigated and discussed. The best performances are attributed to the 850℃-annealed sample, whose resistivity, Seebeck coefficient and power factor at 300 K are 7.4 mΩ cm, 117 μV/K and 0.18 mW/m K-2 respectively, which is even better than those of the thin films deposited on single crystal substrates. The results will provide an effective route to optimize the properties of Ca3Co4O9 thin films using chemical solution deposition by multiple annealing processing even the substrates are polycrystalline. | Yankun Fu Xianwu Tang Jie Yang Hongbin Jian Xuebin Zhu Yuping Sun | 2013 | Journal of Materials Science & Technology2013，29，1： | 1 |
| 15 | LPCAT1 functions as a novel prognostic molecular marker in hepatocellular carcinoma显示文摘This study aimed to investigate the relationships between LPCAT1 expression and clinicopathologic parameters of hepatocellular carcinoma(HCC),further,to explore the effect of LPCAT1 on overall survival(OS)in patients with HCC,and its possible mechanism.Bioinformatics analysis using high throughput RNA-sequencing data from TCGA was utilized to explore the differential expression of LPCAT1 between normal and tumor tissues,and the associations between LPCAT1 expression and clinicopathological parameters.Survival analyses and subgroup survival analyses were utilized to elucidate the effect of LPCAT1 on OS in patients with HCC.Univariate analysis and multivariate analysis were used to investigate the prognostic factors.Potential LPCAT1 related tumor genes were identified by the methodology of differentially expressed genes(DEGs)screening.GO term enrichment analysis,KEGG pathway analysis and the PPI network were used to explore the potential mechanism.LPCAT1 was significantly overexpressed in HCC tumor tissues compared with normal tissues.The LPCAT1 expression was related to tumor grade,ECOG score,AFP and TNM stage,with P values of 0.000,0.000,0.007 and 0.000,respectively.Multivariate analysis demonstrated that LPCAT1 expression was independently associated with OS,with an HR of 1.04(CI:1.01–1.06,P=0.003).The KEGG pathway enrichment analyses showed that overlapped DEGs mainly participate in the cell cycle.Finally,we identified a hub gene,CDK1,which has been reported to act on the cell cycle,consistent with the result of KEGG enrichment analysis.Collectively,these data confirmed LPCAT1 was upregulated in HCC,and was an independent predictor of the prognosis. | Hongbin Zhang Ke Xu Qin Xiang Lijuan Zhao Benxu Tan Ping Ju Xiufu Lan Yi Liu Jian Zhang Zheng Fu Chao Li Jinzhi Wang Jixiang Song Yun Xiao Zhaobo Cheng Yan Wang Shu Zhang Tingxiu Xiang | 2022 | Genes & Diseases2022，9，1： | 0 |
| 16 | Accurate design of spatially separated double active site in Bi_(4)NbO_(8)Cl single crystal to promote Z-Scheme photocatalytic overall water splitting显示文摘The efficiency of photocatalytic overall water splitting was mainly limited by the slow reaction kinetics of water oxidation.How to design effective surface active site to overcome the slow water oxidation reaction was a major challenge.Here,we propose a strategy to accelerate surface water oxidation through the fabrication spatially separated double active sites.FeCoPi/Bi_(4)NbO_(8)Cl-OVs photocatalyst with spatially separated double active site was prepared by hydrogen reduction photoanode deposition method.Due to the high matching of the spatial loading positions of FeCoPi and OVs with the photogenerated charge distribution of Bi_(4)NbO_(8)Cl and corresponding reaction mechanisms of substrate,the FeCoPi and OVs on the(001)and(010)crystal planes of Bi_(4)NbO_(8)Cl photocatalyst provided surface active site for water oxidation reaction and electron shuttle reaction(Fe^(3+)/Fe^(2+)),respectively.Under visible light irradiation,the evolution O_(2)rate of FeCoPi/Bi_(4)NbO_(8)Cl OVs was 16.8μmol h^(-1),as 32.9 times as Bi_(4)NbO_(8)Cl.Furthermore,a hydrogen evolution co-catalyst PtRu@Cr_(2)O_(3)was prepared by sequential photodeposition method.Due to the introduction of Ru,the Schottky barrier between PbTiO_(3)and Pt was effectively reduced,which promoted the transfer of photogenerated electrons to PtRu@Cr_(2)O_(3)thermodynamically,the evolution H_(2)rate on PtRu@Cr_(2)O_(3)/PbTiO_(3)increased to 664.8 times.On based of the synchronous enhancement of the water oxidation performance on FeCoPi/Bi_(4)NbO_(8)Cl-OVs and water reduction performance on PtRu@Cr_(2)O_(3)/PbTiO_(3),a novel Z-Scheme photocatalytic overall water splitting system(FeCoPi/Bi_(4)NbO_(8)Cl-OVs)mediated by Fe^(3+)/Fe^(2+)had successfully constructed.Under visible light irradiation,the evolution rates of H_(2)and O_(2)were 2.5 and 1.3μmol h^(-1),respectively.This work can provide some reference for the design of active site and the controllable synthesis of OVs spatial position.On the other hand,the hydrogen evolution co catalyst(PtRu@Cr_(2)O_(3))and the co catalyst FeCoPi for oxygen evolution contributed to the construction of an overall water splitting system. | Kailong Gao Hongxia Guo Yanan Hu Hongbin He Mowen Li Xiaoming Gao Feng Fu | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 17 | Preclinical Strength Checking for Artificial Pelvic Prosthesis under Multi-activities-A Case Study显示文摘Customized prostheses are normally employed to reconstruct the biomechanics of the pelvis after resection due to tumors or accidents.The objective of this study is to evaluate the biomechanics of the pelvis under different daily activities and to establish a functional evaluation methodology for the customized prostheses.For this purposes,finite element model of a healthy pelvis as well as a reconstructed pelvic model after type II+III resection were built for biomechanical study.The biomechanical perfonnance of the healthy and reconstructed pelvic model was studied under routine activities including standing,knee bending,sitting down,standing up,walking,stair descent and stair ascent.Subsequently,the strength and stability of the prosthesis were evaluated under these activities.Results showed that,for the heathy pelvic model,the stresses were mainly concentrated around the upper part of the sacrum and the sacroiliac joint undergoing different activities,and the maximum stress occurred during stair ascent.As for the reconstructed pelvis,the stress distribution and the tendency of the maximum stress variation predicted for the bone part during all the activities were similar to those of the natural pelvic model,which indicated that the load transferring function of the reconstructed pelvis could be restored by the prosthesis.Moreover,the predicted maximum von Mises stress of the screws and prosthesis was below the fatigue strength of the 3D printed Ti-6A1-4V,which indicated the prosthesis can provide a reliable mechanical performance after implantation. | Enchun Dong Taimoor Iqbal Jun Fu Dichen Li Bin Liu Zheng Guo Alberto Cuadrado Zhen Zhen Ling Wang Hongbin Fan | 2019 | Journal of Bionic Engineering2019，16，6： | 0 |
| 18 | Dissecting the contributions of organic nitrogen aerosols to global atmospheric nitrogen deposition and implications for ecosystems显示文摘Atmospheric deposition of particulate organic nitrogen(ON_(p))is a significant process in the global nitrogen cycle and may be pivotally important for N-limited ecosystems.However,past models largely overlo oked the spatial and chemical inhomogeneity of atmospheric ON_(p)and were thus deficient in assessing global ON_(p)impacts.We constructed a comprehensive global model of atmospheric gaseous and particulate organic nitrogen(ON),including the latest knowledge on emissions and secondary formations.Using this model,we simulated global atmospheric ON_(p)abundances consistent with observations.Our estimated global atmospheric ON deposition was 26 Tg N yr^(-1),predominantly in the form of ON_(p)(23 Tg N yr^(-1))and mostly from wildfires(37%),oceans(22%)and aqueous productions(17%).Globally,ON_(p)contributed as much as 40%to 80%of the total N deposition downwind of biomass-burning regions.Atmospheric ON_(p)deposition thus constituted the dominant external N supply to the N-limited boreal forests,tundras and the Arctic Ocean,and its importance maybe amplified in a future warming climate. | Yumin Li Tzung-May Fu Jian Zhen Yu Xu Yu Qi Chen Ruqian Miao Yang Zhou Aoxing Zhang Jianhuai Ye Xin Yang Shu Tao Hongbin Liu Weiqi Yao | 2023 | National Science Review2023，10，12： | 0 |
| 19 | An Important Insect of the Genus Pseudips: Pseudips mexicanus Hopkins显示文摘At present, there are three species of Pseudips known in the world, and P. mexicanus is an important one. The paper mainly introduced the taxonomic status, morphological characteristics and biological characteristics of P. mexicanus, and provided a key to P. mexicanus and its allied species. There is no distribution of P. mexicanus in China, and the results can provide the reference for further study of the insect. | Jie PAN Yang LI Peize SHAO Yunqing CHEN Maoqiang FU Hongbin ZHU Yulin AN | 2022 | Plant Diseases and Pests2022，13，5： | 0 |
| 20 | Spatial-temporal Variation of Air Temperature for the Recent 40 Years in Lhasa显示文摘It was all known that Lhasa went through a high temperature of 30.8℃in late June 2019,which hit record highs.To better understand the reasons,based on observations recorded at automatic weather stations in Lhasa,the characteristics of temperature variation at multiple time scales were studied using the linear trend method,Mann-Kendall mutation test,Morlet wavelet analysis,R/S analysis and so on.The results showed that:(a)the annual mean temperature(AMT)is rising at a rate of 0.5℃/10 a,and the average temperature for different seasons also increased significantly,especially in winter.(b)Although there was an intersection in 1995,it was found that AMT,did not pass the reliability test of significance levelα=0.05,this means there are no abrupt changes for AMT,the values are 7.97 and 9.15℃respectively before and after the intersection point.(c)AMT has a periodic oscillation for 18-25 and 25-32 a based on a mass of data and the wavelet variance diagrams in Lhasa.AMT has a main cycle of 28 a,cyclic patterns of temperature changes in spring,summer and autumn is similar to AMT,but it is relatively complex in winter.(d)The Hurst index of AMT and different seasons demonstrates that the temperature is likely to continue to rise in the future in Lhasa. | Yang LEI Hongbin WANG Baixue YU Wenxue FU Tongsuo LU Xinyu LIU Dong WEI | 2021 | Meteorological and Environmental Research2021，12，1： | 0 |
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