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| 1 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012,,9813: | 10 |
| 2 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet . 2012 (9813)2012,,9813: | 7 |
| 3 | Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters. | V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun | 2003 | World Journal of Gastroenterology2003,9,10: | 5 |
| 4 | Early pancreatic cancer in Ig G4-related pancreatic mass:A case report显示文摘BACKGROUND IgG4-related disease can manifest diversely,including autoimmune pancreatitis and IgG4-related cholangiopathy.We are reporting a very unusual cause of pancreatic cancer triggered in a previously unknown IgG4-related disease.CASE SUMMARY A 75-year-old man was diagnosed with a 43 mm×33 mm pancreatic head tumor after consulting for abdominal pain and jaundice.A pancreaticoduodenectomy was carried out uneventfully,and the histopathology report showed an early stage of acinar-cell pancreatic cancer.The patient reconsulted on the 30th postoperative day with fever,jaundice and asthenia.Magnetic resonance cholangiopancreatography evidenced an extense bile duct stricture.A percutaneous biliary drainage proved to be ineffective,even after exchanging it with larger bore drainage.Reviewing the surgical specimen,features compatible with IgG4-related disease were observed.Consequently,empiric treatment with steroids was initiated achieving excellent results.CONCLUSION IgG4-related disease may cause chronic inflammation of the pancreas and can condition pancreatic malignancies. | Juan Glinka Francisco Calderón Martín de Santibanes Sung Ho Hyon Adrián Gadano Eduardo Mullen Melina Pol Juan Spina Eduardo de Santibanes | 2019 | World Journal of Gastrointestinal Surgery2019,11,12: | 3 |
| 5 | Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells显示文摘 | Kadowaki N Antonenko S Ho s | 2001 | Exp Med2001,193,10: | 3 |
| 6 | Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Young-Woo Kim Han-Kwang Yang Hyun Cheol Chung Young-Kyu Park Kyung Hee Lee Keun-Wook Lee Yong Ho Kim Sang-Ik Noh Jae Yong Cho Young Jae Mok Yeul Hong Kim Jiafu Ji Ta-Sen Yeh Peter Button Florin Sirzén Sung Hoon Noh | 2012 | The Lancet2012,,9813: | 3 |
| 7 | The US national cholesterol education programe adult treatment panel Ⅲ(NCEPATP Ⅲ) prevalence of the meta bolic syndrome in a Chinese population显示文摘 | THOMAS G N HO S Y JANUS E D | 2005 | Diabetes Res Clin Pract2005,67,: | 1 |
| 8 | Encoding a fork head-related protein,is mutated in X-linked autoimmunity-allergic disregulation syndrome显示文摘 | Blaeser F Ho N | 2000 | J Clin Invest2000,106,12: | 1 |
| 9 | Probiotics in poultry:Modes of action Worlds Poult显示文摘 | Jin L Z Ho Y W Abdullah N | 1997 | Sci J1997,53,: | 1 |
| 10 | Engineering hybrid genes without the use of restriction enzymesgene splicing by overlap extension显示文摘 | HORTON R M HUNT H D HO S N | 1989 | Gene1989,77,1: | 1 |
| 11 | Early urinary CCL2 is associated with the later development ofinterstitial fibrosis and tubular atrophy in renal allografts显示文摘 | Ho J Rush D N Gibson I W Karpinski M Storsley L Bestland J etal | 2010 | Trans-plantation2010,90,: | 1 |
| 12 | Site directed mutagenesis by over lap extension using the polymerase chain reaction 显示文摘 | Ho S N Hunt H D Horton R N | 1989 | Gene1989,77,: | 1 |
| 13 | Neuroendoscopic third ventriculostomy for hydrocephalus in adults: report of a single unit's experience with 63 cases 显示文摘 | Buxton N Ho KJ Macarthur D | 2001 | surg Neurol2001,55,2: | 1 |
| 14 | p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle显示文摘 | Ho R C Alcazar O Fujii N | 2004 | Am J Physiol Regul Integr Comp Physiol2004,286,2: | 1 |
| 15 | An incremental method for studying the steady state performance of induction motors using time stepping finite Transactions on Magnetics, element model显示文摘 | S L Ho W N Fu | 1997 | IEEE1997,33,2: | 1 |
| 16 | Antibacterial activity of chitosans and chitosan oligomers with different molecular weights显示文摘 | No H K Young Park N Ho Lee S Meyers S P | 2002 | International Journal of Food Microbiology2002,74,12: | 1 |
| 17 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009,458,7238: | 1 |
| 18 | Successful design and development of genetically engineered Saccharomyces yeasts for effective cofermentation of glucose and xylose from cellulosic biomass to fuel ethanol显示文摘 | Ho N W Y Chen Z Brainard A P | 1999 | Adv Biochem Engn Biotech1999,65,: | 1 |
| 19 | S-allyl cysteine reduces oxidant load in cells involved in the atherogenic process显示文摘 | Ho SE Ide N Lau BH | 2001 | Phytomedicine2001,8,1: | 1 |
| 20 | Prognostic significance of T helper 1 and 2 and T cytotoxic 1 and 2 cells in patients with non-small cell lung cancer 显示文摘 | ho N Suzuki Y raniguchi Y | 2005 | Anticancer Res2005,25,3: | 1 |