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	题名	作者	年代	出处	被引量
1	Adrenomedullin in cirrhotic and non-cirrhotic portal hypertension显示文摘AIM:Adrenomedullin (ADM) is a potent vasodilator peptide.ADM and nitric oxide (NO) are produced in vascular endothelial cells. Increased ADM level has been linked to hyperdynamic circulation and arterial vasodilatation in cirrhotic portal hypertension (CPH). The role of ADM in non-cirrhotic portal hypertension (NCPH) is unknown, plasma ADM levels were studied in patients with NCPH, compensated and decompensated cirrhosis in order to determine its contribution to portal hypertension (PH) in these groups.METHODS: There were 4 groups of subjects. Group 1consisted of 27 patients (F/M: 12/15) with NCPH due to portal and/or splenic vein thrombosis (mean age: 41±12years), group 2 consisted of 14 patients (F/M: 6/8) with compensated (Child-Pugh A) cirrhosis (mean age: 46±4),group 3 consisted of 16 patients (F/M: 6/10) with decompensated (Child-Pugh C) cirrhosis (mean age: 47±12).Fourteen healthy subjects (F/M: 6/8) (mean age: 44±8) were used as controls in Group 4. ADM level was measured by ELISA. NO was determined as nitrite/nitrate level by chemoluminescence.RESULTS: Adl level in Group 11 (236±61.4 pg/mL) was significantly higher than that in group 2 (108.4±28.3 pg/mL)and group 4 (84.1±31.5 pg/mL) (both P<0.0001) but was lower than that in Group3 (324±93.7 pg/mL) (P=0.002). NO level in group 1 (27±1.4 μmol/L) was significantly higher than that in group 2 (19.8±2.8 μmol/L) and group 4 (16.9±1.6μmol/L) but was lower than that in Group 3 (39±3.6 μmol/L)(for all three P<0.0001). A strong correlation was observed between ADM and NO levels (r=0.827, P<0.0001).CONCLUSION: Adrenomedullin and NO levels were high in both non-cirrhotic and cirrhotic portal hypertension and were closely correlated, Adrenomedullin and NO levels increased proportionally with the severity of cirrhosis, and were significantly higher than those in patients with NCPH.Portal hypertension plays an important role in the increase of ADM and NO. Parenchymal damage in cirrhosis may contribute to the increase in these parameters.	V Tahan E Avsar C Karaca E Uslu F Eren S Aydin H Uzun HO Hamzaoglu F Besisik C Kalayci A Okten N Tozun	2003	World Journal of Gastroenterology2003，9，10：	5
2	Distinct cytokine profiles of neonatal natural killer T cells after expansion with subsets of dendritic cells显示文摘	Kadowaki N Antonenko S Ho s	2001	Exp Med2001，193，10：	3
3	The US national cholesterol education programe adult treatment panel Ⅲ(NCEPATP Ⅲ) prevalence of the meta bolic syndrome in a Chinese population显示文摘	THOMAS G N HO S Y JANUS E D	2005	Diabetes Res Clin Pract2005，67，：	1
4	Engineering hybrid genes without the use of restriction enzymesgene splicing by overlap extension显示文摘	HORTON R M HUNT H D HO S N	1989	Gene1989，77，1：	1
5	Site directed mutagenesis by over lap extension using the polymerase chain reaction 显示文摘	Ho S N Hunt H D Horton R N	1989	Gene1989，77，：	1
6	An incremental method for studying the steady state performance of induction motors using time stepping finite Transactions on Magnetics, element model显示文摘	S L Ho W N Fu	1997	IEEE1997，33，2：	1
7	Antibacterial activity of chitosans and chitosan oligomers with different molecular weights显示文摘	No H K Young Park N Ho Lee S Meyers S P	2002	International Journal of Food Microbiology2002，74，12：	1
8	Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘	Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C	2009	Nature2009，458，7238：	1
9	Microbial Colonisation and degradation of some fibrous crop residues in the rumen of goats显示文摘	Ho Y Abdullah N Jalaludin S	1996	Asian Australasian Journal of animal sciences1996，9，：	1
10	A power-balanced time-stepping finite element method for transient magnetic field computation显示文摘	S L Ho S X Niu W N Fu	2012	IEEE Transactions on Magnetics2012，48，2：	1
11	Optimization of permanent magnet surface shapes of electric motors for minimization of cogging torque using FEM显示文摘	Chen Ningning Ho S L Fu W N	2010	IEEE Transactions on Magnetics2010，46，6：	1
12	Unsteady aerodynamics and flow control for flapping wing flyers显示文摘	Ho S Nassef H Pornsinsirirak N		0，，8：	1
13	Site-directed mutgenesis by overlap extension using, the polymerase chain reaction 显示文摘	Ho S N Hunt H D Horton R M	1989	Gene1989，，77：	1
14	Peonidin 3- glucoside inhibits lung cancer metastasis by downregulation of proteinases activities and MAPK pathway 显示文摘	Ho M L Chen P N Chu S C	2010	Nutrition and Cancer2010，62，4：	1
15	Enhanced cofermentationof glucose and xylose by recombinantSaccharomyces yeast strains in batchand continuous operating modes显示文摘	TOON S T PHILIPPIDIS G P HO N W Y	1997	Applied Biochemistry and Biotech-nology1997，6365，：	1
16	Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens显示文摘	Kadowaki N Ho S Antonenko S	2001	J Exp Med2001，194，：	1
17	Subsets of human dendritic cell precursors express different toll-like receptors and response to different microbial antigen显示文摘	Kadowaki N Ho S Antonenko S	2001	J Exp Med2001，194，：	1
18	The mechanism of action of cyclosporinA and FK506显示文摘	Ho S Clipstone N Timmermann L	1996	Clin Immunopathol1996，80，32：	1
19	Implications of nursing care in the occurrence and consequences of unplanned extubation in adult intensive care units显示文摘	Yeh S H Lee L N Ho T H		0，，03：	1
20	Protective effects of aucubinisolated from Eucommia ulmoides against UVB - induced oxida-tive stress in human skin fibroblasts 显示文摘	Ho J N Lee Y H Park J S	2005	Biol Pharm Bull2005，28，：	1

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