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| 1 | 橄榄叶提取物对大鼠急性炎症和痛觉过敏的研究显示文摘本文采用鹿角菜胶诱导的大鼠急性炎症模型观察橄榄叶提取物(OLE)的抗炎与镇痛作用及对致炎因子TNF-α和IL-1β的mRNA表达。用鹿角菜胶注射到大鼠右后足内,分别于鹿角菜胶注射前30 min和注射后120 min灌胃给予OLE 100、250和500 mg/kg体重。鹿角菜胶处理后测量足跖肿胀度及痛域。用RT-PCR检测足跖垫内组织TNF-α、IL-1β和IL-10的mRNA表达。结果显示,经灌胃给予OLE100、250和500 mg/kg体重,均能明显降低大鼠后足肿胀度,增加痛域,并明显降低致炎因子TNF-α和IL-1β的mRNA表达。本研究提示OLE具有抗炎和镇痛作用,其作用机制可能与抑制TNF-α和IL-1β的mRNA表达有关。 | 耿成燕 宫德正 姜丽平 曹军 Hiroyuki Yoshimura 仲来福 | 2011 | 天然产物研究与开发2011，23，5： | 8 |
| 2 | Overexpression of ETS-1 is associated with malignan' biological features of prostate cancer显示文摘E26 transformation-specific-1 ( ETS-1 ),一个 et 家庭抄写因素,被报导了在前列腺癌症( PCa )在 ETS-1 表示的许多生理、病理学的过程,而是临床的含意起一个重要作用,特别地高风险的案例,包括对雄激素剥夺的反应,治疗( ADT )还得被阐明。我们用针活体检视从 69 个主要先进的 PCa 病人获得的嵌入石蜡的前列腺癌织物染色的 immunohistochemical 检验了 ETS-1 的表示。ETS-1 表示与 69 个病人的 clinicopathological 特征相比,包括 25 作为主要治疗经历了 ADT。作为结果,有 ETS-1 的更高的表示的 PCa 病人是显著地,可能舞台高的更多得分(P< 0.05 ) 。在 ETS-1 表示和起始的前列腺特定的抗原(PSA ) 水平之间没有重要协会。在 ADT 对待的 25 个病人,为 ETS-1 的染色的分数显著地在 24 个月以内与阉割抵抗的疾病的快速的开发被联系(P< 0.05 ) ,而格利森分数和 PSA 水平不是。在结论,增加了 ETS-1 表示与到阉割抵抗的前进的一个更高的阶段,更高级的格利森分数和更短的时间被联系。这些数据建议为 ETS-1 的 immunostaining 能是为为 PCa 病人预言差的临床的结果的一个分子的标记,特别地那些与高风险的疾病。 | Bo Li Yosuke Shimizu Takashi Kobayashi Naoki Terada Koji Yoshimura Tomomi Kamba Yoshiki Mikami Takahiro Inoue Hiroyuki Nishiyama Osamu Ogawa | 2012 | Asian Journal of Andrology2012，14，6： | 2 |
| 3 | Improvement of vitamin E quality and quantity in tobacco and lettuce by chloroplast genetic engineering显示文摘 | Yukinori Yabuta Hiroyuki Tanaka Sahoko Yoshimura | 2013 | Transgenic Res2013，22，： | 1 |
| 4 | Preparation of samples for gas chromatographymass spectrometry analysis of phthalate and adipate esters in plasma and beverages by steam distillation and extraction显示文摘 | KAYOKO KATO YOSHIHIRO YOSHIMURA HIROYUKI NAKAZAWA | 2002 | Journal of AOAC International2002，85，3： | 1 |
| 5 | Personality Assessment Based on the Five-factor Model of Personality Structure in Patients with Primary Open-Angle Glaucoma显示文摘 | Fumihiko Mabuchi Kimio Yoshimura Kenji Kashiwagi Kunihiko Shioe Shigenobu Kanba Hiroyuki Iijima Shigeo Tsukahara | 2005 | Japanese Journal of Ophthalmology2005，，1： | 1 |
| 6 | Risk factors for an adverse outcome in early invasive colorectal carcinoma显示文摘 | Hideki Ueno Hidetaka Mochizuki Yojiro Hashiguchi Hideyuki Shimazaki Shinsuke Aida Kazuo Hase Susumu Matsukuma Tadao Kanai Hiroyuki Kurihara Kotaro Ozawa Kazuyoshi Yoshimura Shinya Bekku | 2004 | Gastroenterology2004，，2： | 1 |
| 7 | Column-switching high-performance liquid chromatography electrospray mass spectrometry coupled with on-line of extraction for the determination of mono- and di-(2-ethylhexyl) phthalate in blood samples显示文摘 | Koichi Inoue Migaku Kawaguchi Fumio Okada Yoshihiro Yoshimura Hiroyuki Nakazawa | 2003 | Analytical and Bioanalytical Chemistry2003，，4： | 1 |
| 8 | Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells显示文摘 | Paul Kievit Jane K. Howard Michael K. Badman Nina Balthasar Roberto Coppari Hiroyuki Mori Charlotte E. Lee Joel K. Elmquist Akihiko Yoshimura Jeffrey S. Flier | 2006 | Cell Metabolism2006，，2： | 1 |
| 9 | Characterization of glutamate decarboxylase mediating γ-amino butyric acid increase in the early germination stage of soybean ( Glycine max [L.] Merr)显示文摘 | Aya Matsuyama Kazuma Yoshimura Chie Shimizu Yoshihiro Murano Hiroyuki Takeuchi Masao Ishimoto | 2009 | Journal of Bioscience and Bioengineering2009，，5： | 1 |
| 10 | Determination of l -menthol in pharmaceutical products by high performance liquid chromatography with polarized photometric detection显示文摘 | Kouji Hamasaki Kayoko Kato Takaho Watanabe Yoshihiro Yoshimura Hiroyuki Nakazawa Atsushi Yamamoto Akinobu Matsunaga | 1998 | Journal of Pharmaceutical and Biomedical Analysis1998，，8： | 1 |
| 11 | Oxidative catalytic cracking of n -butane to lower alkenes over layered BiOCl catalyst显示文摘 | Norihito Kijima Koichi Matano Masao Saito Tomo Oikawa Tomohiro Konishi Hiroyuki Yasuda Toshio Sato Yuji Yoshimura | 2001 | Applied Catalysis A General2001，，2： | 1 |
| 12 | One -step nucleic acid amplification for intraoperative detection of lymph node metastasis in oral cancer显示文摘 | Hiroyuki Goda Koh-ichi Nakashiro Tomohide Yoshimura Hidetomo Nishikawa Tomoki Sumida Hiroyuki Hamakawa | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 13 | Adverse effect on proliferation of human salivary gland tumor cells by estrogen and progesterone after introduction of their receptor显示文摘 | Tomoki Sumida Tomohide Yoshimura Akiko Onishi Koh-ichi Nakashiro Hiroyuki Hamakawa | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
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