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| 1 | Urgent endoscopic ultrasound-guided choledochoduodenostomy for acute obstructive suppurative cholangitis-induced sepsis显示文摘Acute obstructive suppurative cholangitis(AOSC) due to biliary lithiasis is a life-threatening condition that requires urgent biliary decompression. Although endoscopic retrograde cholangiopancreatography(ERCP) with stent placement is the current gold standard for biliary decompression, it can sometimes be difficult because of failed biliary cannulation. In this retrospective case series, we describe three cases of successful biliary drainage with recovery from septic shock after urgent endoscopic ultrasound-guided choledochoduodenostomy(EUS-CDS) was performed for AOSC due to biliary lithiasis. In all three cases, technical success in inserting the stents was achieved and the patients completely recovered from AOSC with sepsis in a few days after EUS-CDS. There were no procedure-related complications. When initial ERCP fails, EUS-CDS can be an effective life-saving endoscopic biliary decompression procedure that shortens the procedure time and prevents post-ERCP pancreatitis, particularly in patients with AOSC-induced sepsis. | Kosuke Minaga Masayuki Kitano Hajime Imai Kentaro Yamao Ken Kamata Takeshi Miyata Shunsuke Omoto Kumpei Kadosaka Tomoe Yoshikawa Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，16： | 18 |
| 2 | Frequent loss of heterozygosity in two distinct regions,8p23.1 and 8p22, in hepatocellular carcinoma显示文摘AIM: To identify the precise location of putative tumor suppressor genes (TSGs) on the short arm of chromo- some 8 in patients with hepatocellular carcinoma (HCC). METHODS: We used 16 microsatellite markers informative in Japanese patients, which were selected from 61 pub- lished markers, on 8p, to analyze the frequency of loss of heterozygosity (LOH) in each region in 33 cases (56 lesions) of HCC. RESULTS: The frequency of LOH at 8p23.2-21 with at least one marker was 63% (20/32) in the informative cases. More specifically, the frequency of LOH at 8p23.2, 8p23.1, 8p22, and 8p21 was 6%, 52%, 47%, and 13% in HCC cases. The LOH was significantly more frequent at 8p23.1 and 8p22 than the average (52% vs 22%, P = 0.0008; and 47% vs 22%, P = 0.004, respectively) or others sites, such as 8p23.2 (52% vs 6%, P = 0.003; 47% vs 22%, P = 0.004) and 8p21 (52% vs 13%, P = 0.001; 47% vs 13%, P = 0.005) in liver cancer on the basis of cases. Notably, LOH frequency was significantly higher at D8S277, D8S503, D8S1130, D8S552, D8S254 and D8S258 than at the other sites. However, no allelic loss was detected at any marker on 8p in the lesions of nontumor liver tissues. CONCLUSION: Deletion of 8p, especially the loss of 8p23.1-22, is an important event in the initiation or promotion of HCC. Our results should be useful in identi- fying critical genes that might lie at 8p23.1-22. | Tomoe Lu Hiroshi Hano Keisuke Nagatsuma Satoru Chiba Masahiro Ikegami | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 3 | Dispersoid Formation and Recrystallization Behavior in an Al-Mg-Si-Mn Alloy显示文摘The nucleation and precipitation of Mn-containing dispersoids in an Al-Mg-Si-Mn alloy (6082) have been studied by optical microscopy,EPMA (electron probe microanalysis) and TEM (transmission electron microscopy).The influence of Mn-containing dispersoids on the recrystallization behavior was also investigated.The size and distribution of dispersoids were strongly affected by both the homogenization process and the alloying element distribution formed in the direct chill cast procedure.The Mn-containing dispersoids were observed to nucleate preferentially on the β-Mg 2 Si phase and to be aligned along the <100> direction of the matrix.After cold deformation,the morphology of dispersoids greatly influences the recrystallization and grain growth behavior in the annealing process. | Rong Hu Tomo Ogura Hiroyasu Tezuka Tatsuo Sato Qing Liu | 2010 | Journal of Materials Science & Technology2010，26，3： | 10 |
| 4 | Biomarkers in autoimmune pancreatitis and immunoglobulin G4-related disease显示文摘Solitary organ autoimmune disorders,formerly known as autoimmune pancreatitis(AIP),autoimmune sialadenitis,and autoimmune sclerosing cholangitis,are now considered organ-specific manifestations of systemic immunoglobulin G4-related disease(IgG4-RD).AIP and IgG4-RD are characterized by elevated serum concentration of IgG4 antibody(Ab),accumulation of IgG4-expressing plasmacytes in the affected organs,and involvement of multiple organs.It is well established that enhanced IgG4 Ab responses are a hallmark of AIP and IgG4-RD for diagnosis and monitoring disease activity.However,a significant fraction of patients with AIP and IgG4-RD who develop chronic fibroinflammatory responses have normal serum concentrations of this IgG subtype.In addition,disease flare-up is sometimes seen even in the presence of normalized serum concentrations of IgG4 Ab after successful induction of remission by prednisolone.Therefore,it is necessary to identify new biomarkers based on the understanding of the pathophysiology of AIP and IgG4-RD.Recently,we found that activation of plasmacytoid dendritic cells producing both interferon-α(IFN-α)and interleukin-33(IL-33)mediate murine AIP and human IgG4-RD.More importantly,we provided evidence that serum concentrations of IFN-αand IL-33 could be useful biomarkers for the diagnosis and monitoring of AIP and IgG4-RD activity after induction of remission in these autoimmune disorders.In this Frontier article,we have summarized and discussed biomarkers of AIP and IgG4-RD,including Igs,autoAbs,and cytokines to provide useful information not only for clinicians but also for researchers. | Akane Hara Tomohiro Watanabe Kosuke Minaga Tomoe Yoshikawa Ken Kamata Masatoshi Kudo | 2021 | World Journal of Gastroenterology2021，27，19： | 8 |
| 5 | Nitrifiers activity and community characteristics under stress conditions in partial nitrification systems treating ammonium-rich wastewater显示文摘Long-term exposure of nitrifiers to high concentrations of free ammonia(FA) and free nitrous acid(FNA) may affect nitrifiers activity and nitrous oxide(N_2O) emission.Two sequencing batch reactors(SBRs) were operated at influent ammonium nitrogen(NH_4-N) concentrations of 800 mg/L(SBRH) and 335 mg/L(SBRL),respectively.The NH_4-N removal rates in SBRHand SBRLwere around 2.4 and 1.0 g/L/day with the nitritation efficiencies of 99.3% and 95.7%,respectively.In the simulated SBR cycle,the N_2O emission factors were 1.61% in SBRH and 2.30% in SBRL.N_2O emission was affected slightly by FA with the emission factor of0.22%–0.65%,while N_2O emission increased with increasing FNA concentrations with the emission factor of 0.22%–0.96%.The dominant ammonia oxidizing bacteria(AOB) were Nitrosomonas spp.in both reactors,and their relative proportions were 38.89% in SBRHand13.36% in SBRL.Within the AOB genus,a species(i.e.,operational taxonomic unit [OTU] 76) that was phylogenetically identical to Nitrosomonas europaea accounted for 99.07% and 82.04% in SBRHand SBRL,respectively.Additionally,OTU 215,which was related to Nitrosomonas stercoris,accounted for 16.77% of the AOB in SBRL. | Jia Miao Qidong Yin Tomoyuki Hori Tomo Aoyagi Hiroshi Habe Guangxue Wu | 2018 | Journal of Environmental Sciences2018，30，11： | 8 |
| 6 | Instrumental detection of cystic duct stones during laparoscopic cholecystectomy显示文摘Residual cystic duct stones (CDSs) after cholecystectomy have been recognized as a cause of post cholecystectomy pain. This study was undertaken to determine the incidence of CDSs during laparoscopic cholecystectomy(LC). A cohort of 330 consecutive patients (80 males and 250females) undergoing LC between November 2006 and May2010 was studied. Their age ranged between 16 and 88 years(median 50, IQR: 36.62). The data were prospectively collected of preoperative liver function tests, imaging, the presence of intraoperative CDSs, and common bile duct stones at on-table cholangiogram. CDSs were detected intraoperatively in 64 of the 330 patients (19%). Ultrasound failed to detect CDSs in any of these cases. Deranged liver function tests were noted in 73% of the patients with CDSs and in 57% without CDSs Common bile duct stones were detected in 9% (29) of the 330patients. CDSs occur commonly at routine cholecystectomy, and preoperative investigations are not helpful in their diagnosis As CDSs may lead to postoperative morbidity, they should be actively sought out during surgery if present. | Amir Kambal Tomos Richards Harsha Jayamanne Zeyed Sallami Ashraf Rasheed Taha Lazim | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，2： | 3 |
| 7 | Mesenteric vein thrombosis following impregnation via in vitro fertilization-embryo transfer显示文摘Pregnancy is an acquired hypercoagulable state. Most patients with thrombosis that develops during pregnancy present with deep vein leg thrombosis and/or pulmonary embolism, whereas the development of mesenteric vein thrombosis(MVT) in pregnant patients is rare. We report a case of MVT in a 34-year-old woman who had achieved pregnancy via in vitro fertilization-embryo transfer(IVFET). At 7 wk of gestation, the patient was referred to us due to abdominal pain accompanied by vomiting and hematochezia, and she was diagnosed with superior MVT. Following resection of the gangrenous portion of the small intestine, anticoagulation therapy with unfractionated heparin and thrombolysis therapy via a catheter placed in the superior mesenteric artery were performed, and the patient underwent an artificial abortion. Oral estrogen had been administered for hormone replacement as part of the IVF-ET procedure, and additional precipitating factors related to thrombosis were not found. Pregnancy itself, in addition to the administered estrogen, may have caused MVT in this case. We believe that MVT should be included in the differential diagnosis of a pregnant patient who presents with an acute abdomen. | Masaaki Hirata Hiroko Yano Tomoe Taji Yoshiharu Shirakata | 2017 | World Journal of Gastrointestinal Surgery2017，9，10： | 2 |
| 8 | Modified single transluminal gateway transcystic multiple drainage technique for a huge infected walled-off pancreatic necrosis: A case report显示文摘We report a successful endoscopic ultrasonographyguided drainage of a huge infected multilocular walledoff necrosis(WON) that was treated by a modified single transluminal gateway transcystic multiple drainage(SGTMD) technique. After placing a widecaliber fully covered metal stent, follow-up computed tomography revealed an undrained subcavity of WON. A large fistula that was created by the wide-caliber metal stent enabled the insertion of a forward-viewing upper endoscope directly into the main cavity, and the narrow connection route within the main cavity to the subcavity was identified with a direct view, leading to the successful drainage of the subcavity. This modified SGTMD technique appears to be useful for seeking connection routes between subcavities of WON in some cases. | Kosuke Minaga Masayuki Kitano Hajime Imai Kentaro Yamao Ken Kamata Takeshi Miyata Tomohiko Matsuda Shunsuke Omoto Kumpei Kadosaka Tomoe Yoshikawa Masatoshi Kudo | 2016 | World Journal of Gastroenterology2016，22，21： | 2 |
| 9 | Changes in physicochemical properties of proteins in Kayserian Pastirma made from the M.semimembranosus muscle of cows during traditional processing显示文摘In the current study,we examined the effects of beef processing to produce pastirma on the physicochemical properties of proteins in M.semimembranosus(SEM)muscle.Protein concentrations significantly increased in pastirma muscles(P<0.01),as a result of the salting and curing process.The surface hydrophobicity values of processed samples were higher than those without processing at all guanidine-HCl concentrations,suggesting hydrophobicity increased,which may attribute to the new generated peptides during the traditional pastirma-making process.The metmyoglobin content greatly increased(by as much as 89%)in pastirma samples compared with the unprocessed samples.The images of histology also demonstrate that the pastirma processing had no negative impact on the structure of the muscle.The results from this study suggest that the traditional pastirma-making process catalyzed the enzymatic digestion of muscle proteins,and the differences in some physicochemical parameters between the control and pastirma samples were thus likely to be contributable to protein digestion.Thus,the traditional pastirma-making process results in the degradation of many proteins into peptides,which might then be obtainable as functional components to treat human dietand lifestyle-related diseases such as hypertension,hyperglycemia syndromes or to be used as nutraceuticals.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Abdulatef Mrghni Ahhmed Gen Kaneko Hideki Ushio Tomo Inomata Hasan Yetim Safa Karaman Michio Muguruma Ryoichi Sakata | 2013 | Food Science and Human Wellness2013，2，1： | 2 |
| 10 | Meibomitis-Related Keratoconjunctivitis: Implications and Clinical Significance of Meibomian Gland Inflammation显示文摘 | Tomo Suzuki | 2012 | Cornea2012，，： | 1 |
| 11 | A late Neolithic expansion of Y chromosomal haplogroup O2a1-M95 from east to west显示文摘Y-Chromosomal haplogroup O2a1-M95 的起源和疏开,越过 Austro 分布式东方和南亚的亚洲说带,充分还有待于被理解。各种各样的研究也建议了一个东方印第安人或 O2a1-M95 的东南亚洲起源。我们从印度,老挝,和中国由采样 8748 人处理了古代的问题和 O2a1-M95 的疏开并且从从文学拿的另外的干涉区域把他们比作 3307 件样品。一个总数上的 haplogroup 频率和 Y-STR 数据的分析 2413 个 O2a1-M95 染色体表明老挝样品拥有了 O2a1-M95 的最高的频率(74%与> 0.5 )并且它的祖先的 haplogroups ( O2 *-P31, O *象有 14STR-median haplotype 的样品的一个更高的比例一样的-M175)( 17 取样在里面 14 张人口),深结合时间( 5.7 ± 0.3 Kya )和 consorted O2a1-M95 扩大从 STR 证实了进化。所有这些建议老挝将在学习区域之中带 O2a1-M95 的深古代。在西方的从东方的扩大时间的连续减少:在老挝,在东北印度的 5.2 ± 0.6,和在东方印度的 4.3 ± 0.2 的 5.7 ± 0.3 Kya,建议到西方的晚过时的东方从老挝系 O2a1-M95 传播了。 | GaneshPrasad Arunkumar Lan-Hai Wei Valampuri John Kavitha Adhikarla Syama Varatharajan Santhakumari Arun Surendra Sathua Raghunath Sahoo R. Balakrishnan Tomo Riba Jharna Chakravarthy Bapukan Chaudhury Premanada Panda Pradipta K. Das Prasanna K. Nayak Hui Li Ramasamy Pitchappan 无 | 2015 | Journal of Systematics and Evolution2015，53，6： | 1 |
| 12 | Administration of Phosphoatidylcholine Increases brain acetylcholine concentration and improves memory in mice with dementia显示文摘 | Shu-Ying Chung Tomoe Moriyama Eiko Uezu | 1994 | Journal of Nutrition1994，12，： | 1 |
| 13 | Peptidotri- azoles on solid phase : -Triazoles by regiospecific copper(I) -catalyzed 1,3-dipolar cycloadditions of termi- nal alkynes to azides 显示文摘 | TomOe Christian W Christensen C Meldal M | 2002 | J Org Chem2002，67，： | 1 |
| 14 | Production of intergeneric hybrid plants between Sandersonia aurantiaca and Gloriosa rothschildiana via ovule culture (Colchicaceae)显示文摘 | Toru Nakamura Sachiko Kuwayama Shigefumi Tanaka Tomo Oomiya Hiroyuki Saito Masaru Nakano | 2005 | Euphytica2005，，3： | 1 |
| 15 | Im- provement of efficiency interals based on DEA by adjusting inputs and outputs 显示文摘 | Tomoe Entani Hideo Tanaka | 2006 | Eouropean Journal of Operational Research2006，，172： | 1 |
| 16 | Thermoelastic analysis of cracked woven GFRP laminates at cryogenic temperatures 显示文摘 | Tomo T Y S Fumio N Susumu K | 2002 | Cryogenics2002，，42： | 1 |
| 17 | Does market structure matter on banks'profitability and stability?显示文摘 | AliMirzaei tomoe moore Guy liu | 2013 | Journal of Banking & Finance2013，37，8： | 1 |
| 18 | Orientation and nearest neighbor analysis of psbI gene product in the photosystem II reaction center complex using bifunctional cross-linkers 显示文摘 | Tomo T Enami I Satoh K | 1993 | FEBS Lett1993，323，： | 1 |
| 19 | Digastric muscle of the kangaroo: a comparative anatomical study显示文摘 | Tomo S Tomo I Townsend GC | 1998 | The Anatomical Record1998，251，： | 1 |
| 20 | Comparison between the effects of ultrasound and γ-rays on the inactivation of Saccharomyces cerevisiae : Analyses of cell membrane permeability and DNA or RNA synthesis by flow cytometry显示文摘 | Ikuko Oyane Tomo Takeda Yasunori Oda Takashi Sakata Masakazu Furuta Kenji Okitsu Yasuaki Maeda Rokuro Nishimura | 2009 | Ultrasonics - Sonochemistry2009，，4： | 1 |
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