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| 1 | Clinical benefit of radiation therapy and metallic stenting for unresectable hilar cholangiocarcinoma显示文摘AIM:To determine the efficacy of external beam radiotherapy(EBRT),with or without intraluminal brachytherapy(ILBT),in patients with non-resected locally advanced hilar cholangiocarcinoma.METHODS:We analyzed 64 patients with locally advanced hilar cholangiocarcinoma,including 25 who underwent resection(17 curative and 8 non-curative),28 treated with radiotherapy,and 11 who received best supportive care(BSC).The radiotherapy group received EBRT(50 Gy,30 fractions),with 11 receiving an additional 24 Gy(4 fractions) ILBT by iridium-192 with remote after loading.ILBT was performed using percutaneous transhepatic biliary drainage(PTBD) route.Uncovered metallic stents(UMS) were inserted into nonresected patients with obstructive jaundice,with the exception of four patients who received percutaneous transhepatic biliary drainage only.UMS were placed endoscopically or percutaneously,depending on the initial drainage procedure.The primary endpoints were patient death or stent occlusion.Survival time of patients in the radiotherapy group was compared with that of patients in the resection and BSC groups.Stent patency was compared in the radiotherapy and BSC groups.RESULTS:No statistically significant differences in patient characteristics were found among the resection,radiotherapy,and BSC groups.Three patients in the radiotherapy group and one in the BSC group did not receive UMS insertion but received PTBD alone;cholangitis occurred after endoscopic stenting,and patients were treated with PTBD.A total of 16 patients were administered additional systemic chemotherapy(5-fluorouracil-based regimen in 9,S-1 in 6,and gemcitabine in 1).Overall survival varied significantly among groups,with median survival times of 48.7 mo in the surgery group,22.1 mo in the radiotherapy group,and 5.7 mo in the BSC group.Patients who underwent curative resection survived significantly longer than those who were not candidates for surgery(P = 0.0076).Cumulative survival in the radiotherapy group was significantly longer than in the BSC group(P = 0.0031),but did not differ significantly from those in the non-resection group.Furthermore,the median survival time of patients in the radiotherapy group who were considered for possible resection(excluding the seven patients who were not candidates for surgery due to comorbid disease or age) was 25.9 mo.Stent patency was evaluated only in the 24 patients who received a metallic stent.Stent patency was significantly longer in the radiotherapy than in the BSC group(P = 0.0165).Biliary drainage was not eliminated in any patient.To determine the efficacy of ILBT,we compared survival time and stent patency in the EBRT alone and EBRT plus ILBT groups.However,we found no significant difference in survival time between groups or for stent patencies.Hemorrhagic gastroduodenal ulcers were observed in 5 patients(17.9%),three in the EBRT plus ILBT group and two in the EBRT alone group.Ulcers occurred 5 mo,7 mo,8 mo,16 mo,and 29 mo following radiotherapy.All patients required hospitalization,but blood transfusions were unnecessary.All 5 patients recovered following the administration of anti-ulcer medication.CONCLUSION:Radiotherapy improved patient prognosis and the patency of uncovered metallic stents in patients with locally advanced hilar cholangiocarcinoma,but ILBT provided no additional benefits. | Hiroyuki Isayama Takeshi Tsujino Yousuke Nakai Takashi Sasaki Keiichi Nakagawa Hideomi Yamashita Taku Aoki Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，19： | 24 |
| 2 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 3 | MicroRNA-31 expression in colorectal serrated pathway progression显示文摘MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers(CRC).We have recently observed that microRNA-31(miR-31)expression is associated with BRAF mutation and prognosis in CRC.Moreover,high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps(HPs).These results suggest that miR-31 may contribute to the progression of serrated lesions.At a follow-up colonoscopy,we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features.Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component.Higher miR-31 expression was observed in the carcinoma component(57-fold increase)and the HP component(8-fold increase)compared with the paired normal mucosa,suggesting that miR-31 may be one of the key molecules in serrated pathway progression. | Hironori Aoki Katsuhiko Nosho Hisayoshi Igarashi Miki Ito Kei Mitsuhashi Takafumi Naito Eiichiro Yamamoto Tokuma Tanuma Masafumi Nomura Hiroyuki Maguchi Toshiya Shinohara Hiromu Suzuki Hiroyuki Yamamoto Yasuhisa Shinomura | 2014 | World Journal of Gastroenterology2014，20，34： | 5 |
| 4 | Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects显示文摘AIM: To evaluate effects of dietary supplementation of sulforaphane(SF)-rich broccoli sprout(BS) extract on hepatic abnormalities in Japanese male participants.METHODS: In a randomized,placebo-controlled,double blind trial,male participants with fatty liver received either BS capsules containing glucoraphanin [GR; a precursor of SF(n = 24)] or placebo(n = 28) for 2 mo. Liver function markers,serum levels of aspartate and alanine aminotransferases(AST and ALT,respectively) and γ-glutamyl transpeptidase(γ-GTP) and an oxidative stress marker,urinary levels of 8-hydroxydeoxyguanosine(8-OHd G),were measured and compared in participants before and after the trial period. In an animal model,chronic liver failure was induced in Sprague-Dawley rats by successive intraperitoneal injection with N-nitrosodimethylamine(NDMA) for 4 wk. Concomitantly,rats received AIN-76 diets supplemented with or without BS extract. Thereafter,rats were sacrificed,and their sera and livers were collected to measure serum liver function markers and hepatic levels of thiobarbituric acid reactive substances(TBARS) levels and hepatic glutathione S-transferase(GST) activity,a prototypical phase 2 antioxidant enzyme.RESULTS: Dietary supplementation with BS extract containing SF precursor GR for 2 mo significantly decreased serum levels of liver function markers,ALT [median(interquartile range),before: 54.0(34.5-79.0) vs after supplementation: 48.5(33.3-65.3) IU/L,P < 0.05] and γ-GTP [before: 51.5(40.8-91.3) vs after: 50.0(37.8-85.3) IU/L,P < 0.05],as well as the alkali phosphatase activity. Placebo showed no significant effects on the markers. The urinary level of 8-OHd G,an established oxidative stress marker,was significantly reduced in participants who had received BS capsules but not the placebo [before: 6.66(5.51-9.03) vs after: 5.49(4.89-6.66) ng/mg-creatinine,P < 0.05]. The reduction of urinary 8-OHd G was significantly correlated with decreased levels of both ALT and γ-GTP [?8-OHd G and ?ALT: Spearman r(r) 0.514 and P = 0.012,?8-OHd G and ?γ-GTP: r = 0.496 and P = 0.016]. Intake of BS extract prevented NDMA-induced chronic liver failure in rats,which was attributable to the suppression of the increase in TBARS through induction of hepatic phase 2 antioxidant enzymes including hepatic GST(86.6 ± 95.2 vs 107.8 ± 7.7 IU/g,P < 0.01).CONCLUSION: Dietary supplementation with BS extract containing the SF precursor GR is likely to be highly effective in improving liver function through reduction of oxidative stress. | Masahiro Kikuchi Yusuke Ushida Hirokazu Shiozawa Rumiko Umeda Kota Tsuruya Yudai Aoki Hiroyuki Suganuma Yasuhiro Nishizaki | 2015 | World Journal of Gastroenterology2015，21，43： | 3 |
| 5 | Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells显示文摘 | Dai Shida Joji Kitayama Hironori Yamaguchi Kotaro Hama Junken Aoki Hiroyuki Arai Hiroharu Yamashita Ken Mori Akihiro Sako Tsuyoshi Konishi Toshiaki Watanabe Teruyuki Sakai Rika Suzuki Hideo Ohta Yoh Takuwa Hirokazu Nagawa | 2004 | Experimental Cell Research2004，，2： | 2 |
| 6 | Flavone glycosides of Veronicastrum sibiricum var japonicum and the synthesis of luteolin 7- neohesperidoside (veronicastroside) 显示文摘 | Inouye Hiroyuki Aoki Yasuhiko Wagner Hildebert | 1969 | Chemische Berichte1969，102，9： | 1 |
| 7 | Development of a Novel Degassing Process Consisting With Single Large Immersion Snorkel and a Bottom Bubbling Ladle 显示文摘 | Shin-ya Kitamura Hiroyuki Aoki Ken ichiro Miyamoto | 2000 | ISIJ International2000，40，5： | 1 |
| 8 | Development of a Novel Degassing Process Consisting With Single Large Immersion Snorkel and a Bottom Bubbling Ladle 显示文摘 | Shinya Kitamum Hiroyuki Aoki Kenichiro Miyamoto | 2000 | ISIJ International2000，40，5： | 1 |
| 9 | The Gene Encoding the Elongation Factor P Protein Is Essential for Viability and Is Required for Protein Synthesis 显示文摘 | Hiroyuki Aoki Katalin Dekany Sally-Lin Adams | 1997 | J Biol Chem1997，，32： | 1 |
| 10 | Lysophosphatidic receptor, LPA 3 , is positively and negatively regulated by progesterone and estrogen in the mouse uterus显示文摘 | Kotaro Hama Junken Aoki Koji Bandoh Asuka Inoue Tomoko Endo Tomokazu Amano Hiroshi Suzuki Hiroyuki Arai | 2006 | Life Sciences2006，，18： | 1 |
| 11 | Role of nuclear transcription factor kappa B (NF-kappaB) for MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahyropyridine)-induced apoptosis in nigral neurons of mice显示文摘 | Eriko Aoki Ryohei Yano Hironori Yokoyama Hiroyuki Kato Tsutomu Araki | 2008 | Experimental and Molecular Pathology2008，，1： | 1 |
| 12 | 3T propeller diffusion tensor fiber tractography:a feasibility study for cranial nerve fiber tracking显示文摘 | Hiroyuki Kabasawa Yoshitaka Masutani Shigeki Aoki | 2007 | Japanese Journal of Radiology2007，25，9： | 1 |
| 13 | Double-balloon enteroscope-assisted enteral stent placement for malignant afferent-loop obstruction after Roux-en-Y reconstruction显示文摘 | Takashi Sasaki Hiroyuki Isayama Hirofumi Kogure Atsuo Yamada Taku Aoki Norihiro Kokudo Kazuhiko Koike | 2014 | Endoscopy2014，，： | 1 |
| 14 | 3T PRO-PELLER diffusion tensor fiber tractography: a feasibility study for cranial nerve fiber tracking显示文摘 | Hiroyuki Kabasawa Yoshitaka Masutani Shigeki Aoki | 2007 | Japanese Journal of Radiology2007，25，9： | 1 |
| 15 | Stand- ardized mathematical expression for stress-strain relations of structure steel under monotonic and uniaxial tension loading 显示文摘 | Ben Kato Hirofumi Aoki Hiroyuki Yamanouchi | 1990 | Material and Structure1990，23，： | 1 |
| 16 | Intracardiac Fontan procedure for heterotaxy syndrome with complex systemic and pulmonary venous anomalies ☆显示文摘 | Yuji Naito Mitsuru Aoki Kozo Matsuo Hiromichi Nakajima Hiroyuki Aotsuka Tadashi Fujiwara | 2010 | European Journal of Cardio-Thoracic Surgery2010，，1： | 1 |
| 17 | Coefficients of friction of TiN coatings with preferred grain orientations under dry condition显示文摘 | Akira Azushima Yasuo Tanno Hiroyuki Iwata Kohshiro Aoki | 2008 | Wear2008，，7： | 1 |
| 18 | New closure technique for large mucosal defects after endoscopic submucosal dissection of colorectal tumors (with video)显示文摘 | Yosuke Otake Yutaka Saito Taku Sakamoto Takaya Aoki Takeshi Nakajima Naoya Toyoshima Takahisa Matsuda Hiroyuki Ono | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 19 | Conophylline suppresses hepatic stellate cells and attenuates thioacetamide‐induced liver fibrosis in rats显示文摘 | Norio Kubo Rie Saito Kunihisa Hamano Masahiro Nagasawa Fumiaki Aoki Izumi Takei Kazuo Umezawa Hiroyuki Kuwano Itaru Kojima | 2014 | Liver Int2014，，7： | 1 |
| 20 | Identification of Causative Pathogens in Eyes with Bacterial Conjunctivitis by Bacterial Cell Count and Microbiota Analysis显示文摘 | Rumi Aoki Kazumasa Fukuda Midori Ogawa Takako Ikeno Hiroyuki Kondo Akihiko Tawara Hatsumi Taniguchi | 2012 | Ophthalmology2012，，： | 1 |
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