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4篇 您的检索式:作者名="Tokuma Tanuma"
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1MicroRNA-31 expression in colorectal serrated pathway progression显示文摘MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers(CRC).We have recently observed that microRNA-31(miR-31)expression is associated with BRAF mutation and prognosis in CRC.Moreover,high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps(HPs).These results suggest that miR-31 may contribute to the progression of serrated lesions.At a follow-up colonoscopy,we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features.Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component.Higher miR-31 expression was observed in the carcinoma component(57-fold increase)and the HP component(8-fold increase)compared with the paired normal mucosa,suggesting that miR-31 may be one of the key molecules in serrated pathway progression.Hironori Aoki Katsuhiko Nosho Hisayoshi Igarashi Miki Ito Kei Mitsuhashi Takafumi Naito Eiichiro Yamamoto Tokuma Tanuma Masafumi Nomura Hiroyuki Maguchi Toshiya Shinohara Hiromu Suzuki Hiroyuki Yamamoto Yasuhisa Shinomura 2014World Journal of Gastroenterology2014,20,34:5
2Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)显示文摘Hiroaki Takahashi Yoshiaki Arimura Hosokawa Masao Satoshi Okahara Tokuma Tanuma Junichi Kodaira Hidetoshi Kagaya Yuichi Shimizu Kaku Hokari Hiroyuki Tsukagoshi Yasuhisa Shinomura Masahiro Fujita 2010Gastrointestinal Endoscopy2010,,2:2
3Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)显示文摘Hiroaki Takahashi Yoshiaki Arimura Hosokawa Masao Satoshi Okahara Tokuma Tanuma Junichi Kodaira Hidetoshi Kagaya Yuichi Shimizu Kaku Hokari Hiroyuki Tsukagoshi Yasuhisa Shinomura Masahiro Fujita 2010Gastrointestinal Endoscopy2010,,2:1
4Endoscopic submucosal dissection is superior to conventional endoscopic resection as a curative treatment for early squamous cell carcinoma of the esophagus (with video)显示文摘Hiroaki Takahashi Yoshiaki Arimura Hosokawa Masao Satoshi Okahara Tokuma Tanuma Junichi Kodaira Hidetoshi Kagaya Yuichi Shimizu Kaku Hokari Hiroyuki Tsukagoshi Yasuhisa Shinomura Masahiro Fujita 2010Gastrointestinal Endoscopy2010,,2:1
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