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| 1 | TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation显示文摘AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell lines.METHODS: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation assay.RESULTS: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell lines.CONCLUSION: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer. | Yuji Toiyama Akira Mizoguchi Kazushi Kimura Junichirou Hiro Yasuhiro Inoue Tomonari Tutumi Chikao Miki Masato Kusunoki | 2007 | World Journal of Gastroenterology2007，13，19： | 4 |
| 2 | Genetic factors related to gastric cancer susceptibility identified using a genome‐wide association study显示文摘 | Norihisa Saeki Hiroe Ono Hiromi Sakamoto Teruhiko Yoshida | 2012 | Cancer Sci2012，，1： | 3 |
| 3 | Prognostic Nutritional Index Predicts Postoperative Outcome in Colorectal Cancer显示文摘 | Yasuhiko Mohri Yasuhiro Inoue Koji Tanaka Junichirou Hiro Keiichi Uchida Masato Kusunoki | 2013 | World Journal of Surgery2013，，11： | 3 |
| 4 | Evaluation of stapler hepatectomy during a laparoscopic liver resection显示文摘 | Joseph F. Buell Brice Gayet Ho‐Seong Han Go Wakabayashi Ki‐Hun Kim Giulio Belli Robert Cannon Bob Saggi Hiro Keneko Alan Koffron Guy Brock Ibrahim Dagher | 2013 | HPB2013，，11： | 3 |
| 5 | Inverted Meckel's diverticulum preoperatively diagnosed using double-balloon enteroscopy显示文摘An inverted Meckel's diverticulum is a rare gastrointestinal congenital anomaly that is difficult to diagnose prior to surgery and presents with anemia, abdominal pain, or intussusception. Here, we report the case of 57-year-old men with an inverted Meckel's diverticulum, who was preoperatively diagnosed using doubleballoon enteroscopy. He had repeatedly experienced epigastric pain for 2 mo. Ultrasonography and computed tomography showed intestinal wall thickening in the pelvis. Double-balloon enteroscopy via the anal route was performed for further examination, which demonstrated an approximately 8-cm, sausage-shaped, submucosal tumor located approximately 80 cm proximal to the ileocecal valve. A small depressed erosion was observed at the tip of this lesion. Forceps biopsy revealed heterotopic gastric mucosa. Thus, the patient was diagnosed with an inverted Meckel's diverticulum, and single-incision laparoscopic surgery was performed. This case suggests that an inverted Meckel's diverticulum should be considered as a differential diagnosis for a submucosal tumor in the ileum. Balloon-assisted enteroscopy with forceps biopsy facilitate a precise diagnosis of this condition. | Kosuke Takagaki Satoshi Osawa Tatsuhiro Ito Moriya Iwaizumi Yasushi Hamaya Hiroe Tsukui Takahisa Furuta Hidetoshi Wada Satoshi Baba Ken Sugimoto | 2016 | World Journal of Gastroenterology2016，22，17： | 2 |
| 6 | Extrapancreatic neural plexus invasion by carcinomas of the pancreatic head region: evaluation using thin-section helical CT显示文摘 | Hui Tian Hiromu Mori Shunro Matsumoto Yasunari Yamada Hiro Kiyosue Masayuki Ohta Seigo Kitano | 2007 | Radiation Medicine2007，，4： | 2 |
| 7 | SPATA17的单核苷酸多态性可能是日本减速分裂阻滞患者的遗传危险因素显示文摘遗传机制已经成为一些男性患者不育的一个病因。近年来,通过人类睾丸组织的基因芯片分析鉴定了10个与人类精子发生相关的新基因。其中一个是精子发生相关17基因(SPATA17)。为了研究是否SPATA17基因缺陷与减数分裂导致的无精症有关,我们进行了突变分析,将18个日本减数分裂导致的无精症患者的SPATA17编码区域进行了测序,以及统计分析,其中包括18个减数分裂阻滞患者,20个唯支持细胞综合征(SCOS)患者和96个健康对照男性。没有SPATA17发生突变。但是,减数分裂阻滞患者组检测到了3个单核苷酸多态性(cSNPs:SNPI—SNP3)。减数分裂阻滞患者与其他患者的SNP1和SNP2基因型与等位基因频率无明显不同。但是,SNP3的等位基因频率在减数分裂阻滞患者组中明显升高(P〈0.05)。这项研究表明,sPATA17在人类精子发生,尤其是减数分裂中可能起关键性作用。 | Toshinobu Miyamoto Akira Tsujimura Yasushi Miyagawa Eitetsu Koh Naoko Sakugawa Hiroe Miyakawa Hisashi Sato Mikio Namiki Akihiko Okuyama Kazuo Sengoku | 2009 | Asian Journal of Andrology2009，11，5： | 2 |
| 8 | 高动态范围LCD区域亮度控制伪像的评价方法显示文摘区域亮度控制LCD显示质量高,但无法使用常规性能评价体系测评伪像。例如,当完全关闭背光源时,区域亮度控制显示器可以实现完美的黑阶,因此'对比度'的有效值将会变为无穷大。本文引入了有效的、有意义的测评指标,来测试静态和动态晕环的伪像(halo artifact),并得到心理学实验的证明。 | Anders Ballestad Thomas Wan Hiroe Li Helge Seetzen 石琳 | 2009 | 现代显示2009，，6： | 2 |
| 9 | Tenascin-C Regulates Recruitment of Myofibroblasts during Tissue Repair after Myocardial Injury显示文摘 | Masashi Tamaoki Kyoko Imanaka-Yoshida Kazuto Yokoyama Tomohiro Nishioka Hiroyasu Inada Michiaki Hiroe Teruyo Sakakura Toshimichi Yoshida | 2005 | The American Journal of Pathology2005，，： | 2 |
| 10 | Differential effects of selective and non- selective musearinie antagonists on gastrointestinal transit and bowel function in healthy women 显示文摘 | Bharucha AE Isowa H Hiro S | 2013 | Neurogastroenterol Motil2013，25，01： | 1 |
| 11 | Deformation and fragmentation behaviour of exploded metal cylinders and the effects of wall materials, configuration, explosive energy and initiated locations显示文摘 | T. Hiroe K. Fujiwara H. Hata H. Takahashi | 2008 | International Journal of Impact Engineering2008，，12： | 1 |
| 12 | Hypoxia Induces Apoptosis With Enhanced Expression of Fas Antigen Messenger RNA in Cultured Neonatal Rat Cardiomyocytes显示文摘 | Masato Tanaka Hiroshi Ito Susumu Adachi Hajime Akimoto Toshio Nishikawa Takeshi Kasajima Fumiaki Marumo Michiaki Hiroe | 1994 | Circulation Research1994，，3： | 1 |
| 13 | Detection of lipid-laden atherosclerotic plaque by wavelet analysis of radiofrequency intravascular ultrasound signals:in vitro validation and preliminary in vivo application显示文摘 | Murashige A Hiro T Fujii T | 2005 | J Am Coll Cardiol2005，45，12： | 1 |
| 14 | Constituents of Amomum tsao-ko and their radical scavenging and antioxidant activities显示文摘 | Teresita S Martin Hiroe Kikuzaki Masashi Hisamoto | 2000 | Journal of the American Oil Chemists Society2000，77，6： | 1 |
| 15 | Effect of liquid myce- lial culture used as spawn on sawdust cultivation of shiitake(Lentinula edodes) 显示文摘 | Genshiro K Hiroe K Yaichi F | 1996 | Mycoscience1996，37，： | 1 |
| 16 | Adsorptive and photocatalytic properties of Ag - loaded BiVO4 on the degradation of 4 - n - alkylphenols under visible light'irradiation 显示文摘 | Kohtani S Hiro J Yamamoto N | 2005 | Catal Commun2005，6，3： | 1 |
| 17 | Tenascin-C modulates adhesion of cardiornyocytes to extracellular matrix during tissue remodeling after myocardial infarction显示文摘 | lmanaka-Yoshida K Hiroe M Nishikawa T | 2001 | Lab In- vest2001，81，7： | 1 |
| 18 | Correlation of ultrasound-meas- ured common carotid artery stiffness with pathological findings 显示文摘 | Wada T Kodaira K Fajis hiro K | 1994 | Ar- terioscler Thromb Vasc Biol1994，14，2： | 1 |
| 19 | Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes 显示文摘 | Hirata Y Hiroe M | 1991 | Circ Res1991，69，1： | 1 |
| 20 | Angioplasty for chronic total occlusion by using tapered-tip guidewires显示文摘 | Saito S Tanaka S Hiroe Y | 2003 | Catheter Cardiovasc Interv2003，59，3： | 1 |
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