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| 1 | Intrahepatic natural killer T cell populations are increased in human hepatic steatosis显示文摘AIM: To determine if natural killer T cell (NKT) populations are affected in nonalcoholic fatty liver disease (NAFLD). METHODS: Patients undergoing bariatric surgery underwent liver biopsy and blood sampling during surgery. The biopsy was assessed for steatosis and immunocyte infiltration. Intrahepatic lymphocytes (IHLs) were isolated from the remainder of the liver biopsy, and peripheral blood mononuclear cells (PBMCs) were isolated from the blood. Expression of surface proteins on both IHLs and PBMCs were quantified using flow cytometry. RESULTS: Twenty-seven subjects participated in thisstudy. Subjects with moderate or severe steatosis had a higher percentage of intrahepatic CD3+/CD56+ NKT cells (38.6%) than did patients with mild steatosis (24.1%, P = 0.05) or those without steatosis (21.5%, P = 0.03). Patients with moderate to severe steatosis also had a higher percentage of NKT cells in the blood (12.3%) as compared to patients with mild steatosis (2.5% P = 0.02) and those without steatosis (5.1%, P = 0.05). CONCLUSION: NKT cells are significantly increased in the liver and blood of patients with moderate to severe steatosis and support the role of NKT cells in NAFLD. | Michael Adler Sarah Taylor Kamalu Okebugwu Herman Yee Christine Fielding George Fielding Michael Poles | 2011 | World Journal of Gastroenterology2011，17，13： | 10 |
| 2 | Regeneration of hepatocyte ‘buds’ in cirrhosis from intrabiliary stem cells显示文摘 | Olga Falkowski Hee Jung An I.Andreea Ianus Luis Chiriboga Herman Yee A.Brian West Neil D Theise | 2003 | Journal of Hepatology2003，，3： | 1 |
| 3 | Multiorgan resection for gastric cancer: intraoperative and computed tomography assessment of locally advanced disease is inaccurate显示文摘 | Kari L. Colen M.D. Stuart G. Marcus M.D. Elliot Newman M.D. Russell S. Berman M.D. Herman Yee M.D. Spiros P. Hiotis M.D. Ph.D | 2004 | Journal of Gastrointestinal Surgery2004，，7： | 1 |
| 4 | Senescence of Activated Stellate Cells Limits Liver Fibrosis显示文摘 | Valery Krizhanovsky Monica Yon Ross A. Dickins Stephen Hearn Janelle Simon Cornelius Miething Herman Yee Lars Zender Scott W. Lowe | 2008 | Cell2008，，4： | 1 |
| 5 | Fascin Expression in Serous Tumors of Ovary Correlates With Aggressiveness of Malignancy显示文摘 | Yong H. Wen Herman Yee Sunanda Goswami Pratibha Sharma Shukla | 2009 | International Journal of Gynecological Pathology2009，，2： | 1 |
| 6 | Hematopoietic progenitor kinase 1 is a critical component of prostaglandin E2-mediated suppression of the anti-tumor immune response显示文摘 | Saba Alzabin Saiju Pyarajan Herman Yee Friedemann Kiefer Akira Suzuki Steven Burakoff Sansana Sawasdikosol | 2010 | Cancer Immunology Immunotherapy2010，，3： | 1 |
| 7 | Alterations in the expression of Pded4 inductal carcinoma of the breast显示文摘 | YONG W LUIS CHIRIBOGA HERMAN YEE | 2007 | ONCOLOGY REPORTS2007，18，6： | 1 |
| 8 | Surface ozone variations at the Great Wall Station,Antarctica during austral summer显示文摘Surface ozone(O3)is a secondary pollutant harmful to human health and a greenhouse gas which is one of the prime climate forcers.Due to the clean atmospheric environment of the Antarctic region and given the complexity of O3 chemistry,the observation of surface O3 variability in this region is necessary in the quest to better understand the potential sources and sink of polar surface O3.In this paper,we highlighted our observations on O3 variability at the Great Wall Station(GWS)during austral summer in December 2018 and January 2019.The continuous surface O3 measurement at the GWS,Antarctica was carried out using the Ecotech Ozone analyzer.To understand the roles of the meteorological conditions on the temporal variations of O3,meteorological data was obtained from the conventional auto-observational station at the GWS.The Hybrid Single-Particle Lagrangian Integrated Trajectory(HYSPLIT)model was employed to investigate the air mass transport over the region.The observed austral summer surface O3 concentrations at the GWS exhibited variability and were significantly lower than those previously observed at other permanent coastal stations in Antarctica.The surface ozone variability at the GWS was strongly influenced by the synoptic change of air mass origin although the roles of photochemistry production and destruction were still uncertain.Marine characteristics and stable surface O3 characterized the air masses that reached the GWS.The unique characteristic of surface O3 at the coastal site of GWS was emphasized by its synoptic air mass characteristics,which displayed a significant influence on surface O3 variability.Air mass that traveled over the ocean with relatively shorter distance was linked to the lower O3 level,whereby the marine transport of reactive bromine(Br)species was thought to play a significant role in the tropospheric chemistry that leads to O3 destruction.Meanwhile,the diurnal variation indicated that the O3 background concentration levels were not strongly associated with the local atmospheric conditions. | Justin SENTIAN Franky HERMAN Mohd Sharul MOHD NADZIR Vivian Kong WAN YEE | 2020 | Advances in Polar Science2020，31，2： | 0 |
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