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| 1 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 2 | Distributed modeling of monthly air temperatures over the rugged terrain of the Yellow River Basin显示文摘Our analyses of the monthly mean air temperature of meteorological stations show that altitude,global solar radiation and surface effective radiation have a significant impact on air temperature.We set up a physically-based empirical model for monthly air temperature simulation.Combined the proposed model with the distributed modeling results of global solar radiation and routine meteorological observation data,we also developed a method for the distributed simulation of monthly air temperatures over rugged terrain.Spatial distribution maps are generated at a resolution of 1 km×1 km for the monthly mean,the monthly mean maximum and the monthly mean minimum air temperatures for the Yellow River Basin.Analysis shows that the simulation results reflect to a considerable extent the macro and local distribution characteristics of air temperature.Cross-validation shows that the proposed model displays good stability with mean absolute bias errors of 0.19℃-0.35℃.Tests carried out on local meteorological station data and case year data show that the model has good spatial and temporal simulation capacity.The proposed model solely uses routine meteorological data and can be applied easily to other regions. | ZENG Yan QIU XinFa HE YongJian SHI GuoPing LIU ChangMing | 2009 | Science China Earth Sciences2009，52，5： | 11 |
| 3 | A Review of Technical Advances,Barriers,and Solutions in the Power to Hydrogen(P2H)Roadmap显示文摘Power to hydrogen(P2H)provides a promising solution to the geographic mismatch between sources of renewable energy and the market,due to its technological maturity,flexibility,and the availability of technical and economic data from a range of active demonstration projects.In this review,we aim to provide an overview of the status of P2H,analyze its technical barriers and solutions,and propose potential opportunities for future research and industrial demonstrations.We specifically focus on the transport of hydrogen via natural gas pipeline networks and end-user purification.Strong evidence shows that an addition of about 10%hydrogen into natural gas pipelines has negligible effects on the pipelines and utilization appliances,and may therefore extend the asset value of the pipelines after natural gas is depleted.To obtain pure hydrogen from hydrogen-enriched natural gas(HENG)mixtures,end-user separation is inevitable,and can be achieved through membranes,adsorption,and other promising separation technologies.However,novel materials with high selectivity and capacity will be the key to the development of industrial processes,and an integrated membrane-adsorption process may be considered in order to produce high-purity hydrogen from HENG.It is also worth investigating the feasibility of electrochemical separation(hydrogen pumping)at a large scale and its energy analysis.Cryogenics may only be feasible when liquefied natural gas(LNG)is one of the major products.A range of other technological and operational barriers and opportunities,such as water availability,byproduct(oxygen)utilization,and environmental impacts,are also discussed.This review will advance readers’understanding of P2H and foster the development of the hydrogen economy. | Guoping Hu Chao Chen Hiep Thuan Lu Yue Wu Congmin Liu Lefu Tao Yuhan Men Guangli He Kevin Gang Li | 2020 | Engineering2020，6，12： | 7 |
| 4 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 5 | Discrete time transfer matrix method for dynamics analysis of complex weapon systems显示文摘Efficient, precise dynamic modeling and analysis for complex weapon systems have become more and more important in their dynamic design and performance optimizing. As a new method developed in recent years, the discrete time transfer matrix method of multibody system is highly efficient for multibody system dynamics. In this paper, taking a shipboard gun system as an example, by deducing some new transfer equations of elements, the discrete time transfer matrix method of multibody sys- tem is used to solve the dynamics problems of complex rigid-flexible coupling weapon systems successfully. This method does not need the global dynamic equations of system and has the low order of system matrix, high computational efficiency. The proposed method has advantages for dynamic design of complex weapon systems, and can be carried over straightforwardly to other complex mechanical systems. | RUI XiaoTing RONG Bao WANG GuoPing HE Bin | 2011 | Science China(Technological Sciences)2011，54，5： | 5 |
| 6 | Topological r-entropy and measure-theoretic r-entropy of a continuous map显示文摘In this paper,we introduce the concept of measure-theoretic r-entropy of a continuous map on a compact metric space,and get the results as follows:1.Measure-theoretic entropy is the limit of measure-theoretic r-entropy and topological entropy is the limit of topological r-entropy(r → 0);2.Topological r-entropy is more than or equal to the supremum of 4r-entropy in the sense of Feldman's definition,where the measure varies among all the ergodic Borel probability measures. | REN YunLi HE LianFai LV JinFeng ZHENG GuoPing | 2011 | Science China Mathematics2011，54，6： | 5 |
| 7 | A comparative study of hydrothermal aging effect on cerium and lanthanum doped Cu/SSZ-13 catalysts for NH_(3)-SCR显示文摘Ce-or La-doped Cu/SSZ-13 catalysts were prepared by a hydrothermal method and Cu,Ce or La ions were incorporated through stepwise ion exchange,The catalyst activity was measured for the ammonia selective catalytic reduction reaction.The structure and composition of catalyst were characterized by using X-ray diffraction,scanning electron microscopy,inductively coupled plasma mass spectrometry solid-state NMR,NH_(3)-TPD techniques,and the active components were examined by XPS and XANES.The results indicate that the Ce and La doping can both completely preserve the SCR activity of Cu/SSZ-13 above 300℃,but there is also a decrease of activity below 200℃.On the other hand,Ce doping is beneficial to the formation of framework aluminum,stabilizes molecular sieve framework and Cu active sites of Cu/SSZ-13,thereby improves the catalyst hydrothermal stability.But La doping will decrease the amount of framework aluminum and Cu active sites of Cu/SSZ-13 after hydrothermally aging,even destroy zeolite CHA structure.This is quite harmful to the catalyst hydrothermal stability. | Di Deng Shujun Deng Dandan He Zhiheng Wang Zhipeng Chen Yi Ji Guoping Yan Guangjin Hou Licheng Liu Hong He | 2021 | Journal of Rare Earths2021，39，8： | 5 |
| 8 | Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity显示文摘定期聚类短 palindromic 重复的 interspaced (CRISPR ) 在细菌和 archaea 的 -CRISPR-associated (Cas ) 系统对入侵外国 nucleic 酸提供适应免疫。以前的研究建议某些细菌采用他们的类型 II CRISPR-Cas 系统指向他们的自己的基因,因此躲避主人免疫。然而,另外的 CRISPR-Cas 系统是否在主机房间的细菌的侵略期间有类似的函数,仍然保持未知。这里,我们为类型识别一个新奇角色我在在 Pseudomonas aeruginosa 躲避主人防卫的 CRISPR-Cas 系统拉紧 UCBPP-PA14。类型我 PA14 的 CRISPR-Cas 系统指向细菌的察觉到治安法官的管理者 LasR 的 mRNA 阻抑由像使用费的受体的识别 4,因此减少在房间和鼠标模型的主机的支持 inflammatory 回答。机械学地,这调停核酸酶的 RNA 降级在类型的 Cas3 在目标 mRNA,和 HD 和 DExD/H 领域要求一个 5-GGN-3 识别主题我 CRISPR-Cas 系统。作为 LasR 和类型我 CRISPR-Cas 系统在细菌是无所不在地在场的,我们的调查结果阐明重要普通机制内在的细菌的毒力。 | Rongpeng Li Lizhu Fang Shirui Tan Min Yu Xuefeng Li Sisi He Yuquan Wei Guoping Li Jianxin Jiang Min Wu | 2016 | Cell Research2016，26，12： | 4 |
| 9 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 10 | Multi-proxy evidence of environmental change related to collapse of the Liangzhu Culture in the Yangtze Delta,China显示文摘The Liangzhu Culture(5300–4300 cal.a BP)has been regarded as the culmination of the Neolithic Age in the Yangtze Delta and as an archaic state.However,the reason behind the collapse of the Liangzhu Culture remains controversial.Some scholars attributed it to social conflicts or foreign invasions,while others suggested that environmental deterioration,such as cold episodes,inundation and palaeo-typhoon events,disrupted the civilization.Notably,the yellowish silty sediments widely overlying the Liangzhu group sites have been presumed to be one of the vital clues to resolving these issues.The process and cause of their formation are key to understanding the decline in the Liangzhu Culture.In this study,two typical profiles composed of the Liangzhu cultural layer and yellowish silty sediments were collected in Liangzhu Ancient City.Multiple proxies,including pollen,phytoliths and diatoms,along with radiocarbon and optically stimulated luminescence dating and synthesized geochemical evidence from different sediments,were applied to reconstruct ecological and hydrological changes and discuss their linkage to cultural collapse.The regional ecology was typical freshwater wetlands during 4800–4400 cal.a BP,which facilitated rice farming and large-scale architectural engineering in Liangzhu Ancient City.Evidence from microfossils and dating of the yellowish silty sediments indicated that Liangzhu Ancient City was significantly affected by seawater after abandonment during 4300–3400 cal.a BP.Furthermore,geochemical evidence,including trace element and Sr-Nd isotopic compositions,suggested that the primary provenance of the yellowish silt was a mixture of sediments from the Qiantang River,East China Sea,Yangtze River and Yellow River,which had been transported to Liangzhu Ancient City by the Yellow Sea Coastal Current and a marine transgression.Therefore,based on evidence from archaeological sites and numerical simulation in the Yangtze Delta,it was supposed that the short-term accelerated relative sea-level rise at approximately 4400 cal.a BP caused a marine transgression around Taihu Lake,formed a large range of yellowish silty sediments,destroyed rice farming production,and ultimately led to the collapse of the Liangzhu Culture. | Keyang HE Houyuan LU Guoping SUN Xiang JI Yonglei WANG Kaikai YAN Xinxin ZUO Jiangping ZHANG Bin LIU Ningyuan WANG | 2021 | Science China Earth Sciences2021，64，6： | 3 |
| 11 | The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus显示文摘A mutation network for the hemagglutinin gene(HA) of the novel type A(H1N1) influenza virus was constructed.Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic.Based on the 658A and 1408T mutations in HA,the viruses evolving into this epidemic were divided into three categories,the Mexico,the transitional and the New York type.The three groups of viruses presented distinctive clustering features in their geographic distributions. | HE YunGang DING GuoHui BIAN Chao HUANG Zhong LAN Ke SUN Bing WANG XueCai LI YiXue WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang JIN WeiRong XIONG Hui DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenAn ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN Li | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 12 | Novel approach to and implementation of design and analysis of armored face conveyor power train显示文摘An armored face conveyor(AFC) is a key piece of equipment for a fully mechanized long-wall mining system and is currently the only means for transporting bulk material in hard coal mines. To date, the AFC power train design has mainly been based on heuristics obtained via experience, coupled with simple calculations, which cannot take the dynamic behaviors and coupling effects of the components into consideration. Therefore, model-based and simulation-driven design is preferred. In this paper, a new design and analysis methodology for an AFC power train is presented to achieve the optimal dynamic characteristics and transmission performance. A preliminary design procedure for a power train is first introduced. Then, a system-level hydro-mechatronic model of the power train is built to evaluate and optimize the preliminary scheme. Sub-models, including those for the motors, fluid couplers, gearboxes, and chain, are obtained according to their individual disciplines and assembled to form the system-level model. The chain sub-system is discretized into multiple finite elements. Governing equations are established for each element based on the Newton Euler approach and assembled according to the topological structure of the chain system. In order to make the new approach applicable for engineers, a design and analysis software is developed, with a graphical user interface that involves the whole design process. MATLAB/SIMULINK is used as the computational engine, and Visual C++ is adopted to develop the interactive software framework. Simulations for the SGZ1000/2000 type AFC are provided as an illustrative case study to validate the effectiveness and practicality of the model and software package. | NIE Rui HE BaiYan YUAN PengFei ZHANG LianHong LI GuoPing | 2015 | Science China(Technological Sciences)2015，58，12： | 3 |
| 13 | Experimentai Research on Saturated-Gain for Soft X-Ray Laser from Neon-Like Germanium Plasma显示文摘AmpliHcation of spontaneous emissions at 19.6,23.2 and 23.6 nm have been observed by a “ultiple-Target Series Coupling”design in Ge plasma,.The combined length for four targets is up to 56mm.The gain length product(GL)of small signal is up to 18 for both lines at 23.2 and 23.6 nmt and the effective GL is 16.4 and 15.7 for these two lines respectively.This two lines are obviously tending to saturation.The divergence of x-ray laser beam is about 4 mrad. | WANG Shiji GU Yuan ZHOU GuanUn NI Yuanlong YU Songyu FU Sizu MAO Chusheng TAO Zucong CHEN Wannian LIN Zunqi FAN Dianyuan ZHANG Guoping SHENG Jiatian YANG Minglun ZHANG Tanxin SHAO Yunfeng PENG Huimin HE Xiantu YU Min | 1991 | Chinese Physics Letters1991，8，12： | 3 |
| 14 | A hierarchical updating method for finite element model of airbag buffer system under landing impact显示文摘In this paper, we propose an impact finite element(FE) model for an airbag landing buffer system. First, an impact FE model has been formulated for a typical airbag landing buffer system. We use the independence of the structure FE model from the full impact FE model to develop a hierarchical updating scheme for the recovery module FE model and the airbag system FE model.Second, we define impact responses at key points to compare the computational and experimental results to resolve the inconsistency between the experimental data sampling frequency and experimental triggering. To determine the typical characteristics of the impact dynamics response of the airbag landing buffer system, we present the impact response confidence factors(IRCFs) to evaluate how consistent the computational and experiment results are. An error function is defined between the experimental and computational results at key points of the impact response(KPIR)to serve as a modified objective function. A radial basis function(RBF) is introduced to construct updating variables for a surrogate model for updating the objective function, thereby converting the FE model updating problem to a soluble optimization problem. Finally, the developed method has been validated using an experimental and computational study on the impact dynamics of a classic airbag landing buffer system. | He Huan Chen Zhe He Cheng Ni Lei Chen Guoping | 2015 | Chinese Journal of Aeronautics2015，28，6： | 2 |
| 15 | Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus显示文摘In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses. | WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing LI YiXue CAO ZhiWei | 2009 | Chinese Science Bulletin2009，54，13： | 2 |
| 16 | Decoding Cortical Glial Cell Development显示文摘Mouse cortical radial glial cells(RGCs)are primary neural stem cells that give rise to cortical oligodendrocytes,astrocytes,and olfactory bulb(OB)GABAergic interneurons in late embryogenesis.There are fundamental gaps in understanding how these diverse cell subtypes are generated.Here,by combining single-cell RNA-Seq with intersectional lineage analyses,we show that beginning at around E16.5,neocortical RGCs start to generate ASCL1^(+)EGFR^(+)apical multipotent intermediate progenitors(MIPCs),which then differentiate into basal MIPCs that express ASCL1,EGFR,OLIG2,and MKI67.These basal MIPCs undergo several rounds of divisions to generate most of the cortical oligodendrocytes and astrocytes and a subpopulation of OB interneurons.Finally,single-cell ATAC-Seq supported our model for the genetic logic underlying the specification and differentiation of cortical glial cells and OB interneurons.Taken together,this work reveals the process of cortical radial glial cell lineage progression and the developmental origins of cortical astrocytes and oligodendrocytes. | Xiaosu Li Guoping Liu Lin Yang Zhenmeiyu Li Zhuangzhi Zhang Zhejun Xu Yuqun Cai Heng Du Zihao Su Ziwu Wang Yangyang Duan Haotian Chen Zicong Shang Yan You Qi Zhang Miao He Bin Chen Zhengang Yang | 2021 | Neuroscience Bulletin2021，37，4： | 2 |
| 17 | Re-characterization of an extrachromosomal circular plasmid in the pathogenic Leptospira interrogans serovar Lai strain 56601显示文摘在中国,(str.56601 ) 螺旋体 interrogans serovar Lai 紧张 56601 是在人和动物引起严重细螺旋体病的主要病原的紧张之一。完全在 2003 定序的这 organismwas 的染色体。在 2011,然而,我们由于广泛地在螺旋体染色体散布的重复序列在 str.56601 染色体识别了并且改正一些集会错误。在这研究,我们重新分析以前报导在染色体 andrectified 的活动、噬菌体相关的 genomic 岛用各种各样的试验性的方法在 plasmid 和染色体详细说明了顺序信息。分开的圆形的 extrachromosomal plasmid 也是的 presenceof 证实岛在 L 报导了,并且它在 genomic 区域的地点是到 genomic 的 determinedrelative。由基于的脉搏地胶化电气泳动和 plasmid 的联合的 interrogans serovar Lai 基于抽取的南部的污点 analysis.This 报告证实分开的 extrachromosomal 通报 plasmid 不集成于 L 的染色体。interrogans str.56601 并且显著地改进了我们 L 的 genomic 组织,进化,和致病的理解。interrogans。特别地,这 extrachromosomal 通报 plasmid 的描述将在病原的螺旋体种类贡献 geneticmanipulation 系统的开发。 | Lili Huang Weinan Zhui Ping He Yan Zhang Xuran Zhuang Guoping Zhao Xiaokui Guo Jinhong Qin Yongzhang Zhu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，7： | 1 |
| 18 | Renal protective effect of Rosa laevigata Michx. by the inhibition ofoxidative stress in streptozotocin-induced diabetic rats显示文摘 | Yujuan Zhou Qianjin Liao Yuping Luo Zhenqi Qing Qiuju Zhang Guoping He | 2012 | Molecular Medicine Reports2012，，6： | 1 |
| 19 | An Active Strategy Based on theMultiplier Function or the Gradient 显示文摘 | Sun Li Fang Liang He Guoping | 2010 | Application of Mathemat-ics2010，55，4： | 1 |
| 20 | Discrete Time Transfer Matrix Method for Multibody System Dynamics显示文摘 | Xiaoting Rui Bin He Yuqi Lu Wenguang Lu Guoping Wang | 2005 | Multibody System Dynamics (-)2005，，3： | 1 |
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