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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Novel approach to and implementation of design and analysis of armored face conveyor power train显示文摘An armored face conveyor(AFC) is a key piece of equipment for a fully mechanized long-wall mining system and is currently the only means for transporting bulk material in hard coal mines. To date, the AFC power train design has mainly been based on heuristics obtained via experience, coupled with simple calculations, which cannot take the dynamic behaviors and coupling effects of the components into consideration. Therefore, model-based and simulation-driven design is preferred. In this paper, a new design and analysis methodology for an AFC power train is presented to achieve the optimal dynamic characteristics and transmission performance. A preliminary design procedure for a power train is first introduced. Then, a system-level hydro-mechatronic model of the power train is built to evaluate and optimize the preliminary scheme. Sub-models, including those for the motors, fluid couplers, gearboxes, and chain, are obtained according to their individual disciplines and assembled to form the system-level model. The chain sub-system is discretized into multiple finite elements. Governing equations are established for each element based on the Newton Euler approach and assembled according to the topological structure of the chain system. In order to make the new approach applicable for engineers, a design and analysis software is developed, with a graphical user interface that involves the whole design process. MATLAB/SIMULINK is used as the computational engine, and Visual C++ is adopted to develop the interactive software framework. Simulations for the SGZ1000/2000 type AFC are provided as an illustrative case study to validate the effectiveness and practicality of the model and software package. | NIE Rui HE BaiYan YUAN PengFei ZHANG LianHong LI GuoPing | 2015 | Science China(Technological Sciences)2015，58，12： | 3 |
| 3 | Dynamic Modeling of Flexible Multibody Systems with Parameter Uncertainty 显示文摘 | Wang Shuxin Wang Yanhui He Baiyan | 2008 | Chaos Solitons and Fractals2008，36，3： | 1 |
| 4 | Numerical Simulation of Residual Stress Field in Green Powder Metallurgy Compacts by Modified Drucker-Prager Cap Model显示文摘 | Zhou Rui Zhang Lianhong He Baiyan | 2013 | Trans Nonferrous Met Soc China2013，23，8： | 1 |
| 5 | Dynamic modeling of flexible multibody systems with parameter uncertainty显示文摘 | Wang Shuxin Wang Yanhui He Baiyan | 2008 | Chaos Solitons and Fractals2008，36，3： | 1 |
| 6 | Metformin and Lactic Acidosis in Diabetic Patients显示文摘Metfommin is the basic drug in the clinical treatment of Diabetes,often used in the treatment of Type 2 Diabetes Mellitus(T2DM).Its effect has been fully verificd in the clinical treatment of T2DM.However,in the treatment of T2DM with metformin,there is still a certain probability of related lactic acidosis,and the fatality rate is high.Therefore,is the use of metformin drug treatment a direct risk factor for lactic acidosis in diabetic patients?This paper will review the hypoglycemic mechanism of metformin and related studies on lactic acidosis,so as to further explore the relationship between metformin and lactic acidosis in diabetic patients,and provide help and reference for metformin drugs in the clinical treatment ofT2DM. | Baiyan Zhao Zhilu Li Zhangyi He Xinxin Zhou Yiying Yu Kerong Ren Pingping Yan | 2021 | Journal of Endocrinology Research2021，3，1： | 0 |
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