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		题名	作者	年代	出处	被引量
	1	Special features of the 2009 pandemic swine-origin influenza AH1N1 hemagglutinin and neuraminidase显示文摘Since the 2009 pandemic H1N1 swine-origin influenza A virus (09 S-OIV) has reminded the world about the global threat of the ever changing influenza virus,many questions regarding the detailed re-assortment of influenza viruses yet remain unanswered.Influenza A virus is the causative agent of the pandemic flu and contains 2 major antigenic glycoproteins on its surface:(i) hemagglutinin (HA);and (ii) neuraminidase (NA).The structures of the 09 S-OIV HA and NA proteins (09H1 and 09N1) have recently been resolved in our laboratory and provide some clues as to why the 09 S-OIV re-assortment virus is highly infectious with severe consequences in humans.For example,the 09H1 is highly similar to the HA of the 1918 influenza A pandemic virus in overall structure and especially in regards to its 5 defined antibody binding epitopes.For 09N1,its most distinctive feature is the lack of a 150-loop active site cavity,which was previously predicted to be present in all N1 NAs,and we hypothesize that the 150-loop may play a important role in the substrate specificity (α2,3 or α2,6 linked sialic acid receptors) and enzymatic mechanism of influenza NA.Combination of the HA and NA with special characteristics for the 09 S-OIV might contribute to its high increased transmissibility in humans.	VAVRICKA Christopher John LIU Yue LI Qing SHI Yi WU Yan SUN YePing QI JianXun GAO George Fu	2011	Chinese Science Bulletin2011，56，17：	2
	2	Two interesting biological fields:Avian influenza virus and epigenetics显示文摘The highly pathogenic avian influenza virus H5N1 attracted much attention in 2009,when the human death toll due to infection with this virus in China created a potential world-wide pandemic alert.	HUA QingXin	2010	Chinese Science Bulletin2010，55，35：	0

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