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| 1 | 人工湿地系统对污水磷的净化效果显示文摘建立以亚热带湿生、水生植物为主的十二套下行流—上行流人工湿地系统作为处理城镇生活污水的对策。以其中四套研究其在不同的水力负荷及气候条件下对污水中磷的去除效果。人工湿地系统随处理运行时间的推移趋于稳定 ,对污水中的总磷、无机磷显示较好的净化效率 ,平均去除率在冬季达到 40 %以上 ,夏季达到 60 %以上 ,出水达到国家地面水Ⅲ级标准。水生植物在系统中起到明显作用 ,有植物系统的除磷效率及稳定性均高于无植物对照 ,其中 2号茭白—石菖蒲系统的效果最好 ,总磷平均去除率为 65%。 4号草—苔草系统在高水力负荷下的净化效果优于 2号。 | WU Zhen-bin CHEN Hui-rong HE Feng CHENG Shui-ping FU Gui-ping JIN Jian-ming QIU Dong-ru REN Ming-xun 任明迅 金建明 贺锋 陈辉蓉 付贵萍 吴振斌 邱东茹 成水平 | 2001 | 水生生物学报2001，25，1： | 188 |
| 2 | FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis显示文摘 | Xu Zhao Ying Yang Bao-Fa Sun Yue Shi Xin Yang Wen Xiao Ya-Juan Hao Xiao-Li Ping Yu-Sheng Chen Wen-Jia Wang Kang-Xuan Jin Xing Wang Chun-Min Huang Yu Fu Xiao-Meng Ge Shu-Hui Song Hyun Seok Jeong Hiroyuki Yanagisawa Yamei Niu Gui-Fang Jia Wei Wu Wei-Min Tong Akimitsu Okamoto Chuan He Jannie M Rendtlew Danielsen Xiu-Jie Wang Yun-Gui Yang | 2014 | Cell Research2014，24，12： | 109 |
| 3 | Chemical characteristics of PM_(2.5) during a typical haze episode in Guangzhou显示文摘The chemical characteristics(water-soluble ions and carbonaceous species) of PM2.5 in Guangzhou were measured during a typical haze episode.Most of the chemical species in PM2.5 showed significant difference between normal and haze days.The highest contributors to PM2.5 were organic carbon(OC),nitrate,and sulfate in haze days and were OC,sulfate,and elemental carbon(EC) in normal days.The concentrations of secondary species such as,NO3-,SO42-,and NH4+ in haze days were 6.5,3.9,and 5.3 times higher than those in normal days,respectively,while primary species(EC,Ca2+,K+) show similar increase from normal to haze days by a factor about 2.2-2.4.OC/EC ratio ranged from 2.8 to 6.2 with an average of 4.7 and the estimation on a minimum OC/EC ratio showed that SOC(secondary organic carbon) accounted more than 36.6% for the total organic carbon in haze days.The significantly increase in the secondary species(SOC,NO3-,SO42-,and NH4+),especially in NO3-,caused the worst air quality in this region.Simultaneously,the result illustrated that the serious air pollution in haze episodes was strongly correlated with the meteorological conditions.During the sampling periods,air pollution and visibility had a good relationship with the air mass transport distance;the shorter air masses transport distance,the worse air quality and visibility in Guangzhou,indicating the strong domination of local sources contributing to haze formation.High concentration of the secondary aerosol in haze episodes was likely due to the higher oxidation rates of sulfur and nitrogen species. | TAN Jihua DUAN Jingchun HE Kebin MA Yongliang DUAN Fengkui CHEN Yuan FU Jiamo | 2009 | Journal of Environmental Sciences2009，21，6： | 71 |
| 4 | The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis显示文摘上皮间充质的转变(EMT ) 把上皮的肿瘤房间变换成侵略、变形的癌症房间,导致在癌症病人的死亡。尽管扭曲为胸和另外的癌症是 EMT 和转移的一个主人管理者,为调停扭曲的基因抄写负责的机制仍然保持未知。在这研究, TWIST 蛋白质建筑群的纯化和描述表明那扭曲与改变的 Mi2/nucleosome 和 deacetylase (Mi2/NuRD ) 的几个部件交往建筑群, MTA2, RbAp46, Mi2 和 HDAC2,和成员他们到为 transcriptional 压抑的 E-cadherin 倡导者的近似区域。从取决于的房间线高效地为转移扭曲的癌症的这些扭曲建筑群部件的弄空在老鼠在文化和肺转移压制房间移植和侵略。这些调查结果不仅提供在扭曲和 Mi2/NuRD 建筑群之间的新奇机械学、功能的连接而且为在癌症复杂的 Mi2/NuRD 的部件建立新必要角色转移。 | Junjiang Fu Li Qin Tao He Jun Qin Jun Hong Jiemin Wong Lan Liao Jianming XU | 2011 | Cell Research2011，21，2： | 51 |
| 5 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 6 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 7 | MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes显示文摘piRNA 机械在调停以它的角色著名 transposons 的 epigenetic silencing。最近的研究建议这功能也包含导出 transposon 的抄本的指导 piRNA 的劈开。同样多 piRNAs 也看起来有能力指向多样的 mRNAs,这提起 piRNAs 可以与 siRNAs 比广泛地扮演降级的吸引人的可能性特定的 mRNAs。直接测试这个假设,我们比较了联系的老鼠 PIWI (MIWI ) 有从老鼠睾丸的试验性地识别的劈开的 mRNA 碎片的 piRNAs,和主要发生在的观察劈开地点从 5 ′ 放 10;通常认为的指向结束 piRNAs。我们也注意了强壮的偏爱因为分别地,在核苷酸的 U 和 A 残余在 piRNAs 和 mRNA 碎片放 1 和 10,由“乒乓球”类似于 piRNA 扩大的模式的特征骑车。通过由介绍的 CLIP-seq 和基因表示 MIWI-RNA 相互作用印射,我们发现许多潜在的指向 piRNA 的 mRNAs 直接与 MIWI 交往,表演在 Miwi 的睾丸提高了表达式层次催化变异的鼠标。基于记者的试金进一步揭示了在调停 piRNA 的目标压抑的为 slicer 活动和 MIWI 的装载 piRNA 能力的在 piRNAs 和 mRNA 目标和要求之间的基础配对的重要性。重要地,我们证明某些关键 piRNA 目标的那合适的周转为精子形成是必要的。一起,这些调查结果为男细菌房间开发和成熟在鼠标睾丸和它的中央要求揭示 piRNA 机械的象 siRNA 一样函数。 | Peng Zhang Jun-Yan Kang Lan-Tao GOU Jiajia Wang Yuanchao Xue Geir Skogerboe Peng Dai Da-Wei Huang Runsheng Chen Xiang-Dong Fu Mo-Fang Liu Shunmin He | 2015 | Cell Research2015，25，2： | 35 |
| 8 | Analysis of Factors Associated with Death in Maintenance Hemodialysis Patients: A Multicenter Study in China显示文摘 | Kang-Kang Song De-Long Zhao Yuan-Da Wang Yong Wang Xue-Feng Sun Li-Ning Miao Zhao-Hui Ni Hong-Li Lin Fu-You Liu Ying Li Ya-Ni He Nian-Song Wang Cai-Li Wang Ai-Hua Zhang Meng-Hua Chen Xiao-Ping Yang Yue-Yi Deng Feng-Min Shao Shu-Xia Fu Jing-Ai Fang Guang-Yan Cai Xiang-Mei Chen | 2017 | Chinese Medical Journal2017，，8： | 39 |
| 9 | Contamination of Fungi and Mycotoxins in Foodstuffs in High Risk Area of Esophageal Cancer显示文摘Fungal and mycotoxin contamination has been found in fordstuffs from Cixian County, an area with a high incidence of esophageal carcinoma (Eca). To set a scientific foundation for the prevention of Eca at the etiological level, fungal and mycotoxin contaminations of local foodstuffs in Cixian County were analyzed using classical fungal culture methods and HPLC. From 1990 to 1994, 220 corn/wheat samples and 34 corn samples were studied. As a control, 26 corn samples collected from a relatively low incidence area of Eca in Zanhuang County were analyzed for mycotoxins in 1990. The results showed that fungal contamination in corn and wheat was severe and that several of the predominant contaminating fungi such as Furasium moniliforme, etc. were carcinogenic. HPLC results showed that the detection rate and mean content of the mycotoxin sterigmatocystin (ST) in the mountainous area (5/8; 9. 14 μg/kg) were significantly higher than those in the hilly (0; 0) and plain areas (1/18; 1. 29 μg/kg) as well as in low risk area control samples (3/26; 0. 76 μg/kg). Detection rates of deoxynivalenol (DON) in mountainous and hilly areas (5/8, 4/8 respectively) were slightly higher than that in plain area (8/18), while the mean content of DON in the plain area was significantly higher (90. 45-170. 22 vs 50. 56 and 46. 45 μg/kg).Among the different aflatoxins, AFB1 was detected in samples from the two villages in the plain area for the subsequent two years. The mean content of AFB1 was 0. 0183μg/kg, and the highest level was 0. 0497 μg/kg. No AFB1 was detected in the samples from mountainous and hilly areas. AFG1 was detected in more than half of all the samples, and its concentration ranged from 8. 77 to 46. 51 ng/kg. No AFG2 was found in the samples. Thus, the results suggest that at present, fungal and mycotoxin contamination of foodstuffs in Cixian County are quite common. | ZHANG XIANG-HONG XIE TONG-XIN LI SHAO-SEN WANG JUN-LING YAN XIA WANG ZHAO-YI WANG FENG-RONG AND FU CHENG-GUANG(Department of Experimental Pathology, Hebei Medical University,Shijiazhuang 050017, China Research Center of Physical and Chemical Analysis, He | 1998 | Biomedical and Environmental Sciences1998，11，2： | 38 |
| 10 | Cardioprotective effects of simvastatin on reversing electrical remodeling induced by myocardial ischemia-reperfusion in normocholesterolemic rabbits显示文摘背景:最近的研究表明了有 statin 的那个预告的处理在阻止心律不齐,而是它的电镀物品是有效的生理的机制不清楚。这研究被进行在颠倒在经历 ischemia-reperfusion 的兔子心的左室的 myocytes 的电的改变上调查 simvastatin 的 cardioprotective 效果,以便探索为 statin 的反没有节奏的效果负责的离子的机制。方法:45 只兔子随机被划分成三个组:ischemic-reperfusion 组(红外) , simvastatin 干预组(Statin ) 和假冒操作控制组(反对) 。Anesthetized 兔子被左前面的下降冠的动脉和 60 分钟的灌注的结扎在 5 mg x kg 的口头的 simvastatin 的一个 3 天的政府以后受到 30 分钟的局部缺血(-1) x d (在 Statin 组的 -1) 或在红外的安慰剂组织。单个室的 myocytes 被孤立从 infracted 区域的 epicardial 地区的酶的联盟者在 CON 动物在红外和 Statin 组和一样的解剖区域源于心。整个房间斑夹钳技术被用来记录膜离子电流,包括钠电流(我(Na )) , L 类型钙电流(我(Ca-L )) 并且短暂的外面的钾电流(我(到)) 。同时,浆液胆固醇的水平被检验。结果:在在三个组之中的浆液胆固醇集中没有有效差量。山峰我( Na )当前的密度(在 -30 mV )显著地在红外被减少((-22.46+/-5.32) pA/pF , n=12 )与反对相比((-42.78+/-5.48) pA/pF , n=16 , P<0.01 )并且 Statin ((-40.66+/-5.89) pA/pF , n=15 , P<0.01 ),当时山峰我( Na )在 Statin 组的当前的密度不与反对( P>0.05 )不同。山峰我( Ca-L )当前的密度(在 0 mV )显著地在红外被增加((-4.34+/-0.92) pA/pF , n=15 )与反对相比((-3.13+/-1.22) pA/pF , n=13 , P<0.05 )并且 Statin ((-3.46+/-0.85) pA/pF , n=16 , P<0.05 ),当时山峰我( Ca-L )在 Statin 的当前的密度不与反对( P>0.05 )不同。我(到)当前的密度(在 +60 mV )显著地在红外被减少(( 9.49+/-1.91 ) pA/pF , n=11 )与反对相比(( 17.41+/-3.13 ) pA/pF , n=15 , P<0.01 )并且 Statin (( 14.54+/-2.41 ) pA/pF , n=11 , P<0.01 ),尽管与反对( P<0.05 )相比在 Statin 组有细微减小。结论:ischemia-reperfusion 导致重要下面规定,这被暗示我(Na ) 并且我(到) 并且起来规定我(Ca-L ) ,它可以位于改变的电的活动和幸存的长反常的 transmembrane 动作电位持续时间下面室的 myocytes,因此在尖锐 ischemia-reperfusion 期间贡献室的心律不齐时期。有 simvastatin 的预告的处理能稀释这些变化并且颠倒没有降低浆液胆固醇水平的这电的改变,贡献在在胆固醇的减少的心律不齐独立人士的处理的 statin 的离子的机制。 | DING Chao FU Xiang-hua HE Zhen-shan CHEN Hui-xiao XUE Ling LI Jun-xia | 2008 | Chinese Medical Journal2008，，6： | 26 |
| 11 | Biological character of human adipose-derived adult stem cells and influence of donor age on cell replication in culture显示文摘To investigate the biological character of human adipose-derived adult stem cells (hADAS cells) when cultured in vitro and the relationship between hADAS cell’s replication activity and the donor’s age factor, and to assess the stem cells as a new source for tissue engineering. hADAS cells are isolated from human adipose tissue of different age groups (from adolescents to olds: <20 years old, 21―40 years old, 41―60 years old and >61 years old groups). The protein markers (CD29, CD34, CD44, CD45, CD49d, HLA-DR, CD106) of hADAS cells were detected by flow cytometry (FCM) to identify the stem cell, and the cell cycle was examined for P20 hADAS cells to evaluate the safety of the subculture in vitro. The generative activity of hADAS cells in different age groups was also examined by MTT method. The formula “ log2T D = t logN t ? logN 0” was used to get the time doubling (TD) of the cells. The results showed that the cells kept heredity stabilization by chromosome analysis for at least 20 passages. The TD of these cells increased progressively by ageing, and the TD of the <20 years old group was lower than that of the >61 years old group (statistical analysis of variance (ANOVA), P=0.002, P<0.05). These find- ings suggested that a higher level of hADAS cells replication activity was found in the younger dona- tors, and they represent novel and valuable seed cells for studies of tissue engineering. | LEI Lei, LIAO WeiMing, SHENG PuYi, FU Ming, HE AiShan & HUANG Gang Department of Orthopedics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China | 2007 | Science China(Life Sciences)2007，50，3： | 25 |
| 12 | Aerosol scattering coefficients and major chemical compositions of fine particles observed at a rural site in the central Pearl River Delta,South China显示文摘During November-December 2010 aerosol scattering coefficients were monitored using a single-waved (525 nm) Nephelometer at a regional monitoring station in the central Pearl River Delta region and 24-hr fine particle (PM 2.5) samples were also collected during the period using quartz filters for the analysis of major chemical components including organic carbon (OC),elemental carbon (EC),sulfate,nitrate and ammonium.In average,these five components accounted for about 85% of PM 2.5 mass and contributed 42% (OC),19% (SO 4 2 -),12% (NO 3 -),8.4% (NH 4+) and 3.7% (EC),to PM 2.5 mass.A relatively higher mass scattering efficiency of 5.3 m 2/g was obtained for fine particles based on the linear regression between scattering coefficients and PM 2.5 mass concentrations.Chemical extinction budget based on IMPROVE approach revealed that ammonium sulfate,particulate organic matter,ammonium nitrate and EC in average contributed about 32%,28%,20% and 6% to the light extinction coefficients,respectively. | Xinming Wang Xiang Ding Xiaoxin Fu Quanfu He Shaoyi Wang Francois Bernard Xiuying Zhao Dui Wu | 2012 | Journal of Environmental Sciences2012，24，1： | 25 |
| 13 | ZIKA virus isolated from mosquitoes:a field and laboratory investigation in China,2016显示文摘A field investigation of arboviruses was conducted in Dejiang, Guizhou Province in the summer of 2016. A total of 8,795 mosquitoes, belonging to four species of three genera, and 1,300 midges were collected. The mosquito samples were identified on site according to their morphology, and the pooled samples were ground and centrifuged in the laboratory. The supernatant was incubated with mosquito tissue culture cells(C6/36) and mammalian cells(BHK-21) for virus isolation. The results indicated that 40%(3,540/8,795) were Anopheles sinensis, 30%(2,700/8,795) were Culex pipiens quinquefasciatus, and 29%(2,530/8,795)were Armigeres subbalbeatus. Furthermore, a total of eight virus isolates were obtained, and genome sequencing revealed two Zika viruses(ZIKVs) isolated from Culex pipiens quinquefasciatus and Armigeres subbalbeatus, respectively; three Japanese encephalitis viruses(JEVs) isolated from Culex pipiens quinquefasciatus; two Banna viruses(BAVs) isolated from Culex pipiens quinquefasciatus and Anopheles sinensis, respectively; and one densovirus(DNV) isolated from Culex pipiens quinquefasciatus.The ZIKVs isolated from the Culex pipiens quinquefasciatus and Armigeres subbalbeatus mosquitoes represent the first ZIKV isolates in China's Mainland. This discovery presents new challenges for the prevention and control of ZIKV in China, and prompts international cooperation on this global issue. | Shihong Fu Song Song Hong Liu Yuanyuan Li Xiaolong Li Xiaoyan Gao Ziqian Xu Guoping Liu Dingming Wang Zhenzao Tian Jingzhu Zhou Ying He Wenwen Lei Huanyu Wang Bin Wang Xiaoqing Lu Guodong Liang | 2017 | Science China(Life Sciences)2017，60，12： | 25 |
| 14 | Sparse representation and blind source separation of ill-posed mixtures显示文摘Bofill et al. discussed blind source separation (BSS) of sparse signals in the case of two sensors. However, as Bofill et al. pointed out, this method has some limitation. The potential function they introduced is lack of theoretical basis. Also the method could not be extended to solve the problem in the case of more than three sensors. In this paper, instead of the potential function method, a K-PCA method (combining K-clustering with PCA) is proposed. The new method is easy to be used in the case of more than three sensors. It is easy to be implemented and can provide accurate estimation of mixing matrix. Some criterion is given to check the effect of the mixing matrix A . Some simulations illustrate the availability and accuracy of the method we proposed. | HE Zhaoshui XIE Shengli FU Yu | 2006 | Science in China(Series F)2006，49，5： | 24 |
| 15 | Effect of Long-Term Application of Chemical Fertilizers on Microbial Biomass and Functional Diversity of a Black Soil显示文摘An experiment with seven N, P, K-fertilizer treatments, i.e., control (no fertilizer), NP, NK, PK, NPK, NP2K, and NPK2 where P2 and K2 indicate double amounts of P and K fertilizers respectively, was conducted to examine the effect of long-term continuous application of chemical fertilizers on microbial biomass and functional diversity of a black soil (Udoll in the USDA Soil Taxonomy) in Northeast China. The soil microbial biomass C ranged between 94 and 145 mg kg-1, with the NK treatment showing a lower biomass; the functional diversity of soil microbial community ranged from 4.13 to 4.25, with an increasing tendency from control to double-fertilizer treatments, and to triple-fertilizer treatments. The soil microbial biomass, and the microbial functional diversity and evenness did not show any significant differences among the different fertilizer treatments including control, suggesting that the long-term application of chemical fertilization would not result in significant changes in the microbial characteristics of the black soil. | KONG Wei-Dong ZHU Yong-Guan FU Bo-Jie HAN Xiao-Zeng ZHANG Lei HE Ji-Zheng | 2008 | Pedosphere2008，18，6： | 22 |
| 16 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 17 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 18 | Autoantibody to MOG suggests two distinct clinical subtypes of NMOSD显示文摘We characterized a unique group of patients with neuromyelitis optica spectrum disorder(NMOSD) who carried autoantibodies of aquaporin-4(AQP4) and myelin-oligodendrocyte glycoprotein(MOG). Among the 125 NMOSD patients, 10(8.0%) were AQP4- and MOG-ab double positive, and 14(11.2%) were MOG-ab single positive. The double-positive patients had a multiphase disease course with a high annual relapse rate(P=0.0431), and severe residual disability(P<0.0001). Of the double-positive patients, 70% had MS-like brain lesions, more severe edematous, multifocal regions on spinal magnetic resonance imaging(MRI), pronounced decreases of retinal nerve fiber layer thickness and atrophy of optic nerves. In contrast, patients with only MOG-ab had a higher ratio of monophasic disease course and mild residual disability. Spinal cord MRI illustrated multifocal cord lesions with mild edema, and brain MRIs showed more lesions around lateral ventricles. NMOSD patients carrying both autoantibodies to AQP4 and MOG existed and exhibited combined features of prototypic NMO and relapsing-remitting form of MS, whereas NMOSD with antibodies to MOG only exhibited an 'intermediate' phenotype between NMOSD and MS. Our study suggests that antibodies against MOG might be pathogenic in NMOSD patients and that determination of anti-MOG antibodies maybe instructive for management of NMOSD patients. | Yaping Yan Yujing Li Ying Fu Li Yang Lei Su Kaibin Shi Minshu Li Qiang Liu Aimee Borazanci Yaou Liu Yong He Jeffrey L Bennett Timothy L Vollmer Fu-Dong Shi | 2016 | Science China(Life Sciences)2016，59，12： | 20 |
| 19 | Diagnostic Values of Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptor for Benign and Malignant Hydrothorax显示文摘 | Yan Gu Min Zhang Guo-Hua Li Jun-Zhen Gao Liping Guo Xiao-Juan Qiao Li-Hong Wang Lan He Mei-Ling Wang Li Yan Xiu-Hua Fu | 2015 | Chinese Medical Journal2015，，3： | 19 |
| 20 | miR-30b inhibits autophagy to alleviate hepatic ischemiareperfusion injury via decreasing the Atg12-Atg5 conjugate显示文摘AIM: To explore the role and potential mechanism of miR-30 b regulation of autophagy in hepatic ischemiareperfusion injury(IRI).METHODS: An animal model of hepatic IRI was generated in C57BL/6 mice. For in vitro studies, AML12 cells were immersed in mineral oil for 1 h and then cultured in complete Dulbecco's Modified Eagle's Medium(DMEM)/F12 to simulate IRI. Mice and cells were transfected with miR-30 b agomir/mimics or antagomir/inhibitor to examine the effect of miR-30 b on autophagy to promote hepatic IRI. The expression of miR-30 b was measured by real-time polymerase chain reaction. Apoptotic cells were detected by terminal uridine nickend labeling(TUNEL) staining, and cell viability was detected by methylthiazole tetrazolium assay. The expression of light chain 3, autophagy-related gene(Atg)12, Atg5, P62, and caspase-3 were detected by western blotting analysis.RESULTS: miR-30 b levels were significantly downregulated after hepatic IRI, and the numbers of autophagosomes were increased in response to IRI both in vivo and in vitro. These findings demonstrate that low levels of miR-30 b could promote hepatic IRI. Furthermore, we found that miR-30 b interacted with Atg12-Atg5 conjugate by binding to Atg12. Overexpression of miR-30 b diminished Atg12 and Atg12-Atg5 conjugate levels, which promoted autophagy in response to IR. In contrast, downregulation of miR-30 b was associated with increased Atg12-Atg5 conjugate levels and increased autophagy.CONCLUSION: miR-30 b inhibited autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate. | Shi-Peng Li Jin-Dan He Zhen Wang Yao Yu Shu-Yu Fu Hai-Ming Zhang Jian-Jun Zhang Zhong-Yang Shen | 2016 | World Journal of Gastroenterology2016，22，18： | 19 |
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