|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry显示文摘瞄准:为颜色检测新浆液简历标记由浆液蛋白质与提高表面的激光解吸附作用 ionisation 介绍的表面的癌症(CRC )-- 飞行团分光术(SELDI-TOF MS ) 的时间。方法:二个独立浆液样品集合与 ProteinChip 技术独立被分析(集合 A:40 CRC+49 健康控制;集合 B:37 CRC+31 健康控制) ,有一个弱阳离子的使用的芯片交换一半和缓冲区 pH 5。差别的歧视的力量表示了蛋白质与一个分类树算法被估计。产生分类树的敏感和特性被盲目地从集合 B 并且反过来也如此从集合 A 把数据用于产生的树获得。CRC 浆液蛋白质侧面也与从胸的那些相比,卵巢,前列腺,和非小的房间肺癌症。结果:Mass-to-charge 比率(m/z ) 3.1x10 (3 ) , 3.3x10 (3 ) , 4.5x10 (3 ) , 6.6x10 (3 ) 和 28x10 (3 ) 在最好执行的分类树上被用作分类器。树敏感和特性在 65% 和 90% 之间。大多数这些歧视的 m/z 价值在调查的另外的瘤类型也是不同的。M/z 3.3x10 (3 ) ,在大多数树上的主要分类器,是 6.6x10 (3 ) 的一种二倍地控告的形式 -Da 蛋白质。后者作为 apolipoprotein C-I 被识别。M/z 3.1x10 (3 ) 作为 apolipoprotein A-I 作为白朊,和 m/z 28x10 (3 ) 的 N 终端碎片被识别。结论:分类树模式分析跟随的 SELDI-TOF MS 是为为 CRC 发现新浆液标记的一种合适的技术。Biomarkers 能与高敏感和特性在独立样品集合被识别并且 reproducibly 检测了。尽管为 CRC 不特定,这些简历标记在监视的疾病和治疗有一个潜在的角色。 | Judith YMN Engwegen Helgi H Helgason Annemieke Cats Nathan Harris Johannes MG Bonfrer Jan HM Schellens Jos H Beijnen | 2006 | World Journal of Gastroenterology2006，12，10： | 45 |
| 2 | 世界卫生组织(WHO)造血与淋巴组织肿瘤分类方案:临床顾问委员会会议报告显示文摘引言 :从 1995年开始 ,欧洲病理学工作者协会和血液病理学会一直致力于制定一个新的世界卫生组织 (WHO)血液恶性肿瘤分类方案 ,该分类方案包括淋巴系肿瘤、髓系肿瘤、组织细胞肿瘤和肥大细胞肿瘤。 材料与方法 :此项 WHO计划共组成十个病理学工作者委员会 ,负责确定病种和作出定义。另外还成立一个由国际血液学家和肿瘤学家组成的临床顾问委员会 (CAC)以保证该分类的临床实用性。 1997年 11月召开会议讨论了与该分类有关的临床问题。 结果 :WHO采纳了 1994年国际淋巴瘤研究组 (IL SG)报告的修订欧美淋巴系肿瘤分类 (REAL)方案作为淋巴系肿瘤的分类方案。该方案的分类方法遵循以下原则 :分类应是联合应用形态学、免疫表型、遗传特征及临床特征能够清楚界定的“真实存在”(“real”)病种的名录 ,上述各项特征的相对重要性因病种不同而异 ,不存在任何“金标准”。 WHO将 REAL分类原则延用于髓系肿瘤和组织细胞肿瘤 ,髓系肿瘤的分类包括联合应用细胞形态学和细胞遗传学异常能够界定的各个病种。围绕一系列临床问题召集的这次 CAC会议 ,就提交的大多数问题达成共识 ,这些问题及共识将详述于下。对于另外一些问题 ,CAC认为淋巴系肿瘤临床分组既无必要也不必需 ,患者的治疗取决于淋巴瘤的具体类型 ,如有? | N L Harris E S Jaffe J Diebold G Flandrin H K Muller-Hermelink J Vardiman T A Lister C D Bloomfield 张凤奎 郝玉书 | 2001 | 白血病.淋巴瘤2001，10，3： | 20 |
| 3 | Highly efficient GaAs solar cells by limiting light emission angle显示文摘In a conventional flat plate solar cell under direct sunlight,light is received from the solar disk,but is re-emitted isotropically.This isotropic emission corresponds to a significant entropy increase in the solar cell,with a corresponding drop in efficiency.Here,using a detailed balance model,we show that limiting the emission angle of a high-quality GaAs solar cell is a feasible route to achieving power conversion efficiencies above 38%with a single junction.The highest efficiencies are predicted for a thin,light trapping cell with an ideal back reflector,though the scheme is robust to a non-ideal back reflector.Comparison with a conventional planar cell geometry illustrates that limiting emission angle in a light trapping geometry not only allows for much thinner cells,but also for significantly higher overall efficiencies with an excellent rear reflector.Finally,we present ray-tracing and detailed balance analysis of two angular coupler designs,show that significant efficiency improvements are possible with these couplers,and demonstrate initial fabrication of one coupler design. | Emily D Kosten Jackson H Atwater James Parsons Albert Polman Harry A Atwater | 2013 | Light(Science & Applications)2013，2，1： | 9 |
| 4 | 墨西哥湾布什山冷泉碳酸盐岩沉积岩石学及地球化学显示文摘对墨西哥湾布什山采集的7块冷泉碳酸盐岩样品进行了沉积岩石学及地球化学研究,结果表明:冷泉碳酸盐岩以结壳的形式产出,结壳中双壳类和管状蠕虫等冷泉生物碎屑发育,结壳主要由泥晶、微晶和亮晶文石组成(含量89%~99%,平均94%)。碳酸盐岩13C中等亏损(δ13C最负值为-29.4‰,PDB),表明碳的来源主要是非甲烷的碳烃化合物,18O相对富集(δ18O为+2.4‰~+5.0‰,PDB),可能与原地水合物分解形成富集18O的孔隙水有关。碳酸盐矿物相(5%硝酸可溶部分)的稀土元素总量较低(0.40×10-6~20.85×10-6),稀土元素Ce异常特征和页岩标准化配分模式在不同样品、甚至同一样品结晶程度不同的碳酸盐矿物相(泥晶、微晶和亮晶)中变化显著,表明布什山冷泉碳酸盐岩形成过程中氧化还原条件复杂多变,控制氧化环境变化的主要因素可能是流体的渗漏速率。 | 邸鹏飞 冯东 陈多福 Harry H Roberts | 2009 | 海洋地质与第四纪地质2009，29，2： | 5 |
| 5 | Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure显示文摘AIM:To determine the short-term cost-utility of mo-lecular adsorbent recirculating system(MARS) treatment in acute liver failure(ALF).METHODS:A controlled retrospective study was conducted with 90 ALF patients treated with MARS from 2001 to 2005.Comparisons were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit(ICU) specializing in liver diseases.The 3-year outcomes and number of liver transplantations were recorded.All direct liver disease-related medical expenses from 6 mo before to 3 years after ICU treatment were determined for 31 MARS patients and 16 control patients.The health-related quality of life(HRQoL) before MARS treatment was estimated by a panel of ICU doctors and after MARS using a mailed 15D(15-dimensional generic healthrelated quality of life instrument) questionnaire.The HRQoL,cost,and survival data were combined and the incremental cost/quality-adjusted life years(QALYs) was calculated.RESULTS:In surviving ALF patients,the health-related quality of life after treatmeant was generally high and comparable to the age-and gender-matched general Finnish population.Compared to the controls,the average cost per QALY was considerably lower in the MARS group(64 732€ vs 133 858€) within a timeframe of 3.5 years.The incremental cost of standard medical treatment alone compared to MARS was 10 928€,and the incremental number of QALYs gained by MARS was 0.66.CONCLUSION:MARS treatment combined with standard medical treatment for ALF in an ICU setting is more cost-effective than standard medical treatment alone. | Taru Kantola Suvi Mklin Anna-Maria Koivusalo Pirjo Rsnen Anne Rissanen Risto Roine Harri Sintonen Krister Hckerstedt Helena Isoniemi | 2010 | World Journal of Gastroenterology2010，16，18： | 3 |
| 6 | 腹腔镜、开腹和机器人手术切除直肠癌的肿瘤学和围手术期结果:一项多中心、倾向评分加权队列研究显示文摘目的:尽管进行了多个随机对照试验,但微创和传统开腹直肠癌手术的短期和长期结果仍不清楚。本研究的目的是比较腹腔镜、开腹和机器人直肠癌切除术的成功率和术后结果。方法:这是一项使用倾向评分加权的多中心、准实验队列研究。数据源于2016年'美国外科医生学院国家外科手术质量改善计划(NSQIP)'中所有年龄在18~89岁的接受开腹、腹腔镜或机器人直肠癌切除术的成年患者。主要结果是代表肿瘤切除术成功的复合指标,包括远端切缘阴性、环周切缘阴性、至少评估12枚淋巴结。次要结果是全身和手术部位的并发症,以及再入院、再手术、手术时间和住院时间。 | 孙凌宇 KETHMAN W C HARRIS A H S MORRIS A M | 2020 | 结直肠肛门外科2020，26，1： | 2 |
| 7 | Salpingotomy versus salpingectomy in women with tubal pregnancy (ESEP study): an open-label, multicentre, randomised controlled trial显示文摘 | Femke Mol Norah M van Mello Annika Strandell Karin Strandell Davor Jurkovic Jackie Ross Kurt T Barnhart Tamer M Yalcinkaya Harold R Verhoeve Giuseppe C M Graziosi Carolien A M Koks Ingmar Klinte Lars Hogstr?m Ineke C A H Janssen Harry Kragt Annemieke Hoek | 2014 | The Lancet2014，，： | 2 |
| 8 | Single-molecule DNA sequencing of a viral genome显示文摘 | Harris TD Buzby PR Babcock H | 2008 | Science2008，320，5872： | 1 |
| 9 | Frictional characteristics of teflon-steel interfaces under dynamic conditions显示文摘 | Constantinou M C Caccese J Harris H G | 1987 | Earthquake Engineering and Structural Dynamics1987，15，6： | 1 |
| 10 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 11 | Macrophage infiltration and angiogenesis in human malignancy显示文摘 | Knowles H Leek R Harris AL | 2004 | Novartis Found Syrup2004，256，： | 1 |
| 12 | Empirical Extended-Range Prediction of the Madden-Julian Oscillation显示文摘 | LO Fiona HENDON Harry H | 2000 | Mon Wea Rev2000，128，8： | 1 |
| 13 | Work - life Benefits and Positive Organizational Behavior:Is There A Connection 显示文摘 | Muse L Harris S G Giles W F Feild H S | 2008 | Journal of Or- ganizational Behavior2008，29，2： | 1 |
| 14 | Regulation of progenitor cell proliferation and granulocyte function by microRNA-223 显示文摘 | Johnnidis J B Harris M H Wheeler R T | 2008 | Nature2008，451，7182： | 1 |
| 15 | Plasmas as antennas: Theory, experiment and applications显示文摘 | Borg G G Harris J H Martin N M etal | 2000 | Phys Plasmas2000，7，7： | 1 |
| 16 | Chloroplast transformation in Chlamydomonas with high velocity microprojectiles显示文摘 | BOYNTON J E GILLHAN N W HARRIS E H | 1988 | Science1988，240，： | 1 |
| 17 | The value relevance of German accounting measures:An empirical analysis显示文摘 | Harris M S Moller H P | 1994 | Journal of Accounting Research1994，32，： | 1 |
| 18 | Failure of acetabular autogenous grafts in total hip arthroplasty,Increasing incidence;A follow up note显示文摘 | MULROY Jr R D HARRIS W H | 1990 | J Bone Joint Surg(Am)1990，72，： | 1 |
| 19 | Thining and opening of carbon nanotubes by oxidation using carbon dioxide 显示文摘 | Tsang S C Harris P J F Green M L H | 1993 | Nature1993，362，： | 1 |
| 20 | Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth ractor in HaCaT keratinocytes 显示文摘 | Harris I R Hoppner H Siefken W | 2000 | J Invest Dermatol2000，114，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员