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| 1 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 2 | Macrophage infiltration and angiogenesis in human malignancy显示文摘 | Knowles H Leek R Harris AL | 2004 | Novartis Found Syrup2004，256，： | 1 |
| 3 | Mechanism of action of Bocillus thuringiensis in- secticidalδ-endotoxins 显示文摘 | Knowles B H | 1994 | Advances in Insect Physiology1994，24，： | 1 |
| 4 | Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction 显示文摘 | Knowles JW Wang H Itakura H | 2007 | Am Heart J2007，154，6： | 1 |
| 5 | Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients显示文摘 | HIRSCH H H KNOWLES W DICKENMANN M | 2002 | N Engl J Med2002，347，7： | 1 |
| 6 | Visceral hypersensitivity in nonerosive reflux disease 显示文摘 | Knowles C H Aziz Q | 2008 | Gut2008，57，5： | 1 |
| 7 | Restoring tropical forests on lands mined for bauxite: Examples from the Brazilian Amazon显示文摘 | Parrotta J A Knowles O H | 2001 | Ecological Engineering2001，17，2： | 1 |
| 8 | Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction显示文摘 | Knowles JW Wang H Itakura H | 2007 | Am Heart J2007，154，6： | 1 |
| 9 | Macrophage infiltration and angio-genesis in human malignancy显示文摘 | Knowles H Leek R Harris AL | 2004 | Novartis Found Symp2004，256，： | 1 |
| 10 | Harvesting intensity afects forest structure and composition in an upland Amazonian forest显示文摘 | Parrotta J A Francis J K Knowles O H | 2002 | For Ecol Manage2002，169，： | 1 |
| 11 | Antibody against an Anaplasma marginale MSP5 epitope common to tick and ery-throcyte stages identified persistently infected cattle 显示文摘 | Knowles D P Torioni E S Palmer G H | 1996 | J Clin Microbiol1996，34，9： | 1 |
| 12 | Molecular analysis of duck hepatitis virus type 1 indicates should be assigned to a new genus 显示文摘 | Tseng C H Knowles N J Tsai H J | 2006 | Virus Research2006，07，： | 1 |
| 13 | Genetic causes of bronchiectasis: primary ciliary dyski- nesia显示文摘 | MORILLAS H N ZARIWALA M KNOWLES M R | 2007 | Respiration2007，74，： | 1 |
| 14 | Biochar for the miti- gation of nitrate leaching from soil amended with biosolids显示文摘 | Knowles O A Robinson B H Contangelo A | 2011 | Science of the Total Environment2011，409，17： | 1 |
| 15 | Land use,scale,and bird distributions in Phoenix metropolitan area显示文摘 | MAKE H KNOWLES Y K | 2002 | Landscape and Urban Planning2002，936，： | 1 |
| 16 | Molecular epidemiology of foot- and-mouth disease virus显示文摘 | Knowled H J Samuel A R | 2003 | Virus Res2003，91，： | 1 |
| 17 | The landscape adaptive particle swarm optimize 显示文摘 | YISU J KNOWLES J LI H | 2007 | Applied Soft Computing (S1568-4946)2007，8，1： | 1 |
| 18 | Hypoxia-inducible factor is ex pressed in giant cell tumour of bone and mediates paracrine effects of hypoxia on monocyte-osteoclast differentiation via induction of VEGF显示文摘 | Knowles H J Athanasou NA | 2008 | J Pathol2008，215，1： | 1 |
| 19 | Clozapine induced diabetes ketoacidosis 显示文摘 | Smith H Kenny-herbert J Knowles L | 1999 | Aust N Z J Psychiatry1999，33，1： | 1 |
| 20 | Development of hydroxyapatite bone scaffold for controlled drug release via poly (ε-caprolactone) and hydroxyapatite hybrid coatings 显示文摘 | KIM HW KNOWLES JC KIM H E | 2004 | J Biomed Mater Res Part B: Appl Biomater2004，70，： | 1 |
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