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| 1 | Effect of thermomechanical treatment on microstructure and properties of Cu-Cr-Zr-Ag alloy显示文摘The effects of thermomechanical treatment on the properties and microstructure of Cu-Cr-Zr alloy and Cu-Cr-Zr-Ag alloy were investigated. Ag addition improves the mechanical properties of the alloy through solid solution strengthening and brings a little effect on the electrical conductivity of the alloy. A new Cu-Cr-Zr-Ag alloy was developed, which has an excellent combination of the tensile strength, elongation, and electrical conductivity reaching 476.09 MPa, 15.43% and 88.68% IACS respectively when subjected to the optimum thermomechanical treatment, i.e., solution-treating at 920°C for 1 h, cold drawing to 96% deformation, followed by aging at 400°C for 3 h. TEM analysis re-vealed two kinds of finely dispersed precipitates of Cr and Cu4Zr. It is very important to use the mechanisms of solid solution strengthening, work hardening effect as well as precipitate pinning effect of dislocations to improve tensile strength of the alloy without adversely affecting its electrical conductivity. | XIE Haofeng MI Xujun HUANG Guojie GAO Baodong YIN Xiangqian LI Yanfeng | 2011 | Rare Metals2011，30，6： | 17 |
| 2 | High glucose enhance expression of matrix metalloproteinase—2 in smooth muscle cells显示文摘AIM:To investigate the effects of high glucose on expression of matrix metalloproteinase-2(MMP-2) in rat aortic smooth muscle cells and the influence of matrix remodeling on atherogenesis in diabetic patients. METHODS: The smooth muscle cells were cultured from the thoracic aorta of Sprague-Dawley (SD) rat. MMP-2 mRNA was determined by reverse transcriptase-polymerase chain reaction(RT-PCR),MMP-2 protein was measured by Western blotting, and MMP-2 activity in conditioned medium was observed by zymography. RESULTS:In comparison with the control, there was no difference in the expression of MMP-2 when glucose concentration was 1g/L,whereas MMP-2 activity in smooth muscle cells was significantly increased by the glucose 5 g/L(P<0.01). CONCLUSION:High glucose enhanced the expression and activity of MMP-2 in smooth muscle cells, which may provide an explanation for the phenomenon that diabetes patients are prone to have atherosclerotic lesions. | HAOFeng YUJin-De | 2003 | Acta Pharmacologica Sinica2003，24，6： | 7 |
| 3 | Reconfigurable directional coupler in lithium niobate crystal fabricated by three-dimensional femtosecond laser focal field engineering显示文摘For crystals, depressed cladding waveguides have advantages such as preservation of the spectroscopic as well as non-linear properties and the capability to guide both horizontal and vertical polarization modes, but fabrication is always quite time consuming. In addition, it is usually difficult to couple modes propagating in different depressed cladding waveguides through evanescent field overlap, so it is often required to dynamically reconfigure photonic waveguide devices using external fields for classical or quantum applications. Here, we experimentally demonstrate the single-scan femtosecond laser transverse writing of depressed cladding waveguides to form a 2 × 2 directional coupler inside lithium niobate crystal, which is integrated with two deeply embedded microelectrodes on both sides of the interaction region to reconfigure the coupling. By focal field engineering of the femtosecond laser, we specially generate a three-dimensional longitudinally oriented ring-shaped focal intensity profile composed of 16 discrete spots to simultaneously write the entire cladding region. The fabricated waveguides exhibit good single guided modes in two orthogonal polarizations at 1550 nm. By applying voltage to the deeply embedded microelectrodes fabricated with the femtosecond laser ablation followed by selective electroless plating, we successfully facilitate the light coupling from the input arm to the cross arm and thus actively tune the splitting ratio. These results open new important perspectives in the efficient fabrication of reconfigurable complex three-dimensional devices in crystals based on depressed cladding waveguides. | Qian Zhang Meng Li Jian Xu Zijie Lin Haofeng Yu Min Wang Zhiwei Fang Ya Cheng Qihuang Gong Yan Li | 2019 | Photonics Research2019，7，5： | 7 |
| 4 | Crystal structure of SARS-CoV-2 main protease in complex with protease inhibitor PF-07321332显示文摘Dear Editor,Since December 2019,the pandemic of coronavirus disease 2019(COVID-19)has taken a heavy toll on global health,creating an urgent need to develop effective strategies for prevention and treatment.The etiological agent,known as severe acute respiratory syndrome coronavirus 2(SARSCoV-2),has infected nearly 229.2 million people worldwide with more than 4.7 million deaths as of September 15,2021.Older age and preexisting health conditions are associated with worse clinical prognosis including higher mortality rates(Zhou et al.,2020).The global race to combat this pandemic has led to rapid deployment of numerous effective vaccines against SARS-CoV-2(Tregoning et al.,2021).However,the emergence of viral variants,including the Delta variant(B.1.617.2),compromised vaccine effectiveness with resurgence of SARS-CoV-2 infection among highly vaccinated population(Keehner et al.,2021).Therefore,development of therapeutics against the more conserved viral targets would be essential to contain the spread of COVID-19 and reduce mortality. | Yao Zhao Chao Fang Qi Zhang Ruxue Zhang Xiangbo Zhao Yinkai Duan Haofeng Wang Yan Zhu Lu Feng Jinyi Zhao Maolin Shao Xiuna Yang Leike Zhang Chao Peng Kailin Yang Dawei Ma Zihe Rao Haitao Yang | 2022 | Protein & Cell2022，13，9： | 6 |
| 5 | The analysis of electrical performances of nanowires silicon solar cells显示文摘A theoretical model of silicon solar cells with ultra-small textured surface has been established based on depletion approximation and drift diffusion theory. The ultra-small textured surface achieves the low reflectance by multiple reflections among the silicon nanowires(NWs) . The electrical performances of the solar cells,including open circuit voltage(Voc),short circuit current(Isc) and conversion efficiency(η),are analyzed by the theoretical model. The results show that the low reflectance is not the only pursuit in manufacturing the Si NWs solar cells. Other factors including optimizing the surface passivation,improving the silicon wafers quality and designing the proper nanowire length should be considered together with NWs structure. | LI HaoFeng JIA Rui DING WuChang CHEN Chen MENG YanLong LIU XinYu | 2011 | Science China(Technological Sciences)2011，54，12： | 4 |
| 6 | Nonfatal Child Pedestrian Injury in Two Urban Cities of Guangdong Province,China:Results from a Cross-sectional Survey显示文摘Objective To describe the epidemiological characteristics of nonfatal child pedestrian injuries and provide information to help understand an important public-health problem.Methods This was a school-based,cross-sectional questionnaire survey.The sample (42 750 children) was obtained from two urban cities of Guangdong Province,China,using multi-stage randomized sampling.Information was collected by the respondents self-reporting in the classroom.Results The incidence rate of nonfatal child pedestrian injuries in the cities was 2.0%.Boys had a higher incidence rate (2.6%) than girls (1.4%).Compared to other children,those aged 10 years are at the highest risk.The primary places of occurrence were sidewalks,residential roads,and crosswalks.High-risk behavior of the children immediately prior to injury included mid-block crossings,playing on roads,and crossing on red lights.The major vehicles that caused pedestrian injuries were bicycles,car or vans,and motorcycles.Bruises,fractures,and injuries to the internal organs were the top three types of injuries.Almost 40% of victims were hospitalized,and nearly 30% of the victims suffered long-term disabilities.Conclusion This study shows that nonfatal child pedestrian injuries are a very serious public-health problem in the urban cities of Guangdong.Based on the epidemiological characteristics,prevention strategies and further research should be carried out to reduce the occurrence of injuries. | MA WenJun NIE ShaoPing XU HaoFeng XU YanJun XIE HuiYan ZHANG YuRun | 2011 | Biomedical and Environmental Sciences2011，24，4： | 4 |
| 7 | Film Cooling Performance of a Row of Dual-fanned Holes at Various Injection Angles显示文摘Film cooling performance about a row of dual-fanned holes with injection angles of 30°, 60 ° and 90° were experimentally investigated at blowing ratios of 1.0 and 2.0. Dual-fanned hole is a novel shaped hole which has both inlet expansion and outlet expansion. A transient thermochromic liquid crystal technique was used to reveal the local values of film cooling effectiveness and heat transfer coefficient. The results show that injection angles have strong influence on the two dimensional distributions of film cooling effectiveness and heat transfer coefficient. For the small injection angle of 30 degree and small blowing ratio of 1.0, there is only a narrow spanwise region covered with film. The increase of injection angle and blowing ratio both leads to the enhanced spanwise film diffusion, but reduced local cooling ability far away from the hole. Injection angles have comprehensive influence on the averaged film cooling effectiveness for various x/d locations. As injection angles are 30 and 60 degree, two bands of high heat transfer coefficients are found in mixing region of the gas and coolant. As injection angle increases to 90 degree, the mixing leads to the enhanced heat transfer region near the film hole. The averaged heat transfer coefficient increases with the increase of injection angle. | LI Guangchao WANG Haofeng ZHANG Wei KOU Zhihai XU Rangshu | 2017 | Journal of Thermal Science2017，26，5： | 4 |
| 8 | Recent progress in the discovery of inhibitors targeting coronavirus proteases显示文摘Coronaviruses(CoVs) can cause highly prevalent diseases in humans and animals. The fatal outbreak of severe acute respiratory syndrome(SARS) and Middle East respiratory syndrome(MERS) highlights the threat posed by this unique virus subfamily. However, no specific drugs have been approved to treat CoV-associated diseases to date. The CoV proteases, which play pivotal roles in viral gene expression and replication through a highly complex cascade involving the proteolytic processing of replicase polyproteins, are attractive targets for drug design. This review summarizes the recent advances in biological and structural studies, together with the development of inhibitors targeting CoV proteases, particularly main proteases(M^(pro)s), which could help develop effective treatments to prevent CoV infection. | Haofeng Wang Song Xue Haitao Yang Cheng Chen | 2016 | Virologica Sinica2016，31，1： | 4 |
| 9 | Timing and structural controls on skarn-type and vein-type mineralization at the Xitian tin-polymetallic deposit, Hunan Province, SE China显示文摘Xitian tin-polymetallic deposit, located in the eastern Hunan Province, SE China, hosts quartz vein and skarn in the contact zone between carbonate and two stages granites. Critical geodynamic questions for South China are whether different types of mineralization form in the same time and how the magmatism–tectonic system controls the ore-forming process. Based on the distribution of the orebodies, six cassiterite samples from different types of mineralization are collected for dating. In-situ LA-MCICP-MS U–Pb isotopic data yielded concordia low intercept ages between 154 and 157 Ma, indicating that different types of mineralization belong to the same magmatism–mineralization system. Coupled with the study of the kinematic indicators, it suggests that the structural control of the wall rocks constrain the types of mineralization. These results provide further evidence of a close temporal link between the structure and the tin-polymetallic mineralization in Xitian deposit. Considering the structure in the district, granite dome plays an important role in the ore-forming process. The age and structural signatures in Xitian deposit are the response to the subduction of Pacific Plate. | Miao He Quanlin Hou Qing Liu Jiheng Zhang Jinfeng Sun Shichong Wu Haofeng Zhu | 2018 | Acta Geochimica2018，37，2： | 4 |
| 10 | METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression显示文摘Background:Hepatocellular carcinoma(HCC)is one of the most prevalent cancers in the world,with a high likelihood of metastasis and a dismal prognosis.The reprogramming of glucosemetabolism is critical in the development ofHCC.TheWarburg effect has recently been confirmed to occur in a variety of cancers,including HCC.However,little is known about the molecular biological mechanisms underlying the Warburg effect in HCC cells.In this study,we sought to better understand how methyltransferase 5,N6-adenosine(METTL5)controls the development of HCC and theWarburg effect.Methods:In the current study,quantitative real-time polymerase chain reaction and Western blotting were used to detect the expression of METTL5 in HCC tissues and cell lines.Several different cell models and animal models were established to determine the role of METTL5 in glucose metabolism reprogramming and the underlying molecularmechanism of HCC.Glutathione-S-transferase pulldown,coimmunoprecipitation,RNA sequencing,non-targeted metabolomics,polysome profiling,and luciferase reporter assays were performed to investigate the molecular mechanisms of METTL5 in HCC cells.Results:We discovered that METTL5 drove glucose metabolic reprogramming to promote the proliferation and metastasis of HCC.Mechanistically,upregulation of METTL5 promoted c-Myc stability and thus activated its downstream glycolytic genes lactate dehydrogenase A(LDHA),enolase 1(ENO1),triosephosphate isomerase 1(TPI1),solute carrier family 2 member 1(SLC2A1),and pyruvate kinase M2(PKM2).The c-Box and ubiquitin binding domain(UBA)regions of ubiquitin specific peptidase 5(USP5)binded to c-Myc protein and inhibited K48-linked polyubiquitination of c-Myc.Further study revealed that METTL5 controled the USP5 translation process,which in turn regulated the ubiquitination of c-Myc.Furthermore,we identified cAMP responsive element binding protein 1(CREB1)/P300 as a critical transcriptional regulator ofMETTL5 that promoted the transcription of METTL5 in HCC.In patient-derived tumor xenograft(PDX)models,adenovirus-mediated knockout of METTL5 had a good antitumor effect and prolonged the survival of PDX-bearing mice.Conclusions:These findings point to a novel mechanism by which CREB1/P300-METTL5-USP5-c-Myc controls abnormal glucose metabolism and promotes tumor growth,suggesting that METTL5 is a potential therapeutic target and prognostic biomarker for HCC. | Peng Xia Hao Zhang Haofeng Lu Kequan Xu Xiang Jiang Yuke Jiang Xiangdong Gongye Zhang Chen Jie Liu Xi Chen Weijie Ma Zhonglin Zhang Yufeng Yuan | 2023 | Cancer Communications2023，43，3： | 3 |
| 11 | Establishment of transgenic mice carrying gene encoding human zinc finger protein 191显示文摘AIM:Human zinc finger protein 191 (ZNF191) was cloned and characterized as a Krueppel-like transcription factor, which might be relevant to many diseases such as liver cancer,neuropsychiatric and cardiovascular diseases. Although progress has been made recently, the biological function of ZNF191 remains largely unidentified. The aim of this study was to establish a ZNF191 transgenic mouse model,which would promote the functional study of ZNF191.METHODS:Transgene fragments were microinjected into fertilized eggs of mice.The manipulated embryos were transferred into the oviducts of pseudo-pregnant female mice.The offsprings were identified by PCR and Southern blot analysis.ZNF191 gene expression was analyzed by RT-PCR.Transgenic founder mice were used to establish transgenic mouse lineages.The first generation (F1) and the second generation (F2) mice were identified by PCR analysis.Ten-week transgenic mice were used for pathological examination.RESULTS: Four mice were identified as carrying copies of ZNF191 gene.The results of RT-PCR showed that ZNF191 gene was expressed in the liver,testis and brain in one of the transgenic mouse lineages.Genetic analysis of transgenic mice demonstrated that ZNF191 gene was integrated into the chromosome at a single site and could be transmitted stably. Pathological analysis showed that the expression of ZNF 191 did not cause obvious pathological changes in multiple tissues of transgenic mice.CONCLUSION:ZNF191 transgenic mouse model would facilitate the investigation of biological functions of ZNF191 in vivo. | Jian-ZhongLi XiaChen HuaYang Shui-LiangWang Xue-LianGong HaoFeng Bao-YuGuo LongYu Zhu-GangWang Ji-LiangFu | 2004 | World Journal of Gastroenterology2004，10，2： | 3 |
| 12 | An accurate solution of point kinetics equations of one-group delayed neutrons and an extraneous neutron source for step reactivity insertion显示文摘The continuous indication of the neutron density and its rate of change are important for the safe startup and operation of reactors. The best way to achieve this is to obtain analytical solutions of the neutron kinetics equations because none of the developed numerical methods can well satisfy the need for real-time or even super-time computation for the safe startup and operation of reactors in practice. In this paper, an accurate analytical solution of point kinetics equations with one-group delayed neutrons and an extraneous neutron source is proposed to calculate the change in neutron density, where the whole process from the subcritical stage to critical and supercritical stages is considered for step reactivity insertions. The accurate analytical solution can also be used as a benchmark of all numerical methods employed to solve stiff neutron kinetics equations. | LI HaoFeng SHANG XueLi CHEN WenZhen | 2010 | Chinese Science Bulletin2010，55，36： | 3 |
| 13 | Phase transformation and liquid density redistribution during solidification of Ni-based superalloy Inconel 718显示文摘The influences of chemical segregation and phase transformation on liquid density variation during solidification of Ni-based supperalloy Inconel 718 were investigated using SEM and EDS. It was found that significant segregation in liquid prompts high Nb phase to precipitate directly from liquid, which results in the redistribution of alloy elements and liquid density in their vicinity. The term 'inter-precipitate liquid density' is therefore proposed and this concept should be applied to determine the solidification behavior of superalloy Inconel 718. | Wang Ling Gong He Zhao Haofeng Dong Jianxin Zhang Maicang | 2012 | China Foundry2012，9，3： | 3 |
| 14 | A triple-RBD-based mucosal vaccine provides broad protectionagainst SARS-CoV-2 variants of concern显示文摘The rapid mutation and spread of SARS-CoV-2 variants urge the development of effective mucosal vaccines to provide broadspectrum protection against the initial infection and thereby curb the transmission potential.Here,we designed a chimeric tripleRBD immunogen,3Ro-NC,harboring one Delta RBD and two Omicron RBDs within a novel protein scaffold.3Ro-NC elicits potent and broad RBD-specific neutralizing immunity against SARS-CoV-2 variants of concern.Notably,intranasal immunization with 3RoNC plus the mucosal adjuvant KFD(3Ro-NC+KFDi.n)elicits coordinated mucosal IgA and higher neutralizing antibody specificity(closer antigenic distance)against the Omicron variant.In Omicron-challenged human ACE2 transgenic mice,3Ro-NC+KFDi.n immunization significantly reduces the tissue pathology in the lung and lowers the viral RNA copy numbers in both the lung(85.7-fold)and the nasal turbinate(13.6-fold).Nasal virologic control is highly correlated with RBD-specific secretory IgA antibodies.Our data show that 3Ro-NC plus KFD is a promising mucosal vaccine candidate for protection against SARS-CoV-2 Omicron infection,pathology and transmission potential. | Jingyi Yang Mei-Qin Liu Lin Liu Xian Li Mengxin Xu Haofeng Lin Shuning Liu Yunqi Hu Bei Li Bowen Liu Min Li Ying Sun Yao-Qing Chen Zheng-Li Shi Huimin Yan | 2022 | Cellular & Molecular Immunology2022，19，11： | 3 |
| 15 | Improving photosynthesis of microalgae by changing the ratio of light-harvesting pigments显示文摘Changing the ratio of light-harvesting pigments was regarded as an efficient way to improve the photosyn-thesis rate in microalgae, but the underlying mechanism is still unclear. In the present study, a mutant of Anabeana simensis (called SP) was selected from retrieved satellite cul-tures. Several parameters related with photosynthesis, such as the growth, photosynthesis rate, the content of photosyn-thetic pigment, low temperature fluorescence spectrum (77K) and electron transport rate, were compared with those of the wild type. It was found that the change in the ratio of light-harvesting pigments in the mutant led to more efficient light energy transfer and usage in mutant than in the wild type. This may be the reason why the mutant had higher photosynthesis and growth rates. | WANG Gaohong CHEN Lanzhou LI Genbao LI Dunhai HU Chunxiang CHEN Haofeng LIU Yongding SONG Lirong | 2005 | Chinese Science Bulletin2005，50，15： | 3 |
| 16 | Swansea criteria score in acute fatty liver of pregnancy显示文摘To the Editor:Acute fatty liver of pregnancy(AFLP)is an uncommon but potentially fatal disease unique to pregnancy that typically occurs in the third trimester and is one of the leading causes of maternal mortality in critically ill patients.^([1])The Swansea diagnostic criteria have been widely used in the diagnosis of AFLP worldwide since their proposal.The Swansea criteria include clinical symptoms and laboratory tests,imaging,and pathological examination results. | Jianbo Tan Fei Hou Haofeng Xiong Lin Pu Pan Xiang Chuansheng Li | 2022 | Chinese Medical Journal2022，，7： | 2 |
| 17 | Research on ultra-small textured surface of multicrystalline silicon solar cell显示文摘The ultra-small textured surface of multicrystalline silicon solar cell,prepared by electroless chemical-etching method,shows an excellent anti-reflection property over a wide spectral bandwidth.A novel back surface protection method and front surface passivation method have been used in the multicrystalline solar cells with ultra-small textured surfaces.With these improvements,the back surface remains intact after the etch process and the efficient minority lifetime is apparently increased.The test result shows that the solar cell with ultra-small textured surface can obtain better electrical performances by these improvements. | LI HaoFeng JIA Rui DOU BingFei CHEN Chen XING Zhao YANG YongZhou DING WuChang MENG YanLong LIU XinYu YE TianChun LI ShangQing | 2013 | Science China(Technological Sciences)2013，56，4： | 2 |
| 18 | ABNORMAL SHOOT 6 interacts with KATANIN 1 and SHADE AVOIDANCE 4 to promote cortical microtubule severing and ordering in Arabidopsis显示文摘Plant interphase cortical microtubules(cMTs)mediate anisotropic cell expansion in response to environmental and developmental cues.In Arabidopsis thaliana,KATANIN 1(KTN1),the p60 catalytic subunit of the conserved MT-severing enzyme katanin,is essential for cMT ordering and anisotropic cell expansion.However,the regulation of KTN1-mediated cMT severing and ordering remains unclear.In this work,we report that the Arabidopsis IQ67 DOMAIN(IQD)family gene ABNORMAL SHOOT 6(ABS6)encodes a MT-associated protein.Overexpression of ABS6 leads to elongated cotyledons,directional pavement cell expansion,and highly ordered transverse cMT arrays.Genetic suppressor analysis revealed that ABS6-mediated cMT ordering is dependent on KTN1 and SHADE AVOIDANCE 4(SAV4).Live imaging of cMT dynamics showed that both ABS6 and SAV4 function as positive regulators of cMT severing.Furthermore,ABS6 directly interacts with KTN1 and SAV4 and promotes their recruitment to the cMTs.Finally,analysis of loss-of-function mutant combinations showed that ABS6,SAV4,and KTN1 work together to ensure the robust ethylene response in the apical hook of dark-grown seedlings.Together,our findings establish ABS6 and SAV4 as positive regulators of cMT severing and ordering,and highlight the role of cMT dynamics in fine-tuning differential growth in plants. | Yuanfeng Li Meng Deng Haofeng Liu Yan Li Yu Chen Min Jia Hui Xue Jingxia Shao Jun Zhao Yafei Qi Lijun An Fei Yu Xiayan Liu | 2021 | Journal of Integrative Plant Biology2021，63，4： | 2 |
| 19 | Programmed death‐1/B7‐H1 negative costimulation protects mouse liver against ischemia and reperfusion injury显示文摘 | Haofeng Ji Xiuda Shen Feng Gao Bibo Ke Maria Cecilia S. Freitas Yoichiro Uchida Ronald W. Busuttil Yuan Zhai Jerzy W. Kupiec‐Weglinski | 2010 | Hepatology2010，，4： | 1 |
| 20 | Utilization of synergetic effect of weak interactions in the design of polymeric sorbents with high sorption selectivity显示文摘 | Guodong Liu Haofeng Yu Husheng Yan | 2002 | Journal of Chromatography A2002，952，： | 1 |
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