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| 1 | TGF-β signaling in cancer metastasis显示文摘转变生长因素(TGF )- 发信号的事件是众所周知的控制多样的进程和众多的回答例如房间增长,区别, apoptosis,和移植。在癌症的 TGF- 发信号戏上下文依赖者角色:在 pre 恶意的房间, TGF- 首先作为肿瘤 suppressor 工作,当在癌症的以后的阶段发信号的 TGF- 支持侵略和转移时。最近的研究也建议了在 TGF- 发信号和另外的发信号的小径之间的串音例如河马, Wnt, EGFR/RAS,和 PI3K/AKT 小径,可以实质地贡献我们 TGF- 发信号和癌症的当前的理解。由于 TGF- 的广阔效果, TGF- 和它的下游的发信号部件的封锁提供多重治疗学的机会。因此,为为众多的疾病表明治疗的 anti-TGF- 的眼界显得明亮并且将提供珍贵信息并且想在这药上分子的设计。在这评论,我们集中于最近的卓见进在可以贡献新奇指向癌症的治疗的发展的癌症转移发信号的 TGF- 的规定。 | Feng Xie Li Ling Hans van Dam Fangfang Zhou Long Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 36 |
| 2 | Combined detection of serum tumor markers for differential diagnosis of solid lesions located at the pancreatic head显示文摘BACKGROUND: The differential diagnosis of solid lesions located at the pancreatic head is very important for choosing therapies and setting up surgical tactics. This study was designed to evaluate the clinical significance of combined measurement of multiple serum tumor markers and the application of the receiver-operating characteristic (ROC) curves in the differential diagnosis of solid lesions located at the pancreatic head. METHODS: The serum levels of CA19-9, CA242, CA50 and carcinoembryonic antigen (CEA) in 112 patients with carcinoma of the pancreatic head and 38 patients with focal chronic pancreatitis in the pancreatic head were measured with ELISA. The sensitivity, specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) of the four serum tumor markers were calculated. The ROC curves for the four serum tumor markers were constructed and the area under the curve (AUC) was calculated. RESULTS: The AUCs of CA19-9, CA242, CA50 and CEA were 0.805, 0.749, 0.738 and 0.705; the PLRs were 1.91, 3.43, 5.09 and 5.46; and the NLRs were 0.41, 0.56, 0.59 and 0.71, respectively. Combined measurements increased the diagnostic specificity, and parallel combined testing increased the diagnostic sensitivity. CONCLUSIONS: Combined measurement of serum tumor markers CA19-9, CA242, CA50 and CEA is valuable in differential diagnosis of solid lesions located at the pancreatic head, and CA19-9 has the best diagnostic ability. Combined measurements can increase the specificity ofdiagnosis. Evaluation with the ROC curve is better than the sensitivity or specificity alone and the results are more integrated and objective. | Liao, Quan Zhao, Yu-Pei Yang, Ying-Chi Li, Li-Jun Long, Xiao Han, Shao-Mei | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，6： | 27 |
| 3 | ;he regulation of TGF-β/SMAD signaling by protein deubiquitination显示文摘 | Juan Zhang Xiaofei Zhang Feng Xie Zhengkui Zhang Hans van Dam Long Zhang Fangfang Zhou | 2014 | Protein & Cell2014，5，7： | 27 |
| 4 | Overexpression of P53 and its risk factors in esophageal cancer in urban areas of Xi′an显示文摘OverexpressionofP53anditsriskfactorsinesophagealcancerinurbanareasofXi′anQIAOGuiBin1,HANChengLong2,JIANGRenChao1,SUNChang?.. | QIAO GuiBin1, HAN ChengLong2, JIANG RenChao1, SUN ChangSheng3, WANG Yan3 and WANG YunJie3 | 1998 | World Journal of Gastroenterology1998，4，1： | 21 |
| 5 | Knockdown of survivin expression by siRNAs enhances chemosensitivity of prostate cancer cells and attenuates its tumorigenicity显示文摘Survivin, apoptosis 家庭蛋白质的禁止者的一个成员,为肿瘤房间生存能力在肿瘤房间和它的重要角色由于它的选择表示在癌症成为了一个吸引人的治疗学的目标。这里,我们在前列腺癌症房间显示出那基于向量的小介入 RNA (siRNAs ) silenced survivin 表情,导致显著地减少了房间增长并且提高了 apoptosis,并且增加了前列腺癌症房间(PC-3 ) 的敏感到导致 apoptosis 代理人, platinol。而且,有表示 siRNA 向量的 PC-3 房间 transfected 在 vivo 在裸体老鼠异种皮移植显示出更低的肿瘤形成。这些结果证明由 siRNA 的 survivin 表示的抑制稀释了前列腺癌症房间的恶意的显型,并且可以为雄激素无关的前列腺癌症的基因治疗提供一条新奇途径。 | Jianjun Shen Jiayun Liu Yin Long Yinye Miao Mingquan Su Qing Zhang Hua Han Xiaoke Hao | 2009 | Acta Biochimica et Biophysica Sinica2009，41，3： | 19 |
| 6 | GPER agonist G1 suppresses neuronal apoptosis mediated by endoplasmic reticulum stress after cerebral ischemia/reperfusion injury显示文摘Studies have confirmed a strong association between activation of the endoplasmic reticulum stress pathway and cerebral ischemia/reperfusion(I/R) injury.In this study,three key proteins in the endoplasmic reticulum stress pathway(glucose-regulated protein 78,caspase-12,and C/EBP homologous protein) were selected to examine the potential mechanism of endoplasmic reticulum stress in the neuroprotective effect of G protein-coupled estrogen receptor.Female Sprague-Dawley rats received ovariectomy(OVX),and then cerebral I/R rat models(OVX+ I/R) were established by middle cerebral artery occlusion.Immediately after I/R,rat models were injected with 100 μg/kg E2(OVX + I/R +E2),or 100 μg/kg G protein-coupled estrogen receptor agonist G1(OVX + I/R + G1) in the lateral ventricle.Longa scoring was used to detect neurobehavioral changes in each group.Infarct volumes were measured by 2,3,5-triphenyltetrazolium chloride staining.Morphological changes in neurons were observed by Nissl staining.Terminal dexynucleotidyl transferase-mediated nick end-labeling staining revealed that compared with the OVX + I/R group,neurological function was remarkably improved,infarct volume was reduced,number of normal Nissl bodies was dramatically increased,and number of apoptotic neurons in the hippocampus was decreased after E2 and G1 intervention.To detect the expression and distribution of endoplasmic reticulum stress-related proteins in the endoplasmic reticulum,caspase-12 distribution and expression were detected by immunofluorescence,and mRNA and protein levels of glucose-regulated protein 78,caspase-12,and C/EBP homologous protein were determined by polymerase chain reaction and western blot assay.The results showed that compared with the OVX+ I/R group,E2 and G1 treatment obviously decreased mRNA and protein expression levels of glucose-regulated protein 78,C/EBP homologous protein,and caspase-12.However,the G protein-coupled estrogen receptor antagonist G15(OVX + I/R + E2 + G15) could eliminate the effect of E2 on cerebral I/R injury.These results confirm that E2 and G protein-coupled estrogen receptor can inhibit the expression of endoplasmic reticulum stress-related proteins and neuronal apoptosis in the hippocampus,thereby improving dysfunction caused by cerebral I/R injury.Every experimental protocol was approved by the Institutional Ethics Review Board at the First Affiliated Hospital of Shihezi University School of Medicine,China(approval No.SHZ A2017-171) on February 27,2017. | Zi-Wei Han Yue-Chen Chang Ying Zhou Hang Zhang Long Chen Yang Zhang Jun-Qiang Si Li Li | 2019 | Neural Regeneration Research2019，14，7： | 16 |
| 7 | Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells显示文摘组织蛋白酶 L (CTSL ) , lysosomal 酸半胱氨酸朊酶,被知道在肿瘤起重要作用转移和化疗抵抗。在这研究,我们调查了在人的肺癌症 cells.Methods 由 CTSL 位于 chemoresistance 的规定下面的分子的机制:人的肺癌症 A549 房间, A549/PTX (paclitaxel 抵抗) 房间和 A549/DDP (cisplatin 抵抗) 房间被测试。到 cisplatin 或 paclitaxel 的抵抗用 MTT 和殖民地形成试金被检测。肌动朊改变与 FITC-Phalloidin 被观察荧光灯的染色或 immunofluorescence。愈合创伤的试金或 Transwell 试金被用来估计迁居或侵略能力。CTSL 和上皮、间充质的标记的表示与西方的弄污和 immunofluorescence 被分析。联系 EMT 的抄写因素的表示与西方的弄污或 q-PCR 被测量。BALB/c 裸体老鼠与 A549 房间 overexpressing CTSL 皮下地被植入,并且老鼠是管理 paclitaxel (10, 15 mg/kg, ip ) 为 5 times.Results 的每 3 d:Cisplatin 或 paclitaxel 治疗(10-80 ng/mL ) 在 A549 房间导致了 CTSL 表示。CTSL 层次比在 A549 房间在 A549/PTX 和 A549/DDP 房间是高得多的。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 chemoresistance,而 CTSL 的 overexpression 稀释了 A549 房间的敏感到 cisplatin 或 paclitaxel。而且, A549/DDP 和 A549/TAX 房间经历了词法并且有增加的房间侵略和迁居能力的细胞骨架变化,由上皮的标记( E-cadherin 和 cytokeratin-18 )的减少的表示伴随了并且增加间充质的标记( N-cadherin 和 vimentin )的表示,以及 联系EMT 的抄写因素的 upregulation 蜗牛,蛞蝓, ZEB1 和 ZEB2 。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 EMT;相反, CTSL 的 overexpression 在 A549 房间导致了 EMT。在异种皮移植裸体人鼠标模型,与 A549 房间 overexpressing CTSL 植入的鼠标展出了显著地减少的敏感到 paclitaxel 处理,并且在肿瘤 tissues.Conclusion 增加了联系 EMT 的蛋白质和抄写因素的表示:Cisplatin 和 paclitaxel 抵抗在 A549 房间与 CTSL 导致 upregulation 的 EMT 被联系。因此,调停 CTSL 的 EMT 可以作为一个目标被利用对肺癌症和恶意的另外的类型提高 cisplatin 或 paclitaxel 的功效。 | Mei-ling HAN Yi-fa n ZHAO Cai-hong TAN Ya-jie XIONG Wen-juan WANG Feng WU Yao FEI Long WANG Zhong-qin LIANG | 2016 | Acta Pharmacologica Sinica2016，37，12： | 15 |
| 8 | Response-surface-based structural reliability analysis with random and interval mixed uncertainties显示文摘Traditional reliability analysis requires probability distributions of all the uncertain parameters.However,in many practical applications,the variation bounds can be only determined for the parameters with limited information.A complex hybrid reliability problem then will be caused when the random and interval variables coexist in a same structure.In this paper,by introducing the response surface technique,we develop a new hybrid reliability method to efficiently compute the interval of the failure probability of the structure due to the probability-interval hybrid uncertainty.The present method consists of a sequence of iterations.At each step,a response surface model is constructed for the limit-state function by using a quadratic polynomial and a modified axial experimental design method.An approximate hybrid reliability problem is created based on the response surface model,which is subsequently solved by an efficient decoupling approach.An updating strategy is suggested to improve the quality of the response surface and whereby ensure the reliability analysis precision.A computational procedure is then summarized for the whole iterations.Four numerical examples and also a practical application are provided to demonstrate the effectiveness of the present method. | HAN Xu JIANG Chao LIU LiXin LIU Jie LONG XiangYun | 2014 | Science China(Technological Sciences)2014，57，7： | 14 |
| 9 | Effect of endotoxin on fibronectin synthesis of rat primary cultured hepatocytes显示文摘EfectofendotoxinonfibronectinsynthesisofratprimaryculturedhepatocytesJIAJinBin,HANDeWu,XURuiLing,GAOFei,ZHAOLongFeng,ZHA... | JIA JinBin, HAN DeWu, XU RuiLing, GAO Fei, ZHAO LongFeng, ZHAO YuanChang, YAN JinPin and MA XueHuiKeywords liver cirrhosis endotoxins fibronectin/analysis liver/cytology cells, cultured lipopolysaccharide | 1998 | World Journal of Gastroenterology1998，4，4： | 14 |
| 10 | Performance analysis of ghost imaging lidar in background light environment显示文摘The effect of background light on the imaging quality of three typical ghost imaging(GI) lidar systems(namely narrow pulsed GI lidar, heterodyne GI lidar, and pulse-compression GI lidar via coherent detection) is investigated. By computing the signal-to-noise ratio(SNR) of fluctuation-correlation GI, our analytical results, which are backed up by numerical simulations, demonstrate that pulse-compression GI lidar via coherent detection has the strongest capacity against background light, whereas the reconstruction quality of narrow pulsed GI lidar is the most vulnerable to background light. The relationship between the peak SNR of the reconstruction image andσ(namely, the signal power to background power ratio) for the three GI lidar systems is also presented, and theresults accord with the curve of SNR-σ. | CHENJIN DENG LONG PAN CHENGLONG WANG XIN GAO WENLIN GONG SHENSHENG HAN | 2017 | Photonics Research2017，5，5： | 13 |
| 11 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 12 | The Coix Genome Provides Insights into Panicoideae Evolution and Papery Hull Domestication显示文摘Coix is a grass crop domesticated as early as the Neolithic era.It is still widely cultivated for both highly nutritional food and medicinal use.However,the genetic study and breeding of this crop are hindered by the lack of a sequenced genome.Here,we report de novo sequencing and assembly of the 1619-Mb genome of Coix,and annotation of 75.39%repeats and 39629 protein-coding genes.Comparative genomics analysis showed that Coix is more closely related to sorghum than maize,but intriguingly only Coix and maize had a recent genome duplication event,which was not detected in sorghum.We further constructed a genetic map and mapped several important traits,especially the strength of hull.Selection of papery hull(thin:easy dehulling)from the stony hull(thick:difficult dehulling)in wild progenitors was a key step in Coix domestication.The papery hull makes seed easier to process and germinate.Anatomic and global transcriptome analysis revealed that the papery hull is a result of inhibition of cell division and wall biogenesis.We also successfully demonstrated that seed hull pressure resistance is controlled by two major quantitative trait loci(QTLs),which are associated with hull thickness and color,respectively.The two QTLs were further fine mapped within intervals of 250 kb and 146 kb,respectively.These resources provide a platform for evolutionary studies and will facilitate molecular breeding of this important crop. | Chao Guo Yanan Wang Aiguo Yang Jun He Chaowen Xiao Shanhua Lv Fengming Han Yibing Yuan Yuan Yuan Xiaolong Dong Juan Guo YawenYang-Hailan Liu Ningzhi Zuo Yaxi Hu Kangxu Zhao Zhengbo Jiang Xing Wang Tingting Jiang Yaou Sherf Moju Cao Yuan Wang Zhaobo Long Tingzhao Rong Luqi Huang Shufeng Zhou | 2020 | Molecular Plant2020，13，2： | 11 |
| 13 | Facile synthesis of ultrathin metal-organic framework nanosheets for Lewis acid catalysis显示文摘Ultrathin metalorganic framework (MOF) nanosheets are attracting great interest in catalysis due to their unique and intriguing two-dime nsional (2D) features. Although many progresses have been achieved, it is still highly desirable to develop novel strategies for controllable synthesis of the well-defined ultrathin MOF nanosheets. Herein we report a polyvinylpyrrolidone (PVP)-assisted route to synthesize the ultrathin Ni-MOF nanosheets characteristic of 1.5 nm in thickness, in which PVP is reacted with 2-aminoterephthalic acid (H2BDC-NH2) via formation of C=N bon d, followed by coord inatio n with Ni2+ io ns to form the ultrathi n MOF n anosheets. Impressively, when used in the Kno eve nagel condensation reactions of propane dinitrile with different aldehydes, ultrathin Ni-MOF nanosheets display the significantly enhanced catalytic activity and good stability in respect with the bulk Ni-MOF, mainly owing to the exposed active sites as well as facile mass transfer and diffusion of substrates and products. | Xiaofei Zhang Lin Chang Zhongjie Yang Yanan Shi Chang Long Jianyu Han Binhao Zhang Xueying Qiu Guodong Li Zhiyong Tang | 2019 | Nano Research2019，12，2： | 11 |
| 14 | Super-resolution dipole orientation mapping via polarization demodulation显示文摘Fluorescence polarization microscopy(FPM)aims to detect the dipole orientation of fluorophores and to resolve structural information for labeled organelles via wide-field or confocal microscopy.Conventional FPM often suffers from the presence of a large number of molecules within the diffraction-limited volume,with averaged fluorescence polarization collected from a group of dipoles with different orientations.Here,we apply sparse deconvolution and least-squares estimation to fluorescence polarization modulation data and demonstrate a super-resolution dipole orientation mapping(SDOM)method that resolves the effective dipole orientation from a much smaller number of fluorescent molecules within a sub-diffraction focal area.We further apply this method to resolve structural details in both fixed and live cells.For the first time,we show that different borders of a dendritic spine neck exhibit a heterogeneous distribution of dipole orientation.Furthermore,we illustrate that the dipole is always perpendicular to the direction of actin filaments in mammalian kidney cells and radially distributed in the hourglass structure of the septin protein under specific labelling.The accuracy of the dipole orientation can be further mapped using the orientation uniform factor,which shows the superiority of SDOM compared with its wide-field counterpart as the number of molecules is decreased within the smaller focal area.Using the inherent feature of the orientation dipole,the SDOM technique,with its fast imaging speed(at sub-second scale),can be applied to a broad range of fluorescently labeled biological systems to simultaneously resolve the valuable dipole orientation information with super-resolution imaging. | Karl Zhanghao Long Chen Xu-San Yang Miao-Yan Wang Zhen-Li Jing Hong-Bin Han Michael Q Zhang Dayong Jin Jun-Tao Gao Peng Xi | 2016 | Light(Science & Applications)2016，5，1： | 11 |
| 15 | Proportion of Uterine Malignant Tumors in Patients with Laparoscopic Myomectomy: A National Multicenter Study in China显示文摘 | Hua Yang Xiao-Chuan Li Chen Yao Jing-He Lang Hang-Mei Jin Ming-Rong Xi Gang Wang Lu-Wen Wang Min Hao Yan Ding Jie Chen Jian-Qing Zhang Lu Han Cheng-Xiu Guo Xiang Xue Yan Li Jian-Hua Zheng Man-Hua Cui Huai-Fang Li Guang-Shi Tao Long Chen Su-Min Wang An-Wei LU Ze-Hua Huang Qing Liu Ya-Li Zhuang Xiang-Hua Huang Gen-Hai Zhu Ou-Ping Huang Li-Na Hu Mu-Jun Li Hong-Lin Zhou Jing-Hui Song Lan Zhu | 2017 | Chinese Medical Journal2017，，22： | 10 |
| 16 | Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury显示文摘Mild therapeutic hypothermia has been shown to mitigate cerebral ischemia, reduce cerebral edema, and improve the prognosis of patients with cerebral ischemia. Adipose-derived stem cell-based therapy can decrease neuronal death and infiltration of inflammatory cells, exerting a neuroprotective effect. We hypothesized that the combination of mild therapeutic hypothermia and adipose-derived stem cells would be neuroprotective for treatment of stroke. A rat model of transient middle cerebral artery occlusion was established using the nylon monofilament method. Mild therapeutic hypothermia(33°C) was induced after 2 hours of ischemia. Adipose-derived stem cells were administered through the femoral vein during reperfusion. The severity of neurological dysfunction was measured by a modified Neurological Severity Score Scaling System. The area of the infarct lesion was determined by 2,3,5-triphenyltetrazolium chloride staining. Apoptotic neurons were detected by terminal deoxynucleotidyl transferase-mediated d UTP-biotin nick end labeling(TUNEL) staining. The regeneration of microvessels and changes in the glial scar were detected by immunofluorescence staining. The inflammatory responses after ischemic brain injury were evaluated by in situ staining using markers of inflammatory cells. The expression of inflammatory cytokines was measured by reverse transcription-polymerase chain reaction. Compared with mild therapeutic hypothermia or adipose-derived stem cell treatment alone, their combination substantially improved neurological deficits and decreased infarct size. They synergistically reduced the number of TUNEL-positive cells and glial fibrillary acidic protein expression, increased vascular endothelial growth factor levels, effectively reduced inflammatory cell infiltration and down-regulated the m RNA expression of the proinflammatory cytokines interleukin-1β, tumor necrosis factor-α and interleukin-6. Our findings indicate that combined treatment is a better approach for treating stroke compared with mild therapeutic hypothermia or adipose-derived stem cells alone. | Kai Zhao Rui Li Sheng Bi Yu Li Long Liu Yu-Long Jia Peng Han Chang-Cong Gu Xi-Ze Guo Wan-Ping Zhang Chun Wang Chun-Ying Pei Lin-Lu Tian Li-Xian Li | 2018 | Neural Regeneration Research2018，13，10： | 9 |
| 17 | Is Chinese Medicine Injection Applicable for Treating Acute Lung Injury and Acute Respiratory Distress Syndrome?A Systematic Review and Meta-analysis of Randomized Controlled Trials显示文摘Objective To assess the efficacy and safety of Chinese medicine injection(CMI)for treating acute lung injury/acute respiratory distress syndrome(ALI/ARDS).Methods Randomized controlled trials(RCTs)were identified by searching 3 English databases and 4 Chinese databases from their inceptions until February 2019.The Cochrane Handbook was used to evaluate risk of bias in the included studies.Data analysis was conducted using RevMan 5.3.3 software.Results A total of 19 eligible RCTs involving 1,334 participants was included in this systematic review and meta-analysis.The main meta-analysis showed that CMI combined with conventional therapy(CT)was more effective than CT alone in reducing the acute physiology and chronic health evaluation(APACHE)H score[mean difference(MD):−1.74 points,95%confidence interval(CI):−2.77 to−0.71,I^2=0]and increasing the total effective rate[relative risk(RR):1.35,95%CI:1.17 to 1.56,I^2=37%].Compared with CT,CMI combined with CT showed improvements in the arterial partial pressure of oxygen(PaO2,MD:9.25 mm Hg,95%CI:0.87 to 17.63,I^2=98%)and oxygenation index[arterial partial pressure of oxygen(PaO2)/fraction of inspired oxygen(FiO2),MD:50.75 mm Hg,95%CI:35.18 to 66.31,I^2=94%].CMI plus CT was superior to CT in reducing the systemic inflammatory response syndrome(SIRS)score(MD:−0.84 points,95%CI:−1.26 to−0.42,I^2=65%),length of hospital stay(MD:−4.22 days,95%CI:−6.49 to−1.95,I^2=92%),and duration of mechanical ventilation(MD:−2.94 days,95%CI:−4.68 to−1.21,I^2=89%).Only 1 study reported adverse events.Conclusions CMI as an adjuvant therapy showed great potential benefits for the treatment of ALI/ARDS.However,we could not make a definite conclusion due to low quality of included studies and uncertain security.Future studies should focus on improving research design,especially in blindness and placebo.The reporting of adverse events was also needed. | CHEN Yuan-bin LIU Qiao XIE Han YIN Shuo-miao WU Lei YU Xu-hua FAN Long LIN Lin | 2020 | Chinese Journal of Integrative Medicine2020，26，11： | 9 |
| 18 | Application of atomic force microscopy to living samples from cells to fresh tissues显示文摘Atomic force microscopy is a novel method for imaging and characterization in biomedicine. However, high-resolution imaging of living samples from cells to tissues still remains a challenge. In this paper, two types of AFM working mode (contact mode and tapping mode) which are utilized for the imaging of living cells and tissues are discussed. A new magnetic tapping mode (MAC mode), which is more suitable for living samples, and a novel data collecting system named TREC, are also introduced. | CHEN PeiPei DONG HongTao CHEN Long SUN QuanMei HAN Dong | 2009 | Chinese Science Bulletin2009，54，14： | 8 |
| 19 | Simulation of Morphological Development of Soil Cracks in Yuanmou Dry-hot Valley Region, Southwest China显示文摘Soil cracking is an important process influencing water and solutes transport in the Yuanmou Dry-hot Valley region of Southwest China. Studying the morphological development of soil cracks helps to further reveal the close relationship between the soil cracking process and water movement in such semi-arid regions. Here we report regular changes on surface morphology of soil cracks with decreasing water in four different soils (Typ-Ustic Ferrisols,Ver-Ustic Ferrisols,Tru-Ustic Vertisols and Typ-Ustic Vertisols) through simulation experiments. Our results indicate the following: 1) Different soils ultimately have different development degrees of soil cracks,according to their various values of crack area density. Soil cracks in Typ-Ustic Ferrisols can only develop to the feeble degree,while those in the other three soils are capable of developing into the intensive degree,and even into the extremely intensive degree. 2) Soil crack complexity,as expressed by the value of the area-weighted mean of crack fractal dimension (AWMFRAC),is found to continuously decrease as a whole through the whole cracking process in all the studied soils. 3) Soil crack connectivity shows a uniform trend in the studied soils,that is to say,connectivity gradually increases with soil crack development. | XIONG Donghong YAN Dongchun LONG Yi LU Xiaoning HAN Jianning HAN Xueqin SHI Liangtao | 2010 | Chinese Geographical Science2010，20，2： | 8 |
| 20 | Development of a large-scale isolation chamber system for the safe and humane care of medium-sized laboratory animals harboring infectious diseases显示文摘The close phylogenetic relationship between humans and non-human primates makes non-human primates an irreplaceable model for the study of human infectious diseases.In this study,we describe the development of a large-scale automatic multi-functional isolation chamber for use with medium-sized laboratory animals carrying infectious diseases.The isolation chamber,including the transfer chain,disinfection chain,negative air pressure isolation system,animal welfare system,and the automated system,is designed to meet all biological safety standards.To create an internal chamber environment that is completely isolated from the exterior,variable frequency drive blowers are used in the air-intake and air-exhaust system,precisely controlling the filtered air flow and providing an air-barrier protection.A double door transfer port is used to transfer material between the interior of the isolation chamber and the outside.A peracetic acid sterilizer and its associated pipeline allow for complete disinfection of the isolation chamber.All of the isolation chamber parameters can be automatically controlled by a programmable computerized menu,allowing for work with different animals in different-sized cages depending on the research project.The large-scale multi-functional isolation chamber provides a useful and safe system for working with infectious medium-sized laboratory animals in high-level bio-safety laboratories. | Xin PAN Jian-cheng QI Ming LONG Hao LIANG Xiao CHEN Han LI Guang-bo LI Hao ZHENG | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，10： | 8 |
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