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| 1 | Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus显示文摘AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0.0002 and P = 0.001, respectively), but no association with IL28 B haplotype was observed.CONCLUSION IL28 B and OAS polymorphisms are associated with different clinical outcomes in CHB children treated with interferon. | Krzysztof Domagalski Malgorzata Pawlowska Agnieszka Zalesna Malgorzata Pilarczyk Pawel Rajewski Waldemar Halota Andrzej Tretyn | 2016 | World Journal of Gastroenterology2016，22，41： | 7 |
| 2 | Long‐term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B显示文摘 | Ting‐Tsung Chang Yun‐Fan Liaw Shun‐Sheng Wu Eugene Schiff Kwang‐Hyub Han Ching‐Lung Lai Rifaat Safadi Samuel S. Lee Waldemar Halota Zachary Goodman Yun‐Chan Chi Hui Zhang Robert Hindes Uchenna Iloeje Suzanne Beebe Bruce Kreter | 2010 | Hepatology2010，，： | 4 |
| 3 | Acute liver failure caused by concurrent autoimmune hepatitis and hepatitis B in a 16-year old girl显示文摘A 16 year-old girl was admitted to hospital because of fatigue and somnolence,nausea,epistaxis and jaund ice.Physical examination revealed jaundice,an enlarged liver and tenderness of upper right abdom en.Laboratory tests revealed an increased level of acute liver failure,bilirubin,bile acids,GGTP and a decreased prot hrombin ratio,with elevated gamma-globulin and IgG levels,and the presence of anti-mitochondrial M2 antibodies and HBV infection markers.The patient was diagnosed with liver failure resulting from chronic hepatitis B with an autoimmune component.The treatment consisted of steroids,azathioprine,vitam in K,low-protein diet and lactulose enemas.After undergoing a molecular test(HBV DNA 3.23 × 105 IU/mL and mutations 204 and 80),the treatment was mo tient was discharged in good clinical condition,with the recommendation of continued entecavir,prednisone and azathioprine.In subsequent months,no clinical deter ioration or abnormal biochemical liver function test results were found,despite the discontinuation of immunos up pressive therapy after 10 mo.The patient cont inues entecavir therapy. | Ma■gorzata Paw■owska Waldemar Halota | 2010 | World Journal of Hepatology2010，2，10： | 3 |
| 4 | What's new in hepatitis C virus infections in children?显示文摘The number of hepatitis C virus(HCV) infection cases is relatively low in children. This low number may be connected with the lack of screening tests and the asymptomatic course of infection. Currently,mother-toinfant transmission is the most common cause of HCV infection amongst children in developed countries. It is important to introduce routine screening tests for HCV in pregnant women. The risk of vertical transmission of HCV is estimated at approximately 5%(3%-10%). Currently,we do not have HCV transmission prevention methods. Some factors could potentially be eliminated by elective caesarean section. Currently,the method of prevention of perinatal HCV infection is the early identification and effective treatment of infections in young women in the preconception period. We describe genetic tests(IL-28 B single nucleotide polymorphisms) to identify children with an increased chance of spontaneous clearance or sustained virologic response achievement and vitamin D level as a potential predictor of treatment response in children. It is also important to develop non-invasive tests that can predict liver fibrosis. The existence of differences in the mechanisms leading to liver injury between children and adults creates new perspectives of action to reduce liver disease progression in children in the early years of life. | Malgorzata Pawlowska Krzysztof Domagalski Anna Pniewska Beata Smok Waldemar Halota Andrzej Tretyn | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 5 | Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4显示文摘 | K. Domagalski M. Paw?owska A. Tretyn W. Halota M. Pilarczyk E. Smukalska K. Linkowska T. Grzybowski | 2013 | European Journal of Clinical Microbiology & Infectious Diseases2013，，6： | 1 |
| 6 | Serum neopterin and beta2-mieroglobulin concentrations as'prognostic markers'of AIDS显示文摘 | Halota W Jaruga B Pawlowska M | 2002 | Pol Merkuriusz Lek2002，13，： | 1 |
| 7 | Depres- sive symptoms and cognitive dysfunction in patients with hepatitis C treated with interferon -e and ribavirine显示文摘 | DROZDZ W BORKOWSKA A HALOTA W | 2008 | Arch Psychiat Psychother2008，1，： | 1 |
| 8 | Serum IL-2 and sIL- 2R concentration in children with chronic hepatitis B显示文摘 | Pawlowska M Halota W Smukahka E otal | 2005 | Pol Merkur Lekarski2005，18，103： | 1 |
| 9 | Forecasting the disease burden of chronic hepatitis C virus in Poland显示文摘 | Robert Flisiak Waldemar Halota Krzysztof Tomasiewicz Kaja Kostrzewska Homie A. Razavi Erin E. Gower | 2015 | European Journal of Gastroenterology & Hepatology2015，，1： | 1 |
| 10 | HBV DNA suppression during entecavir treat- ment in previously treated children with chronic hepati- tis B显示文摘 | PAWEOWSKA M HALOTA W SMUKALSKA E | 2012 | Eur J Clin Microbiol Infect Dis2012，31，： | 1 |
| 11 | Serum neopterin and β2-microglobulin concentrations as'prognostic markers' of AIDS显示文摘 | Halota W Jaruga B Pawlowska M | 2002 | Pol Merkur Lekarski2002，13，： | 1 |
| 12 | Plasma selenium concentration glutathione peroxidase and glutathione S-transferase activities in patients with chronic liver diseases显示文摘 | Czuczejko J Halota W Zachara BA | 2002 | Pol Merkuriusz Lek2002，13，76： | 1 |
| 13 | Interferon-induced thyroiditis during treatment of chronic hepatitis C 显示文摘 | Kozielewicz D Halota W | 2012 | Endokrynol Pol2012，63，1： | 1 |
| 14 | Prevalence and risk factors of HCV infection in Poland显示文摘 | Robert Flisiak Waldemar Halota Andrzej Horban Jacek Juszczyk Malgorzata Pawlowska Krzysztof Simon | 2011 | European Journal of Gastroenterology & Hepatology2011，，12： | 1 |
| 15 | Plasma selenium concentration glutathione peroxidase and glutathione S-transferase activities in patients with chronic liver diseases 显示文摘 | Czuczejko J Halota W Zachara B A | 2002 | Pol Merkttriusz Lek2002，13，76： | 1 |
| 16 | HBV DNA suppression during entecavir treatment in previously treated children with chronic hepatitis B 显示文摘 | PAWLOWSKA M HALOTA W SMUKALSKA E | 2012 | Eur J Clin Mi- crobiol Infect Dis2012，31，4： | 1 |
| 17 | Serum IL-2 and sI2R COncentrafionin childrenwith chronic hepatitis B 显示文摘 | Pawlowska M Halota W Smukalska E ct al | 2005 | PolMerkurLkarski2005，18，103： | 1 |
| 18 | Serum IL-2 and SIL-2R concentration in children with chronic hepatitis B显示文摘 | Pawlowska M Halota W Smukalska E | 2005 | Pol Merkur Lekarski2005，8，103： | 1 |
| 19 | Virologic re- sponse to treatment with pegylated interferon alfa-2h and ribavirin chric hepatitis C in children显示文摘 | Pawlowska M Pilarczyk M Halota W | 2008 | Hepatology2008，48，4： | 1 |
| 20 | Plasma selenium concentration glutathione peroxidase and glutathione Sransferase activities in patients with chronic liver diseases显示文摘 | Czuczejko J Halota W Zachara BA | 2002 | Pol Merkur Lekarski2002，13，76： | 1 |
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