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| 1 | 肝内胆管细胞癌诊断及治疗的现状与挑战显示文摘肝内胆管细胞癌(intrahepatic cholangiocarcinoma,ICC)是一类起源于肝内胆管上皮细胞的恶性肿瘤。ICC发病较隐匿,早期无明显的临床症状,临床上尚缺少特异度高的早期筛查诊断标志物,很多患者在发现时已进展到中晚期,失去采取根治性切除术治疗的机会;即使手术切除,复发及转移等诸多因素也会导致ICC患者病死率高、远期生存预后差的局面。国际上尚无成熟的ICC个体化精准治疗推荐策略,现有的分期及预后模型主要基于手术切除的患者所创建,缺少普适性,临床应用受限。因此提高ICC患者早期确诊率、制定精准的治疗策略、探索预后风险因素是临床改善生存结局的途径。本文结合ICC研究进展,分析了ICC的诊断和治疗现状以及面临的挑战。 | 张宁 卢姗姗 Rifaat Safadi Roberts R.Lewis 陆荫英 | 2018 | 传染病信息2018，31，1： | 8 |
| 2 | Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy显示文摘Objective:Hepatocellular carcinoma(HCC),the main type of liver cancer,has a high morbidity and mortality,and a poor prognosis.RNA helicase DDX5,which acts as a transcriptional co-regulator,is overexpressed in most malignant tumors and promotes cancer cell growth.Heat shock protein 90(HSP90)is an important molecular chaperone in the conformational maturation and stabilization of numerous proteins involved in cell growth or survival.Methods:DDX5 m RNA and protein expression in surgically resected HCC tissues from 24 Asian patients were detected by quantitative real-time PCR and Western blot,respectively.The interaction of DDX5-HSP90 was determined by molecular docking,immunoprecipitation,and laser scanning confocal microscopy.The autophagy signal was detected by Western blot.The cell functions and signaling pathways of DDX5 were determined in 2 HCC cell lines.Two different murine HCC xenograft models were used to determine the function of DDX5 and the therapeutic effect of an HSP90 inhibitor.Results:HSP90 interacted directly with DDX5 and inhibited DDX5 protein degradation in the AMPK/ULK1-regulated autophagy pathway.The subsequent accumulation of DDX5 protein induced the malignant phenotype of HCC by activating theβ-catenin signaling pathway.The silencing of DDX5 or treatment with HSP90 inhibitor both blocked in vivo tumor growth in a murine HCC xenograft model.High levels of HSP90 and DDX5 protein were associated with poor prognoses.Conclusions:HSP90 interacted with DDX5 protein and subsequently protected DDX5 protein from AMPK/ULK1-regulated autophagic degradation.DDX5 and HSP90 are therefore potential therapeutic targets for HCC. | Ting Zhang Xinrui Yang Wanping Xu Jing Wang Dawei Wu Zhixian Hong Shengxian Yuan Zhen Zeng Xiaodong Jia Shanshan Lu Rifaat Safadi Sen Han Zhihong Yang Leonard M.Neckers Suthat Liangpunsakul Weiping Zhou Yinying Lu | 2021 | Cancer Biology & Medicine2021，18，3： | 7 |
| 3 | Long‐term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B显示文摘 | Ting‐Tsung Chang Yun‐Fan Liaw Shun‐Sheng Wu Eugene Schiff Kwang‐Hyub Han Ching‐Lung Lai Rifaat Safadi Samuel S. Lee Waldemar Halota Zachary Goodman Yun‐Chan Chi Hui Zhang Robert Hindes Uchenna Iloeje Suzanne Beebe Bruce Kreter | 2010 | Hepatology2010，，： | 4 |
| 4 | Water Quality Assessment of the River Nile System:An Overview显示文摘Objectives The main objective of the present article is to assess and evaluate the characteristics of the Nile water system, and identify the major sources of pollution and its environmental and health consequences. The article is also aimed to highlight the importance of water management via re-use and recycle of treated effluents for industrial purpose and for cultivation of desert land. Method An intensive effort was made by the authors to collect, assess and compile the available data about the River Nile. Physico-chemical analyses were conducted to check the validity of the collected data. For the determination of micro-pollutants, Gas Chromatography (GC) and High Performance Liquid Chromatography (HPLC) were used. Heavy metals were also determined to investigate the level of industrial pollution in the river system. Results The available data revealed that the river receives a large quantity of industrial, agriculture and domestic wastewater. It is worth mentioning that the river is still able to recover in virtually all the locations, with very little exception. This is due to the high dilution ratio. The collected data confirmed the presence of high concentrations of chromium and manganese in all sediment samples. The residues of organo-chlorine insecticides were detected in virtually all locations. However, the levels of such residues are usually below the limit set by the WHO for use as drinking water. The most polluted lakes are Lake Maryut and Lake Manzala.Groundwater pollution is closely related to adjacent (polluted) surface waters. High concentrations of nutrients, E. coli, sulfur, heavy metals, etc. have been observed in the shallow groundwater, largely surpassing WHO standards for drinking water use. Conclusion A regular and continuous monitoring scheme shall be developed for the River Nile system. The environmental law shall be enforced to prohibit the discharge of wastewater (agricultural, domestic or industrial) to River Nile system. | RIFAAT A.WAHAAB MOHAMED I.BADAWY | 2004 | Biomedical and Environmental Sciences2004，17，1： | 4 |
| 5 | Utilizing third harmonic 100% stator ground fault protection,a cogeneration experience显示文摘 | | 2000 | The 2000 IEEE Conference of Industry Applications2000，，5： | 1 |
| 6 | Free anterolateral thigh flapfor reconstruction of major craniofacial defects 显示文摘 | Amin A Rifaat M Civantos F | 2006 | J ReconstrMicrosurg2006，22，2： | 1 |
| 7 | Seasonal fluxes of phosphate across the sediment-water interface in Edku Lagoon, Egypt 显示文摘 | Khalil M K Rifaat A E | 2013 | Oceanologia2013，55，1： | 1 |
| 8 | The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation显示文摘 | Rifaat MA Abdel Gawad WS | 2005 | Egypt Natl Cane Inst2005，17，3： | 1 |
| 9 | The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation 显示文摘 | RIFAAT MA ABDEL GAWAD WS | 2005 | J Egypt Natl Canc Inst2005，17，3： | 1 |
| 10 | Development of a plant derived subunit vaccine candidate against hepatitis C virus 显示文摘 | Liang TJ Rifaat MM | 2000 | Arch Virol2000，145，： | 1 |
| 11 | Lymphoepithelioma- like carcinoma of the urinary bladder: report of a rare case 显示文摘 | Singh NG Mannan AA Rifaat AA | 2009 | Ann Saudi Med2009，29，： | 1 |
| 12 | Investigation on rhizoplane actinomycete communities of cattail (Typha angustifolia) from a Hungarian wetland显示文摘 | Rifaat H M Márialigeti K & Kovács G | | Suo0，51，3： | 1 |
| 13 | The use of tensor fascia lata pedicled flap in reconstructing full thickness abdominal wall defects and groin defects following tumor ablation显示文摘 | Rifaat MA Abdel Gawad WS | 2005 | J Egypt Natl Canc Inst2005，17，3： | 1 |
| 14 | Lower lip reconstruction after tumor resection:a single author's experience with various methods 显示文摘 | Rifaat M A | 2006 | J Egypt Natl Canc lnst2006，18，4： | 1 |
| 15 | Streptomyces virginiae: Taxonomy, identification and biological activities 显示文摘 | Hala M Rifaat Amany L K | 2000 | Arab J Biotech2000，71，： | 1 |
| 16 | Lower lip reconstruction after tumor resection;a single author’s experience with various methods显示文摘 | Rifaat M A | 2006 | Egypt Natl Canc Inst2006，18，4： | 1 |
| 17 | Development of a plant-derived subunit vaccine candidate against hepatitis C virus 显示文摘 | Nemchinov L G Liang T J Rifaat M M | 2000 | Arch Virol2000，145，12： | 1 |
| 18 | Development of a plant-derived subunit vaccine candidate against hepatitis C virus显示文摘 | Nemchinov LG Liang TJ Rifaat MM | 2000 | Arch Virol2000，145，： | 1 |
| 19 | Paroti- dectomy for benign parotid tumors: an aesthetic ap- proach显示文摘 | AMIN A MOSTAFA A RIFAAT M | 2011 | JEgyptNatlCancInst2011，23，： | 1 |
| 20 | Parotidectomy for benign parotid tumors:An aesthetic approach 显示文摘 | Amin A Mostafa A Rifaat M | 2011 | J Egypt Natl Canc Inst2011，23，2： | 1 |
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