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| 1 | Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus显示文摘AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0.0002 and P = 0.001, respectively), but no association with IL28 B haplotype was observed.CONCLUSION IL28 B and OAS polymorphisms are associated with different clinical outcomes in CHB children treated with interferon. | Krzysztof Domagalski Malgorzata Pawlowska Agnieszka Zalesna Malgorzata Pilarczyk Pawel Rajewski Waldemar Halota Andrzej Tretyn | 2016 | World Journal of Gastroenterology2016，22，41： | 7 |
| 2 | Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4显示文摘 | K. Domagalski M. Paw?owska A. Tretyn W. Halota M. Pilarczyk E. Smukalska K. Linkowska T. Grzybowski | 2013 | European Journal of Clinical Microbiology & Infectious Diseases2013，，6： | 1 |
| 3 | Arteries of the uterine cer-vix in reproductive age in microangiographic studies 显示文摘 | Pilarczyk K Kozik W Czerwinski F | 2002 | GinekoJ Pol2002，73，12： | 1 |
| 4 | Emissions at coke plants: European environmental regulations and measures for emission control 显示文摘 | PILARCZYK E SOWA F KAISER M | 2013 | Transactions of the Indian institute of Metals2013，66，56： | 1 |
| 5 | General cerebral and systemic metabolic disturbances occurring in ischemic stroke with special emphasis on glucose and its metabolites显示文摘 | Pilarczyk M Krasinska-Czerlunczakiewicz H Tynccka-Turowska M | 1999 | Neurol Neurochir Pot1999，32，： | 1 |
| 6 | Investigations of the possibility of electrochemical nickel and copper coating of bead wires 显示文摘 | Bogdan Golis Jan W Pilarczyk Henryk Dyja | 2002 | Wire Journal International2002，，11： | 1 |
| 7 | Impact of genetic and dietary factors on immune response of carp显示文摘 | Pilarczyk A | 1998 | Rozprawy-Akademia-Rolnicza-w-Szczecinie1998，181，： | 1 |
| 8 | Progress in develop- ment of molecularly imprinted polymers as sorbents for sample preparation 显示文摘 | Kloskowski A Pilarczyk M Przyjazny A | 2009 | Crit Rev Anal Chem2009，，39： | 1 |
| 9 | Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization 显示文摘 | Pilarczyk K Sattler K J Galili O | 2008 | Atherosclerosis2008，196，1： | 1 |
| 10 | A production attempt of Ni50Ti50 and Ni52Ti41Nb7 alloys by mechanical alloying method显示文摘 | Pilarczyk W Nowosielski R Pilarczyk A | 2011 | Archives of Materials Science and Engineering2011，47，1： | 1 |
| 11 | Urinary * for early prediction of acute kidney injury after coronary artery bypass surgery 显示文摘 | PILARCZYK K EDAYADIYIL-DUDASOVA M WENDT D | 2015 | Ann Intensive Care2015，5，1： | 1 |
| 12 | Calculation of Rope Fatigue Strength on the Basis of Mechanical Proper-ties of Wires显示文摘 | Golis B Pilarczyk J W Blazejowski Z | 2005 | Wire Journal International2005，38，9： | 1 |
| 13 | Changes in specific carp immune reaction caused by addition of fish oil to pellets 显示文摘 | Pilarczyk A | 1995 | Aquaculture1995，129，14： | 1 |
| 14 | et al Calculation of Rope Fatigue Strength on the Basis of Mechanical Properties of Wires显示文摘 | Goiis B Pilarczyk J W Blazejowski Z | 2005 | Wire Journal International2005，38，9： | 1 |
| 15 | Seleni-um Concentration and Glutathione Peroxidase(GSH-Px)Activity in Ser-um of Cows at Different Stages of Lactation显示文摘 | PILARCZYK B JANKOWIAK D TOMZA-MARCINIAK A | 2012 | Biological Trace ElementResearch2012，147，13： | 1 |
| 16 | The study of glass forming ability of Fe-based alloy for welding processes显示文摘 | Pilarczyk W | 2012 | Journal of Achievements in Materials and Manufacturing Engineering2012，52，2： | 1 |
| 17 | Drawing practice of steel wires with pressure dies 显示文摘 | Bogdan Golis Jan w Pilarczyk | 1997 | Wire Journal International1997，38，： | 1 |
| 18 | Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization 显示文摘 | Pilarczyk K Sattler K J Galili O | 2008 | Atherosclerosis2008，196，1： | 1 |
| 19 | Impact of genetic and dietary factors on immune response of carp 显示文摘 | Pilarczyk A | 1998 | Rozprawy-Akademia-Rolnicza-w- Szczecinie1998，181，： | 1 |
| 20 | Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization显示文摘 | Pilarczyk K Sattler KJ Galili O | 2008 | Atherosclerosis2008，196，1： | 1 |
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