|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of IL28B and OAS gene family polymorphisms on interferon treatment response in Caucasian children chronically infected with hepatitis B virus显示文摘AIM To investigate the impact of IL28 B and OAS gene polymorphisms on interferon treatment responses in children with chronic hepatitis B.METHODS We enrolled 52 children(between the ages of 4 and 18) with hepatitis B e antigen-negative chronic hepatitis B(CHB), who were treated with pegylated interferon alfa for 48 wk. Single nucleotide polymorphisms in the OAS1(rs1131476), OAS2(rs1293747),OAS3(rs2072136), OASL(rs10849829) and IL28B(rs12979860, rs12980275 and rs8099917) genes were studied to examine their associations with responses to IFN treatment in paediatric patients. We adopted two criteria for the therapeutic response, achieving an hepatitis B virus(HBV) DNA level < 2000 IU/m L and normalization of ALT activity(< 40 IU/L). To perform the analyses, we compared the patients in terms of achieving a partial response(PR) and a complete response(CR) upon measurement at the 24-wk posttreatment follow-up. RESULTS The PR and CR rates were 80.8% and 42.3%, respectively. Factors such as age, gender and liver histology had no impact on the type of response(partial or complete). A statistically significant relationship between higher baseline HBV DNA and ALT activity levels and lower rates of PR and CR was shown(P < 0.05). The allele association analysis revealed that only the IL-28 B rs12979860(C vs T) and IL28 B rs12980275(A vs G) markers significantly affected the achievement of PR(P = 0.021, OR = 3.3, 95%CI: 1.2-9.2 and P = 0.014, OR = 3.7, 95%CI: 1.3-10.1, respectively). However, in the genotype analysis, only IL-28 B rs12980275 was significantly associated with PR(AA vs AG-GG, P = 0.014, OR = 10.9, 95%CI: 1.3-93.9). The association analysis for CR showed that the TT genotype of IL28 B rs12979860 was present only in the no-CR group(P = 0.033) and the AA genotype of OASL rs10849829 was significantly more frequent in the noCR group(P = 0.044, OR = 0.26, 95%CI: 0.07-0.88). The haplotype analysis revealed significant associations between PR and CR and OAS haplotype(P = 0.0002 and P = 0.001, respectively), but no association with IL28 B haplotype was observed.CONCLUSION IL28 B and OAS polymorphisms are associated with different clinical outcomes in CHB children treated with interferon. | Krzysztof Domagalski Malgorzata Pawlowska Agnieszka Zalesna Malgorzata Pilarczyk Pawel Rajewski Waldemar Halota Andrzej Tretyn | 2016 | World Journal of Gastroenterology2016，22，41： | 7 |
| 2 | What's new in hepatitis C virus infections in children?显示文摘The number of hepatitis C virus(HCV) infection cases is relatively low in children. This low number may be connected with the lack of screening tests and the asymptomatic course of infection. Currently,mother-toinfant transmission is the most common cause of HCV infection amongst children in developed countries. It is important to introduce routine screening tests for HCV in pregnant women. The risk of vertical transmission of HCV is estimated at approximately 5%(3%-10%). Currently,we do not have HCV transmission prevention methods. Some factors could potentially be eliminated by elective caesarean section. Currently,the method of prevention of perinatal HCV infection is the early identification and effective treatment of infections in young women in the preconception period. We describe genetic tests(IL-28 B single nucleotide polymorphisms) to identify children with an increased chance of spontaneous clearance or sustained virologic response achievement and vitamin D level as a potential predictor of treatment response in children. It is also important to develop non-invasive tests that can predict liver fibrosis. The existence of differences in the mechanisms leading to liver injury between children and adults creates new perspectives of action to reduce liver disease progression in children in the early years of life. | Malgorzata Pawlowska Krzysztof Domagalski Anna Pniewska Beata Smok Waldemar Halota Andrzej Tretyn | 2015 | World Journal of Gastroenterology2015，21，38： | 3 |
| 3 | Impact of IL-28B polymorphisms on pegylated interferon plus ribavirin treatment response in children and adolescents infected with HCV genotypes 1 and 4显示文摘 | K. Domagalski M. Paw?owska A. Tretyn W. Halota M. Pilarczyk E. Smukalska K. Linkowska T. Grzybowski | 2013 | European Journal of Clinical Microbiology & Infectious Diseases2013，，6： | 1 |
| 4 | The chemical characteristic and distribution of brassinos- teroids in plants显示文摘 | BAJGUZ A TRETYN R | 2003 | Phytochemistry2003，62，7： | 1 |
| 5 | Sequencing technologies and genome sequencing显示文摘 | Pareek CS Smoczynski R Tretyn A | | 0，，04： | 1 |
| 6 | Acetylcholine in plants: Presence, metabolism and mechanism of action显示文摘 | Andrzej Tretyn Richard E. Kendrick | 1991 | The Botanical Review1991，，1： | 1 |
| 7 | Biochemical evidence lot a calcium-dependent protein kinase from Pharbitis nil and its involvement in photopariodic flower induction 显示文摘 | JAWORSKI K Szmidt-Jaworska A TRETYN A | 2003 | Phytcehem2003，62，： | 1 |
| 8 | Se-quencing technologies and genome sequencing 显示文摘 | PAREEK C S SMOCZYNSKI R TRETYN A | 2011 | J Ap-pl Genet2011，52，4： | 1 |
| 9 | Acetylcholine in plants: presence,metabolism and mechanism of action 显示文摘 | Tretyn A Kendrick R E | 1991 | Bot Rev1991，57，： | 1 |
| 10 | Sequencing technologies and genome sequencing显示文摘 | Pareek C S Smoczynski R Tretyn A | 2011 | J Appl Genet2011，52，4： | 1 |
| 11 | Acetylcholine in plants: Presence, metabolism and mechanism of action显示文摘 | Andrzej Tretyn Richard E. Kendrick | 1991 | The Botanical Review1991，，1： | 1 |
| 12 | Influence of acetylcholine agonists and antagonists on the swelling of etiolated wheat (Triticum aestivum L.) mesophyll protoplasts显示文摘 | Andrzej Tretyn Richard E. Kendrick Margreet E. Bossen Willem J. Vredenberg | 1990 | Planta1990，，4： | 1 |
| 13 | Acetylcholine in plants: Presence, metabolism and mechanism of action显示文摘 | Andrzej Tretyn Richard E. Kendrick | 1991 | The Botanical Review1991，，1： | 1 |
| 14 | Calcium-dependent signal transduction pathways in plants phytochrome mechanism of action as an example显示文摘 | Tretyn A | 1999 | Polish J Plarmacol1999，51，2： | 1 |
| 15 | The chemical characteristic and distribution of brassinosteroids in plants显示文摘 | Bajguz A Tretyn A | 2003 | Phytochemistry2003，62，： | 1 |
| 16 | The Mechanism of Calcium action on flower induction in Pharbitis nil 显示文摘 | TRETYN A CZAPLEWSKA J CYMERSKY J | 1994 | Journal of Plant Physiology1994，144，： | 1 |
| 17 | The role of light and polar auxin transport in root regeneration from hypocotyls of tomato seedling cuttings显示文摘 | TYBURSK1 J TRETYN A | 2004 | Plant Growth Regul2004，42，1： | 1 |
| 18 | Biochemical evidence lot a calcium-dependent protein kinase from Pharbitis nil and its involvement in photoperiodic flower induction显示文摘 | Jaworski K Szmidt-Jaworska A Tretyn A | 2003 | Phytochen2003，62，： | 1 |
| 19 | The role of light and polar auxin transport in root regeneration from hypoeotyls of tomato seedling cuttings显示文摘 | TYBURSKI J TRETYN A | 2004 | Plant Growth Regul2004，42，： | 1 |
| 20 | The mechanism of calcium action on flower induction in Pharbitisnil显示文摘 | TRETYN A CZAPLEWSKA J CYMERSKI M | 1994 | Plant Physiol1994，144，45： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员