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| 1 | Prediction of undrained shear strength using extreme gradient boosting and random forest based on Bayesian optimization显示文摘Accurate assessment of undrained shear strength(USS)for soft sensitive clays is a great concern in geotechnical engineering practice.This study applies novel data-driven extreme gradient boosting(XGBoost)and random forest(RF)ensemble learning methods for capturing the relationships between the USS and various basic soil parameters.Based on the soil data sets from TC304 database,a general approach is developed to predict the USS of soft clays using the two machine learning methods above,where five feature variables including the preconsolidation stress(PS),vertical effective stress(VES),liquid limit(LL),plastic limit(PL)and natural water content(W)are adopted.To reduce the dependence on the rule of thumb and inefficient brute-force search,the Bayesian optimization method is applied to determine the appropriate model hyper-parameters of both XGBoost and RF.The developed models are comprehensively compared with three comparison machine learning methods and two transformation models with respect to predictive accuracy and robustness under 5-fold cross-validation(CV).It is shown that XGBoost-based and RF-based methods outperform these approaches.Besides,the XGBoostbased model provides feature importance ranks,which makes it a promising tool in the prediction of geotechnical parameters and enhances the interpretability of model. | Wengang Zhang Chongzhi Wu Haiyi Zhong Yongqin Li Lin Wang | 2021 | Geoscience Frontiers2021，12，1： | 33 |
| 2 | Soluble CD40 ligand is associated with angiographic severity of coronary artery disease in patients with acute coronary syndrome显示文摘 | Zhao Wei | 2014 | Chinese Medical Journal2014，，12： | 11 |
| 3 | miRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocardial infarction显示文摘Although microRNAs(miRNAs) have been intensively studied in cardiac fibrosis,their roles in drug-mediated anti-fibrotic therapy are still unknown.Previously,Pioglitazone attenuated cardiac fibrosis and increased miR-711 experimentally.We aimed to explore the role and mechanism of miR-711 in pioglitazone-treated myocardial infarction in rats.Our results showed that pioglitazone significantly reduced collagen-I levels and increased miR-711 expression in myocardial infarction heart.Pioglitazone increased the expression of miR-711 in cardiac fibroblasts,and overexpression of miR-711 suppressed collagen-I levels in angiotensin II(Ang II)-treated or untreated cells.Transfection with antagomir-711 correspondingly abolished the pioglitazone-induced reduction in collagen-I levels.Bioinformatics analysis identified SP1,which directly promotes collagen-I synthesis,as the putative target of miR-711.This was confirmed by luciferase assay and western blot analysis.Additionally,increased SP1 expression was attenuated by pioglitazone in myocardial infarction heart.Furthermore,transfection of antagomir-711 attenuated pioglitazone-reduced SP1 expression in cardiac fibroblasts with or without Ang II stimulation.We conclude that pioglitazone up-regulated miR-711 to reduce collagen-I levels in rats with myocardial infarction.The miR-711-SP1-collagen-I pathway may be involved in the anti-fibrotic effects of pioglitazone.Our findings may provide new strategies for miRNA-based anti-fibrotic drug research. | ZHAO Na YU HaiYi YU HaiTao SUN Min ZHANG YouYi XU Ming GAO Wei | 2013 | Science China(Life Sciences)2013，56，5： | 9 |
| 4 | Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders显示文摘Human genetic adaptation to high altitudes(>2500 m)has been extensively studied over the last few years,but few functional adaptive genetic variants have been identified,largely owing to the lack of deep-genome sequencing data available to previous studies.Here,w e build a list of putative adaptive variants,including 63 missense,7 loss-of-function;1,298 evolutionarily conserved variants and 509 expression quantitative traits loci.Notably,the top signal of selection is located in TMEM 247,a transmembrane protein-coding gene.The Tibetan version of TMEM 247 harbors one high-frequency(76.3%)missense variant,rsl 16983452(c.248C>T;p.Ala83Val);with the T allele derived from archaic ancestry and carried by>94%of Tibetans but absent or in low frequencies(<3%)in non-Tibetan populations.The rsl 16983452-T is strongly and positively correlated with altitude and significantly associated with reduced hemoglobin concentration(p=5.78×10^-5),red blood cell count(p=5.72×10^-7)and hematocrit(p=2.57×10^-6).In particular,TMEM247-rs 116983452 shows greater effect size and better predicts the phenotypic outcome than any E P A S1 variants in association with adaptive traits in Tibetans.Modeling the interaction between TM£M247-rsl 16983452 and EPAS1 variants indicates weak but statistically significant epistatic effects.Our results support that multiple variants may jointly deliver the fitness of the Tibetans on the plateau,where a complex model is needed to elucidate the adaptive evolution mechanism. | Lian Deng Chao Zhang Kai Yuan Yang Gao Yuwen Pan Xueling Ge Yaoxi He Yuan Yuan Yan Lu Xiaoxi Zhang Hao Chen Haiyi Lou Xiaoji Wang Dongsheng Lu Jiaojiao Liu Lei Tian Qidi Feng Asifullah Khan Yajun Yang Zi-Bing Jin Jian Yang Fan Lu Jia Qu Longli Kang Bing Su Shuhua Xu | 2019 | National Science Review2019，6，6： | 9 |
| 5 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 6 | Genome editing in Drosophila melanogaster: from basic genome engineering to the multipurpose CRISPR-Cas9 system显示文摘Nowadays, genome editing tools are indispensable for studying gene function in order to increase our knowledge of biochemical processes and disease mechanisms. The extensive availability of mutagenesis and transgenesis tools make Drosophila melanogaster an excellent model organism for geneticists. Early mutagenesis tools relied on chemical or physical methods,ethyl methane sulfonate(EMS) and X-rays respectively, to randomly alter DNA at a nucleotide or chromosomal level. Since the discovery of transposable elements and the availability of the complete fly genome, specific genome editing tools, such as P-elements, zinc-finger nucleases(ZFNs) and transcription activator-like effector nucleases(TALENs), have undergone rapid development. Currently, one of the leading and most effective contemporary tools is the CRISPR-cas9 system made popular because of its low cost, effectiveness, specificity and simplicity of use. This review briefly addresses the most commonly used mutagenesis and transgenesis tools in Drosophila, followed by an in-depth review of the multipurpose CRISPR-Cas9 system and its current applications. | Xingjie Ren Kristof Holsteens Haiyi Li Jin Sun Yifan Zhang Lu-Ping Liu Qingfei Liu Jian-Quan Ni | 2017 | Science China(Life Sciences)2017，60，5： | 5 |
| 7 | De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation显示文摘Structural variants(SVs) may play important roles in human adaptation to extreme environments such as high altitude but have been under-investigated. Here, combining long-read sequencing with multiple scaffolding techniques, we assembled a high-quality Tibetan genome(ZF1), with a contig N50 length of 24.57 mega-base pairs(Mb) and a scaffold N50 length of 58.80 Mb. The ZF1 assembly filled 80 remaining N-gaps(0.25 Mb in total length) in the reference human genome(GRCh38). Markedly, we detected17 900 SVs, among which the ZF1-specific SVs are enriched in GTPase activity that is required for activation of the hypoxic pathway. Further population analysis uncovered a 163-bp intronic deletion in the MKL1 gene showing large divergence between highland Tibetans and lowland Han Chinese. This deletion is significantly associated with lower systolic pulmonary arterial pressure, one of the key adaptive physiological traits in Tibetans. Moreover, with the use of the high-quality de novo assembly, we observed a much higher rate of genome-wide archaic hominid(Altai Neanderthal and Denisovan) shared non-reference sequences in ZF1(1.32%–1.53%) compared to other East Asian genomes(0.70%–0.98%),reflecting a unique genomic composition of Tibetans. One such archaic hominid shared sequence-a662-bp intronic insertion in the SCUBE2 gene-is enriched and associated with better lung function(the FEV1/FVC ratio) in Tibetans. Collectively, we generated the first high-resolution Tibetan reference genome, and the identified SVs may serve as valuable resources for future evolutionary and medical studies. | Ouzhuluobu Yaoxi He Haiyi Lou Chaoying Cui Lian Deng Yang Gao Wangshan Zheng Yongbo Guo Xiaoji Wang Zhilin Ning Jun Li Bin Li Caijuan Bai Baimakangzhuo Gonggalanzi Dejiquzong Bianba Duojizhuoma Shiming Liu Tianyi Wu Shuhua Xu Xuebin Qi Bing Su | 2020 | National Science Review2020，7，2： | 4 |
| 8 | GEOMETRY AND DIMENSION OF SELF-SIMILAR SET显示文摘The authors show that the self-similar set for a finite family of contractive similitudes (sim-ilarities, i.e., |fi(x) - fi(y)| = ai|x - y|, x,y ∈ RN, where 0 < ai < 1) is uniformly perfectexcept the case that it is a singleton. As a corollary, it is proved that this self-similar set haspositive Hausdorff dimension provided that it is not a singleton. And a lower bound of theupper box dimension of the uniformly perfect sets is given. Meanwhile the uniformly perfectset with Hausdorff measure zero in its Hausdorff dimension is given. | YIN YONGCHENG JIANG HAIYI SUN YESHUN | 2003 | Chinese Annals of Mathematics,Series B2003，24，1： | 2 |
| 9 | Superconducting nanowire single-photon detectors:recent progress显示文摘Research of superconducting nanowire singlephoton detectors(SNSPDs) has been progressing rapidly in recent years. The combined properties of high efficiency,low noise, and fast speed of SNSPDs permit its applications ranging from long-distance quantum teleportation to moonto-earth optical communications. Here we briefly discussed recent progress of SNSPDs, in particular(1) tungstensilicide SNSPDs,(2) waveguide-integrated SNSPDs, and(3) a few applied demonstrations. | Xiaolong Hu Yuhao Cheng Chao Gu Xiaotian Zhu Haiyi Liu | 2015 | Science Bulletin2015，60，23： | 2 |
| 10 | A rapid real-time recombinase polymerase amplification assay for diagnosis of acute hepatopancreatic necrosis disease in shrimp显示文摘Acute hepatopancreatic necrosis disease(AHPND)is an emerging disease in the shrimp farming industry with a high mortality rate that causes serious economic losses in Asia,Africa,and America[1].AHPND is also known as early mortality syndrome because of its early onset of the disease at 5-30 days of shrimp postlarvae stocking and a high mortality rate up to 100%.Symptoms of AHPND include lighter hepatopancreas,atrophy,jejunal empty stomach,softened carapace,and loss of vitality.AHPND is caused by infection of special strains of Vibrio parahaemolyticus(referred to VPAHPND in this study)containing the 69-kb pVA1 plasmid with the binary toxic Photorhabdus insect-related genes PirA and PirB(referred to PirAB in this study)[2].In January 2016,the World Organization for Animal Health(OIE)added AHPND to the OIE List of Aquatic Animal Diseases.Rapid,sensitive,and reliable diagnosis assays for AHPND are demanded by the shrimp farming industry to prevent the disease and reduce economic loss. | Haiyi Yu Xiaohan Yang Juan Zhang Haitao Yang Panpan Zhao Hui Shen Ge Jiang Jing Ji Jingquan Dong Song Gao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 2 |
| 11 | Bladder paraganglioma in adults: MR appearance in four patients显示文摘 | Haiyi Wang Huiyi Ye Aitao Guo Zhitao Wei Xu Zhang Yan Zhong Zhiwei Fan Ye Wang Dianjun Wang | 2010 | European Journal of Radiology2010，，： | 2 |
| 12 | Application of Matter-element Model in Soil Nutrient Evaluation of Ecological Fragile Region显示文摘On the basis of the soil environment investigation in Da′an City, Jilin Province, China, 40 soil samples from main land use types were obtained and tested by standard method. Soil organic matter (SOM), total N (TN), total P (TP), total K (TK), available N (AN), available P (AP) and available K (AK) were chosen as the evaluation factors. A regional soil nutrient evaluation model was developed based on the matter-element model. The results show that the soil samples with nutrient grade Ⅱ–Ⅴ respectively account for 10%, 30%, 32.5% and 27.5%, and those with grade Ⅳ and Ⅴ account for 60% in all samples. The relationship between soil nutrients and land types indicates that the nutrients of farmland are relatively good, with 41.7% of soil samples with the nutrient grade Ⅳ and Ⅴ. The nutrients of saline-alkali land and sandy land are the worst, with 100% of soil samples with the nutrient grade Ⅳ and Ⅴ. And the ratios of soil samples grade Ⅳ and Ⅴ in grassland and wasteland are respectively 62.5 % and 54.55%. Generally speaking, the soil nutrients status in Da′an City is poor, 60% of soil samples are in poor and extremely poor conditions, indicating that the soil has been severely eroded. Being a relatively superior evaluation method with more accurate re- sults and spatial distribution consistency, matter-element analysis is more suitable for regional soil nutrient evaluation than previous models. | TANG Jie WANG Chenye LIN Nianfeng LI Zhaoyang LI Haiyi MAO Zilong | 2009 | Chinese Geographical Science2009，19，2： | 2 |
| 13 | Electrochemi- cal sensing platform based on palladium modified ceria nano- particles显示文摘 | Qu Fengli Sun Haiyi Zhang Shufang | 2012 | Electroehim Aeta2012，6117，313： | 1 |
| 14 | Geometric analysis and tooth profiling of a three-lobe helical rotor of the Roots blower 显示文摘 | Ligang Yao Zhonghe Ye Haiyi Cal | 2005 | Journal of Materials Processing Technology2005，，170： | 1 |
| 15 | Study on properties of ultra-low dielectric loss mPPO/MTCLT composites prepared by injection molding显示文摘A novel category of polyphenylene oxide/high-impact polystyrene(PPO/HIPS)alloy was used as the polymer matrix(abbreviated as mPPO)and loaded with different volume fractions(0,10,20,30,40,50 vol.%)of MgTiO_(3)-Ca_(0.7)La_(0.2)TiO_(3)(abbreviated as MTCLT)ceramics to prepare composites by injection molding.Its micromorphology,density,dielectric,thermal and mechanical properties were analyzed in detail.The experimental results show that the composites possess a compact microstructure because HIPS increases the fluidity of PPO.Due to the excellent dielectric properties of both mPPO and MTCLT,the composites have an extremely low dielectric loss.The realization of the high ceramic filler fraction greatly limits the thermal expansion of the polymer chain by introducing the interphase,so that the coefficient of thermal expansion of the composite material could be as low as 21.8 ppm/°C.At the same time,the presence of ceramic particles could reinforce the mechanical property of the compos-ites.When the ceramic filler fraction is higher than 20 vol.%,the bending strength of the composite material is around 110 MPa.When the ceramic filler fraction is 40 vol.%,the composite possesses the best comprehensive performance.The dielectric constant is 6.81,the dielectric loss is 0.00104,the thermal expansion coefficient is as low as 25.3 ppm/°C,and the bending strength is 110.4 MPa.Due to its excellent properties,this material can be a good candidate in the field of microwave communication. | Yahan Liu Haiyi Peng Xiaogang Yao Minmin Mao Kaixin Song Huixing Lin | 2022 | Journal of Advanced Dielectrics2022，12，3： | 1 |
| 16 | Implication of expression of osteopontin and its receptor integrin ανβ3 in the placenta in the development of preeclampsia显示文摘 | Junxia Xia Fuyuan Qiao Fangmin Su Haiyi Liu | 2009 | Journal of Huazhong University of Science and Technology2009，，6： | 1 |
| 17 | Phase III, randomized, open‐label, first‐line study in Asia of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non‐small‐cell lung cancer: evaluation of patients recruited from mainland China显示文摘 | Yi‐Long WU Da‐Tong CHU Baohui HAN Xuyi LIU Li ZHANG Caicum ZHOU Meilin LIAO Tony MOK Haiyi JIANG Emma DUFFIELD Masahiro FUKUOKA | 2012 | Asia‐Pacific Journal of Clinical Oncology2012，，3： | 1 |
| 18 | Ursodeoxycholic Acid in the Treatment of Intrabeptic Cholestasis of Pregnancy显示文摘 | LIU Yuling QIAO Fuyuan LIU Haiyi | 2006 | Journal of Huazhong University of Science and Technology [ Med Sci ]2006，26，3： | 1 |
| 19 | Geometric analysis and tooth profiling of a three - lobe helical rotor of the Roots blower 显示文摘 | Ligang Yao Zhonghe Ye Haiyi Cai | 2005 | Journal of Materials Processing Technology2005，，170： | 1 |
| 20 | Geometric analysis and tooth profiling of a three-lobe helical rotor of the roots blower显示文摘 | Yao Ligang Ye Zhonghe Dai Jian S Cai Haiyi | | 0，，1： | 1 |
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