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| 1 | Pathological and molecular examinations of postmortem testis biopsies reveal SARS-CoV-2 infection in the testis and spermatogenesis damage in COVID-19 patients显示文摘In late December 2019,the novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),was identified in Wuhan,China,and the ensuing pandemic has led to more than 50 million infected individuals and more than one million deaths by November 10,2020(http://gffzze7c39cdc9e894ca6swff6bcf9fxx6669b.ffgz.tsg.suse.edu.cn/).Pathologic investigations of autopsy tissue have focused primarily on the lung,heart,and kidney,whereas morphologic data on testis injury and the effects of SARS-CoV-2 infection on spermatogenesis are limited.Although two groups did not detect SARS-CoV-2 in the semen or testes of recovered COVID-19 patients,1,2 another group confirmed SARS-CoV-2 in the semen of patients.3 Therefore,it is currently unknown whether SARS-CoV-2 infection impacts spermatogenesis and male fertility.In the present study,we evaluated the effects of SARS-CoV-2 infection on spermatogenesis by examining the pathophysiology and molecular features of testes obtained from five male COVID-19 patients at autopsy. | Xixiang Ma Chuhuai Guan Rong Chen Yunyun Wang Shenglei Feng Rongshuai Wang Guoqiang Qu Sijia Zhao Fengli Wang Xiaoli Wang Dingyu Zhang Liang Liu Aihua Liao Shuiqiao Yuan | 2021 | Cellular & Molecular Immunology2021，18，2： | 6 |
| 2 | Hexagonal boron nitride nanosheet for effective ambient N2 fixation to NH3显示文摘Industrial production of NH3 from N2 and H2 significantly relies on Haber-Bosch process,which suffers from high energy consume and CO2 emission.As a sustainable and environmentally-benign alternative process,electrochemical artificial N2 fixation at ambient conditions,however,is highly required efficient electrocatalysts.In this study,we demonstrate that hexagonal boron nitride nanosheet (h-BNNS) is able to electrochemically catalyze N2 to NH3.In acidic solution,h-BNNS catalyst attains a high NH3 formation rate of 22.4 μg·h-1·mg-1cat.and a high Faradic efficiency of 4.7% at-0.75 V vs.reversible hydrogen electrode,with excellent stability and durability.Density functional theory calculations reveal that unsaturated boron at the edge site can activate inert N2 molecule and significantly reduce the energy barrier for NH3 fonmation. | Ya Zhang Huitong Du Yongjun Ma Lei Ji Haoran Guo Ziqi Tian Hongyu Chen Hong Huang Guanwei Cui Abdullah M. Asiri Fengli Qu Liang Chen Xuping Sun | 2019 | Nano Research2019，12，4： | 5 |
| 3 | Electrochemi- cal sensing platform based on palladium modified ceria nano- particles显示文摘 | Qu Fengli Sun Haiyi Zhang Shufang | 2012 | Electroehim Aeta2012，6117，313： | 1 |
| 4 | 显示文摘 | Lu Limin Li Hongbo Qu Fengli | 2011 | Biosens Bioelec- tron2011，26，8： | 1 |
| 5 | A nano-Ni based ul- trasensitive nonenzymatic electrochemical sensor for glu- cose: Enhancing sensitivity through a nanowire array strate- gy显示文摘 | Lu Limin Zhang Li Qu Fengli | 2009 | Biosensors Bioelectron2009，25，1： | 1 |
| 6 | Preparation and characterization of prussian blue nanowire array and bioapplication for glucose biosensing显示文摘 | QU Fengli SHI Aiwu YU Ruqin | 2007 | Anal Chim Acta2007，605，1： | 1 |
| 7 | Amperometric biosensor for choline based on layer-by-layer assembled functionalized carbon nanotube and polyaniline multilayer film显示文摘 | Qu Fengli Yang Minghui Jiang Jianhui | 2005 | Analytical Biochemistry2005，244，1： | 1 |
| 8 | In situ synthesis of palladium nanoparticle-graphene nanohybrids and their appli- cation in nonenzymatic glucose biosensors显示文摘 | Lu Limin Li Hongbo Qu Fengli | 2011 | Biosensors Bioelectron2011，26，8： | 1 |
| 9 | Colorimetric platform for visual detection of cancer biomarker based on intrinsic peroxidase activity of graphene oxide显示文摘 | Qu Fengli Li Ting Yang Minghui | 2011 | Biosens Bioelectron2011，26，9： | 1 |
| 10 | Enzyme-functionalized gold nanowires for the fabrication of biosensors显示文摘 | Yashuang Lu Minghui Yang Fengli Qu | 2007 | Bioelectrochemistry2007，，71： | 1 |
| 11 | Direct electrochemistry of hemoglobin in gold nanowire array显示文摘 | Minghui Yang Fengli Qu Yongjun Li | 2007 | Biosensors Bioelectronics2007，23，3： | 1 |
| 12 | Amperometric H202 biosensor based on poly-thionine nanowire/HRP/nano-Au-modified glassy carbon electrode显示文摘 | SHI Aiwu QU Fengli YANG Minghui | 2008 | Sensors and Actuators B: Chemical2008，129，： | 1 |
| 13 | Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques显示文摘SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries,how-ever,the underlying mechanism,in particular immune responses in different organs,remains elusive.In this study,comprehensive transcriptomic alterations of 14 tissues from rhesus macaque infected with SARS-CoV-2 were analyzed.Compared to normal controls,SARS-CoV-2 infection resulted in dysregulation of genes involving diverse functions in various examined tissues/organs,with drastic transcriptomic changes in cerebral cortex and right ventricle.Intriguingly,cerebral cortex exhibited a hyperinflammatory state evidenced by sig-nificant upregulation of inflammation response-related genes.Meanwhile,expressions of coagulation,angio-genesis and fibrosis factors were also up-regulated in cerebral cortex.Based on our findings,neuropilin 1(NRP1),a receptor of SARS-CoV-2,was significantly elevated in cerebral cortex post infection,accompanied by active immune response releasing inflammatory factors and signal transmission among tissues,which enhanced infection of the central nervous system(CNS)in a positive feedback way,leading to viral encephalitis.Overall,our study depicts a multi-tissue/organ tran-scriptomic landscapes of rhesus macaque with early infection of SARS-CoV-2,and provides important insights into the mechanistic basis for COVID-19-asso-ciated clinical complications. | Chun-Chun Gao Man Li Wei Deng Chun-Hui Ma Yu-Sheng Chen Yong-Qiao Sun Tingfu Du Qian-Lan Liu Wen-Jie Li Bing Zhang Lihong Sun Si-Meng Liu Fengli Li Feifei Qi Yajin Qu Xinyang Ge Jiangning Liu Peng Wang Yamei Niu Zhiyong Liang Yong-Liang Zhao Bo Huang Xiao-Zhong Peng Ying Yang Chuan Qin Wei-Min Tong Yun-Gui Yang | 2022 | Protein & Cell2022，13，12： | 1 |
| 14 | Metal-organic framework as a multi-component sensor for detection of Fe^(3+),ascorbic acid and acid phosphatase显示文摘In this research,a hydroxyl group functionalized metal-organic framework(MOF),UiO-66-(OH)_(2),was synthesized as a 'on-off-on' fluore scent switching nanoprobe for highly sensitive and selective detection of Fe^(3+),ascorbic acid(AA) and acid phosphatase(ACP).UiO-66-(OH)_(2) emits yellow-green light under ultraviolet light,when Fe^(3+) was added,Fe^(3+) was chelated with hydroxyl group,the electrons in the excited state S_1 of the MOF transferred to the half-filled 3 d orbits of Fe^(3+),resulting in fluorescence quenching because of the nonradiative electron/hole recombination annihilation.AA could reduce Fe^(3+) to Fe^(2+),which can destroy the electron transfer between UiO-66-(OH)_(2) and Fe^(3+) after AA adding,resulted in nonoccurrence of the nonradiative electron transfer,leading to the recovery of UiO-66-(OH)_(2) fluorescence intensity.The probe can also be used to detect ACP based on the enzymolysis of 2-phospho-L-ascorbic acid(AAP) to produce AA.Benefitting from the hydroxyl group and the characteristics of UiO-66,including the high porosity and large surface area,the developed UiO-66-(OH)_(2) showed extensive advantages as a fluorescent probe for detection of multi-component,such as high sensitivity and selectivity,colorimetric detection,fast response kinetics and easy to operate,economical and secure.This is the first time to use active group functionalized MOFs as a multicomponent sensor for these three substances detection. | Hao Wang Xiuli Wang Rong-Mei Kong Lian Xia Fengli Qu | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
| 15 | CuO/Cu2O nanowire array photoelectrochemical biosensor for ultrasensitive detection of tyrosinase显示文摘Photoelectrochemical(PEC) biosensors have shown great promise in bioanalysis and diagnostic applications in recent years. In this work, the CuO/Cu2O nanowire array(CuO/Cu2O Nanowire) supported on copper foam was prepared as a photocathode for detection of tyrosinase though quinone-chitosan conjugation chemistry method. The in-situ generated quinones that were the catalytic product of tyrosinase acted as electron acceptors, which were captured by the chitosan deposited on the surface of the electrode. Direct immobilization of electron acceptor on the electrode surface improved the photocurrent conversion efficiency and thus sensitivity. The as-prepared biosensor can realize a rapid response in a wide linear range of 0.05 U/mL to 10 U/mL with the detection limit as low as 0.016 U/mL of tyrosinase. The current work provides a new perspective to design and develop highly sensitive and selective PEC biosensor. | Xiaoxi Guo Jinghua Wu Lian Xia Meihao Xiang Fengli Qu Jinghong Li | 2020 | Science China Chemistry2020，63，7： | 0 |
| 16 | Colorimetric-assisted photoelectrochemical sensing for dual-model detection of sialic acid via oxidation-power mediator integration显示文摘Development of sensitive and accurate methods for sialic acid(SA) determination is of great significance in early cancer diagnosis.Here,a colorimetric-assisted Photoelectrochemical(PEC) sensor was constructed for SA detection based on the two pairs of cis-diol groups in SA molecule.With the specific recognition of SA via the two pairs of cis-diol groups,the prepared gold-modified Bi_(2)S_(3)(AuNPs@Bi_(2)S_(3)) and metal organic framework(Au@PCN-224) were introduced to the electrode and formed a sandwich structure.Based on the properties of inert electroconductivity and nanozyme of the PCN-224,dual-readout of photocurrent and visualization was achieved with the presence of 3',3',5',5'-tetramethylbenzidine(TMB).Moreover,to intensify the visualization signal,Ce^(3+) was employed as the mediator to boost the catalysis capability by transferring energy from PCN-224 surface to the whole system.With the unique SA recognition and the mediation of Ce^(3+),both the photocurrent and the visualization signals sensitively responded with the SA concentration linearly.The present method showed greatly high sensitivity,selectivity and accuracy for SA detection with a limit of detection of 1.44μmol/L and a wide linear range of 5-1000μmol/L.This method provided a new promising platform for SA detection and a potential strategy for design of novel biosensors with dual-model readout. | Yuanyuan Cheng Rong-Mei Kong Wenao Hu Xiaoxia Tian Lingdong Zhang Lian Xia Fengli Qu | 2023 | Chinese Chemical Letters2023，34，3： | 0 |
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