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| 1 | FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation显示文摘Tyrosine kinase inhibitors(TKIs)targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials,suggesting the need for combination with other drugs.We investigated the combination of FLT3 TKIs(Gilteritinib or Sorafenib),with Venetodax,a BCL-2 selective inhibitor(BCL-2i),on FLT3/ITD leukemia cells.The combination of a FLT3 TKI and a BCL-2i synergistically reduced cell proliferation and enhanced apoptosis/cell death in FLT3/ITD cell lines and primary AML samples.Venetoclax also re-sensitized FLT3 TKI-resistant cells to Gilteritinib or Sorafenib treatment,mediated through MAPK pathway inhibition.Gilteritinib treatment alone dissociated BIM from MCL-1 but increased the binding of BIM to BCL-2.Venetoclax treatment enhanced the binding of BIM to MCL-1 but dissociated BIM from BCL-2.Treatment with the drugs together resulted in dissociation of BIM from both BCL-2 and MCL-1,with an increased binding of BIM to the cell death mediator BAX,leading to increased apoptosis.These findings suggest that Venetoclax mitigates the unintended pro-survival effects of FLT3 TKI mainly through the dissociation of BIM and BCL-2 and also decreased BIM expression.This study provides evidence that the addition of BCL-2i enhances the effect of FLT3 TKI therapy in FLT3/ITD AML treatment. | Ruiqi Zhu Li Li Bao Nguyen Jaesung Seo Min Wu Tessa Seale Mark Levis Amy Duffield Yu Hu Donald Small | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 2 | Revealing the linguistic and geographical disparities of public awareness to Covid-19 outbreak through social media显示文摘The Covid-19 has presented an unprecedented challenge to public health worldwide.However,residents in different countries showed diverse levels of Covid-19 awareness during the outbreak and suffered from uneven health impacts.This study analyzed the global Twitter data from January 1st to June 30th,2020,to answer two research questions.What are the linguistic and geographical disparities of public awareness in the Covid-19 outbreak period reflected on social media?Does significant association exist between the changing Covid-19 awareness and the pandemic outbreak?We established a Twitter data mining framework calculating the Ratio index to quantify and track awareness.The lag correlations between awareness and health impacts were examined at global and country levels.Results show that users presenting the highest Covid-19 awareness were mainly those tweeting in the official languages of India and Bangladesh.Asian countries showed more disparities in awareness than European countries,and awareness in Eastern Europe was higher than in central Europe.Finally,the Ratio index had high correlations with global mortality rate,global case fatality ratio,and country-level mortality rate,with 21-31,35-42,and 13–18 leading days,respectively.This study yields timely insights into social media use in understanding human behaviors for public health research. | Binbin Lin Lei Zou Nick Duffield Ali Mostafavi Heng Cai Bing Zhou Jian Tao Mingzheng Yang Debayan Mandal Joynal Abedin | 2022 | International Journal of Digital Earth2022，15，1： | 2 |
| 3 | Lateral performance of cold-formed steel-framed domestic structures 显示文摘 | Gad E F Duffield C F Hutchinson G L | 1999 | Engineering Structures1999，21，： | 1 |
| 4 | Multicast topology inference from measured end- toend loss显示文摘 | Duffield N Horowitz J LO Presti F | 2002 | IEEE Trans Inform2002，48，： | 1 |
| 5 | Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial 显示文摘 | DUFFIELD A J LILLICO M E REID B W | 2002 | Cancer Epidemi Biomarkers Prey2002，11，： | 1 |
| 6 | Methods for the quanti- tation of abscisic acid and its precursors from plant tissues显示文摘 | DUFFIELD P H NETHNG A G | 2001 | Anal Biochem2001，289，2： | 1 |
| 7 | PRM-151(recombinant human serum amyloid P/pentraxin 2)for the treatment of fibrosis显示文摘 | Duffield JS Lupher ML Jr | | 0，，： | 1 |
| 8 | Effect of a prepartum administration of monensin in a controlled-release capsule on apparent digestibilities and nitrogen utilization in transition dairy cows显示文摘 | Plaizier J C Martin A Duffield T F | | 0，，12： | 1 |
| 9 | Estimating flow distributions from sampled flow statistics显示文摘 | Duffield N Lund C Thorup M | 2005 | IEEE/ACM Transactions on Networking(TON)2005，13，5： | 1 |
| 10 | Generic as- pects of tool design for electrochemical machining 显示文摘 | WESTLEY J A ATKINSON J DUFFIELD A | 2004 | Journal of Material Processing Technology2004，149，13： | 1 |
| 11 | Network tomography of binary network performance characteristics显示文摘 | Duffield N G | 2006 | IEEE Transactions on Information Theory2006，52，12： | 1 |
| 12 | Fetal growth restric- tion, catch - up growth and the early origins of insulin resistance and visceral obesity 显示文摘 | Morrison JL Duffield JA Muhlhausler BS | 2010 | Pediatr Nephrol2010，25，4： | 1 |
| 13 | Fetal growth restriction, catch - up growth and the early origins of insulin resistance and visceral obesity显示文摘 | Morrison JL Duffield JA Muhlhausler BS | 2010 | Pediatr Nephro12010，25，4： | 1 |
| 14 | Network losstomography using striped unicast probes显示文摘 | DUFFIELD N G PRESTI F L PAXSON V | 2006 | IEEE/ACM Trans onNetworking2006，14，4： | 1 |
| 15 | FLT3/D835Y mutation knock - in mice display less aggressive disease compared with FLT3/internal tandem duplication (1TD)mice 显示文摘 | Bailey E Li L Duffield A S | 2013 | Proc Natl Acad Sci U S A2013，110，21： | 1 |
| 16 | Effect of a monensin controlled release capsule on metabolic parameters in transition dairy cows显示文摘 | Duffield T F Leblanc S Bagg R | 2003 | J Dairy Sci2003，86，： | 1 |
| 17 | Network tomography of binary network performance characteristics显示文摘 | DUFFIELD N G | 2006 | IEEE Transactions on Information Theory2006，52，12： | 1 |
| 18 | Multicast-based lossinference with missing data显示文摘 | DUFFIELD N G HOROWITZ J TOWSLEY D | 2002 | IEEE Journal on Selected Areasin Communications2002，20，4： | 1 |
| 19 | Endometrial cytology and ultrasonography for the detection of subclinical endometritis in postpartum dairy cows显示文摘 | Kasimanickam R Duffield TF Foster RA | 2004 | Theriogenology2004，62，12： | 1 |
| 20 | An estimation of selenium requirements for new Zealanders显示文摘 | Duffield A J Thomson CD Hill KE | 1999 | Am J Clin Nutr1999，70，： | 1 |
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