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| 1 | Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury显示文摘The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan,Hubei province,and rapidly spread to many provinces in China as well as other countries.Here we report the epidemiological,clinical,laboratory,and radiological characteristics,as well as potential biomarkers for predicting disease severity in 2019-nCoV-infected patients in Shenzhen,China.All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS).The most common laboratory abnormalities were hypoalbuminemia,lymphopenia,decreased percentage of lymphocytes (LYM) and neutrophils (NEU),elevated C-reactive protein (CRP) and lactate dehydrogenase (LDH),and decreased CD8 count.The viral load of 2019-nCoV detected from patient respiratory tracts was positively linked to lung disease severity.ALB,LYM,LYM (%),LDH,NEU (%),and CRP were highly correlated to the acute lung injury.Age,viral load,lung injury score,and blood biochemistry indexes,albumin (ALB),CRP,LDH,LYM (%),LYM,and NEU (%),may be predictors of disease severity.Moreover,the Angiotensin Ⅱlevel in the plasma sample from 2019-nCoV infected patients was markedly elevated and linearly associated to viral load and lung injury.Our results suggest a number of potential diagnosis biomarkers and angiotensin receptor blocker (ARB) drugs for potential repurposing treatment of 2019-nCoV infection. | Yingxia Liu Yang Yang Cong Zhang Fengming Huang Fuxiang Wang Jing Yuan Zhaoqin Wang Jinxiu Li Jianming Li Cheng Feng Zheng Zhang Lifei Wang Ling Peng Li Chen Yuhao Qin Dandan Zhao Shuguang Tan Lu Yin Jun Xu Congzhao Zhou Chengyu Jiang Lei Liu | 2020 | Science China(Life Sciences)2020，63，3： | 157 |
| 2 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 3 | Mapping the elastic properties of two-dimensional MoS_(2) via bimodal atomic force microscopy and finite element simulation显示文摘Elasticity is a fundamental mechanical property of two-dimensional(2D)materials,and is critical for their application as well as for strain engineering.However,accurate measurement of the elastic modulus of 2D materials remains a challenge,and the conventional suspension method suffers from a number of drawbacks.In this work,we demonstrate a method to map the in-plane Young’s modulus of mono-and bi-layer MoS_(2) on a substrate with high spatial resolution.Bimodal atomic force microscopy is used to accurately map the effective spring constant between the microscope tip and sample,and a finite element method is developed to quantitatively account for the effect of substrate stiffness on deformation.Using these methods,the in-plane Young’s modulus of monolayer MoS_(2) can be decoupled from the substrate and determined as 265±13 GPa,broadly consistent with previous reports though with substantially smaller uncertainty.It is also found that the elasticity of mono-and bi-layer MoS_(2) cannot be differentiated,which is confirmed by the first principles calculations.This method provides a convenient,robust and accurate means to map the in-plane Young’s modulus of 2D materials on a substrate. | Yuhao Li Chuanbin Yu Yingye Gan Peng Jiang Junxi Yu Yun Ou Dai-Feng Zou Cheng Huang Jiahong Wang Tingting Jia Qian Luo Xue-Feng Yu Huijuan Zhao Cun-Fa Gao Jiangyu Li | 2018 | npj Computational Materials2018，，1： | 3 |
| 4 | Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice显示文摘Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression.Discs large homolog 1(Dlg1),an adaptor protein,regulates cell polarization and the function of K?channels,which are reported to regulate the activation of microglia.However,little is known about the role of Dlg1 in microglia and the maintenance of central nervous system homeostasis.In this study,we found that Dlg1 knockdown suppressed lipopolysaccharide(LPS)-induced inflammation by downregulating the activation of nuclear factor-jB signaling and the mitogen-activated protein kinase pathway in microglia.Moreover,using an inducible Dlg1 microglia-specific knockout(Dlg1flox/flox;CX3CR1CreER)mouse line,we found that microglial Dlg1 knockout reduced the activation of microglia and alleviated the LPS-induced depressionlike behavior.In summary,our results demonstrated that Dlg1 plays a critical role in microglial activation and thus provides a potential therapeutic target for the clinical treatment of depression. | Zhixin Peng Xiaoheng Li Jun Li Yuan Dong Yuhao Gao Yajin Liao Meichen Yan Zengqiang Yuan Jinbo Cheng | 2021 | Neuroscience Bulletin2021，37，12： | 2 |
| 5 | Superconducting nanowire single-photon detectors:recent progress显示文摘Research of superconducting nanowire singlephoton detectors(SNSPDs) has been progressing rapidly in recent years. The combined properties of high efficiency,low noise, and fast speed of SNSPDs permit its applications ranging from long-distance quantum teleportation to moonto-earth optical communications. Here we briefly discussed recent progress of SNSPDs, in particular(1) tungstensilicide SNSPDs,(2) waveguide-integrated SNSPDs, and(3) a few applied demonstrations. | Xiaolong Hu Yuhao Cheng Chao Gu Xiaotian Zhu Haiyi Liu | 2015 | Science Bulletin2015，60，23： | 2 |
| 6 | Sapphirine-Bearing Pelitic Granulite from Ailaoshan Orogen,West Yunnan,China: Metamorphic Conditions and Tectonic Setting显示文摘To reveal the petrological characteristics, metamorphic evolution histon and tectonic setting of the pelitic granulites from Ailaoshan Orogen, Uest Yunnan, China, a comprehensive study in mineral chemistry, petrogeochemistry and geochronology studies is presented in this paper. Two metamorphic stages of the granulites can be established:(1) the peak metamorphism recorded by the mineral assemblage of garnet, kyanite, K-feidspar and rutile, and the initial retrograde metamorphism shown by the mineral assemblage of garnet, sillimanite, sapphirine, spinel, K-feldspar, plagioclase and biotite;(2) the superim-posed metamorphism recorded by the mineral assemblage of biotite, muscovite, plagioclase, quartz and ilmenite. Zircon LA-ICP-MS U-Pb dating indicates that the protolith of the granulite was deposited after 337 Ma. The initial retrograde metamorphism occurred at P-T conditions of 8.6-12 kbar at 850-920℃ estimated by mineral assemblages, the low pressure limit of kyanite stability and GBPQ geothermobarometer in Indosinian (about 235 Ma), and the late superimposed metamorphism occurred at the P-T condition of 3.5-3.9 kbar at 572-576℃ estimated by GBPQ geothermobarometer since 33Ma. The first stage was related to the amalgamation of the South China and Indochina blocks during the Triassic, and the second stage was possibly related with the large scale sinistral slip-shearing since the Oligocene. It is inferred that the upper continental crust was suhducted/underthrusted to the lower continental crust (deeper than 30 km) and underwent granulite-facies metamorphism and then quickly exhumed to the middle-upper crust (10-12 km) and initial retrograde metamorphism occurred due to the collision of the Indochina and South China blocks during Indosinian, which was followed by superimposition of the second stage of metamorphism since the Oligocene. | Cheng Wei Yuhao Zhao Luhua Zhu Xuexiang Qi Zhihui Cai Xufeng Liu Guangfei Ma | 2019 | Journal of Earth Science2019，30，3： | 1 |
| 7 | A small microring array that performs large complex-valued matrix-vector multiplication显示文摘As an important computing operation,photonic matrix-vector multiplication is widely used in photonic neutral networks and signal processing.However,conventional incoherent matrix-vector multiplication focuses on real-valued operations,which cannot work well in complex-valued neural networks and discrete Fourier transform.In this paper,we propose a systematic solution to extend the matrix computation of microring arrays from the real-valued field to the complex-valued field,and from small-scale(i.e.,4×4)to large-scale matrix computation(i.e.,16×16).Combining matrix decomposition and matrix partition,our photonic complex matrix-vector multiplier chip can support arbitrary large-scale and complex-valued matrix computation.We further demonstrate Walsh-Hardmard transform,discrete cosine transform,discrete Fourier transform,and image convolutional processing.Our scheme provides a path towards breaking the limits of complex-valued computing accelerator in conventional incoherent optical architecture.More importantly,our results reveal that an integrated photonic platform is of huge potential for large-scale,complex-valued,artificial intelligence computing and signal processing. | Junwei Cheng Yuhe Zhao Wenkai Zhang Hailong Zhou Dongmei Huang Qing Zhu Yuhao Guo Bo Xu Jianji Dong Xinliang Zhang | 2022 | Frontiers of Optoelectronics2022，15，2： | 1 |
| 8 | Upregulation of miR-15b in NAFLD models and in the serum of patients with fatty liver disease显示文摘 | Yuhao Zhang Xixiang Cheng Zhiqiang Lu Jingkun Wang Hongyan Chen Weiwei Fan Xin Gao Daru Lu | 2012 | Diabetes Research and Clinical Practice2012，，： | 1 |
| 9 | Efficient Evergreen Plant Regeneration of Cinnamomum japonicum Sieb.through in vitro Organogenesis显示文摘Cinnamomum japonicum Sieb.is an excellent roadside tree and medicinal tree species with considerable ornamental and economic value.In this study,we successfully developed a large-scale micropropagation protocol for C.japonicum for the first time.Sterilized shoots were excised and used as explants for shoot induction on several basal media,supplemented with different concentrations of plant growth regulators(PGRs),such as Thidiazuron(TDZ),N^(6)-Benzyladenine(6-benzylaminopurine)(BA),α-naphthaleneacetic acid(NAA)and Gibberellic acid(GA_(3)).After comparison,the most efficient medium for shoot regeneration was 1/2 Murashige and Skoog(MS)medium containing 0.5 mg L^(-1)BA,0.05 mg L^(-1)NAA and 0.2 mg L^(-1)GA_(3),which resulted in an average number of induced shoots per explant and shoot length of 5.2 and 1.62 cm at 28 d,respectively.Then,elongated adventitious shoots were transferred to induce roots.86.7%of shoots was able to root on 1/2 MS medium supplemented with 0.5 mg L^(-1)NAA and 0.1 mg L^(-1)BA.The earliest rooting time observed was after 21 d and the average root length was up to 3.3 cm after 28 d.Our study shows that C.japonicum can be successfully regenerated through de novo organogenesis,which lays a foundation for future transformation research on this tree. | Jiaji Zhang Xiaofei Long Yuhao Weng Tielong Cheng Jisen Shi Jinhui Chen | 2021 | Phyton-International Journal of Experimental Botany2021，90，2： | 0 |
| 10 | Research on the Change of Airfoil Geometric Parameters of Horizontal Axis Wind Turbine Blades Caused by Atmospheric Icing显示文摘Icing can significantly change the geometric parameters of wind turbine blades,which in turn,can reduce the aerodynamic characteristics of the airfoil.In-depth research is conducted in this study to identify the reasons for the decline of wind power equipment performance through the icing process.An accurate experimental test method is proposed in a natural environment that examines the growth and distribution of ice formation over the airfoil profile.The mathematical models of the airfoil chord length,camber,and thickness are established in order to investigate the variation of geometric airfoil parameters under different icing states.The results show that ice accumulation varies considerably along the blade span.By environmental temperature drop,the minimum and maximum extents of ice accumulation are observed near the blade root(0.2 R)and the blade tip(0.95 R),respectively(R represents the blade length).The icing process steadily increases the chord length and decreases the airfoil curvature,reaching the largest value at the blade tip region.Furthermore,the maximum curvature is reduced to 41.50%of the original curvature.The maximum camber position of the airfoil moves towards the trailing edge,and the most prominent position occurs at the middle blade region(0.6 R),where it moves back by 19.43%.Ice accumulation steadily increases airfoil thickness.It leads to the maximum thickness growth of 53.40%that occurs at the blade tip region and moves forward to the leading edge by 10%.The research results can provide the required theoretical support for further monitoring the blades operating conditions to ensure reliable wind turbines’operation. | Xiyang Li Yuhao Jia Hui Zhang Bin Cheng | 2022 | Energy Engineering2022，119，6： | 0 |
| 11 | Treatment of wastewater from food waste hydrothermal carbonization via Fenton oxidization combined activated carbon adsorption显示文摘Hydrothermal carbonization(HTC)of food waste can produce hydrochar for further utilization as high-quality fuel or carbon materials,but the by-product of liquid effluent,named HTC wastewater,has a high chemical oxygen demand(COD)content and other organic pollutants.This study focused on the feasibility of Fenton oxidation combined with activated carbon(AC)to reduce COD in HTC wastewater.The effects of different parameters including pH,dosage of hydrogen peroxide,molar ratio of Fe^(2+)/H_(2)O_(2),and reaction time were tested and discussed.Eventually,through the optimized Fenton oxidation(pH=3,H_(2)O_(2)dosage=1.5 mol/L,Fe^(2+)/H_(2)O_(2)=1:15,reaction time=60 min)combined optimized AC adsorption process(AC dosage=30 g/L),the COD value reduced from 42,000 mg/L to 3075 mg/L,indicating a COD removal efficiency of 92.7%and a color removal ratio of 91.9%,respectively.The comparison of GC/MS(gas chromatography mass spectrometer)and FTIR(Fourier transform infrared spectrometer)of liquid residual from different treatment methods also indicated that the types of organic substances in HTC wastewater were significantly reduced through Fenton oxidation and AC adsorption. | Tianchi Shen Mi Yan Yuhao Xia Ruixiong Hu Yayong Yang Cheng Chen Feng Chen Dwi Hantoko | 2022 | Waste Disposal and Sustainable Energy2022，4，3： | 0 |
| 12 | Correction to:Treatment of wastewater from food waste hydrothermal carbonization via Fenton oxidization combined activated carbon adsorption显示文摘Correction to:Waste Disposal&Sustainable Energy(2022)4:205-218 http://gffzz24af94a9f7964b7bs9ccx6fkkcfbw69cb.ffgz.tsg.suse.edu.cn/10.1007/s42768-022-00106-2 The section‘Conflict of Interest'has been amended:‘Mi Yan is the Young Editorial Board member of Waste Disposal&Sustainable Energy'.The revised'Conflict of Interest'is as follows:Mi Yan is the Young Editorial Board member of Waste Disposal&Sustainable Energy. | Tianchi Shen Mi Yan Yuhao Xia Ruixiong Hu Yayong Yang Cheng Chen Feng Chen Dwi Hantoko | 2023 | Waste Disposal and Sustainable Energy2023，5，2： | 0 |
| 13 | Stereoconvergent and stepwise 1,3-dipolar cycloadditions of nitrile oxides and nitrile imines显示文摘The first example of stereoconvergent 1,3-dipolar cycloaddition of nitrile oxides and nitrile imines with E/Z isomeric mixture of electron-deficient olefins is reported,delivering isoxazolines and pyrazolines bearing two vicinal stereogenic tertiary and trifluoromethylated quaternary carbon centers with perfect regioand diastereoselectivities.The possibility of concerted cycloaddition/epimerization sequence under basic condition to form the thermodynamically stable diastereomers is excluded through some control experiments and DFT calculations,and a stepwise mechanism is proposed. | Zhenni Zhao Zhi Ou Subarna Jyoti Kalita Feng Cheng Qian Huang Yangyi Gu Yuhao Wang Yan Zhao Yiyong Huang | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 14 | Direct synthesis of high-quality perovskite nanocrystals on a flexible substrate and deterministic transfer显示文摘Solid-state perovskite nanocrystals are promising coherent light sources, as there is optical feedback within the crystal structure. In order to utilize the high performance of perovskites for on-chip applications, or observe new physical phenomena, these crystals must be integrated with pre-fabricated electronic or photonic structures. However, the material's fragility has made the deterministic transfer a great challenge thus far. Here, we report the first deterministic transfer of perovskite nanocrystals with sub-micron accuracy. Cesium lead halide(CsPbI_3) nanocrystals were directly synthesized on flexible polydimethylsiloxane(PDMS) stamps via chemical vapor deposition(CVD) and subsequently transferred onto arbitrary substrates/structures. We demonstrated the transfer of a CsPbI_3 crystalline nanoplate(NP)onto an 8 mm fiber core and achieved single-mode whispering gallery mode lasing. Our method can be extended to a variety of other arbitrary substrates(e.g., electrodes, photonic structures, micromechanical systems), laying the foundations for previously unattainable opportunities in perovskites-based devices. | Yilun Wang Xing Cheng Kai Yuan Yi Wan Pan Li Yuhao Deng Haoran Yu Xiaolong Xu Yi Zeng Wanjin Xu Yanping Li Renmin Ma Kenji Watanabe Takashi Taniguchi Yu Ye Lun Dai | 2018 | Science Bulletin2018，63，23： | 0 |
| 15 | Control of crystal growth to obtain needle-shaped violet phosphorus with excellent photocatalytic degradation performance显示文摘The control of crystal growth is important but challenging for multi-disciplinary research.Violet phosphorus,the most stable phosphorus allotrope,has recently been produced as a unique semiconducting layered structure.The crystal orientation and morphology bring extra performance due to its unique structure and anisotropy.Herein,the layered violet phosphorus has been controlled to grow along the c-axis to give tunable length up to centimeters with the assistance of tin,while the reported flat bulk ones with thickness are limited to micrometers.The as-produced needle-shaped violet phosphorus has also been demonstrated to significantly enhance the photocatalytic degradation of methyl orange pollutants due to its special crystallographic orientation.About 98.6%of methyl orange pollutants with a concentration of 50 ppm were degraded within 80 min under visible light conditions by needle-shaped violet phosphorus,which is much more effective than that of amorphous red phosphorus with only 14.1%degradation. | Mengting Jin Yanhao Wang Mengyue Gu Xuewen Zhao Rongzheng Zhao Yuhao Zhang Yonghong Cheng Jinying Zhang | 2023 | Nano Research2023，16，2： | 0 |
| 16 | An Empirical Study on the Effects of Social Endowment Insurance Reform in China显示文摘In recent years,China,the world’s largest population country,has also become an aging society.Social endowment insurance is not only a major source of income after retirement but also plays a major role in social stability.In 2005,large-scale social endowment insurance reform was conducted in China.Through this reform,the social endowment insurance became unified and normalized,and the participation of the social endowment insurance was obligated for an employee.In addition,the government has issued various welfare policies so that the unemployed,free job and rural residents can join social endowment insurance.Then,this paper analyzes the effect of the reform of China social endowment insurance on the amount of Insurance premium of social endowment insurance and the distribution of family expenditure by using the DID model and the fixed effect model. | Yuhao Cheng | 2019 | Journal of Finance Research2019，3，2： | 0 |
| 17 | Microscopic mechanism of imprint in hafnium oxide-based ferroelectrics显示文摘Hafnia-based ferroelectrics have greatly revived the field of ferroelectric memory(FeRAM),but certain reliability issues must be satisfactorily resolved before they can be widely applied in commercial memories.In particular,the imprint phenomenon severely jeopardizes the read-out reliability in hafnia-based ferroelectric capacitors,but its origin remains unclear,which hinders the development of its recovery schemes.In this work,we have systematically investigated the imprint mechanism in TiN/Hf_(0.5)Zr_(0.5)O_(2)(HZO)/TiN ferroelectric capacitors using experiments and first-principles calculations.It is shown that carrier injection-induced charged oxygen vacancies are at the heart of imprint in HZO,where other mechanisms such as domain pinning and dead layer are less important.An imprint model based on electron de-trapping from oxygen vacancy sites has been proposed that can satisfactorily explain several experimental facts such as the strong asymmetric imprint,leakage current variation,and so forth.Based on this model,an effective imprint recovery method has been proposed,which utilizes unipolar rather than bipolar voltage inputs.The remarkable recovery performances demonstrate the prospect of improved device reliability in hafnia-based FeRAM devices. | Peng Yuan Ge-Qi Mao Yan Cheng Kan-Hao Xue Yunzhe Zheng Yang Yang Pengfei Jiang Yannan Xu Yuan Wang Yuhao Wang Yaxin Ding Yuting Chen Zhiwei Dang Lu Tai Tiancheng Gong Qing Luo Xiangshui Miao Qi Liu | 2022 | Nano Research2022，15，4： | 0 |
| 18 | LAT1 targeted brain delivery of temozolomide and sorafenib for effective glioma therapy显示文摘Glioma is the most common primary craniocerebral tumor caused by the cancerous growth of glial cells in the brain and spinal cord.Currently,standard treatment is the surgical resection followed by concurrent radiation and chemotherapy.However,the blood-brain barrier(BBB)prevents most antitumor drugs from entering the brain and reduces their efficacy,especially in lowgrade glioma.Since L-type amino acid transporter 1(LAT1)is highly expressed in glioma cells and mediates drug transport across the BBB,it is a promising target for drug delivery and treatment of glioma.Temozolomide(TMZ)is the first-line treatment for glioma,however,patients often exhibit drug resistance at advanced stage.A multikinase inhibitor and inducer of ferroptosis,sorafenib can improve the therapeutic effects of TMZ.Therefore,to optimize the glioma treatment and cross the BBB,we designed LAT1-targeting nanoparticles co-loaded with TMZ and sorafenib.Our results from both in vitro and in vivo studies confirmed that LAT1-targeting nanoparticles significantly increased the cellular uptake,cytotoxicity,accumulation at tumor site,and the anti-tumor efficacy compared to the non-target nanoparticles.Therefore,LAT1 can be used as a potential target for braintargeted drug delivery,and sorafenib-induced ferroptosis can aid the anti-glioma efficacy of TMZ. | Yufei Zhang Qian Cheng Yuhao Xue Kai Yao Madiha Zahra Syeda Jian Xu Jianheng Wu Zhenjie Wang Longguang Tang Qingchun Mu | 2023 | Nano Research2023，16，7： | 0 |
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