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| 1 | Genome-wide variants of Eurasian facial shape differentiation and a prospective model of DNA based face prediction显示文摘It is a long-standing question as to which genes define the characteristic facial features among different ethnic groups. In this study, we use Uyghurs, an ancient admixed population to query the genetic bases why Europeans and Han Chinese look different. Facial traits were analyzed based on high-dense 3D facial images; numerous biometric spaces were examined for divergent facial features between European and Han Chinese, ranging from inter-landmark distances to dense shape geometrics. Genome-wide association studies(GWAS) were conducted on a discovery panel of Uyghurs. Six significant loci were identified, four of which, rs1868752, rs118078182, rs60159418 at or near UBASH3B, COL23A1, PCDH7 and rs17868256 were replicated in independent cohorts of Uyghurs or Southern Han Chinese. A prospective model was also developed to predict 3D faces based on top GWAS signals and tested in hypothetic forensic scenarios. | Lu Qiao Yajun Yang Pengcheng Fu Sile Hu Hang Zhou Shouneng Peng Jingze Tan Yan Lu Haiyi Lou Dongsheng Lu Sijie Wu Jing Guo Li Jin Yaqun Guan Sijia Wang Shuhua Xu Kun Tang | 2018 | Journal of Genetics and Genomics2018，45，8： | 7 |
| 2 | Research Data Management Implementation at Peking University Library:Foster and Promote Open Science and Open Data显示文摘Research Data Management(RDM)has become increasingly important for more and more academic institutions.Using the Peking University Open Research Data Repository(PKU-ORDR)project as an example,this paper will review a library-based university-wide open research data repository project and related RDM services implementation process including project kickoff,needs assessment,partnerships establishment,software investigation and selection,software customization,as well as data curation services and training.Through the review,some issues revealed during the stages of the implementation process are also discussed and addressed in the paper such as awareness of research data,demands from data providers and users,data policies and requirements from home institution,requirements from funding agencies and publishers,the collaboration between administrative units and libraries,and concerns from data providers and users.The significance of the study is that the paper shows an example of creating an Open Data repository and RDM services for other Chinese academic libraries planning to implement their RDM services for their home institutions.The authors of the paper have also observed since the PKU-ORDR and RDM services implemented in 2015,the Peking University Library(PKUL)has helped numerous researchers to support the entire research life cycle and enhanced Open Science(OS)practices on campus,as well as impacted the national OS movement in China through various national events and activities hosted by the PKUL. | Hua Nie Pengcheng Luo Ping Fu | 2021 | Data Intelligence2021，3，1： | 5 |
| 3 | DTDE:A new cooperative multi-agent reinforcement learning framework显示文摘A significant body of work on reinforcement learning has been focused on the single-agent tasks where the agent aims to learn a policy thatmaximizes the cumulative reward in a dynamic environment.1 In the past decades,quite a few single-agent-based reinforcement learning algorithms have been developed in the literature.1 Yet,it is increasingly recognized that the single-agentbased reinforcement learning algorithms may fail to effectively handle largescale optimization(decision)tasks with joint features. | Guanghui Wen Junjie Fu Pengcheng Dai Jialing Zhou | 2021 | The Innovation2021，2，4： | 4 |
| 4 | Characterization of novel microsatellite markers of the Emei Shan Liocichla using restriction site-associated DNA sequencing显示文摘Background:The Emei Shan Liocichla(Liocichla omeiensis) is an endemic bird species to southwestern China with a small geographic range. However, little was known about the genetic status of this threatened species.Methods:We applied restriction-site-associated DNA sequencing(RAD-Seq) for rapid mass identification of microsatellite markers of the Emei Shan Liocichla.Results:A total of 11,564 microsatellite sequences were obtained, 600 random loci were designed for screening and 24 polymorphic microsatellite loci were selected for further validation. The average allele number, average observed heterozygosity and average expected heterozygosity were relatively low in our samples, which were 6.08, 0.6618 and 0.7048, respectively, indicating that the Emei Shan Liocichla might have lost some genetic diversity. Further analyses suggested that the populations distributed on two mountains(Daxiangling and Xiaoliangshan) showed a modest degree of genetic differentiation.Conclusions:These novel microsatellite markers provided valuable preliminary knowledge regarding the genetic status of the Emei Shan Liocichla and can be useful in further studies, as well as in the management and conservation of this species. | Ailin Yang De Chen Pengcheng Wang Yiqiang Fu Zhengwang Zhang | 2017 | Avian Research2017，8，2： | 2 |
| 5 | Laboratory Testing Methods for Foamed Asphalt Mix Resilient Modulus显示文摘 | Fu Pengcheng Jones D Harvey J T | 2009 | Journal of Road Materials and Pavement Design2009，10，1： | 1 |
| 6 | The Effects of Asphalt Binder and Granular Material Characteristics on Foamed Asphalt Mix Strength显示文摘 | Fu Pengcheng Jones D Harvey J T | 2011 | Construction and Building Materials2011，25，： | 1 |
| 7 | An Investigation of the Curing Mechanism of Foamed Asphalt Mixes Based on Micromechanics Principles显示文摘 | Pengcheng Fu David Jones etc | 2009 | Journal of Materials in Civil Engineering2009，，： | 1 |
| 8 | Microwave-treated graphite felt as the positive electrode for all-vanadium redox flow battery显示文摘 | Xiaoxin Wu Hongfeng Xu Pengcheng Xu Yang Shen Lu Lu Jicheng Shi Jie Fu Hong Zhao | 2014 | Journal of Power Sources2014，，： | 1 |
| 9 | Immobilization of Candida rugosa lipase on electrospun cellulosenanofiber membrane显示文摘 | HUANG Xiaojun CHEN Pengcheng HUANG Fu | 2011 | J Mol Catal B-Enzym2011，70，： | 1 |
| 10 | Effects ofaeration parameters on effluent quality and membrane fouling ina submerged membrane bioreactor using Box-Behnken responsesurface methodology显示文摘 | Haiyan Fu Pengcheng Xu Guohe Huang | 2012 | Desalination2012，302，： | 1 |
| 11 | Effects of aeration parameters on effluent quality and membrane fouling in a submerged membrane bioreactor using Box- Behnken response surface methodology显示文摘 | Haiyan Fu Pengcheng Xu Guohe Huang | 2012 | Desalination2012，302，： | 1 |
| 12 | Desymmetrization of Cyclic 1,3-Diketones under N-Heterocyclic Carbene Organocatalysis:Access to Organofluorines with Multiple Stereogenic Centers显示文摘Symmetric 1,3-diketones with fluorine or fluorinated substituents on the prochiral carbon remain to be established.Herein,we have developed a novel prochiral fluorinated oxindanyl 1,3-diketone and successfully applied these substrates in carbene-catalyzed asymmetric desymmetrization.Accordingly,a versatile strategy for asymmetric generation of organofluorines with fluorine or fluorinated methyl groups has been developed.Multiple stereogenic centers were selectively constructed with satisfactory outcomes.Structurally diverse enantioenriched organofluorines were generated with excellent results in terms of yields,diastereoselectivities,and enantioselectivities.Notably,exchanging fluorinated methyl groups to fluorine for this prochiral 1,3-diketones leads to switchable stereoselectivity.Mechanistic aspects and origin of stereoselectivity were studied by DFT calculations.Notably,some of the prepared organofluorines demonstrated competitive antibacterial activities. | Guanjie Wang Min Zhang Yezhi Guan Ye Zhang Xianfang Hong Chenlong Wei Pengcheng Zheng Donghui Wei Zhenqian Fu Yonggui Robin Chi Wei Huang | 2021 | Research2021，，1： | 0 |
| 13 | Auction mechanism design of the Chinese national carbon market for carbon neutralization显示文摘The carbon market auction mechanism is an important policy tool for carbon pricing and a key mechanism that supports carbon emission neutralization,especially for China.A few systematic studies exist on China’s carbon market auction mechanism.This article focuses on the five auction mechanisms in Chinese pilot emission trading schemes(ETS),reviews the structures and bidding situation of the five-pilot auction mechanism,extracts the similarities,and analyzes their different features,such as auction mode,bidding scale,participants,pricing mode,auction frequency,and so on.This study conducts an in-depth analysis of the carbon allowance auction mechanism in the Guangdong pilot ETS of China,including its development and the evolution of the key elements,its operational effects,and related disputes.Finally,this study puts forward the trend forecast and suggestions for the Chinese allowance auction mechanism,such as the time window of launching national allowance auctions,the most likely auction mode,carbon pricing,and bidding revenue management.Carbon pricing by auction is the most powerful policy tool for addressing carbon emissions reduction and implementing the Glasgow Climate Pact. | Wenjun Wang Xujie Zhao Qiaqia Zhang Chonghui Fu Pengcheng Xie | 2022 | Chinese Journal of Population,Resources and Environment2022，20，2： | 0 |
| 14 | Antioxidant procyanidin B2 protects oocytes against cryoinjuries via mitochondria regulated cortical tension显示文摘Background:Irreversible cryodamage caused by oocyte vitrification limited its wild application in female fertility preservation.Antioxidants were always used to antagonist the oxidative stress caused by vitrification.However,the comprehensive mechanism underlying the protective role of antioxidants has not been studied.Procyanidin B2(PCB2)is a potent natural antioxidant and its functions in response to vitrification are still unknown.In this study,the effects of PCB2 on vitrified-thawed oocytes and subsequent embryo development were explored,and the mechanisms underlying the protective role of PCB2 were systematically elucidated.Results:Vitrification induced a marked decline in oocyte quality,while PCB2 could improve oocyte viability and further development after parthenogenetic activation.A subsequent study indicated that PCB2 effectively attenuated vitrification-induced oxidative stress,rescued mitochondrial dysfunction,and improved cell viability.Moreover,PCB2 also acts as a cortical tension regulator apart from strong antioxidant properties.Increased cortical tension caused by PCB2 would maintain normal spindle morphology and promote migration,ensure correct meiosis progression and finally reduce the aneuploidy rate in vitrified oocytes.Further study reveals that ATP biosynthesis plays a crucial role in cortical tension regulation,and PCB2 effectively increased the cortical tension through the electron transfer chain pathway.Additionally,PCB2 would elevate the cortical tension in embryo cells at morula and blastocyst stages and further improve blastocyst quality.What's more,targeted metabolomics shows that PCB2 has a beneficial effect on blastocyst formation by mediating saccharides and amino acids metabolism.Conclusions:Antioxidant PCB2 exhibits multi-protective roles in response to vitrification stimuli through mitochondria-mediated cortical tension regulation. | Qingrui Zhuan Jun Li Xingzhu Du Luyao Zhang Lin Meng Yuwen Luo Dan Zhou Hongyu Liu Pengcheng Wan Yunpeng Hou Xiangwei Fu | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 15 | How long should a kiss last between a kinase and its substrate?显示文摘The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly understood.We previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic acid(ABA)and the central growth regulator Target of Rapamycin(TOR)(Wang et al.,2018).Under normal conditions,TOR kinase phosphorylates ABA receptors(PYR1/PYL/RCARs)to abolish their ABA binding ability,thereby preventing stress signaling activation and promoting plant growth. | Chen Zhu Liwen Fu Yan Xiong Pengcheng Wang | 2022 | Journal of Integrative Plant Biology2022，64，4： | 0 |
| 16 | Desymmetrization of Cyclic 1,3-Diketones under N-Heterocyclic Carbene Organocatalysis: Access to Organofluorines with Multiple Stereogenic Centers显示文摘Symmetric 1,3-diketones with fluorine or fluorinated substituents on the prochiral carbon remain to be established.Herein,we have developed a novel prochiral fluorinated oxindanyl 1,3-diketone and successfully applied these substrates in carbene-catalyzed asymmetric desymmetrization.Accordingly,a versatile strategy for asymmetric generation of organofluorines with fluorine or fluorinated methyl groups has been developed.Multiple stereogenic centers were selectively constructed with satisfactory outcomes.Structurally diverse enantioenriched organofluorines were generated with excellent results in terms of yields,diastereoselectivities,and enantioselectivities.Notably,exchanging fluorinated methyl groups to fluorine for this prochiral 1,3-diketones leads to switchable stereoselectivity.Mechanistic aspects and origin of stereoselectivity were studied by DFT calculations.Notably,some of the prepared organofluorines demonstrated competitive antibacterial activities. | Guanjie Wang Min Zhang Yezhi Guan Ye Zhang Xianfang Hong Chenlong Wei Pengcheng Zheng Donghui Wei Zhenqian Fu Yonggui Robin Chi Wei Huang | 2022 | Research2022，，1： | 0 |
| 17 | 肝癌细胞模型库及其药物基因组学“蓝图”显示文摘文章简介原发性肝癌异质性显著,耐药性突出,预后不良。不同国家地区之间肝癌致病因素差异明显,对肝癌的精准治疗带来严重挑战。全球每年超过50%的新增病例和死亡病例均发生在中国。由大量细胞系构成的细胞系平台在乳腺癌、肺癌等癌症研究中证明细胞系平台能够模拟癌症的遗传异质性和药物响应,通过细胞系平台可以发现与药物敏感性相关的分子标志物。 | 邱志欣 李虹 章正涛 Zhenfeng Zhu Sheng He Xujun Wang Pengcheng Wang Jianjie Qin Liping Zhuang Wei Wang Fubo Xie Ying Gu Keke Zou Chao Li Chun Li Chenhua Wang Jin Cen Xiaotao Chen Yajing Shu Zhao Zhang Lulu Sun Lihua Min Yong Fu Xiaowu Huang Hui Lv He Zhou Yuan Ji Zhigang Zhang Zhiqiang Meng 施晓雷 张海斌 李亦学 惠利健 | 2020 | 科学新闻2020，，2： | 0 |
| 18 | Multilocus phylogeography and ecological niche modeling suggest speciation with gene flow between the two Bamboo Partridges显示文摘Background:Understanding how species diversify is a long-standing question in biology.The allopatric speciation model is a classic hypothesis to explain the speciation process.This model supposes that there is no gene flow during the divergence process of geographically isolated populations.On the contrary,the speciation with gene flow model supposes that gene flow does occur during the speciation process.Whether allopatric species have gene flow during the speciation process is still an open question.Methods:We used the genetic information from 31 loci of 24 Chinese Bamboo Partridges(Bambusicola thoracicus)and 23 Taiwan Bamboo Partridges(B.sonorivox)to infer the gene flow model of the two species,using the approxi-mate Bayesian computation(ABC)model.The ecological niche model was used to infer the paleo-distribution during the glacial period.We also tested whether the two species had a conserved ecological niche by means of a back-ground similarity test.Results:The genetic data suggested that the post-divergence gene flow between the two species was terminated before the mid-Pleistocene.Furthermore,our ecological niche modeling suggested that their ecological niches were highly conserved,and that they shared an overlapping potential distribution range in the last glacial maximum.Conclusions:The allopatric speciation model cannot explain the speciation process of the two Bamboo Partridges.The results of this study supported a scenario in which speciation with gene flow occurring between the allopatric species and have contributed to our understanding of the speciation process. | Pengcheng Wang Chiafen Yeh Jiang Chang Hongyan Yao Yiqiang Fu Chengte Yao Xiao Wang Shouhsien Li Zhengwang Zhang | 2021 | Avian Research2021，12，2： | 0 |
| 19 | Comparative metagenomic analysis of the vaginal microbiome in healthy women显示文摘The composition of these vaginal microbiome has a significant impact on women’s health.However,few studies have characterized the vaginal microbiome of healthy Chinese women using metagenomic sequencing.Here,we carried out a comparative metagenomic analysis to survey taxonomic,functional levels,and microbial communities’genome content in healthy women’s vaginal microbiome.Overall,we observed a total of 111 species,including all dominant vaginal Lactobacillus species,such as L.iners,L.crispatus,L.gasseri,and L.jensenii.Unlike microbial taxa,several pathways were ubiquitous and prevalent across individuals,including adenosine ribonucleotides de novo biosynthesis and pyruvate fermentation to acetate and lactate Ⅱ.Notably,our diversity analysis confirmed a significant difference in healthy women from different ethnic groups.Moreover,we binned vaginal assemblies into 62 high-quality genomes,including 9 L.iners,7 A.vaginae,5 L.jensenii,and 5 L.crispatus.We identified the pan and core genomes of L.iners and A.vaginae and revealed the genetic diversity.Primary differences between strains were the hypothetical genes and mobile element-like genes.Our results provide a framework for understanding the implications of the female reproductive tract’s composition and functional potential and highlight the importance of genome-resolved metagenomic analysis to further understand the human vaginal microbiome. | Fei Liu Yingshun Zhou Lisi Zhu Zhiyi Wang LiangKun Ma Yuan He Pengcheng Fu | 2021 | Synthetic and Systems Biotechnology2021，6，2： | 0 |
| 20 | TOR激酶和ABA受体的相互调控平衡植物生长和胁迫应答显示文摘文章简介由于无法通过移动有效的逃避胁迫,植物必须精确地平衡生长发育和胁迫应答,以适应不断变化的环境。在干旱等胁迫来临时,植物需要抑制生长发育并激活胁迫应答过程以维持生存;在胁迫条件解除后,植物又需要及时解除胁迫反应并恢复生长。 | Pengcheng Wang Yang Zhao Zhongpeng Li Chuan-Chih Hsu Xue Liu Liwen Fu Yueh-Ju Hou Yanyan Du Shaojun Xie Chunguang Zhang Jinghui Gao Minjie Cao Xiaosan Huang Yingfang Zhu Kai Tang Xingang Wang W.Andy Tao 熊延 朱健康 | 2019 | 科学新闻2019，0，2： | 0 |
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