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| 1 | 意见不一致时的策略:应用GRADE网格对临床实践指南达成共识显示文摘指南制定委员会的结构庞大和多元化使达成共识变得困难。Roman Jaeschke及其同事阐述了一种达成共识的简单方法,即当无法取得一致时,应用GRADE网格对临床实践指南达成共识。 | Roman Jaeschke Gordon H Guyatt Phil Dellinger Holger Schünemann Mitchell M Levy Regina Kunz Susan Norris Julian Bion 刘芳 陈耀龙 | 2009 | 中国循证医学杂志2009，9，7： | 22 |
| 2 | 诊断性试验和策略的证据质量和推荐强度的分级显示文摘GRADE系统能对诊断性试验或策略的证据质量和推荐强度进行分级。本文旨在阐释在此过程中如何考虑患者的重要结局, | Holger J Schünemann Andrew D Oxman Jan Brozek Paul Glasziou Roman Jaeschke Gunn E Vist John W Williams Jr Regina Kunz Jonathan Craig Victor M Montori Patrick Bossuyt Gordon H Guyatt 李晓 黄程 陈耀龙 李幼平 | 2009 | 中国循证医学杂志2009，9，5： | 7 |
| 3 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 4 | Influence of irritable bowel syndrome on treatment outcome in gastroesophageal reflux disease显示文摘AIM: To investigate the influence of irritable bowel syndrome (IBS)-like symptoms on treatment outcomes with pantoprazole in gastroesophageal reflux disease (GERD) in a real life setting. METHODS: For this prospective, open-label, multinational, multicentre study, 1888 patients assessed by the investigators as suffering from GERD were recruited. The patients were additionally classified as with or without IBS-like symptoms at baseline. They were treated with pantoprazole 40 mg once daily and completed the Reflux Questionnaire (ReQuest) short version daily. Response rates and symptom scores were compared after 4 and 8 wk of treatment for subgroups defined by the subclasses of GERD [erosive(ERD) and non-erosive reflux disease (NERD)] and the presence of IBS-like symptoms. RESULTS: IBS-like symptoms were more prevalent in NERD than in ERD (18.3% vs 12.7%, P = 0.0015). Response rates after 4 and/or 8 wk of treatment were lower in patients with IBS-like symptoms than in patients without IBS-like symptoms in both ERD (Week 4: P < 0.0001, Week 8: P < 0.0339) and NERD (Week 8: P = 0.0088). At baseline, ReQuest 'lower abdominal com- plaints' symptom scores were highest in NERD patients with IBS-like symptoms. Additionally, these patients had the strongest symptom improvement after treatment compared with all other subgroups. CONCLUSION: IBS-like symptoms influence treatment outcome and symptom burden in GERD and should be considered in management. Proton pump inhibitors can improve IBS-like symptoms, particularly in NERD. | Hubert Mnnikes Robert C Heading Holger Schmitt Hubert Doerfler | 2011 | World Journal of Gastroenterology2011，17，27： | 4 |
| 5 | 减少农田硝酸盐淋溶的可能性显示文摘农业土壤对自然水体中的硝酸盐含量有影响。,从土壤中排出的高浓度的硝酸盐溶液关系到饮用水中硝酸盐的高浓度,同时,过量的硝酸盐还会改变河流、湖泊的生态平衡。本文对通过改善农业措施减少硝酸盐淋溶这个重大环境问题进行了讨论。对农业土地硝酸盐淋溶的原因做了简略的解释,对于减少硝酸盐淋溶的现有措施做了描述、分析和评价。减少养分淋溶不是实施有机农业或传统农业所能解决的问题,而是应该通过引进和使用适当的对策来加以解决。为此,本文提出了最大限度地降低农业土壤养分淋溶的下述指导性原则,在某种程度上实施这些指导性原则需要一种新的观念①在分析一个小流域内的养分淋溶时,应考虑到农田的环境指数和空间变异性对其的影响;②通过减少氮肥使用量和降低动物饲养密度,将土壤中的氮肥施用量降低到某一合理的水平,这一水平应稍低于土地预期最适产量的氮需求量;③依据不同地区耕作系统、土壤和气候对硝酸盐淋溶的敏感性,采取相应的对策来控制硝酸盐的淋溶,如作物间作、土地少耕或免耕、调节生物过程等。 | Holger Kirchmann A.E.Johnny Johnston Lars F.Bergstrm 张耀军 | 2002 | AMBIO-人类环境杂志2002，31，5： | 3 |
| 6 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 7 | Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection显示文摘 | Eckart Schott Heiko Witt Holger Hinrichsen Konrad Neumann Viola Weich Alexandra Bergk Juliane Halangk Tobias Müller Sebastian Tinjala Gero Puhl Peter Neuhaus Bertram Wiedenmann Thomas Berg | 2006 | Journal of Hepatology2006，，3： | 2 |
| 8 | Combined evaluation of a panel of protein and miRNA serum‐exosome biomarkers for pancreatic cancer diagnosis increases sensitivity and specificity显示文摘 | Bindhu Madhavan Shijing Yue Uwe Galli Sanyukta Rana Wolfgang Gross Miryam Müller Nathalia A. Giese Holger Kalthoff Thomas Becker Markus W Büchler Margot Z?ller | 2015 | Int. J. Cancer2015，，11： | 2 |
| 9 | Targeting Dexamethasone to Macrophages in a Porcine Endotoxemic Model显示文摘 | Asger Granfeldt Christine Lodberg Hvas Jonas Heilskov Graversen Peter Astrup Christensen Mikkel Due Petersen Gabriela Anton Pia Svendsen Christoffer S?lling Anders Etzerodt Else T?nnesen S?ren Kragh Moestrup Holger Jon M?ller | 2013 | Critical Care Medicine2013，，11： | 2 |
| 10 | Development and practical test of a weighable groundwater lysimeter for floodplain sites 显示文摘 | DOERTHE B S RALPH M E HOLGER R | 2004 | Journal of Plant Nutrition and Soil Science2004，167，： | 1 |
| 11 | Complete reversal of paraplegia after thoracic endovascular aortic repair in a patient with complicated acute aortic dissection using immediate cerebrospinal fluid drainage显示文摘 | Holger Eggebrecht Dirk B?se Thomas Gasser Jaroslav Benedik Petra Mummel Oliver Müller Philipp Kahlert Konstantinos Tsagakis Heinz G. Jakob Raimund Erbel | 2009 | Clinical Research in Cardiology2009，，12： | 1 |
| 12 | Scale-free topology of e-mail networks显示文摘 | Lutz I M Stefan B | 2002 | Phys Rev E2002，66，03： | 1 |
| 13 | Application of partial mutual information variable selection to ANN forecasting of water quality in water distribution systems 显示文摘 | Robert J M Graeme C D Holger R M | 2008 | Environmental Modelling & Software2008，3，8： | 1 |
| 14 | Process monitoring in laser beam cutting on its way to industrial application 显示文摘 | INGO D HOLGER H DIR K M | 1997 | SPIE1997，3097，： | 1 |
| 15 | Synthesis, characterization, and biocompatibility of Polyethylenimine-graft Poly (ethylene glycol) block copolymers 显示文摘 | HOLGER PETERSEN PETRA M FECHNER | 2002 | Macromolecules2002，35，： | 1 |
| 16 | Acquisition of resistance to sterol demethylation inhibitors by populations of Venturia inaequalis 显示文摘 | STEFAN K HOLGER D KURT M | 1997 | Phytopathol1997，87，12： | 1 |
| 17 | Determination of secondary, di--iso-- nonylphthalate (DINP) metabolites in human urine representative for the exposure DINP plasticizers 显示文摘 | M K Holger M Johannes A Jurgen | 2006 | Journal of Chromatography B2006，09，044： | 1 |
| 18 | High throughput tissue microarray analysis to evaluate genes uncovered by cDNA microarray screening in renal cell carcinoma 显示文摘 | Peter S Lukas B | 1999 | Am J Pathol1999，154，4： | 1 |
| 19 | Corporate Governance, Product Market Competition, and Equity Prices 显示文摘 | Xavier G Holger M M | 2011 | Journal of Finance2011，66，2： | 1 |
| 20 | The macrophage scavenger receptor CD163:endocytic properties of cytoplasmic tail variants显示文摘 | Marianne JN Mette M Holger J | 2006 | J Leukoc Biol2006，79，4： | 1 |
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