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| 1 | Decreased hemoglobin after initial treatment is associated with treatment resistance in Kawasaki disease in Kobayashi risk stratification显示文摘Background Although Kawasaki disease(KD)is known to cause anemia,the relationship between its prognosis and hemoglobin level is less well known.Methods We herein performed a secondary analysis of data from a previous study(Post-RAISE).Children aged 6 months to 2 years at the time of KD diagnosis were enrolled.Decreased hemoglobin was defined as a decrease>10%on post-treatment day 2 compared with the level prior to the initial therapy.Results Of 1253 KD cases,treatment resistance was observed in 209(17%)and was significantly more frequent in the decreased hemoglobin group(37/167 vs.172/1086,P=0.041).Multivariable logistic regression analysis revealed that decreased hemoglobin was associated with resistance to the initial treatment(odds ratio 1.53;95%confidence interval 1.00-2.33;P=0.048).Conclusions Decreased hemoglobin was significantly associated with resistance to initial treatment in patients with KD. | Yukari Atsumi Hiroshi Sakakibara Yoshihiko Morikawa Koichi Miyata Hiroyuki Yamagishi Masahiro Misawa Masaru Miura | 2020 | World Journal of Pediatrics2020，16，6： | 5 |
| 2 | Mucosal-incision assisted biopsy for suspected gastric gastrointestinal stromal tumors显示文摘To evaluate the diagnostic yield of the procedure, mucosal-incision assisted biopsy (MIAB), for the histological diagnosis of gastric gastrointestinal stromal tumor (GIST), we performed a retrospective review of the 27 patients with suspected gastric GIST who underwent MIAB in our hospitals. Tissue samples obtained by MIAB were sufficient to make a histological diagnosis (diagnostic MIAB) in 23 out of the 27 patients, where the lesions had intraluminal growth patterns. Alternatively, the samples were insufficient (non-diagnosticMIAB) in remaining 4 patients, three of whom had gastric submucosal tumor with extraluminal growth patterns. Although endoscopic ultrasound and fine needle aspiration is the gold standard for obtaining tissue specimens for histological and cytological analysis of suspected gastric GISTs, MIAB can be used as an alternative method for obtaining biopsy specimens of lesions with an intraluminal growth pattern. | Eikichi Ihara Hiroshi Matsuzaka Kuniomi Honda Yoshitaka Hata Yorinobu Sumida Hirotada Akiho Tadashi Misawa Satoshi Toyoshima Yoshiharu Chijiiwa Kazuhiko Nakamura Ryoichi Takayanagi | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，4： | 3 |
| 3 | X-Ray Stress Measurement Method for Single Crystal with Unknown Stress-free Lattice Parameter显示文摘 | Hiroshi Suzuki Koichi Akita Hiroshi Misawa | 2003 | The Japan Society of Applied Physics2003，，5： | 1 |
| 4 | Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts显示文摘 | Misawa N Hiroshi S | 1998 | Journal of Biotechnology1998，59，： | 1 |
| 5 | Tranexamic Acid Reduces Perioperative Blood Loss in Cervical Laminoplasty: A Prospective Randomized Study显示文摘 | Takahiro Tsutsumimoto Mitsuhiko Shimogata Hiroshi Ohta Mutsuki Yui Isao Yoda Hiromichi Misawa | 2011 | Spine2011，，23： | 1 |
| 6 | Retrospective analysis of 27 consecutive patients treated with docetaxel/nedaplatin combination therapy as a second-line regimen for advanced esophageal cancer显示文摘 | Masashi Kanai Shigemi Matsumoto Takahumi Nishimura Yutaka Shimada Go Watanabe Toshiyuki Kitano Akiko Misawa Hiroshi Ishiguro Kiyotsugu Yoshikawa Kazuhiro Yanagihara Satoshi Teramukai Michihide Mitsumori Tsutomu Chiba Yoshiharu Sakai Masanori Fukushima | 2007 | International Journal of Clinical Oncology2007，，3： | 1 |
| 7 | Retrospective analysis of 27 consecutive patients treated with docetaxel/nedaplatin combination therapy as a second-line regimen for advanced esophageal cancer显示文摘 | Masashi Kanai Shigemi Matsumoto Takahumi Nishimura Yutaka Shimada Go Watanabe Toshiyuki Kitano Akiko Misawa Hiroshi Ishiguro Kiyotsugu Yoshikawa Kazuhiro Yanagihara Satoshi Teramukai Michihide Mitsumori Tsutomu Chiba Yoshiharu Sakai Masanori Fukushima | 2007 | International Journal of Clinical Oncology2007，，3： | 1 |
| 8 | Tranexamic Acid Reduces Perioperative Blood Loss in Cervical Laminoplasty: A Prospective Randomized Study显示文摘 | Takahiro Tsutsumimoto Mitsuhiko Shimogata Hiroshi Ohta Mutsuki Yui Isao Yoda Hiromichi Misawa | 2011 | Spine2011，，23： | 1 |
| 9 | X-ray stress measurement method for sin- gle crystal with unknown stress-free lattice parameter显示文摘 | HIROSHI S UZUKI KOICHI AKIT HIROSHI MISAWA | 2003 | Jpn J Appl Phys2003，42，： | 1 |
| 10 | Prognostic significance of receptor for advanced glycation end products expression in hepatocellular carcinoma after hepatectomy显示文摘 | Ryusuke Ito Yuji Ishii Shigeki Wakiyama Hiroaki Shiba Shuichi Fujioka Takeyuki Misawa Yuichi Ishida Hiroshi Hano Katsuhiko Yanaga | 2014 | Journal of Surgical Research2014，，： | 1 |
| 11 | Metabolic engineering for the production of carotenoids in non-carotenoids bacteria and yeast显示文摘 | Hiroshi Shimada | 1998 | Journal of Biotechology1998，59，： | 1 |
| 12 | Clinical course of gastrointestinal stromal tumor diagnosed by endoscopic ultrasound‐guided fine‐needle aspiration显示文摘 | Masanari Sekine Hiroshi Imaoka Nobumasa Mizuno Kazuo Hara Susumu Hijioka Yasumasa Niwa Masahiro Tajika Tsutomu Tanaka Makoto Ishihara Seiji Ito Kazunari Misawa Yuichi Ito Yasuhiro Shimizu Yasushi Yatabe Hirohide Ohnishi Kenji Yamao | 2015 | Digestive Endoscopy2015，，1： | 1 |
| 13 | Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts显示文摘 | Misawa N Hiroshi S | 1998 | Journal of Biotechnology1998，59，： | 1 |
| 14 | Shear fracture of C/C composites with variable stacking sequence显示文摘 | DENK Lars HATTA Hiroshi MISAWA Akihiro | 2001 | Carbon2001，39，10： | 1 |
| 15 | Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts显示文摘 | Norihiko Misawa Hiroshi Shimada | 1998 | Journal of Biotechnology1998，，3： | 1 |
| 16 | Stenian A-type granitoids in the Namaqua-Natal Belt,southern Africa,Maud Belt,Antarctica and Nampula Terrane,Mozambique:Rodinia and Gondwana amalgamation implications显示文摘We carried out SHRIMP zircon U-Pb dating on A-type granitic intrusions from the Namaqua-Natal Province,South Africa,Sverdrupfjella,western Dronning Maud Land,Antarctica and the Nampula Province of northern Mozambique.Zircon grains in these granitic rocks are typically elongated and oscillatory zoned,suggesting magmatic origins.Zircons from the granitoid intrusions analyzed in this study suggest^1025-1100 Ma ages,which confirm widespread Mesoproterozoic A-type granitic magmatism in the Namaqua-Natal(South Africa),Maud(Antarctica)and Mozambique metamorphic terrains.No older inherited(e.g.,~2500 Ma Achean basement or^1200 Ma island are magmatism in northern Natal)zircon grains were seen.Four plutons from the Natal Belt(Mvoti Pluton,Glendale Pluton,Kwalembe Pluton,Ntimbankulu Pluton)display 1050-1040 Ma ages,whereas the Nthlimbitwa Pluton in northern Natal indicates older 1090-1080 Ma ages.A sample from Sverdrupfjella,Antarctica has^1091 Ma old zircons along with^530 Ma metamorphic rims.Similarly,four samples analysed from the Nampula Province of Mozambique suggest crystallization ages of^1060-1090 Ma but also show significant discordance with two samples showing younger^550 Ma overgrowths.None of the Natal samples show any younger overgrowths.A single sample from southwestern Namaqualand yielded an age of^1033 Ma.Currently available chronological data suggest magmatism took place in the Namaqua-Natal-MaudMozambique(NNMM)belt between^1025 Ma and^1100 Ma with two broad phases between^1060-1020 Ma and 1100-1070 Ma respectively,with peaks at between^1030-1040 Ma and^1070-1090 Ma.The age data from the granitic intrusions from Namaqualand.combined with those from Natal,Antarctica and Mozambique suggest a crude spatial-age relationship with the older>1070 Ma ages being largely restricted close to the eastern and western margins of the Kalahari Craton in northern Natal,Mozambique.Namaqualand and WDML Antarctica whereas the younger<1060 Ma ages dominate in southern Natal and western Namaqualand and are largely restricted to the southern and possibly the western margins of the Kalahari Craton.The older ages of magmatism partially overlap with or are marginally younger than the intracratonic Mkondo Large lgneous Provinee intruded into or extruded onto the Kalahari Craton,suggesting a tectonic relationship with the Maud Belt.Similar ages from granitic augen gneisses in Sri Lanka suggest a continuous belt stretching from Namaqualand to Sri Lanka in a reconstituted Gondwana,formed during the terminal stages of amalgamation of Rodinia and predating the East African Orogen.This contiguity contributes to defining the extent of Rodinia-age crustal blocks,subsequently fragmented by the dispersal of Rodinia and Gondwana. | Tomokazu Hokada Geoffrey H.Grantham Makoto Arima Satoshi Saito Kazuyuki Shiraishi Richard A.Armstrong Bruce Eglington Keiji Misawa Hiroshi Kaiden | 2019 | Geoscience Frontiers2019，10，6： | 1 |
| 17 | Trends and outcomes of liver transplantation among older recipients in the United States显示文摘BACKGROUND The average age of recipients and donors of liver transplantation(LT)is increasing.Although there has been a change in the indications for LT over the years,data regarding the trends and outcomes of LT in the older population is limited.AIM To assess the clinical characteristics,age-related trends,and outcomes of LT among the older population in the United States.METHODS We analyzed data from the United Network for Organ Sharing database between 1987-2019.The sample was split into younger group(18-64 years old)and older group(≥65 years old).RESULTS Between 1987-2019,155758 LT were performed in the United States.During this period there was a rise in median age of the recipients and percentage of LT recipients who were older than 65 years increased(P<0.05)with the highest incidence of LT among older population seen in 2019(1920,23%).Common primary etiologies of liver disease leading to LT in older patients when compared to the younger group,were non-alcoholic steatohepatitis(16.4%vs 5.9%),hepatocellular carcinoma(14.9%vs 6.9%),acute liver failure(2.5%vs 5.2%),hepatitis C cirrhosis(HCV)(19.2%vs 25.6%)and acute alcoholic hepatitis(0.13%vs 0.35%).In older recipient group female sex and Asian race were higher,while model for end-stage liver disease(MELD)score and rates of preoperative mechanical ventilation were lower(P<0.01).Median age of donor,female sex,body mass index(BMI),donor HCV positive status,and donor risk index(DRI)were significantly higher in older group(P<0.01).In univariable analysis,there was no difference in post-transplant length of hospitalization,one-year,three-year and five-year graft survivals between the two groups.In multivariable Cox-Hazard regression analysis,older group had an increased risk of graft failure during the five-year post-transplant period(hazard ratio:1.27,P<0.001).Other risk factors for graft failure among recipients were male sex,African American race,re-transplantation,presence of diabetes,mechanical ventilation at the time of LT,higher MELD score,presence of portal vein thrombosis,HCV positive status,and higher DRI.CONCLUSION While there is a higher risk of graft failure in older recipient population,age alone should not be a contraindication for LT.Careful selection of donors and recipients along with optimal management of risk factors during the postoperative period are necessary to maximize the transplant outcomes in this population. | Kenji Okumura Joon Sub Lee Abhay Dhand Hiroshi Sogawa Gregory Veillette Devon John Ryosuke Misawa Roxana Bodin David C Wolf Thomas Diflo Seigo Nishida | 2022 | World Journal of Transplantation2022，12，8： | 0 |
| 18 | Inferior outcomes of liver transplantation for hepatocellular carcinoma during early-COVID-19 pandemic in the United States显示文摘BACKGROUND Early in the coronavirus disease 2019(COVID-19)pandemic,there was a significant impact on routine medical care in the United States,including in fields of transplantation and oncology.AIM To analyze the impact and outcomes of early COVID-19 pandemic on liver transplantation(LT)for hepatocellular carcinoma(HCC)in the United States.METHODS WHO declared COVID-19 as a pandemic on March 11,2020.We retrospectively analyzed data from the United Network for Organ Sharing(UNOS)database regarding adult LT with confirmed HCC on explant in 2019 and 2020.We defined pre-COVID period from March 11 to September 11,2019,and early-COVID period as from March 11 to September 11,2020.RESULTS Overall,23.5%fewer LT for HCC were performed during the COVID period(518 vs 675,P<0.05).This decrease was most pronounced in the months of March-April 2020 with a rebound in numbers seen from May-July 2020.Among LT recipients for HCC,concurrent diagnosis of non-alcoholic steatohepatitis significantly increased(23 vs 16%)and alcoholic liver disease(ALD)significantly decreased(18 vs 22%)during the COVID period.Recipient age,gender,BMI,and MELD score were statistically similar between two groups,while waiting list time decreased during the COVID period(279 days vs 300 days,P=0.041).Among pathological characteristics of HCC,vascular invasion was more prominent during COVID period(P<0.01),while other features were the same.While the donor age and other characteristics remained same,the distance between donor and recipient hospitals was significantly increased(P<0.01)and donor risk index was significantly higher(1.68 vs 1.59,P<0.01)during COVID period.Among outcomes,90-day overall and graft survival were the same,but 180-day overall and graft were significantly inferior during COVID period(94.7 vs 97.0%,P=0.048).On multivariable Coxhazard regression analysis,COVID period emerged as a significant risk factor of post-transplant mortality(Hazard ratio 1.85;95%CI:1.28-2.68,P=0.001).CONCLUSION During COVID period,there was a significant decrease in LTs performed for HCC.While early postoperative outcomes of LT for HCC were same,the overall and graft survival of LTs for HCC after 180 days were significantly inferior. | Inkyu S Lee Kenji Okumura Ryosuke Misawa Hiroshi Sogawa Gregory Veillette Devon John Thomas Diflo Seigo Nishida Abhay Dhand | 2023 | World Journal of Hepatology2023，15，4： | 0 |
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