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| 1 | Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease显示文摘Emerging data have shown a close association between compositional changes in gut microbiota and the development of nonalcoholic fatty liver disease(NAFLD).The change in gut microbiota may alter nutritional absorption and storage.In addition,gut microbiota are a source of Toll-like receptor(TLR)ligands,and their compositional change can also increase the amount of TLR ligands delivered to the liver.TLR ligands can stimulate liver cells to produce proinflammatory cytokines.Therefore,the gut-liver axis has attracted much interest,particularly regarding the pathogenesis of NAFLD.The abundance of the major gut microbiota,including Firmicutes and Bacteroidetes,has been considered a potential underlying mechanism of obesity and NAFLD,but the role of these microbiota in NAFLD remains unknown.Several reports have demonstrated that certain gut microbiota are associated with the development of obesity and NAFLD.For instance,a decrease in Akkermansia muciniphila causes a thinner intestinal mucus layer and promotes gut permeability,which allows the leakage of bacterial components.Interventions to increase Akkermansia muciniphila improve the metabolic parameters in obesity and NAFLD.In children,the levels of Escherichia were significantly increased in nonalcoholic steatohepatitis(NASH)compared with those in obese control.Escherichia can produce ethanol,which promotes gut permeability.Thus,normalization of gut microbiota using probiotics or prebiotics is a promising treatment option for NAFLD.In addition,TLR signaling in the liver is activated,and its downstream molecules,such as proinflammatory cytokines,are increased in NAFLD.To data,TLR2,TLR4,TLR5,and TLR9 have been shown to be associated with the pathogenesis of NAFLD.Therefore,gut microbiota and TLRs are targets for NAFLD treatment. | Kouichi Miura Hirohide Ohnishi | 2014 | World Journal of Gastroenterology2014，20，23： | 78 |
| 2 | Association between high cystatin C levels and carotid atherosclerosis显示文摘AIM To investigate the association between carotid atherosclerosis and cystatin C(CysC) and to determine the optimal CysC cut-off value.METHODS One hundred twenty-eight subjects were included in this study. Atherosclerosis was defined as a maximum carotid plaque thickness(MCPT) of greater than 2 mm. A receiver operating characteristic curve analysis was used to determine the diagnostic value of serum CysC for atherosclerosis. The subjects were divided into two groups according to the CysC cut-off value. We screenedfor diabetes, hypertension, dyslipidemia, smoking status, alcohol consumption, and exercise behavior. The association between atherosclerosis and CysC levels was assessed using multivariate analysis.RESULTS The subjects were then divided into two groups according to the CysC cut-off value(0.73 mg/L). The median age of the high CysC group was 72 years(85% males), whereas that of the low CysC group was 61 years(63% males). The CysC levels were significantly correlated with Cr and estimated glomerular filtration rate(eGFR) values. Bodymass index, visceral fat area, hypertension, diabetes mellitus, and MCPT were significantly higher in the high CysC group than in the low CysC group. Furthermore, the eG FR was significantly lower in the high CysC group. Regarding lifestyle habits, only the exercise level was lower in the high CysC group than in the low CysC group. Multivariate analysis, adjusted for age and sex, revealed that high CysC levels were significantly associated with an MCPT of ≥ 2 mm(odds ratio: 2.92; 95%CI: 1.13-7.99).CONCLUSION Higher CysC levels were associated with an MCPT of ≥ 2 mm. The CysC cut-off value of 0.73 mg/L appears to aid in the diagnosis of atherosclerosis. | Toshiyuki Kobayashi Hirohide Yokokawa Kazutoshi Fujibayashi Tomomi Haniu Teruhiko Hisaoka Hiroshi Fukuda Toshio Naito | 2017 | World Journal of Cardiology2017，9，2： | 26 |
| 3 | Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine显示文摘AIM: To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine.METHODS: Enteroscopy, using the double-balloon method, was performed between December 1999 and December 2002 at Jichi Medical School Hospital, Japan and strictures of the small intestine were found in 17 out of 62 patients. These 17 consecutive patients were subjected to analysis.RESULTS: The double-balloon enteroscopy contributed to the diagnosis of small intestinal neoplasms found in 3out of 17 patients by direct observation of the strictures as well as biopsy sampling. Surgical procedures were chosen for these three patients, while balloon dilation was chosen for the strictures in four patients diagnosed with inflammation without involvement of neoplasm.CONCLUSION: Double-balloon enteroscopy is a useful method for the diagnosis and treatment of strictures in the small bowel. | Keijiro Sunada Hironori Yamamoto Hiroto Kita Tomonori Yano Hiroyuki Sato Yoshikazu Hayashi Tomohiko Miyata Yutaka Sekine Akiko Kuno Michiko Iwamoto Hirohide Ohnishi Kenichi Ido Kentaro Sugano | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 4 | Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice显示文摘 | Kouichi Miura Yuzo Kodama Sayaka Inokuchi Bernd Schnabl Tomonori Aoyama Hirohide Ohnishi Jerrold M. Olefsky David A. Brenner Ekihiro Seki | 2010 | Gastroenterology2010，，1： | 3 |
| 5 | Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease显示文摘 | Kouichi Miura Ekihiro Seki Hirohide Ohnishi David A. Brenner Ian Nicholas Crispe | 2011 | Gastroenterology Research and Practice2011，，： | 3 |
| 6 | Genomic structure of the whole D–J–C clusters and the upstream region coding V segments of the TRB locus in pig显示文摘 | Tomoko Eguchi-Ogawa Daisuke Toki Hirohide Uenishi | 2009 | Developmental and Comparative Immunology2009，，10： | 2 |
| 7 | Percutaneous local therapies for hepatocellular carcinoma impair gastric function显示文摘TO THE EDITORPercutaneous local therapies,such as percutaneous ethanolinjection(PEI),microwave coagulation and radiofrequencyablation(RFA),are frequently used world,vide for thetreatment of hepatocellular carcinoma(HCC)becauseof their high effectiveness.Although these treatmentmodalities can induce effectively coagulated tumornecrosis in the liver,they may cause adverse effects onextrahepatic abdominal organs.There are,however。 | Fumihiko Kinekawa Kazuya Matsuda Tsutomu Masaki Kazutaka Kurokohchi Hirohito Yoneyama Hideyuki Inoue Hirohide Kurata Yoshihito Uchida Seishiro Watanabe Shigeki Kuriyama | 2006 | World Journal of Gastroenterology2006，12，1： | 2 |
| 8 | Toll‐like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice显示文摘 | Kouichi Miura Ling Yang Nico van Rooijen David A. Brenner Hirohide Ohnishi Ekihiro Seki | 2013 | Hepatology2013，，2： | 2 |
| 9 | Porcine Toll-like receptors: The front line of pathogen monitoring and possible implications for disease resistance显示文摘 | Hirohide Uenishi Hiroki Shinkai | 2008 | Developmental and Comparative Immunology2008，，3： | 2 |
| 10 | Skull metastasis from hepatocellular carcinoma with chronic hepatitis B显示文摘A 56-year-old male visited our hospital for evaluation of an occipital mass.Contrast computed tomography showed hypervascular enhancement with osteolytic change in the skull and a huge enhanced mass in the liver.Magnetic resonance imaging showed bone metastasis in the thoracic vertebrae.Assays for hepatitis B surface antigen and hepatitis B core antibody were positive and his liver condition was Child-Pugh grade A.Our diagnosis was hepatocellular carcinoma(HCC) with skull and vertebrae metastases on chronic hepatitis B.He was treated with radiation therapy for bone metastases and transcatheter arterial chemoembolization for HCC.But he developed acute respiratory failure because of aspiration pneumonia,congestion and oedema with haemorrhage of the lungs and died.Dissection showed HCC with multiple bone metastases.The liver tumor was categorized as well-differentiated HCC,Edmondson classification Ⅰ,trabecular type and pseudoglandular type.In the liver mild infiltration of lymphocytes was seen in Glisson's capsules which were signif icantly enlarged with well preserved limiting plates.Piecemeal necrosis was not obvious.No fibrosis was noted.An 8 cm × 7 cm × 3 cm metastatic lesion had formed in the left occipitotemporal part of the cranial bone.The lesion was osteolytic and showed invasion into the dura mater.Neither the subdural cavity nor the brain showed involvement from the metastatic tumor.However,skull metastasis from HCC is very rare and it affects the patient's prognosis and the quality of life.Therefore,it is very important to make an early diagnosis and carry out proper management of skull metastasis from HCC. | Takashi Goto Takahiro Dohmen Kouichi Miura Shigetoshi Ohshima Kazuo Yoneyama Tomomi Shibuya Ei Kataoka Daisuke Segawa Wataru Sato Yumiko Anezaki Hajime Ishii Daigo Kon Ikuhiro Yamada Kentaro Kamada Hirohide Ohnishi | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 2 |
| 11 | High-speed X-ray phase imaging and X-ray phase tomography with Talbot interferometer and white synchrotron radiation显示文摘 | Atsushi Momose Wataru Yashiro Hirohide Maikusa | 2009 | Optics Express2009，17，12： | 1 |
| 12 | Changes in plasma ghrelin levels, gastric ghrelin production, and body weight after Helicobacter pylori cure显示文摘 | Hiroyuki Osawa Hiroto Kita Hirohide Ohnishi Masamitsu Nakazato Yukari Date Christopher L. Bowlus Yumiko Ishino Eiko Watanabe Tomomi Shiiya Hiroaki Ueno Hiroko Hoshino Kiichi Satoh Kentaro Sugano | 2006 | Journal of Gastroenterology2006，，10： | 1 |
| 13 | Optimal band imaging system can facilitate detection of changes in depressed-type early gastric cancer显示文摘 | Hiroyuki Osawa Mitsuyo Yoshizawa Hironori Yamamoto Hiroto Kita Kiichi Satoh Hirohide Ohnishi Hidetoshi Nakano Masahiro Wada Masayuki Arashiro Mamiko Tsukui Kenichi Ido Kentaro Sugano | 2008 | Gastrointestinal Endoscopy2008，，2： | 1 |
| 14 | Genomic regions affecting backfat thickness and cannon bone circumference identified by genome‐wide association study in a D uroc pig population显示文摘 | Naohiko Okumura Toshimi Matsumoto Takeshi Hayashi Kensuke Hirose Kazuo Fukawa Tetsuya Itou Hirohide Uenishi Satoshi Mikawa Takashi Awata | 2013 | Anim Genet2013，，4： | 1 |
| 15 | Polymorphism distribution and structural conservation in RNA-sensing Toll-like receptors 3, 7, and 8 in pigs显示文摘 | Takeya Morozumi Hirohide Uenishi | 2009 | BBA - General Subjects2009，，4： | 1 |
| 16 | Linking experience, education, perception and earthquake preparedness 显示文摘 | Rajib S Koichi S Hirohide K | 2004 | Disaster Prevention and Management2004，13，1： | 1 |
| 17 | Linking experience, education, perception and earthquake preparedness 显示文摘 | Rajib Shaw Koichi Shiwaku Hirohide Kobayashi Masami Koba- yashi | 2004 | Disaster Prevention and Management2004，13，1： | 1 |
| 18 | Interactive Agents with Artificial Mind显示文摘 | Hirohide Ushida | 2004 | International Journal of Computational Intelligence2004，1，4： | 1 |
| 19 | Linkingexperience* education, perception and earthquake preparedness显示文摘 | Rajib Shaw Koichi Shiwaku? Hirohide Kobayashi er al | 2004 | Disaster Prevention and Management2004，13，1： | 1 |
| 20 | Follow-up study of combination treatment (TAE and PEIT) for unresectable hepatocellular carcinoma显示文摘 | Hideo Tateishi Masakatsu Kinuta Junkou Furukawa Naoki Takata Hirohide Maruyama Hiromichi Oi Eiji Yayoi Jun Okamura | 1994 | Cancer Chemotherapy and Pharmacology1994，，1： | 1 |
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