|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Useful detection of CD147 (EMMPRIN) for pathological diagnosis of early hepatocellular carcinoma in needle biopsy samples显示文摘AIM:To make clear whether CD147 (EMMPRIN) expression in pathological tumor samples with a fine-needle aspiration biopsy is useful for pathological diagnosis of early hepatocellular carcinoma (HCC). METHODS:Twenty-two patients (15 men and 7 women; median age 68 years,range 56-81 years) underwent a liver tissue biopsy in order to make a diagnosis of HCC. Paraffin-embedded liver biopsy tissue samples from 22 patients were stained with anti-CD147 antibody,murine monoclonal antibody 12C3 (MAb12C3) for immunohistochemical analysis. An immunohistochemical analysis of CD147 was performed and the degree of staining compared between tumor and non-tumor tissue. In addition,the degree of staining within tumor tissue was compared according to a number of clinicopathological variables. RESULTS:The degree of staining of CD147 was significantly higher in tumor tissues than non-tumor tissues,even in tumors less than 15 mm in diameter.The expression of this protein was significantly elevated in HCC tissue specimens from patients with a low value of serum AST and γ-GTP. | Satoshi Mamori Keisuke Nagatsuma Tomokazu Matsuura Kiyoshi Ohkawa Hiroshi Hano Masaharu Fukunaga Masato Matsushima Yoshifumi Masui Nao Fushiya Hiroshi Onoda Yasuyuki Searashi Ichiro Takagi Hisao Tajiri | 2007 | World Journal of Gastroenterology2007，13，21： | 20 |
| 2 | Frequent loss of heterozygosity in two distinct regions,8p23.1 and 8p22, in hepatocellular carcinoma显示文摘AIM: To identify the precise location of putative tumor suppressor genes (TSGs) on the short arm of chromo- some 8 in patients with hepatocellular carcinoma (HCC). METHODS: We used 16 microsatellite markers informative in Japanese patients, which were selected from 61 pub- lished markers, on 8p, to analyze the frequency of loss of heterozygosity (LOH) in each region in 33 cases (56 lesions) of HCC. RESULTS: The frequency of LOH at 8p23.2-21 with at least one marker was 63% (20/32) in the informative cases. More specifically, the frequency of LOH at 8p23.2, 8p23.1, 8p22, and 8p21 was 6%, 52%, 47%, and 13% in HCC cases. The LOH was significantly more frequent at 8p23.1 and 8p22 than the average (52% vs 22%, P = 0.0008; and 47% vs 22%, P = 0.004, respectively) or others sites, such as 8p23.2 (52% vs 6%, P = 0.003; 47% vs 22%, P = 0.004) and 8p21 (52% vs 13%, P = 0.001; 47% vs 13%, P = 0.005) in liver cancer on the basis of cases. Notably, LOH frequency was significantly higher at D8S277, D8S503, D8S1130, D8S552, D8S254 and D8S258 than at the other sites. However, no allelic loss was detected at any marker on 8p in the lesions of nontumor liver tissues. CONCLUSION: Deletion of 8p, especially the loss of 8p23.1-22, is an important event in the initiation or promotion of HCC. Our results should be useful in identi- fying critical genes that might lie at 8p23.1-22. | Tomoe Lu Hiroshi Hano Keisuke Nagatsuma Satoru Chiba Masahiro Ikegami | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 3 | Combination of adsorption and biodegradation processes for textile effluent treatment using a granular activated carbon-biofilm configured packed column system显示文摘The objective of this study was to investigate the feasibility of using a granular activated carbon-biofilm configured packed column system in the deeolodzation of azo dye Acid Orange 7-containing wastewater.The Acid Orange 7-degrading microbial from anaerobic sequencing batch reactor which treating the azo dye-containing wastewater for more than 200 d was immobilized on spent granular activated carbon(GAC)through attachment.The GAC-biofilm configured packed column system showed the ability to decolorize... | ONG SoonAn TOORISAKA Eiichi HIRATA Makoto HANO Tadashi | 2008 | Journal of Environmental Sciences2008，20，8： | 6 |
| 4 | 小鼠γδT细胞抗原呈递功能的实验研究显示文摘目的:证实小鼠γδT细胞抗原也具有呈递功能。方法:观察了高度纯化的小鼠γδT细胞体外激活后MHCⅡ分子及其他共刺激分子的表达与其表面特征性TCR的关系。用自身反应抗原IRBP/MOG特异性T细胞株作为反应细胞,以增殖反应及细胞因子表达作为效应指标,观察γδT细胞的抗原呈递功能。结果:小鼠γδT细胞在激活后可表面表达MHCⅡ分子,并能有效呈递抗原给T细胞,使之发生抗原特异性免疫应答。结论:小鼠γδT细胞具有抗原呈递功能,在启动特异性免疫应答的过程中起重要作用。另一方面,不象人γδT细胞,表达MHCⅡ分子限于新激活的小鼠γδT细胞,后者失去了表面γδTCR。当γδT细胞重新获得表面γδTCR时,其MHCⅡ抗原表达则逐渐减少。 | 蓝程 董丽伟 孙晓宁 Gengcheng Hano Deming Sun | 2009 | 中国免疫学杂志2009，25，6： | 4 |
| 5 | Spermatogenesis in aged rats after prenatal 3,3′,4,4′,5-pentachlorobiphenyl exposure显示文摘 | Shin Wakui Fumio Takagi Tomoko Muto Kiyofumi Yokoo Shyou Hirono Yasuko Kobayashi Kinji Shirota Fumiaki Akahori Yoshihiko Suzuki Hiroshi Hano Hitoshi Endou Yoshikatsu Kanai | 2007 | Toxicology2007，，2： | 3 |
| 6 | Antioxidant activity of polyphenols from seeds of Vitis amurvitro in vitro显示文摘 | Wang JN Chen YJ Hano Y | 2000 | Acta Pharmacol Sin2000，21，： | 2 |
| 7 | Pinoresinol–lariciresinol reductase gene expression and secoisolariciresinol diglucoside accumulation in developing flax ( Linum usitatissimum ) seeds显示文摘 | C. Hano I. Martin O. Fliniaux B. Legrand L. Gutierrez R. R. J. Arroo F. Mesnard F. Lamblin E. Lainé | 2006 | Planta2006，，6： | 2 |
| 8 | Decolorization of Orange Ⅱ using an anaerobic sequencing batch reactor with and without co-substrates显示文摘We investigated the decolorization of Orange Ⅱ with and without the addition of co-substrates and nutrients under an anaerobic sequencing batch reactor(ASBR).The increase in COD concentrations from 900 to 1750 to 3730 mg/L in the system treating 100 mg/L of Orange Ⅱ-containing wastewater enhanced color removal from 27% to 81% to 89%,respectively.In the absence of co-substrates and nutrients,more than 95% of decolorization was achieved by the acclimatized anaerobic microbes in the bioreactor treating 600 mg/L of Orange Ⅱ.The decrease in mixed liquor suspended solids concentration by endogenous lysis of biomass preserved a high reducing environment in the ASBR,which was important for the reduction of the Orange Ⅱ azo bond that caused decolorization.The maximum decolorization rate in the ASBR was approximately 0.17 g/hr in the absence of co-substrates and nutrients. | Soon-An Ong Eiichi Toorisaka Makoto Hirata Tadashi Hano | 2012 | Journal of Environmental Sciences2012，24，2： | 2 |
| 9 | Oxidized low-density lipoprotein inhibits vascular endothelial growth factor induced endothelial progenitor cell differentiation 显示文摘 | Imanishi T Hano T Matsuo Y | 2003 | Clin Exp Pharmacol Physiol2003，30，9： | 1 |
| 10 | Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress 显示文摘 | Imanishi Toshio Hano | 2005 | Hypertension2005，23，： | 1 |
| 11 | Oxidized low-density lipoprotein induces endothelial progenitor cell senescence,leading to cellular dysfunction显示文摘 | Imanishi T Hano T Sawamura T | 2004 | Clin Exp Pharmacol Physio12004，31，： | 1 |
| 12 | Predictors of success at six‐month follow‐up at a public smoking cessation clinic in S outh K orea显示文摘 | Soo‐Young Bhang Sam‐Wook Choi Joon‐Ho Ahn Kunwoo Kim Hano Kim Hye‐Kyeong Park | 2013 | Asia‐Pacific Psychiatry2013，，3： | 1 |
| 13 | Effect of Estrogen on Differentiation and Senescence in Endothelial Progeni- tor Cells Derived from Bone Marrow in Spontaneously Hy- pertensive Rats 显示文摘 | Imanishi T Kobayashi K Hano T | 2005 | Hypertens Res2005，28，9： | 1 |
| 14 | Up-regulation of hyaluronan syn- thase genes in cultured human epidermal keratinocytes by UVB irra- diation 显示文摘 | Kakizaki I hano N Kimata K | 2008 | Arch Biochem Bio-phys2008，471，1： | 1 |
| 15 | Oxidized low-density lipoprotein induces endothelial progenitor cells senescence,leading to cellular dysfunction显示文摘 | Imanishi T Hano T Sawamura T | 2004 | Clin Exp Pharmacol Physiol2004，31，7： | 1 |
| 16 | Angiotensin D potentiates vas-cular endothelial growth factor-induced Proliferation andnetwork formation of endothelial Progenitor cell 显示文摘 | Imanish T Hano T Nishio I | 2004 | Hyper-tens Res2004，27，2： | 1 |
| 17 | Oxidized low-density lipoprotein inhibits vascular endothelial growth factor-induced endothelial progenitor cell differentiation显示文摘 | Imanishi T Hano T Matsuo Y | 2003 | Clin Exp Pharmacol Physiol2003，30，9： | 1 |
| 18 | Proceedings of the ISEC'96- value adding through solvent extraction显示文摘 | HANO T MATSUMOTO M HIRATA M | 1996 | J Appl Electrochem1996，，2： | 1 |
| 19 | Catecholamines and estrogen are involved in the path-ogenesis of emotional stress-induced acute heart attack显示文摘 | UEYAMA T KASAMATSU K HANO T | 2008 | Ann N Y Acad Sci2008，1148，： | 1 |
| 20 | Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors : a possible animal model of ' tako - tsubo' cardiomyopathy显示文摘 | Ueyama T Kasamatsu K Hano T | 2002 | Circ J2002，66，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员