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| 1 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 2 | 《过敏性鼻炎及其对哮喘的影响(ARIA)》指南2019版过敏性鼻炎管理路径(中国版)显示文摘2018年12月3日,慢性疾病管理大会在巴黎召开,经过与会的过敏科学及气道疾病领域的专家和患者组织讨论,针对未来鼻炎和哮喘的管理,推荐采用真实世界综合管理路径评估系统,旨在实现数字化、综合化、以人为本的管理。本文是该文件的摘要版,其中也介绍了中国过敏性鼻炎和哮喘的流行状况以及《过敏性鼻炎及其对哮喘的影响》(ARIA)在中国应用的具体情况。 | Bachert C Fokkens WJ Haahtela T Hellings PH Klimek L Papadopoulos N Pham-Thi N PfaarO Valiulis A Ventura MT Onorato G Czarlewski W Bedbrook A Bousquet J 王向东(编译) 王成硕(编译) 郑铭(编译) 杜崑(编译) 张罗(编译) | 2019 | 中国耳鼻咽喉头颈外科2019，26，12： | 23 |
| 3 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 4 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 5 | Phosphorus accumulation and leaching risk of greenhouse vegetable soils in Southeast China显示文摘Over-fertilization has caused significant phosphorus(P)accumulation in Chinese greenhouse vegetable production(GVP)soils.This study,for the first time,quantified profile P accumulation directly from soil P measurements,as well as subsoil P immobilization,in three alkaline coarse-textured GVP soil profiles with 5(S5),15(S15),and 30(S30)years of cultivation in Tongshan,Southeast China.For each profile,soil samples were collected at depths of 0-10(topsoil),10-20,20-40,40-60,60-80,and 80-100 cm.Phosphorus accumulation was estimated from the difference in P contents between topsoil and parent material(60-100 cm subsoil).Phosphorus mobility was assessed from measurements of water-soluble P concentration(P_(Sol)).Finally,P sorption isotherms were produced using a batch sorption experiment and fitted using a modified Langmuir model.High total P contents of 1980(S5),3190(S15),and 2330(S30)mg kg^(-1) were measured in the topsoils versus lower total P content of approximately 600 mg kg^(-1) in the 80-100 cm subsoils.Likewise,topsoil PSol values were very high,varying from 6.4 to 17.0 mg L^(-1).The estimated annual P accumulations in the topsoils were 397(S5),212(S15),and 78(S30)kg ha^(-1) year^(-1).Sorption isotherms demonstrated the dominance of P desorption in highly P-saturated topsoils,whereas the amount of adsorbed P increased in the 80-100 cm subsoils with slightly larger P adsorption capacity.The total P adsorption capacity of the 80-100 cm subsoils at a solution P concentration of0.5 mg L^(-1) was 15.7(S5),8.7(S15),and 6.5(S30)kg ha^(-1),demonstrating that subsoils were unable to secure P concentrations in leaching water below 0.5 mg L^(-1) because of their insufficient P-binding capacity. | Yusef KIANPOOR KALKHAJEH Biao HUANG Helle SORENSEN Peter EHOLM Hans Christian BHANSEN | 2021 | Pedosphere2021，31，5： | 4 |
| 6 | Wound Complications in 1145 Consecutive Transumbilical Single-Incision Laparoscopic Procedures显示文摘 | Helmut G. Weiss Walter Brunner Matthias O. Biebl Jan Schirnhofer Katharina Pimpl Christof Mittermair Christian Obrist Eberhard Brunner Tobias Hell | 2014 | Annals of Surgery2014，，1： | 3 |
| 7 | Complications From Inflammatory Bowel Disease During Pregnancy and Delivery显示文摘 | Gabriella Br?ms Fredrik Granath Marie Linder Olof Stephansson Maria Elmberg Helle Kieler | 2012 | Clinical Gastroenterology and Hepatology2012，，11： | 2 |
| 8 | Anxiety enhances the detrimental effect of depressive symptoms on health status following percutaneous coronary intervention显示文摘 | Susanne S. Pedersen Johan Denollet Helle Spindler Andrew T.L. Ong Patrick W. Serruys Ruud A.M. Erdman Ron T. van Domburg | 2006 | Journal of Psychosomatic Research2006，，6： | 2 |
| 9 | 可充电电池技术和充电方法显示文摘 | Gert Helles | 2004 | 电子产品世界2004，11，09A： | 2 |
| 10 | 欧洲鼻腔鼻窦解剖术语意见书(二)显示文摘2014年,Rhinology刊登了European Position Paper on the Anatomical Terminology of the Internal Nose and Paranasal Sinuses,对于认识鼻科解剖名词具有重要的普及意义。考虑到国内耳鼻喉科医师获取和阅读英文文献的能力有限,但是又急需及时掌握学科领域内解剖名词的表述,我们通过与Rhinology编辑部及作者联系征得同意,翻译而成《欧洲鼻腔鼻窦解剖术语规范意见书》(以下简称《意见书》)。《意见书》中的所有解剖名词同时参考国内《英汉汉英医学分科词典(耳鼻咽喉科学分册)》进行统一,对于《英汉汉英医学分科词典(耳鼻咽喉科学分册)》中没有提及的名词给出了相应的补充。希望《意见书》对国内耳鼻喉科医师掌握并规范应用鼻科名词提供参考。《中国眼耳鼻喉科杂志》从第17卷第2期开始以连载形式刊登《意见书》。 | 王德辉 王德云 于华鹏 孙希才 李晗 刘琢扶 刘全 张焕康 Lund VJ Stammberger H Fokkens WJ Beale T Bernal-Sprekelsen M Eloy P Georgalas C Gerstenberger C Hellings PW Herman P Hosemann WG Jankowski R Jones N Jorissen M Leunig A Onerci M Rimmer J Rombaux P Simmen D Tomazic PV Tschabitscher M Welge-Luessen A | 2017 | 中国眼耳鼻喉科杂志2017，17，3： | 2 |
| 11 | Minimization of methabenzthiazuron residues in leaching water using amended soils and photocatalytic treatment with TiO_2 and ZnO显示文摘In the present work, potential groundwater pollution by methabenzthiazuron(MTBU) and the effect of three different amendments(composted sheep manure, composted pine bark and spent coffee grounds) on its mobility were investigated under laboratory conditions. The efficiency of ZnO and TiO2 suspensions in the photocatalytic degradation of MTBU in leaching water was also investigated. The relative and cumulative breakthrough curves were obtained from disturbed soil columns. The presence and/or addition of organic matter drastically reduced the movement of the herbicide. On other hand, photocatalytic experiments showed that the addition of ZnO and TiO2 strongly enhances the degradation rate of this herbicide compared with the results of photolytic experiments under artificial light. ZnO appeared to be more effective in MTBU oxidation than TiO2. The results obtained point to the interest of using organic wastes and heterogeneous photocatalysis for reducing the pollution of groundwater by pesticide drainage. | Jos Fenoll Pilar Flores Pilar Hellín Joaquín Hern'andez Simón Navarro | 2014 | Journal of Environmental Sciences2014，26，4： | 2 |
| 12 | Accuracy of lattice translation of several multidimensional refinable function显示文摘 | Cabrelli C Hell C Molter U | 1998 | J Approx Theory1998，95，1： | 1 |
| 13 | Compositions of MgTiO3-CaTiO3 ceramics with two borosilicate glasses for LTCC technology 显示文摘 | JANTUNEN Hell RAUTIOAHO Risto UUSIMAKI Antti | 2000 | J Ear Ceram Soc2000，20，： | 1 |
| 14 | Surface Roughening Mechanisms for Printing Paper Containing Mechanical Pulp 显示文摘 | FORSETH T WIIK K HELLE T | 1997 | Nordic Pulp & Paper Research Journal1997，12，1： | 1 |
| 15 | Some aspects on fibre strength and fibre bondings in sulphate and sulphite显示文摘 | Helle T | 1963 | Paper1963，66，24： | 1 |
| 16 | Intrapatient comparion of restenosis between carotid artery angioplasty with stenting and carotid endarterectomy显示文摘 | De Borst GJ Hellings WE Ackerstaff RG | 2006 | J Cardiovasc Surg2006，47，1： | 1 |
| 17 | Xylose fermentation by genetically modified Saccharomyces cerevisiae 259ST in spent sulrite liquor 显示文摘 | Helle S S Murray A Lam J | 2004 | Bioresource Technology2004，92，2： | 1 |
| 18 | The p120 catenin partner Kaiso is a DNA methylation-dependent transcriptional repressor显示文摘 | Anna Prokhortchouk Brian Hendrich Helle Jorgensen | 2001 | Genes & Devlopment2001，15，： | 1 |
| 19 | Regulation of mitochondrial respiration and apoptosis through cell signaling: cytochrome c oxidase and cytochrome c in ischemia/reperfusion injury and inflammation显示文摘 | Hllttemann M Helling S Sanderson TH | 2012 | Biochim Biophys Acta2012，1817，： | 1 |
| 20 | The influence of rock characteristics on acid leach extraction and re-extrac-tion of Cu-oxide and sulfide minerals显示文摘 | Helle S Jerez O Kelm U | 2010 | Minerals En- gineering2010，23，1： | 1 |
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