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| 1 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 2 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 3 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 4 | Ultrasound biomicroscopy in the subtypes of primary angle closure glaucoma显示文摘 | Sihota R Dada T Gupta R | | 0，，： | 2 |
| 5 | Estimation of partial discharge parameters in gis using acoustic emission techniques显示文摘 | Gupta N Ramu T S | 2001 | Journal of Sound and Vibration2001，247，2： | 1 |
| 6 | Primary malignant neoplasms of the spleen显示文摘 | Das Gupta T Coombes B Brasfield RD | 1965 | Surg Gynecol Obstet1965，120，5： | 1 |
| 7 | Primary malignant neoplasms of the spleen显示文摘 | Goombes B Brosfeld RD | 1969 | Surg Gynecol Obstet1969，120，： | 1 |
| 8 | Fragmentation Behavior of Pyrite and Calcite During High-Temperature Processing and Mathematical Simulation 显示文摘 | Yan L Gupta R P Wall T F | 2001 | Energy and Fuels2001，15，2： | 1 |
| 9 | Comparative study of nitro blue tetrazolium (NBT) reduction method for estimation of glycated hemoglobin with glycated HbAlc estimated on DCA2000 + analyzer (immunoagglutination inhibition)显示文摘 | Sahu A Gupta T Sarkar PD | 2010 | J Assoc Physicians India2010，58，1： | 1 |
| 10 | Cyclooxygenase-2 and prostate carcinogenesis 显示文摘 | Hussain T Gupta S Mukhtar H | 2003 | Cancer Lett2003，191，2： | 1 |
| 11 | Endo- vascular treatment of direct carotid cavernous fistula:a pictorial review显示文摘 | Gupta AK Purkayastha S Krishnamoorthy T | 2006 | Neruoradiology2006，48，5： | 1 |
| 12 | Anticlastogenic effects of black tea (World blend) and its two active polypbenols theaflavins and thearubigins in vivo in Swiss albino mice显示文摘 | Gupta S Chaudhuri T Ganguly D K | 2001 | Life Sci2001，69，23： | 1 |
| 13 | Adaptive radiotherapy in lung cancer:dosimetric benefits and clinical outcome显示文摘 | Kataria T Gupta D Bisht SS | 2014 | Br J Radiol2014，87，20： | 1 |
| 14 | Application of zinc oxide varistors显示文摘 | Gupta T K | 1990 | J Am Ceram Soc1990，73，7： | 1 |
| 15 | The role of neurodiag- nostic studies in nerve injuries and other orthopedic disorders 显示文摘 | Strandberg E J Mozaffar T Gupta R | 2007 | J Hand Surg Am2007，32，8： | 1 |
| 16 | MnO2 decorated graphene nanoribhons with superior permittivity and excel- lent microwave shielding properties 显示文摘 | Gupta T K Singh B P Singh V N | 2014 | J Mater Chem A2014，2，12： | 1 |
| 17 | Activated protein C ameliorates LPS-induced acute kidney injury and downregulates renal INOS and angiotensin 2显示文摘 | GUPTA A RHODES GJ BERG D T | 2007 | Am J Physiol Renal Physiol2007，293，： | 1 |
| 18 | Protective or pathogenic immune response to genital chlamydial infection in women-A possible role of cytokine secretion profile of cervical mucosal cells显示文摘 | Agrawal T Gupta R Dutta R | 2009 | Clin Immunol2009，130，3： | 1 |
| 19 | Thermal-Mechanical Modeling of the Rolling-Plus-Sliding with Frictional Heating of a Locomotive Wheel 显示文摘 | Gupta V Hahn G T Bostias P C et aI | 1995 | Transactions of ASME1995，117，8： | 1 |
| 20 | Plasma calcitonin gene-related peptide concentration is comparable to control group among migraineurs and tension type headache sub- jects during inter-ictal period 显示文摘 | Gupta R Ahmed T Banerjee B | 2009 | Headache Pain2009，10，3： | 1 |
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