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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 3 | Overview of the development of a visual based automated bio-micromanipulation system显示文摘 | OUYANG P R ZHANG W J GUPTA M M | 2007 | Mechatronics2007，17，10： | 1 |
| 4 | Relations for reliability measures under length biased sampling显示文摘 | GUPTA R C KEATING J P | 1986 | Scandinavian Journal of Statistics1986，13，： | 1 |
| 5 | Application of RBF neual network to fault classification and location in transmission lines显示文摘 | Mahanty R N Dutta Gupta P B | 2004 | IEEE Proceedings on Gen- eration Transmission and Distribution2004，151，2： | 1 |
| 6 | Fragmentation Behavior of Pyrite and Calcite During High-Temperature Processing and Mathematical Simulation 显示文摘 | Yan L Gupta R P Wall T F | 2001 | Energy and Fuels2001，15，2： | 1 |
| 7 | On the moments of residual life in reliability and some characterization results 显示文摘 | GUPTA P L GUPTA R C | 1983 | Communications in Statistics1983，12，4： | 1 |
| 8 | Molecular markers and their applications in wheat breeding显示文摘 | P K Gupta R K Varshney P C Sharma B Ramesh | 1999 | Plant Breeding1999，118，： | 1 |
| 9 | The Capacity of wireless networks显示文摘 | GUPTA P KUMAR P R | 2000 | IEEE Trans on Information Theory2000，46，： | 1 |
| 10 | Sewer water composition and its effect on soil properties显示文摘 | Gupta A P Narwal R P Antil R P | 1998 | Bioresour Technol1998，65，： | 1 |
| 11 | Overview of the development of a visual based automated bio-micromanipulation system显示文摘 | Ouyang P R Zhang W J Gupta M M | 2007 | Mechatronics2007，17，10： | 1 |
| 12 | Comparison of retroperitoneoscopic nephrectomy with open surgery for tuberculo us nonfunctioning kidneys显示文摘 | Hemal A K Gupta N P Kumar R | 2000 | J Urol2000，164，1： | 1 |
| 13 | The role of magnetic resonance imaging in fetal renal anomalies 显示文摘 | Gupta P Kumar S Sharma R | 2010 | Int J Gynaecol Obstet2010，111，3： | 1 |
| 14 | Development of soft sensor for neural network based control of distillation column显示文摘 | RANI A SINGH V GUPTA J R P | 2013 | ISA Transactions2013，52，3： | 1 |
| 15 | Effect of experimental zinc defficiency on immnuological responses in salmonellar infected guinea pigs 显示文摘 | GUPTA R P | 2000 | J CompPathol2000，123，1： | 1 |
| 16 | 显示文摘 | Patro P K Kulkarni A R Gupta S M | 2007 | Phys B: Condensed Matter2007，400，12： | 1 |
| 17 | The Capacity of Wireless Networks 显示文摘 | Piyush Gupta P R Kumar | 2000 | IEEE Transactions on Information Theory2000，46，2： | 1 |
| 18 | A new compliant mechanical amplifier based on a symmetric five-bar topology 显示文摘 | OUYANG P R ZHANG W J GUPTA M M | 2008 | J Mech Des2008，130，10： | 1 |
| 19 | Oxy-fuel combustion technology for coal-fired power generation显示文摘 | BUHRE B J P ELLIOTT L K SHENG C D GUPTA R P WALL T F | 2005 | Prog Energy Combust2005，31，4： | 1 |
| 20 | Association between portal vein color Doppler findings and the severity of disease in cirrhotic patients with portal hypertension显示文摘 | Mittal P Gupta R Mittal G | 2011 | Iran J Radiol2011，8，4： | 1 |
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