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| 1 | Direct numerical simulation of particle-fluid systems by combining time-driven hard-sphere model and lattice Boltzmann method显示文摘A coupled numerical method for the direct numerical simulation of particle-fluid systems is formulated and implemented,resolving an order of magnitude smaller than particle size.The particle motion is described by the time-driven hard-sphere model,while the hydrodynamic equations governing fluid flow are solved by the lattice Boltzmann method(LBM).Particle-fluid coupling is realized by an immersed boundary method(IBM),which considers the effect of boundary on surrounding fluid as a restoring force added to the governing equations of the fluid.The proposed scheme is validated in the classical flow-around-cylinder simulations,and preliminary application of this scheme to fluidization is reported,demonstrating it to be a promising computational strategy for better understanding complex behavior in particle-fluid systems. | Limin Wang Guofeng Zhou Xiaowei Wang Qingang xiong Wei Ge | 2010 | Particuology2010，8，4： | 12 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Piezotronic effect enhanced Schottky-contact ZnO micro/nanowire humidity sensors显示文摘 | Guofeng Hu Ranran Zhou Ruomeng Yu Lin Dong Caofeng Pan Zhong Lin Wang | 2014 | Nano Research2014，7，7： | 11 |
| 4 | Involvement of Jasmonate- signaling pathway in the herbivore-induced rice plant defense显示文摘The expression patterns of eight defense- related genes in the herbivore-infested and jasmonate- treated (jasmonic acid, JA and its derivative MeJA) rice leaves were analyzed using RT-PCR. The results showed that Spodoptera litura Fabricius (Lepidoptera: Noctuidae) herbi-vory induced the expression of lipoxygenase (LOX) and al-lene oxide synthase (AOS) genes that are involved in the jasmonate-signaling pathway. Moreover, S. litura damage resulted in the expression of farnesyl pyrophosphate syn-thase (FPS), Bowman-birk proteinase inhibitor (BBPI), phenylalanine ammonia-lyase (PAL) and other rice defense- related genes that were also induced by aqueous JA treat-ment or gaseous MeJA treatment. These indicated that in rice leaves, the JA-related signaling pathway was involved in the S. litura-induced chemical defense. Mechanical damage and brown planthopper (BPH), Nilaparvata lugens (St錶) (Homoptera: Delphacidae) damage induced the expression of LOX gene, but both treatments did not induce the expression of AOS gene. However, BPH damage induced the expression of acidic pathogen-related protein 1 (PR-1a), Chitinase (PR-3), and PAL genes, which is involved in the salicylate- signaling pathway. It was suggested that salicylate-related signaling pathway or other pathways, rather than jas-monate-signaling pathway was involved in the BPH-induced rice plant defense. | XU Tao ZHOU Qiang CHEN Wei ZHANG Guren HE Guofeng GU Dexiang ZHANG Wenqing | 2003 | Chinese Science Bulletin2003，48，18： | 6 |
| 5 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 6 | Rapid Urbanization Induced Extensive Forest Loss to Urban Land in the Guangdong-Hong Kong-Macao Greater Bay Area, China显示文摘China has experienced rapid urbanizations with dramatic land cover changes since 1978. Forest loss is one of land cover changes, and it induces various eco-environmental degradation issues. As one of China’s hotspot regions, the Guangdong-Hong KongMacao Greater Bay Area(GBA) has undergone a dramatic urban expansion. To better understand forest dynamics and protect forest ecosystem, revealing the processes, patterns and underlying drivers of forest loss is essential. This study focused on the spatiotemporal evolution and potential driving factors of forest loss in the GBA at regional and city level. The Landsat time-series images from 1987 to2017 were used to derive forest, and landscape metrics and geographic information system(GIS) were applied to implement further spatial analysis. The results showed that: 1) 14.86% of the total urban growth area of the GBA was obtained from the forest loss in1987–2017;meanwhile, the forest loss area of the GBA reached 4040.6 km2, of which 25.60%(1034.42 km2) was converted to urban land;2) the percentages of forest loss to urban land in Dongguan(19.14%), Guangzhou(18.35%) and Shenzhen(15.81%) were higher than those in other cities;3) the forest became increasingly fragmented from 1987–2007, and then the fragmentation decreased from2007 to 2017);4) the landscape responses to forest changes varied with the scale;and 5) some forest loss to urban regions moved from low-elevation and gentle-slope terrains to higher-elevation and steep-slope terrains over time, especially in Shenzhen and Hong Kong.Urbanization and industrialization greatly drove forest loss and fragmentation, and, notably, hillside urban land expansion may have contributed to hillside forest loss. The findings will help policy makers in maintaining the stability of forest ecosystems, and provide some new insights into forest management and conservation. | YANG Chao LIU Huizeng LI Qingquan CUI Aihong XIA Rongling SHI Tiezhu ZHANG Jie GAO Wenxiu ZHOU Xiang WU Guofeng | 2021 | Chinese Geographical Science2021，31，1： | 3 |
| 7 | Residual stress variation in SiC_(f)/SiC composite during heat treatment and its effects on mechanical behavior显示文摘Residual stress originated from thermal expansion mismatch determines the mechanical properties of ceramic matrix composites(CMCs).Here,continuous SiC fiber reinforced SiC matrix(SiC_(f)/SiC)composites were fabricated by nano-infiltration and transient eutectic-phase(NITE)method,and the residual stress of the composites was investigated using high-temperature Raman spectrometer.With temperature increasing from room temperature to 1400℃,the residual stresses of the matrix and the fiber decrease from 1.29 to 0.62 GPa and from 0.84 to 0.55 GPa in compression respectively,while that of the interphase decreases from 0.16 to 0.10 GPa in tension.The variation of residual stress shows little effect on the tensile strength of the composites,while causes a slight decrease in the tensile strain.The suppression of fiber/matrix debonding and fiber pulling-out caused by the residual stress reduction in the interphase is responsible for the decreasing tensile strain.This work can open up new alternatives for residual stress analysis in CMCs. | Xiaowu CHEN Guofeng CHENG Junmin ZHANG Feiyu GUO Haijun ZHOU Chunjin LIAO Hongda WANG Xiangyu ZHANG Shaoming DONG | 2020 | Journal of Advanced Ceramics2020，9，5： | 3 |
| 8 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 9 | Ultra-low thermal conductivity of two-dimensional phononic crystals in the incoherent regime显示文摘Two-dimensional silicon phononic crystals have attracted extensive research interest for thermoelectric applications due to their reproducible low thermal conductivity and sufficiently good electrical properties.For thermoelectric devices in high-temperature environment,the coherent phonon interference is strongly suppressed;therefore phonon transport in the incoherent regime is critically important for manipulating their thermal conductivity.On the basis of perturbation theory,we present herein a novel phonon scattering process from the perspective of bond order imperfections in the surface skin of nanostructures.We incorporate this strongly frequency-dependent scattering rate into the phonon Boltzmann transport equation and reproduce the ultra low thermal conductivity of holey silicon nanostructures.We reveal that the remarkable reduction of thermal conductivity originates not only from the impediment of low-frequency phonons by normal boundary scattering,but also from the severe suppression of high-frequency phonons by surface bond order imperfections scattering.Our theory not only reveals the role of the holey surface on the phonon transport,but also provide a computation tool for thermal conductivity modification in nanostructures through surface engineering. | Guofeng Xie Zhifang Ju Kuikui Zhou Xiaolin Wei Zhixin Guo Yongqing Cai Gang Zhang | 2018 | npj Computational Materials2018，，1： | 2 |
| 10 | Solid rocket motor propellant grain burnback simulation based on fast minimum distance function calculation and improved marching tetrahedron method显示文摘To efficiently compute arbitrary propellant grain evolution of the burning surface with uniform and non-uniform burning rate for solid rocket motor,a unified framework of burning surface regression simulation has been developed based on minimum distance function.In order to speed up the computation of the mini-mum distance between grid nodes of grain and the triangular mesh of burning surface,a fast distance querying method based on the equal size cube voxel structure was employed.An improved marching tetrahedron method based on piecewise linear approximation was carried out on second-order tetrahedral elements,achieved high-efficiency and adequate accuracy of burning surface extraction simultaneously.The cases of star grain,finocyl grain,and non-uniform tube grain were studied to verify the proposed method.The observed result indicates that the grain burnback computation method could realize the accurate simulation on unstructured tetrahedral mesh with a desirable performance on computational time. | Pengfei REN Hongbo WANG Guofeng ZHOU Jiani LI Qiang CAI Jiaquan YU Ya YUAN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 2 |
| 11 | Hexagonal FeS nanosheets with high-energy (001) facets: Counter electrode materials superior to platinum for dye-sensitized solar cells显示文摘材料的催化活动高度依赖于他们的作文和表面结构,特别低坐标的表面原子的密度。在这个工作,我们准备了二维的六角形的 FeS 与高精力(001 ) 经由一个答案阶段化学药品方法的方面(FeS-HE-001 ) 。有暴露的高精力的飞机的 Nanosheets (NS ) 通常拥有更好的反应活动, FeS-HE-001 因此被用作一个柜台为敏化染料的太阳能电池(DSSC ) 的电极(CE ) 材料。FeS-HE-001 完成了 8.88% 的平均力量变换效率(PCE )( 与冠军房间的 PCE 是 9.10%) ,它比在平行测量的基于磅的 DSSC (7.73%) 的高几乎 1.15 倍。周期的 voltammetry 和 Tafel 极化大小向 I 3-/I - 氧化还原作用反应揭示了 FeS-HE-001 的优秀 electrocatalytic 活动。这能被归因于光电子转移的提升,它被电气化学的阻抗光谱学测量并且扫描凯尔文探查,并且强壮我 3- 吸附和减小活动,它用第一原则的计算被调查。存在高精力(001 ) 在 NS 的方面是为改进催化减小的一个重要因素我 3- 。我们相信我们的方法是为为收获的精力的先进 CE 材料的设计和合成的一个有希望的方法。 | Xiuwen Wang Ying xie Buhe Bateer Kai Pan Yangtao Zhou Yi Zhang Guofeng Wang Wei Zhou Honggang Fu | 2016 | Nano Research2016，9，10： | 2 |
| 12 | MgTiO3/MgTi2O5/TiO2 heterogeneous belt-junctions with high photocatalytic hydrogen production activity显示文摘包括 MgTiO 3/MgTi2 O 5/TiO2 异构的带连接被一个热地驾驶的做的方法用镁离子准备。tri 阶段异构的连接被 X 光检查粉末证实衍射(XRD ) ,传播电子显微镜学(TEM ) ,和高分辨率的 TEM (HRTEM ) 。同样准备的 MgTiO 3/MgTi2 O 5/TiO2 异质接面展出了一项很高的 photocatalytic 氢生产活动(356.1 molctive 李 2 由设计碳 nanotube (CNT ) 的 FeSiO 4 指导了三维(3D ) 多孔的李 2 FeSiO 4 合成。当 CNT 框架启用毛孔给予有效电解质穿入的快速的电子运输,和富人,这唯一的 3D 李 2 FeSiO 4-CNT 合成作为提高并且分别地,保护单位改进钴氧化物的能力和稳定性基本联合起来展出 214 mAher 功能的一个高能力。利用 synergistic 效果吗?? | Ling Meng Zhiyu Ren Wei Zhou Yang Qu Guofeng Wang | 2017 | Nano Research2017，10，1： | 2 |
| 13 | Silver nanoparticles crossing through and distribution in the blood-brain barrier in vitro 显示文摘 | Jinglong Tang Ling Xiong Guofeng Zhou | 2010 | Journal of nanoscience and nanotechnology2010，10，10： | 1 |
| 14 | A multi-scale architecture for multi-scale simulation and its application to gas-solid flows显示文摘A multi-scale hardware and software architecture implementing the EMMS(energy-minimization multiscale) paradigm is proven to be effective in the simulation of a two-dimensional gas-solid suspension.General purpose CPUs are employed for macro-scale control and optimization,and many integrated cores(MICs) operating in multiple-instruction multiple-data mode are used for a molecular dynamics simulation of the solid particles at the meso-scale.Many cores operating in single-instruction multipledata mode,such as general purpose graphics processing units(GPGPUs),are employed for direct numerical simulation of the fluid flow at the micro-scale using the lattice Boltzmann method.This architecture is also expected to be efficient for the multi-scale simulation of other complex systems. | Bo Li Guofeng Zhou Wei Ge Limin Wang Xiaowei Wang Li Guo Jinghai Li | 2014 | Particuology2014，12，4： | 1 |
| 15 | Preparation and charcterization of Konjac superabsorbent polymer显示文摘 | Jiang Fatang Li Wanfen Zhan Xiaohui Chen Guofeng Zhou Jun Huang Jing Zhang Shenghua | 2006 | Journal of Wuhan University of Technology - Mater Sci Ed2006，，4： | 1 |
| 16 | Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells显示文摘 | Fanfan Zhou Mei Hong Guofeng You | | 0，，： | 1 |
| 17 | Computer-assisted technique for the design and manufacture of realistic facial prostheses显示文摘 | Zhihong Feng Yan Dong Yimin Zhao Shizhu Bai Bing Zhou Yunpeng Bi Guofeng Wu | 2009 | British Journal of Oral & Maxillofacial Surgery2009，，2： | 1 |
| 18 | Thermal transport in lithium-ion battery: A micro perspective for thermal management显示文摘In recent years, lithium ion (Li-ion) batteries have served as significant power sources in portable electronic devices and electric vehicles because of their high energy density and rate capability. There are growing concerns towards the safety of Li-ion batteries, in which thermal conductivities of anodes, cathodes, electrolytes and separator play key roles for determining the thermal energy transport in Li-ion battery. In this review, we summarize the state-of-the-art studies on the thermal conductivities of commonly used anodes, cathodes, electrolytes and separator in Li-ion batteries, including both theoretical and experimental reports. First, the thermal conductivities of anodes and cathodes are discussed, and the effects of delithiation degree and temperature of materials are also discussed. Then, we review the thermal conductivities of commonly used electrolytes, especially on solid electrolytes. Finally, the basic concept of interfacial thermal conductance and simulation methods are presented, as well as the interfacial thermal conductance between separator and cathodes. This perspective review would provide atomic perspective knowledge to understand thermal transport in Li-ion battery, which will be beneficial to the thermal management and temperature control in electrochemical energy storage devices. | Changqing Xiang Cheng-Wei Wu Wu-Xing Zhou Guofeng Xie Gang Zhang | 2022 | Frontiers of physics2022，17，1： | 1 |
| 19 | A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still rapidly spreading worldwide.Many drugs and vaccines have been approved for clinical use show efficacy in the treatment and prevention of SARS-CoV-2 infections.However,the emergence of SARS-CoV-2 variants of concern(VOCs),such as Delta(B.1.617.2)and the recently emerged Omicron(B.1.1.529),has seriously challenged the application of current therapeutics.Therefore,there is still a pressing need for identification of new broad-spectrum antivirals.Here,we further characterized a human antibody(58G6),which we previously isolated from a patient,with a broadly authentic virus-neutralizing activity that inhibits the Delta and Omicron variants with half-maximal inhibitory concentrations(ICso)of 1.69 ng/ml and 54.31 ng/ml,respectively.58G6 shows prophylactic and therapeutic effcacy in hamsters challenged with the Delta and Omicron variants through nasal delivery.Notably,a very low dosage(2 mg/kg daily)of 58G6 efficiently prevented Omicron variant replication in the lungs.These advantages may overcome the efficacy limitation of currently approved neutralizing antibodies that can be administered only by intravenous injection.In general,58G6 is a promising prophylactic and therapeutic candidate against current circulating VOCs and even future emerging mutants.To the best of our knowledge,58G6 is one of the most potent neutralizing antibodies against Omicron,with a broader spectrum than those approved for clinical use.58G6 could be developed as a nebulized therapy,which would be more cost effective and user friendly and enhance the clinical outcome comparedto thatobtainedwithdirect nasaldelivery. | Xinghai Zhang Huajun Zhang Tingting Li Shaohong Chen Feiyang Luo Junhui Zhou Peiyi Zheng Shuyi Song Yan Wu Tengchuan Jin Ni Tang Aishun Jin Chengyong Yang Guofeng Cheng Rui Gong Sandra Chiu Ailong Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 20 | Regular Quasi Cyclic Low Density Parity Check Codes with Girth 8 from Elementary Number Theory显示文摘This paper is concerned with (3,n) and (4,n) regular quasi-cyclic Low Density Parity Check (LDPC) code constructions from elementary number theory.Given the column weight,we determine the shift values of the circulant permutation matrices via arithmetic analysis.The proposed constructions of quasi-cyclic LDPC codes achieve the following main advantages simultaneously:1) our methods are constructive in the sense that we avoid any searching process;2) our methods ensure no four or six cycles in the bipartite graphs corresponding to the LDPC codes;3) our methods are direct constructions of quasi-cyclic LDPC codes which do not use any other quasi-cyclic LDPC codes of small length like component codes or any other algorithms/cyclic codes like building block;4)the computations of the parameters involved are based on elementary number theory,thus very simple and fast.Simulation results show that the constructed regular codes of high rates perform almost 1.25 dB above Shannon limit and have no error floor down to the bit-error rate of 10-6. | He Guofeng Li Xiangxue Li Qiang Zhou Zhiheng Zheng Dong | 2012 | China Communications2012，9，4： | 1 |
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