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| 1 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 2 | Weakly hydrophobic nanoconfinement by graphene aerogels greatly enhances the reactivity and ambient stability of reactivity of MIL-101-Fe in Fenton-like reaction显示文摘In the pursuit of heterogeneous catalysts with high reactivity,metal organic framework(MOF)nanomaterials have received tremendous attentions.However,many MOF catalysts especially Fe-based MOFs need to be utilized immediately after synthesis or being activated using high temperature,because of the easy loss of reactivity in humid environments resulting from the occupation of active Fe sites by water molecules.Here,we describe an inspiring strategy of growing MIL-101-Fe nanoparticles inside the three-dimensional confined space of graphene aerogel(GA),generating shapeable GA/MIL-101-Fe nanocomposite convenient for practical use.Compared to MIL-101-Fe,GA/MIL-101-Fe as catalyst demonstrates much higher reactivity in Fenton-like reaction,attributing to smaller MIL-101-Fe particle size,presence of active Fe(II)sites,and abundant defects in GA.Strikingly,the weakly hydrophobic nature of the composite greatly inhibits the loss of catalytic reactivity after being stored in humid air and accelerates the recovery of reactivity in mild temperature,by resisting the entrance of water molecules and helping to exclude water molecules.This work demonstrates that a delicate design of nanocomposite structure could not only improve the reactivity of the catalytic component,but also overcome its intrinsic drawback by taking advantage of the properties of host.We hope this functional nanoconfinement strategy could be extended to more scenarios in other fields. | Yuwei Zhang Fei Liu Zhichao Yang Jieshu Qian Bingcai Pan | 2021 | Nano Research2021，14，7： | 2 |
| 3 | Organometallic perovskite single crystals grown on lattice-matched substrate for photodetection显示文摘In this work,we demonstrate that an organometallic perovskite(OP)single crystal for effective photodetection can be grown on a gold(Au)-decorated substrate using liquid phase epitaxy.The covered gold could both control the shape of the epitaxial layer and act as its electrodes.An MAPbCl3 single crystal and an MAPbBr1.5Cl1.5 single crystal were used as the substrate and the epitaxial layer,respectively.The device,with an Au-perovskite-Au structure,can be fully characterized.Due to the high-quality epitaxial layer,the maximum external quantum efficiency(EQE)value is over 60%under the voltage of20 V.In addition,the response speed can reach 200 and 500 ns(ns)rise and fall,respectively.Our work provides an effective and promising method to fabricate efficient perovskite-based photodetectors. | Xin Wang Yuwei Li Yubing Xu Yuzhu Pan Yao Wua Guanwen Li Wei Zhang Shuyi Ding Jing Chen Wei Lei Dewei Zhao | 2020 | Nano Materials Science2020，2，3： | 0 |
| 4 | Information space of sensor networks:Lagrangian,energy-momentum tensor,and applications显示文摘It is a challenge to investigate the interrelationship between the geometric structure and performance of sensor networks due to the increasingly complex and diverse architecture of them.This paper presents two new formulations for the information space of sensor networks,including Lagrangian and energy–momentum tensor,which are expected to integrate sensor networks target tracking and performance evaluation from a unified perspective.The proposed method presents two geometric objects to represent the dynamic state and manifold structure of the information space of sensor networks.Based on that,the authors conduct the property analysis and target tracking of sensor networks.To the best of our knowledge,it is the first time to investigate and analyze the information energy-momentum tensor of sensor networks and evaluate the performance of sensor networks in the context of target tracking.Simulations and examples confirm the competitive performance of the proposed method. | Mo TAO Shaoping WANG Hong CHEN Han PAN Jian SHI Yuwei ZHANG | 2023 | Chinese Journal of Aeronautics2023，36，3： | 0 |
| 5 | Activated carbon fiber mediates efficient activation of peroxymonosulfate systems:Modulation of manganese oxides and cycling of manganese species显示文摘Manganese oxides show a strong catalytic activity in the peroxymonosulfate(PMS)advanced oxidation process but have poor chemical stability and a propensity to cause the aggregation of nanoparticles.Here,a novel composite material(abbreviated as MnO_(x)@ACF)was synthesized,characterized,and applied.Activated carbon fiber(ACF)was selected as a carrier,which modulated the composition of manganese oxides.The results showed that MnO_(x)@ACF had a strong adsorption ability and successfully activated PMS to degrade tetracycline hydrochloride(TCH),with a removal eficiency of 89.0%in 30 min.Influencing factors such as pH and coexisting ion species were investigated,and a five-cycle test was conducted.Singlet oxygen(^(1)O_(2))was predominated in the MnO_(x)@ACF/PMS system.A possible explanatory pathway of TCH was proposed based on the results of the high performance liquid chromatography-mass spectrometry.It was concluded that this study provides a novel insight into the activation of PMS for the degradation of organic matter by carbon-loaded multivalent manganese oxides. | Lixi Xiao Yuwei Deng Huo Zhou Fengjun Lu Chong Ke Yuxuan Ye Xuanyuan Pei Dongsheng Xia Fei Pan | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 6 | Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas显示文摘Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is scant.Here,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism level.Combining single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell resolution.The innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells proportions.Furthermore,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and kidney.Moreover,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of injection.Our findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants. | Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen Fangyuan Bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin | 2022 | Bioactive Materials2022，7，12： | 0 |
| 7 | CSCO guidelines for metastatic colorectal cancer:personalized medicine in clinical practice显示文摘Colorectal cancer(CRC)is the second most common cancer in China,the morbidity and mortality rates of which are rapidly increasing1,2.Among newly-diagnosed CRC patients,20%have metastatic disease at the time of presentation and an additional 25%present with localized disease and will subsequently develop metastases3.The treatment of metastatic colorectal cancer(mCRC)is gradually moving towards the era of precision therapy,which involves guided treatment based on individual genetic characteristics4.Since the first edition of the Chinese Society of Clinical Oncology(CSCO)guidelines was published in 2017,the guidelines have been updated annually according to the latest clinical trial findings5-9.Herein we summarize how the CSCO guidelines enable tailor-made treatments of mCRC with different molecular characteristics(Figure 1). | Mengyuan Yang Ziheng Xu Mi Mi Yuwei Ding Yuefen Pan Ying Yuan Weijing Sun Shanshan Weng | 2023 | Cancer Biology & Medicine2023，20，9： | 0 |
| 8 | Boron promoted Fe^(3+)/peracetic acid process for sulfamethazine degradation:Efficiency,role of boron,and identification of the reactive species显示文摘In this work,boron(B)was used to promote Fe^(3+)/peracetic acid(Fe^(3+)/PAA)for the degradation of sulfamethazine(SMT).An SMT degradation efficiency of 9.1%was observed in the Fe^(3+)/PAA system over 60 min,which was significantly increased to 99.3%in the B/Fe^(3+)/PAA system over 10 min.The B/Fe^(3+)/PAA process also exhibited superior resistance to natural substances,excellent adaptability to different harmful substances,and good removal of antibiotics in natural fresh water samples.The mechanism of action of boron for Fe^(3+)reduction was determined using scanning electron microscopy(SEM),X-ray photoelectron spectroscopy(XPS),Fourier transform infrared(FT-IR)spectroscopy,density functional theory(DFT)calculations,and electrochemical tests.The dominant role of^(·)OH was confirmed using quenching experiments,electron spin resonance(EPR)spectroscopy,and quantitative tests.Organic radicals(R-O^(·))and Fe(IV)also significantly contribute to the removal of SMT.DFT calculations on the reaction between Fe^(2+)and the PAA were conducted to further determine the contribution from ^(·)OH,R-O^(·),and Fe(IV)from the perspective of thermodynamics and the reaction pathways.Different boron dosages,Fe^(3+)dosages,and initial pH values were also investigated in the B/Fe^(3+)/PAA system to study their effect of SMT removal and the production of the reactive species.Fe(IV)production determined the k_(R-O·+Fe(IV))value suggesting that Fe(IV)may play a more important role than R-O^(·).A comparison of the results with other processes has also proved that the procedure described in this study(B/Fe^(3+)/PAA)is an effective method for the degradation of antibiotics. | Yanhong Zhang Guangbing Liu Yuzhu Xue Lichun Fu Yawei Qian Minhui Hou Xiang Li Chen Ling Ying Zhang Yuwei Pan | 2024 | Journal of Environmental Sciences2024，，1： | 0 |
| 9 | Surgical treatment effects in cancer of the cardia and esophagogastric junction显示文摘Objective: To evaluate the treatment effects of total gastrectomy (TG) and proximal gastrectomy (PG) for cancer of the cardia and esophagogastric junction. Methods: forty-five patients with cancer of the cardia and esophagogastric junc- tion underwent surgical resection. Of them, 29 were treated using proximal gastrectomy and 16 total gastrectomy. The 3-year and 5-year survival rate and the postoperative complication rate and mortality rate were followed up and compared between the two groups. Results: The 3-year and 5-year survival rates of group PG were 44.8% and 20.7%, of group TG were 37.5% and 18.8%, respectively, and the differences were not statistically significant (χ2 = 3.84, P > 0.05; χ2 = 3.89, P > 0.05). The postoperative complication and mortality rate of group PG were 13.7% and 6.8%, of group TG was all 6%, respectively. Conclusion: Proximal and total gastrectomy treatment effects can not significantly influence the prognosis of patients in progressive stage of cancer of cardia and esophagogastric junction. | Yumin Zhou Jiong Pan Yuwei Sheng Hao Liu Ziping Fan | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，3： | 0 |
| 10 | A novel protein complex that regulates active DNA demethylation in Arabidopsis显示文摘Active DNA demethylation is critical for altering DNA methylation patterns and regulating gene expression.The 5-methylcytosine DNA glycosylase/lyase ROS1 initiates a base-excision repair pathway for active DNA demethylation and is required for the prevention of DNA hypermethylation at 1000 s of genomic regions in Arabidopsis.How ROS1 is regulated and targeted to specific genomic regions is not well understood.Here,we report the discovery of an Arabidopsis protein complex that contains ROS1,regulates ROS1 gene expression,and likely targets the ROS1 protein to specific genomic regions.ROS1 physically interacts with a WD40 domain protein(RWD40),which in turn interacts with a methyl-DNA binding protein(RMB1)as well as with a zinc finger and homeobox domain protein(RHD1).RMB1 binds to DNA that is methylated in any sequence context,and this binding is necessary for its function in vivo.Loss-of-function mutations in RWD40,RMB1,or RHD1 cause DNA hypermethylation at several tested genomic regions independently of the known ROS1 regulator IDM1.Because the hypermethylated genomic regions include the DNA methylation monitoring sequence in the ROS1 promoter,plants mutated in RWD40,RMB1,or RHD1 show increased ROS1 expression.Importantly,ROS1 binding to the ROS1 promoter requires RWD40,RMB1,and RHD1,suggesting that this complex dictates ROS1 targeting to this locus.Our results demonstrate that ROS1 forms a protein complex with RWD40,RMB1,and RHD1,and that this novel complex regulates active DNA demethylation at several endogenous loci in Arabidopsis. | Pan Liu Wen-Feng Nie Xiansong Xiong Yuhua Wang Yuwei Jiang Pei Huang Xueqiang Lin Guochen Qin Huan Huang Qingfeng Niu Jiamu Du Zhaobo Lang Rosa Lozano-Duran Jian-Kang Zhu | 2021 | Journal of Integrative Plant Biology2021，63，4： | 0 |
| 11 | Flexible thermochromic fabrics enabling dynamic colored display显示文摘Color-changeable fbers can provide diverse functions for intelligent wearable devices such as novel information displays and human-machine interfaces when woven into fabric.This work develops a low-cost,efective,and scalable strategy to produce thermochromic fbers by wet spinning.Through a combination of diferent thermochromic microcapsules,fexible fbers with abundant and reversible color changes are obtained.These color changes can be clearly observed by the naked eye.It is also found that the fbers exhibit excellent color-changing stability even after 8000 thermal cycles.Moreover,the thermochromic fbers can be fabricated on a large scale and easily woven or implanted into various fabrics with good mechanical performance.Driven by their good mechanical and physical characteristics,applications of thermochromic fbers in dynamic colored display are demonstrated.Dynamic quick response(QR)code display and recognition are successfully realized with thermochromic fabrics.This work well confrms the potential applications of thermochromic fbers in smart textiles,wearable devices,fexible displays,and human-machine interfaces. | Pan Li Zhihui Sun Rui Wang Yuchen Gong Yingting Zhou Yuwei Wang Xiaojuan Liu Xianjun Zhou Ju Ouyang Mingzhi Chen Chong Hou Min Chen Guangming Tao | 2022 | Frontiers of Optoelectronics2022，15，3： | 0 |
| 12 | Non-woven cotton fabric based intimately coupling of photocatalysis and biodegradation system for efficient removal of Cu(Ⅱ)complex in water显示文摘The efficient remediation of heavy metal complexes in water has become a difficult and challenging task owing to their high stability and strong mobility.In this study,a novel strategy was employed for highly efficient removal of Cu-citrate by using intimately coupled photocatalysis and biodegradation(ICPB)system with non-woven cotton fabric as a carrier.Experimental results showed that the ICPB system caused94%Cu removal,which was higher than those of single photocatalysis.After 5 cycles,Cu removal efficiency could still reach 78%within 5 h.The existence of 0–40 mg/L citrate had negligible influence,whereas the presence of 60–100 mg/L citrate exhibited a limited adverse effect on Cu removal(~70%).The decomplexation of Cu-citrate was realized via the function of free radicals and microorganisms.Two main processes,such as bio-adsorption of Cu^(2+) by microorganisms,deposition of Cu^(0) on the surface of material,played important role in Cu removal from aqueous solution.The dominant microorganisms in the system were Proteobacteria,Actinobacteria,Bacteroidetes,Chloroflexi,Chlorophyta,Planctomycetes,and Verrucomicrobia.Furthermore,the performance of ICPB system was also validated through treatment of other heavy metal complexes.This study provided a feasible strategy for the decontamination of heavy metal complexes in wastewater. | Yuxuan Ye Peng Yang Yuwei Deng Yezhi Yang Kun Zhang Yueying Wang Wenjing Shang Qiang Li Lei Sun Fei Pan Dongsheng Xia | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 13 | Wearable and interactive multicolored photochromic fiber display显示文摘Endowing flexible and adaptable fiber devices with light-emitting capabilities has the potential to revolutionize the current design philosophy of intelligent,wearable interactive devices.However,significant challenges remain in developing fiber devices when it comes to achieving uniform and customizable light effects while utilizing lightweight hardware.Here,we introduce a mass-produced,wearable,and interactive photochromic fiber that provides uniform multicolored light control.We designed independent waveguides inside the fiber to maintain total internal reflection of light as it traverses the fiber.The impact of excessive light leakage on the overall illuminance can be reduced by utilizing the saturable absorption effect of fluorescent materials to ensure light emission uniformity along the transmission direction.In addition,we coupled various fluorescent composite materials inside the fiber to achieve artificially controllable spectral radiation of multiple color systems in a single fiber.We prepared fibers on mass-produced kilometer-long using the thermal drawing method.The fibers can be directly integrated into daily wearable devices or clothing in various patterns and combined with other signal input components to control and display patterns as needed.This work provides a new perspective and inspiration to the existing field of fiber display interaction,paving the way for future human–machine integration. | Pan Li Yuwei Wang Xiaoxian He Yuyang Cui Jingyu Ouyang Ju Ouyang Zicheng He Jiayu Hu Xiaojuan Liu Hang Wei Yu Wang Xiaoling Lu Qian Ji Xinyuan Cai Li Liu Chong Hou Ning Zhou Shaowu Pan Xiangru Wang Huamin Zhou Cheng-Wei Qiu Yan-Qing Lu Guangming Tao | 2024 | Light(Science & Applications)2024，13，3： | 0 |
| 14 | Pure-Blue Fluorescence Molecule for Nondoped Electroluminescence with External Quantum Efficiency Approaching 13%显示文摘A pure-blue light-emitting material is one of the key components in the preparation of organic lightemitting diode(OLED)displays.Although highefficiency blue OLEDs have been realized in thermally activated delayed fluorescence(TADF)materials,they need to be dispersed into suitable hostmaterials.Hence,exploring efficient nondoped,pure-blue luminous molecules is important. | Xianhao Lv Lei Xu Miao Cang Runze Wang Mizhen Sun Huayi Zhou Yuan Yu Qikun Sun Yuyu Pan Yuwei Xu Dehua Hu Shanfeng Xue Wenjun Yang | 2021 | CCS Chemistry2021，3，9： | 0 |
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