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| 1 | Epigenetic mechanisms in non-alcoholic fatty liver disease:An emerging field显示文摘Non-alcoholic fatty liver disease(NAFLD) is an emerging health concern in both developed and non-developed world, encompassing from simple steatosis to nonalcoholic steatohepatitis(NASH), cirrhosis and liver cancer. Incidence and prevalence of this disease are increasing due to the socioeconomic transition and change to harmful diet. Currently, gold standard method in NAFLD diagnosis is liver biopsy, despite complications and lack of accuracy due to sampling error. Further, pathogenesis of NAFLD is not fully understood, but is well-known that obesity, diabetes and metabolic derangements played a major role in disease development and progression. Besides, gut microbioma and host genetic and epigenetic background could explain considerable interindividual variability. Knowledge that epigenetics, heritable events not caused by changes in DNA sequence, contribute to development of diseases has been a revolution in the last few years. Recently, evidences are accumulating revealing the important role of epigenetics in NAFLD pathogenesis and in NASH genesis. Histone modifications, changes in DNA methylation and aberrant profiles or micro RNAs could boost development of NAFLD and transition into clinical relevant status. PNPLA3 genotype GG has been associated with a more progressive disease and epigenetics could modulate this effect. The impact of epigenetic on NAFLD progression could deserve further applications on therapeutic targets together with future non-invasive methods useful for the diagnosis and staging of NAFLD. | Rocío Gallego-Durán Manuel Romero-Gómez | 2015 | World Journal of Hepatology2015，7，24： | 8 |
| 2 | 生物学标记物诊断非酒精性脂肪性肝病的研究进展显示文摘非酒精性脂肪性肝病(NAFLD)是一种与胰岛素抵抗和遗传易感密切相关的代谢应激性肝脏损伤,近年其在我国的发病率呈逐年上升趋势。目前肝组织活检是诊断NAFLD的金标准,但检查为侵入性,存在一定风险。因此,寻找一种简单、准确的诊断方法成为亟待解决的问题。无创生物学标记物诊断NAFLD是近年的研究热点。本文就生物学标记物诊断NAFLD的研究进展作一综述。 | 周毅骏 钦丹萍 | 2016 | 胃肠病学2016，21，4： | 1 |
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