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| 1 | Functional neuroanatomy in panic disorder:Status quo of the research显示文摘AIM To provide an overview of the current research in the functional neuroanatomy of panic disorder.METHODS Panic disorder(PD) is a frequent psychiatric disease. Gorman et al(1989; 2000) proposed a comprehensive neuroanatomical model of PD, which suggested that fear-and anxiety-related responses are mediated by a so-called 'fear network' which is centered in the amygdala and includes the hippocampus, thalamus, hypothalamus, periaqueductal gray region, locus coeruleus and other brainstem sites. We performed a systematic search by the electronic database PubMed. Thereby, the main focus was laid on recent neurofunctional, neurostructural, and neurochemical studies(from the period between January 2012 and April 2016). Within this frame, special attention was given to the emerging field of imaging genetics. RESULTS We noted that many neuroimaging studies have reinforced the role of the 'fear network' regions in the pathophysiology of panic disorder. However, recent functional studies suggest abnormal activation mainly in an extended fear network comprising brainstem, anterior and midcingulate cortex(ACC and MCC), insula, and lateral as well as medial parts of the prefrontal cortex. Interestingly, differences in the amygdala activation were not as consistently reported as one would predict from the hypothesis of Gorman et al(2000). Indeed, amygdala hyperactivation seems to strongly depend on stimuli and experimental paradigms, sample heterogeneity and size, as well as on limitations of neuroimaging techniques. Advanced neurochemical studies have substantiated the major role of serotonergic, noradrenergic and glutamatergic neurotransmission in the pathophysiology of PD. However, alterations of GABAergic function in PD are still a matter of debate and also their specificity remains questionable. A promising new research approach is 'imaging genetics'. Imaging genetic studies are designed to evaluate the impact of genetic variations(polymorphisms) on cerebral function in regions critical for PD. Most recently, imaging genetic studies have not only confirmed the importance of serotonergic and noradrenergic transmission in the etiology of PD but also indicated the significance of neuropeptide S receptor, CRH receptor, human TransM EMbrane protein(TMEM123D), and amiloride-sensitive cation channel 2(ACCN2) genes. CONCLUSION In light of these findings it is conceivable that in the near future this research will lead to the development of clinically useful tools like predictive biomarkers or novel treatment options. | Thomas Sobanski Gerd Wagner | 2017 | World Journal of Psychiatry2017，7，1： | 5 |
| 2 | Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators显示文摘 | Sebastian S. Gehrke Erika G. Pinto Dietmar Steverding Karin Pleban Andre G. Tempone Robert C. Hider Gerd K. Wagner | 2012 | Bioorganic & Medicinal Chemistry2012，，： | 1 |
| 3 | Antisense RNA regulation in prokaryotes:rapid RNA/RNA interaction facilitated by a general U-turn loop structure显示文摘 | Franch T Petersen M Wagner EG Jacobsen JP Gerdes K | 1999 | J Mol Biol1999，294，5： | 1 |
| 4 | Translocation breakpoints in three patients with campomelic dysplasia and autosomal sex reversal map more than 130 kb from SOX9显示文摘 | Jutta Wirth Thomas Wagner Jobst Meyer Rudolf A. Pfeiffer Hans-Ulrich Tietze Werner Schempp Gerd Scherer | 1996 | Human Genetics1996，，2： | 1 |
| 5 | On the Foundations of UML as an Ontology Representation Language 显示文摘 | Giancarlo Guizzardi Gerd Wagner Heinrieh Herre | 2004 | Engineering Knowledge in the Age of the Semantic Wab2004，3257，： | 1 |
| 6 | Pseudotumor orbitae-a chameleon in di- agnosis and therapy(Article in German)显示文摘 | Wagner W Gerding H Busse H | 1992 | Strahlenther Onko1992，168，： | 1 |
| 7 | The influence of major depression and its treatment on heart rate variability and pupillary light reflex parameters显示文摘 | Karl-Jürgen B?r Wolf Greiner Thomas Jochum Marc Friedrich Gerd Wagner Heinrich Sauer | 2004 | Journal of Affective Disorders2004，，2： | 1 |
| 8 | Is there a role of the Thr164Ile-β2-adrenoceptor polymorphism for the outcome of chronic heart failure?显示文摘 | Kirsten Leineweber Gero Tenderich Christina Wolf S?ren Wagner Armin Zittermann Miriam Elter-Schulz Reiner Moog Norbert Müller Heinz-Günther Jakob Reiner K?rfer Thomas Philipp Gerd Heusch Otto-Erich Brodde PhD | 2006 | Basic Research in Cardiology2006，，6： | 1 |
| 9 | Towards a BPMN Semantics using UML models显示文摘 | Oana Nicolae Mirel Cosulschi Adrian Giurca Gerd Wagner | 2009 | Lecture Notes in Business Information Processing2009，17，8： | 1 |
| 10 | Extended Treatment Duration for Hepatitis C Virus Type 1: Comparing 48 Versus 72 Weeks of Peginterferon-Alfa-2a Plus Ribavirin显示文摘 | Thomas Berg Michael von Wagner Samer Nasser Christoph Sarrazin Tobias Heintges Tilman Gerlach Peter Buggisch Tobias Goeser Jens Rasenack Gerd R. Pape Wolfgang E. Schmidt Birgit Kallinowski Hartwig Klinker Ulrich Spengler Peter Martus Ulrich Alshuth Stefan | 2006 | Gastroenterology2006，，4： | 1 |
| 11 | RNA antitoxins显示文摘 | Gerdes K Wagner EGH | 2007 | Current Opinion in Microbiology2007，10，2： | 1 |
| 12 | Web rules need two kinds of negation显示文摘 | Gerd Wagner | 2003 | Lecture Notesin Computer Science2003，，： | 1 |
| 13 | Suicidal behavior-advances in clinical and neurobiological research and improvement of prevention strategies显示文摘Suicide is the 14^(th)leading cause of death worldwide.It is responsible for 1%-5%of all mortality.This article highlights the latest developments in universal,selective,and indicated prevention strategies.Concerning universal suicide prevention,current research has shown that strategies such as restricting access to lethal means(e.g.,control of analgesics and hot-spots for suicide by jumping)and school-based awareness programs are most efficacious.Regarding selective prevention,substantial progress can be expected in psychological screening methods for suicidal behavior.The measurement of implicit cognition proved to be more valid in predicting future suicide attempts than classic clinical assessment.Latest developments are smartphone-based interventions and realtime monitoring of suicidal behavior.Great effort has been made to establish valid neurobiological screening methods(e.g.,genetic and epigenetic risk factors for suicide,hypothalamic-pituitary-adrenal axis)without yielding a major breakthrough.Potentially,multiple biomarkers rather than a single one are necessary to identify individuals at risk.With regard to indicated prevention in form of psychopharmacological treatment,recent pharmacoepidemiological studies and meta-analyses have supported a protective role of antidepressants,lithium,and clozapine.However,the data concerning a specific anti-suicidal effect of these drugs are currently not consistent.Promising results exist for ketamine in reducing suicidal ideation,independently of its antidepressant effect.Concerning psychotherapy,recent findings suggest that psychotherapeutic interventions specifically designed to prevent suicide re-attempts are most efficacious.Specifically,cognitive behavioral therapy and psychodynamic therapy approaches proved to decrease the number of suicide re-attempts significantly. | Thomas Sobanski Gregor Peikert Ulrich W Kastner Gerd Wagner | 2022 | World Journal of Psychiatry2022，12，9： | 0 |
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