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| 1 | Role and mechanisms of action of escherichia coli nissle 1917 in the maintenance of remission in ulcerative colitis patients: an update显示文摘Ulcerative colitis(UC) is a chronic inflammatory disease, whose etiology is still unclear. Its pathogenesis involves an interaction between genetic factors, immune response and the 'forgotten organ', Gut Microbiota. Several studies have been conducted to assess the role of antibiotics and probiotics as additional or alternative therapies for Ulcerative Colitis. Escherichia coli Nissle(Ec N) is a nonpathogenic Gram-negative strain isolated in 1917 by Alfred Nissle and it is the active component of microbial drug Mutaflor®(Ardeypharm Gmb H, Herdecke, Germany and Ec N, Cadigroup, In Italy) used in many gastrointestinal disorder including diarrhea, uncomplicated diverticular disease and UC. It is the only probiotic recommended in ECCO guidelines as effective alternative to mesalazine in maintenance of remission in UC patients. In this review we propose an update on the role of Ec N 1917 in maintenance of remission in UC patients, including data about efficacy and safety. Further studies may be helpful for this subject to further the full use of potential of Ec N. | Franco Scaldaferri Viviana Gerardi Francesca Mangiola Loris Riccardo Lopetuso Marco Pizzoferrato Valentina Petito Alfredo Papa Jovana Stojanovic Andrea Poscia Giovanni Cammarota Antonio Gasbarrini | 2016 | World Journal of Gastroenterology2016，22，24： | 19 |
| 2 | Effect of rifaximin on gut microbiota composition in advanced liver disease and its complications显示文摘Liver cirrhosis is a paradigm of intestinal dysbiosis. The qualitative and quantitative derangement of intestinal microbial community reported in cirrhotic patients seems to be strictly related with the impairment of liver function. A kind of gut microbial 'fingerprint',characterized by the reduced ratio of 'good' to 'potentially pathogenic' bacteria has recently been outlined,and is associated with the increase in Model for End-Stage Liver Disease and Child Pugh scores. Moreover,in patients presenting with cirrhosis complications such as spontaneous bacterial peritonitis(SBP),hepatic encephalopathy(HE),and,portal hypertension intestinal microbiota modifications or the isolation of bacteria deriving from the gut are commonly reported. Rifaximin is a non-absorbable antibiotic used in the management of several gastrointestinal diseases. Beyond bactericidal/bacteriostatic,immune-modulating and anti-inflammatory activity,a little is known about its interaction with gut microbial environment. Rifaximin has been demonstrated to exert beneficial effects on cognitive function in patients with HE,and also to prevent the development of SBP,to reduce endotoxemia and to improve hemodynamics in cirrhotics. These results are linked to a shift in gut microbes functionality,triggering the production of favorable metabolites. The low incidence of drug-related adverse events due to the small amount of circulating drug makes rifaximin a relatively safe antibiotic for the modulation of gut microbiota in advanced liver disease. | Francesca Romana Ponziani Viviana Gerardi Silvia Pecere Francesca D'Aversa Loris Lopetuso Maria Assunta Zocco Maurizio Pompili | 2015 | World Journal of Gastroenterology2015，21，43： | 16 |
| 3 | Role of Helicobacter pylori infection on nutrition and metabolism显示文摘Helicobacter pylori(H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome. | Francesco Franceschi Tortora Annalisa Di Rienzo Teresa D'Angelo Giovanna Gianluca Ianiro Scaldaferri Franco Gerardi Viviana Tesori Valentina Lopetuso Loris Riccardo Gasbarrini Antonio | 2014 | World Journal of Gastroenterology2014，20，36： | 11 |
| 4 | Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?显示文摘AIM To evaluate the prevalence of nodular lymphoid hyperplasia(NLH) in adult patients undergoing colonoscopy and its association with known diseases. METHODS We selected all cases showing NLH at colonoscopy in a three-year timeframe, and stratified them into symptomatic patients with irritable bowel syndrome(IBS)-type symptoms or suspected inflammatory bowel disease(IBD), and asymptomatic individuals undergoing endoscopy for colorectal cancer screening.Data collection included medical history and final diagnosis. As controls, we considered all colonoscopies performed for the aforementioned indications during the same period.RESULTS One thousand and one hundred fifty colonoscopies were selected. NLH was rare in asymptomatic individuals(only 3%), while it was significantly more prevalent in symptomatic cases(32%). Among organic conditions associated with NLH, the most frequent was IBD, followed by infections and diverticular disease. Interestingly, 31% of IBS patients presented diffuse colonic NLH. NLH cases shared some distinctive clinical features among IBS patients: they were younger, more often female, and had a higher frequency of abdominal pain, bloating, diarrhoea, unspecific inflammation, self-reported lactose intolerance and metal contact dermatitis. CONCLUSION About 1/3 of patients with IBS-type symptoms or suspected IBD presented diffuse colonic NLH, which could be a marker of low-grade inflammation in a conspicuous subset of IBS patients. | Anna Chiara Piscaglia Lucrezia Laterza Valentina Cesario Viviana Gerardi Rosario Landi Loris Riccardo Lopetuso Giovanni Calò Giovanna Fabbretti Massimo Brisigotti Maria Loredana Stefanelli Antonio Gasbarrini | 2016 | World Journal of Gastroenterology2016，22，46： | 2 |
| 5 | Gut Microbial Flora, Prebiotics, and Probiotics in IBD: Their Current Usage and Utility显示文摘 | Franco Scaldaferri Viviana Gerardi Loris Riccardo Lopetuso Fabio Del Zompo Francesca Mangiola Ivo Bo?koski Giovanni Bruno Valentina Petito Lucrezia Laterza Giovanni Cammarota Eleonora Gaetani Alessandro Sgambato Antonio Gasbarrini Michael Mahler | 2013 | BioMed Research International2013，，： | 2 |
| 6 | Bovine leukocyte adhesion deficiency:a review of a modern disease and its implications显示文摘 | GERARDI A S | 1996 | Res Vet Sci1996，61，3： | 1 |
| 7 | Making sense of the subprime crisis 显示文摘 | Gerardi K Lehnert A Sherlund S M | 2008 | Brookings Papers on Economic Activity2008，2008，2： | 1 |
| 8 | The microbiology of anaerobic digesters显示文摘 | Gerardi M H Somerset W | 2004 | Journal of Hazardous Materials2004，106，： | 1 |
| 9 | Oxidative stress and car- diovaseular disease in dialyzed patients 显示文摘 | Usberti M Gerardi GM Gazzotti RaM | 2002 | Nephron2002，91，1： | 1 |
| 10 | Oxidative stress and cardiovascular disease in dialyzed patients 显示文摘 | Usberti M Gerardi GM Gazzotti RM | 2002 | Nephron2002，91，1： | 1 |
| 11 | Advanced an- alytical-experimental procedures facilitating the effective application of micro-blasting on coated tools considering a- mong others the film brittleness 显示文摘 | Bouzakis K-D Skordaris G Gerardis S | 2012 | Journal of Production Engineering2012，15，2： | 1 |
| 12 | Infrared Ther- mometry Study of Nanofluid Pool Boiling Phenomena 显示文摘 | Gerardi C J Buongiorno L W Hu | 2011 | Nanoscale Research Letters2011，，： | 1 |
| 13 | Digital filtering and analysis for a semicon- ductor X - ray detector data acquisition 显示文摘 | Gaetano Gerardi Leonardo Abbene Angelo La Man- na | 2007 | Nuclear Instruments & Methods in Physics Research A2007，571，12： | 1 |
| 14 | Digital filtering and analysis for a semicon-ductor X - ray detector data acquisition 显示文摘 | Gaetano Gerardi Leonardo Abbene Angelo La Man-na | 2007 | Nuclear Instruments & Methods in Physics Research A2007，571，12： | 1 |
| 15 | Real time digital pulse processing for X - ray and gamma ray semicon- ductor detectors 显示文摘 | L Abbene G Gerardi F Principato | 2013 | Nuclear Instruments and Meth- ods in Physics Research A2013，053，： | 1 |
| 16 | 显示文摘 | Gerardi DA Metersky ML | 2000 | Respiration2000，67，2： | 1 |
| 17 | Bovine leukocyte adhesion deficiency:A review of a modern disease and its implications显示文摘 | Gerardi A S | 1996 | Res Vet Sci1996，61，3： | 1 |
| 18 | Pieceise surface flattening for non-dis torted texture mapping显示文摘 | Chakibb Jean-Marcv Gerardi | 1991 | ACM ComputGraphics1991，25，4： | 1 |
| 19 | Gut microbial flora,prebiotics,and probiotics in IBD:their current usage and utility显示文摘 | Scaldaferri F Gerardi V Lopetuso LR | 2013 | Biomed Res Int2013，2013，43： | 1 |
| 20 | Lipoxygenase involvement in ripening strawberry显示文摘 | LEONE A BLEVE-ZACHEO T GERARDI C MELILLO M T LEO L ZACHEO G | 2006 | Agric Food Chem2006，54，18： | 1 |
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