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| 1 | Inflammation, oxidative stress and renin angiotensin system in atherosclerosis显示文摘Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome. The impairment of the endothelium associated with cardiovascular risk factors creates an imbalance between vasodilating and vasoconstricting factors, in particular, an increase in angiotensin Ⅱ(Ang Ⅱ) and a decrease in nitric oxide. The renin-angiotensin system(RAS), and its primary mediator Ang Ⅱ, also have a direct influence on the progression of the atherosclerotic process via effects on endothelial function, inflammation, fibrinolytic balance, and plaque stability. Anti-inflammatory agents [statins, secretory phospholipase A2 inhibitor, lipoprotein-associated phospholipase A2 inhibitor, 5-lipoxygenase activating protein, chemokine motif ligand-2, C-C chemokine motif receptor 2 pathway inhibitors, methotrexate, IL-1 pathway inhibitor and RAS inhibitors(angiotensin-converting enzyme inhibitors)], Ang Ⅱ receptor blockers and ranin inhibitors may slow inflammatory processes and disease progression. Several studies in human using anti-inflammatory agents and RAS inhibitors revealed vascular benefits and reduced progression of coronary atherosclerosis in patients with stable angina pectoris; decreased vascular inflammatory markers, improved common carotid intima-media thickness and plaque volume in patients with diagnosed atherosclerosis. Recent preclinical studies have demonstrated therapeutic efficacy of vitamin D analogs paricalcitol in Apo E-deficient atherosclerotic mice. | Kazim Husain Wilfredo Hernandez Rais A Ansari Leon Ferder | 2015 | World Journal of Biological Chemistry2015，6，3： | 84 |
| 2 | Generating optical orbital angular momentum at visible wavelengths using a plasmonic metasurface显示文摘Light beams with a helical phase-front possess orbital angular momentum along their direction of propagation in addition to the spin angular momentum that describes their polarisation.Until recently,it was thought that these two‘rotational’motions of light were largely independent and could not be coupled during light–matter interactions.However,it is now known that interactions with carefully designed complex media can result in spin-to-orbit coupling,where a change of the spin angular momentum will modify the orbital angular momentum and vice versa.In this work,we propose and demonstrate that the birefringence of plasmonic nanostructures can be wielded to transform circularly polarised light into light carrying orbital angular momentum.A device operating at visible wavelengths is designed from a space-variant array of subwavelength plasmonic nano-antennas.Experiment confirms that circularly polarised light transmitted through the device is imbued with orbital angular momentum of 62'(with conversion efficiency of at least 1%).This technology paves the way towards ultrathin orbital angular momentum generators that could be integrated into applications for spectroscopy,nanoscale sensing and classical or quantum communications using integrated photonic devices. | Ebrahim Karimi Sebastian A Schulz Israel De Leon Hammam Qassim Jeremy Upham Robert W Boyd | 2014 | Light(Science & Applications)2014，3，1： | 39 |
| 3 | Alcohol-induced hypertension: Mechanism and prevention显示文摘Epidemiological, preclinical and clinical studies es-tablished the association between high alcohol con-sumption and hypertension. However the mechanism through which alcohol raises blood pressure remains elusive. Several possible mechanisms have been pro-posed such as an imbalance of the central nervous system, impairment of the baroreceptors, enhanced sympathetic activity, stimulation of the renin-angio-tensin-aldosterone system, increased cortisol levels, increased vascular reactivity due to increase in intracel-lular calcium levels, stimulation of the endothelium to release vasoconstrictors and loss of relaxation due to inflammation and oxidative injury of the endothelium leading to inhibition of endothelium-dependent nitric oxide production. Loss of relaxation due to inflamma-tion and oxidative injury of the endothelium by angio-tensin II leading to inhibition of endothelium-dependent nitric oxide production is the major contributors of the alcohol-induced hypertension. For the prevention of alcohol-induced hypertension is to reduce the amount of alcohol intake. Physical conditioning/exercise trainingis one of the most important strategies to prevent/treat chronic alcohol-induced hypertension on physiological basis. The efficacious pharmacologic treatment includes the angiotensin-converting enzyme(ACE) inhibitors or angiotensin Ⅱ type 1 receptor blockers(ARBs) which have antioxidant activity and calcium channel blockers. The most effective prevention and treatment of alcohol-induced hypertension is physical exercise and the use of ACE inhibitors or ARBs in the | Kazim Husain Rais A Ansari Leon Ferder | 2014 | World Journal of Cardiology2014，6，5： | 8 |
| 4 | Breath test for differential diagnosis between small intestinal bacterial overgrowth and irritable bowel disease:An observation on non-absorbable antibiotics显示文摘AIM: To estimate the prevalence of small intestine bacterial overgrowth (SIBO) among patients with an earlier diagnosis of irritable bowel disease (IBS) in our geographical area, and to collect information on the use of locally acting non-absorbable antibiotics in the management of SIBO. METHODS: A non-interventional study was conducted in 73 consecutive patients with a symptom-based diagnosis.. RESULTS: When the patients underwent a 'breath test', 33 (45.2%) showed the presence of a SIBO. After treatment with rifaximin 1200 mg/d for seven days in 32 patients, 19 (59.4%) showed a negative 'breath test' one week later as well as a significant reduction of symptoms, thus confirming the relationship between SIBO and many of the symptoms claimed by patients. In the other 13 patients, 'breath test' remained positive, and a further cycle of treatment with ciprofloxacin 500 mg/d was given for 7 additional days, resulting in a negative 'breath test' in one patient only. CONCLUSION: (1) about half of the patients with a symptomatic diagnosis of IBS have actually SIBO, which is responsible for most of the symptoms attributed to IBS; (2) only a 'breath test' with lactulose (or with glucose in subjects with an intolerance to lactose) can provide a differential diagnosis between IBS and SIBO, with almost identical symptoms; and (3) the use of non-absorbable antibiotics may be useful to reduce the degree of SIBO and related symptoms; it must be accompanied, however, by the correction of the wrong alimentary habits underlying SIBO. | I Esposito A de Leone G Di Gregorio S Giaquinto L de Magistris A Ferrieri G Riegler | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 5 | A model for calculation of steam injector performance 显示文摘 | Deberne N Leone J F Duque A | 1999 | International J of Multiphase Flow1999，25，1： | 2 |
| 6 | 非酒精性脂肪性肝病和非酒精性脂肪性肝炎的无创性诊断显示文摘非酒精性脂肪性肝病(NAFLD)在美国和世界上许多其他地区都是最常见的慢性肝病,其患病率持续上升,目前美国约1/4的成人和10%的儿童患NAFLD。NAFLD包括多种疾病状态,从通常呈良性、非进展性临床过程的单纯性脂肪肝直至更为严重的、可进展为肝硬化和终末期肝病的非酒精性脂肪性肝炎(NASH)。目前,NASH的诊断依赖于创伤性肝活检,而肝活检存在取样和读片误差的缺陷。NASH的临床危险因素包括糖尿病和代谢综合征,但这些因素本身不足以预测NASH。常规肝酶水平预测可靠性低,新型血浆肝细胞死亡标记物单独或与临床危险因素联合今后可能成为无创性诊断工具。本文对无创性诊断工具在鉴别单纯性脂肪肝与NASH以及确定肝纤维化的存在及其范围中的作用作一概述。 | Leon A ADAMS Ariel E FELDSTEIN 张海燕 钱本余 马雄 | 2011 | 胃肠病学2011，16，3： | 2 |
| 7 | Accumulation of endogenous inhibitor of NO synthesis in chronic renal failure显示文摘 | Vallance P Leone A Calver A | 1992 | Lancet1992，339，： | 2 |
| 8 | 1-Methylcyclopropene treatment affects strawberry fruit decay显示文摘 | Yueming Jiang Daryl C Joyce Leon A Terry | 2001 | Postharvest Biology and Technology2001，，3： | 2 |
| 9 | Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure显示文摘 | Vallance P Leone A Calver A | 1992 | Lancet1992，339，： | 1 |
| 10 | Cloning and DNA sequence of plasmid determinant iss, coding for increased serum survival and surface exclusion, which has homology with lambda DNA显示文摘 | Chuba PJ Leon MA Banerjee A | 1989 | Mol Gen Genet1989，216，23： | 1 |
| 11 | Study of the adsorption of alkyl benzene-derived amphiphiles on asphaltene particles显示文摘 | LEON O ROGEL E URBINA A | 1999 | Langmuir1999，15，22： | 1 |
| 12 | Lichtenstein repair of inguinal hernia with Surgisis inguinal hernia matrix soft-tissue graft in immunodepressed patients显示文摘 | Catena F Ansaloni L Leone A | 2005 | Hernia2005，9，1： | 1 |
| 13 | Evidence for nm23 RNA uverexpression, DNA amplication and mutation in aggressive childhood neuroblastomas显示文摘 | Leone A Seeger RC Hong CN | 1993 | Oneogene1993，8，4： | 1 |
| 14 | Facilitated transport of copper through bulk liquid membranes containing different carriers : compared kinetic study 显示文摘 | Leon G Guzman M A | 2008 | Desalination2008，223，13： | 1 |
| 15 | Coregulator exchange and sphingosinesensitive eooperativity of steroidogenic factor-1, general control nonderepressed5 ,p54 ,and p160 coaetivators regulate cyclic adenosine 3, 5-monophosphatedependent cytochromeP450e17 transcription rate 显示文摘 | Dammer E B Leon A Sewer M B | 2007 | Mol Endocrinol2007，，： | 1 |
| 16 | Free DNA in the serum of cancer patients and the effect of therapy显示文摘 | Leon S A Shapiro B Sklaroff D M | 1977 | Cancer Res1977，37，： | 1 |
| 17 | Clinical and pathologic prognostic indicators in colorectal cancer:A population-based study显示文摘 | Ponz de Leon M Sant M Micheli A | 1992 | Cancer1992，69，3： | 1 |
| 18 | Nerve growth factor:from neurotrophin to neurokine显示文摘 | Levi-Montalcini R Skaper SD Dal Toso R Petrelli L Leon A | 1996 | Trends Neurosci1996，19，11： | 1 |
| 19 | Free DNA in the serum of cancer patients and the effect of therapy显示文摘 | LEON S A SHAPIRO B SKLAROFF D M | 1997 | Cancer Res1997，37，3： | 1 |
| 20 | Identification of salt stress-induced transcripts in potato leaves by cDNA-AFLP 显示文摘 | HMIDA-SAYARI A COSTA A LEONE A | 2005 | Molecular Biotechnology2005，30，： | 1 |
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