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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | A new way to generate seismic waves for continental crustal exploration显示文摘An airgun experiment was conducted in a reservoir,with the total volume of the airgun array being 6000 cubic inch. The energy released by one excitation was estimated to be 6.68×106 J,which corresponded to a 3.4 kg TNT explosion. A 180 km long profile composed of 100 portable short period seismometers was deployed as a receiver system of the airgun signals. Two remarkable results can be drawn from the experiment: (1) the airgun explosion is harmless to the dam and the fish,and this kind of airguns can be regarded as a green and environmental protection seismic source on land; (2) seismic wave gener-ated by this airgun source can be recorded by permanent stations with offset larger than 200 km. And the wave amplitudes recorded by nearby and remote stations are equivalent to the wave generated by 800 kg dynamite explosion. The airguns can be used as a light to illuminate the continental crustal structure of an area of about 100000 km2. | CHEN Yong ZHANG XianKang QIU XueLin GE HongKui LIU BaoJin WANG BaoShan | 2007 | Chinese Science Bulletin2007，52，16： | 24 |
| 3 | Influencing factors of seismic signals generated by un-tuned large volume airgun array in a land reservoir显示文摘Un-tuned large volume airgun array in a water reservoir is recently proposed as a new way to generate seismic waves on land. It can be used to explore the earth velocity structure and its temporal variations as well.However, the characteristics of seismic signals(especially far-field signals) from an airgun array in a reservoir and its affecting factors(firing pressure, airgun towing depth,water level of the reservoir, etc.) has not been adequately studied. We analyzed the seismic data collected from field experiments at Binchuan Transmitting Seismic Station in2011 and 2013 and found that(1) The similarity of seismic signals decrease with distance, which is most likely induced by the decay of signal amplitude and signal to noise ratio(SNR);(2) The amplitudes of far-field airgun signals are almost linearly proportional to the firing pressure;(3) The towing depth of airgun has less effects on the far-field signals;(4) The amplitudes of far-field airgun signals are proportional to the water level of the reservoir. | Meng Chen Wei Yang Weitao Wang Baoshan Wang Hongkui Ge Li Chen Yansheng Ding Jiyan Qiao Yong Chen | 2014 | Earthquake Science2014，27，4： | 19 |
| 4 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 5 | Apparent permeability variation of underground water aquifer induced by an earthquake:A case of the Zhouzhi well and the 2008 Wenchuan earthquake显示文摘Taking the M_2 wave as calibration signals,we extract the phase shifts of the water level relative to the Earth tide in the Zhouzhi well by utilizing the cross-correlation function.And we further obtain the apparent permeability variation in the aquifer of the Zhouzhi well in 2008.Comparison with the commonly used tidal analysis software Baytap-G shows that phase shifts obtained by cross-correlation function are more stable.The resulting apparent permeability of the Zhouzhi well aquifer fluctuates with time,indicating it is a dynamically controlled parameter.The 2008 Wenchuan earthquake caused the apparent permeability increasing drastically, which is interpreted as the combination effects of effective stress changes and the barriers removing in the flow channel due to seismic wave pressure pulse.After the Wenchuan earthquake,the effective stress began to recover and the impurities deposited gradually,causing the apparent permeability to decrease a month later and almost recover to the pre-earthquake level in six months. | Guijuan Lai Fuqiong Huang Hongkui Ge | 2011 | Earthquake Science2011，24，5： | 8 |
| 6 | Active source monitoring at the Wenchuan fault zone:coseismic velocity change associated with aftershock event and its implication显示文摘With the improvement of seismic observation system, more and more observations indicate that earthquakes may cause seismic velocity change. However, the amplitude and spatial distribution of the velocity variation remains a controversial issue. Recent active source monitoring carried out adjacent to Wenchuan Fault Scientific Drilling(WFSD) revealed unambiguous coseismic velocity change associated with a local Ms5.5 earthquake. Here, we carry out forward modeling using two-dimensional spectral element method to further investigate the amplitude and spatial distribution of observed velocity change. The model is well constrained by results from seismic reflection and WFSD coring. Our model strongly suggests that the observed coseismic velocity change is localized within the fault zone with width of *120 m rather than dynamic strong ground shaking. And a velocity decrease of *2.0 %within the fault zone is required to fit the observed travel time delay distribution, which coincides with rock mechanical experiment and theoretical modeling. | Wei Yang Hongkui Ge Baoshan Wang Jiupeng Hu Songyong Yuan Sen Qiao | 2014 | Earthquake Science2014，27，6： | 6 |
| 7 | Study of the Reservoir Damage during Cyclic Injection and Extraction Process in the Hutubi Gas Storage显示文摘During the injection and extraction process in gas storage,cyclic loading stress is applied to the reservoir pore structure,affecting the capacity and service life of gas storage. To study the influence of cyclic injection and extraction on reservoir physical property,a finite-element model of reservoir elastoplastic damage under the effect of pore pressure is established based on elastoplastic mechanics and fatigue-damage mechanics. Considering the mechanical property of the Hutubi reservoir and the injection-extraction mode of gas storage,the finite-element model is used to study the pore pressure and porosity change,fault safety,and ground surface deformation. The results show that the change in pore pressure and porosity,the deformation of the Hutubi fault,as well as the uplift and sink of the grounds surface are controlled by the fatigue damage of the reservoir pore structure during the injection-extraction process. After a 6-year service life, the cumulative deformation of the reservoir pore reaches its limit,causing pore structure collapse and porosity decrease. As a result,storage capacity declines and the ground surface starts to sink. Through this study,the safety of the Hutubi gas storage is evaluated,and some suggestions for field operations are offered. | Wang Jianbo Ge Hongkui Wang Xiaoqiong Liu Tongyuan Liu Dunqing Zhang Yanjun Wu Shan | 2018 | Earthquake Research in China2018，32，2： | 4 |
| 8 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 4 |
| 9 | Semiannual velocity variations around the 2008 M_w 7.9 Wenchuan Earthquake fault zone revealed by ambient noise and ACROSS active source data显示文摘We continuously monitor the long-term seismic velocity variation of one of the major ruptured faults of the devastating 2008 Mw7.9 Wenchuan earthquake in China from July 2009 to January 2012,jointly using accurately controlled routinely operated signal system active source and seismic noise-based monitoring technique.Our measurements show that the temporal velocity change is not homogeneous and highly localized in the damaged fault zone and the adjacent areas.Velocity variations from the active and passive methods are quite consistent,which both are characterized by ±0.2 % seasonal variation,with peak and trough at winter and summer,respectively.The periodic velocity variation within fault zone exhibits remarkably positive correlation with barometric pressure with stress sensitivity in the order of 10-6Pa-1,suggesting that the plausible mechanism might be the crack density variation of the shallow subsurface medium of the damaged fault zone in response to the cyclic barometric pressure loading. | Haichao Chen Hongkui Ge Fenglin Niu | 2014 | Earthquake Science2014，27，5： | 4 |
| 10 | Fired Models of Air-gun Source and Its Application显示文摘Air-gun is an important active seismic source.With the development of the theory about air-gun array,the technique for air-gun array design becomes mature and is widely used in petroleum exploration and geophysics.In order to adapt it to different research domains,different combination and fired models are needed.At the present time,there are two fired models of air-gun source,namely,reinforced initial pulse and reinforced first bubble pulse.The fired time,space between single guns,frequency and resolution of the two models are different.This comparison can supply the basis for its extensive application. | Luo Guichun Ge Hongkui Wang Baoshan Hu Ping Mu Hongwang Chen Yong | 2008 | Earthquake Research in China2008，22，2： | 3 |
| 11 | Experiment and Simulation of Large Capacity Air-guns in Deep Structure Exploration显示文摘The air-gun source has important applications as a new, environmentally, green active source in regional scale deep exploration. In the past, the air gun source was used mainly in small-scale, high-resolution shallow oil exploration, but has a lack of adequate research in deep exploration. In order to study the selection of work parameters and field conditions of the air gun source in deep exploration, this paper does the following work: ① analyze the characteristics of the air gun source using air gun experiments; ② simulate the air gun signal and air gun-array signal based on the theory of free bubble oscillation to analyze the influence of bubble oscillation and study the wavelet energy and spectrum characteristics needed in deep exploration; ③ on the basis of theoretical simulation, study the influence of work parameters, such as air-gun capacity, work stress and depth on air gun signal and analyze the influence of air-gun array inspired moment and spacing of different air guns on air gun-array signals; and ④ study energy reflection and transmission coefficients for different underwater interfaces, which is very useful for choosing suitable field conditions. | Tang Jie Wang Baoshan Ge Hongkui Chen Yong | 2009 | Earthquake Research in China2009，23，4： | 3 |
| 12 | Influence of Bedding and Mineral Composition on Mechanical Properties and Its Implication for Hydraulic Fracturing of Shale Oil Reservoirs显示文摘The premise of hydraulic fracturing is to have an accurate and detailed understanding of the rock mechanical properties and fracture propagation law of shale reservoirs. In this paper,a comprehensive evaluation of the mechanical properties of the shale oil reservoir in the south of Songliao Basin is carried out. Based on the experiments and the in-situ stress analysis, the fracture propagation law of three types of shale reservoirs is obtained,and the suggestions for fracturing are put forward. The results have shown that the fracture propagation of pure shale and low mature reservoir is easy to open along the bedding plane under compression loading,which is greatly influenced by the bedding. Sand-bearing shale is slightly better,the fractures of which are not easy to open along the bedding plane. The mechanical experimental results show that all the samples have the characteristics of low compressive strength,low Young’s modulus and strong anisotropy,indicating that the shale oil reservoir is certain plastic,which is related to its high clay mineral content and controlled by the bedding development. Compared with pure shale and low mature shale,the sandbearing shale has less clay content and less developed bedding,which maybe the main reason for its slightly better brittleness. Overall,the expansion of hydraulic fracture is controlled by in-situ stress and bedding. Because of the development of bedding,it is easy to form horizontal fractures. Thus it is not suitable for horizontal well fracturing.Because of the high content of clay minerals,the applicability of conventional slick hydraulic fracturing fluid is poor. It is suggested to use vertical well or directional well to carry out volume fracturing. In this way,the effect of bedding can be effectively used to open and connect the bedding and form a larger fracture network. | WANG Xiaoqiong XU Jianguo ZHAO Chenxu LIU Tongyuan GE Hongkui SHEN Yinghao WU Shan YU Jiayao HUANG Rongyan | 2020 | Earthquake Research in China2020，34，2： | 2 |
| 13 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science . 2013 (6146)2013，，： | 2 |
| 14 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 2 |
| 15 | Monitoring the Modal Frequency and Velocity Variations of Bridges under Ambient Excitation显示文摘We conducted a long-term monitoring experiment on the Lutuanxilu Bridge located in Changping District of Beijing, employing our recently developed real-time bridge monitoring system based on the Guralp CMG-6TD broadband seismometer. We identified the modal parameters with the stochastic subspace identification( SSI) algorithm,and continuously monitored the temporal velocity variation with coda wave interferometry.The results show that:( 1) the highly sensitive Guralp CMG-6TD broadband seismometer,which records the three-component vibration signal within broad frequency range,is well suited for long-term bridge health monitoring.( 2) With the continuous vibration signal from ambient excitation,the stochastic subspace algorithm can robustly identify the low-order modal parameters and the coda wave interferometry can accurately monitor the tiny velocity variation.( 3) The elastic modulus of bridge materials changes significantly associated with varying temperature,leading to diurnal velocity variation with amplitude of approximately 1%. The velocity variation shows strong negative correlation with temperature fluctuation. Meanwhile,the modal frequencies remain quite stable,suggesting that the velocity variation may be a more sensitive quantitative damage index.( 4) While the modal frequencies reflect the integrated health status of the bridge,the velocity variation can be utilized to monitor the local elastic modulus. Therefore,it is crucial for bridge health monitoring to continuously monitor the two key damage indexes under ambient excitation. | Chen Haichao Ge Hongkui Meng Fanbao Wang Xiaoqiong Yang Wei | 2015 | Earthquake Research in China2015，29，4： | 1 |
| 16 | Practices and Advances in Exploring the Subsurface Structure and Its Temporal Evolution with Repeatable Artificial Sources显示文摘The earth's structure may change with time under natural or anthropogenic loading.Monitoring the subtle changes of the subsurface structure with repeatable seismic sources such as repeating earthquakes,ambient seismic noise and artificial sources has become one of the hot topics in seismological research. These studies provide important clues in understanding the physical process of hazardous events such as earthquakes and volcanic eruptions. In this review we introduce the practices and advances in exploring and monitoring the subsurface structure with artificial seismic sources. This review is orgainzed as follows. Firstly,we describe the studies on the characteristics of different types of seismic source( especially the airgun source). Then the advances on data processing and mechanical understanding are depicted. At the end of this review,we reveal the prospects of future study of exploration and monitoring of the subsurface structure and its temporal variations using artificial sources. | Wang Baoshan Ge Hongkui Wang Bin Wang Haitao Zhang Yuansheng CaiHuiteng Chen Yong | 2016 | Earthquake Research in China2016，30，3： | 1 |
| 17 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | 2013 (6146)2013，，6146： | 1 |
| 18 | Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers显示文摘 | Jian Shu Chen Wu Yetao Wu Zhiyuan Li Sida Shao Wenhui Zhao Xing Tang Huan Yang Lijun Shen Xiaohan Zuo Weifeng Yang Yan Shi Xiaochun Chi Hongquan Zhang Ge Gao Youmin Shu Kehu Yuan Weiwu He Chao Tang Yang Zhao Hongkui Deng | 2013 | Cell2013，，5： | 1 |
| 19 | Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts显示文摘 | Haisong Liu Fangfang Zhu Jun Yong Pengbo Zhang Pingping Hou Honggang Li Wei Jiang Jun Cai Meng Liu Kai Cui Xiuxia Qu Tingting Xiang Danyu Lu Xiaochun Chi Ge Gao Weizhi Ji Mingxiao Ding Hongkui Deng | 2008 | Cell Stem Cell2008，，6： | 1 |
| 20 | Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts显示文摘 | Haisong Liu Fangfang Zhu Jun Yong Pengbo Zhang Pingping Hou Honggang Li Wei Jiang Jun Cai Meng Liu Kai Cui Xiuxia Qu Tingting Xiang Danyu Lu Xiaochun Chi Ge Gao Weizhi Ji Mingxiao Ding Hongkui Deng | 2008 | Cell Stem Cell2008，，6： | 1 |
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