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| 1 | Liver angiogenesis as a risk factor for hepatocellularcarcinoma development in hepatitis C virus cirrhotic patients显示文摘AIM: To evaluate the predictive value of hepatocyte proliferation and hepatic angiogenesis for the occurrence of Hepatocellular carcinoma (HCC) in hepatitis C virus (HCV) cirrhotic patients. METHODS: One hundred-five patients (69 males, 36 females; age range, 51-90 year; median 66 year) with biopsy proven HCV cirrhosis were prospectively monitored for HCC occurrence for a median time of 64 mo. Angiogenesis was assessed by using microvessel density (MVD), hepatocyte turnover by MIB1 and PCNA indexes at inclusion in liver biopsies. RESULTS: Forty six patients (43.8%) developed HCC after a median time of 55 (6-120) mo while 59 (56.2%) did not. Patients were divided into two groups according to the median value of each index. The difference between patients with low (median MVD = 3; range 0-20) and high (median MVD = 7; range 1-24) MVD was statistically significant (χ2 = 22.06; P < 0.0001) which was not the case for MIB1 or PCNA (MIB-1: χ2 = 1.41; P = 0.2351; PCNA: χ2 = 1.27; P = 0.2589). The median MVD was higher in patients who developed HCC than in those who did not. HCC-free interval was significantly longer in patients with the MVD ≤ 4 (P = 0.0006). No relationship was found between MIB1 or PCNA and MVD (MIB-1 r2 = 0.00007116, P = 0.9281; PCNA: r2 =0.001950; P = 0.6692). MVD only was able to predict the occurrence of HCC in these patients. Among other known risk factors for HCC, only male sex was statistically associated with an increased risk. CONCLUSION: Liver angiogenesis has a role for in HCV- related liver carcinogenesis and for defining patients at higher risk. | Roberto Mazzanti Luca Messerini Camilla E Comin Lorenzo Fedeli Nathalie Gannè-Carrie Michel Beaugrand | 2007 | World Journal of Gastroenterology2007，13，37： | 3 |
| 2 | Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis显示文摘 | Gisèle N’Kontchou Jacques Paries Myint Tin Tin Htar Nathalie Ganne–Carrie Lydie Costentin Véronique Grando–Lemaire Jean–Claude Trinchet Michel Beaugrand | 2006 | Clinical Gastroenterology and Hepatology2006，，8： | 2 |
| 3 | Tomatoes or lycopene versus prostate cancer:is evolution anti -reductionist?显示文摘 | Gann P H Khachik F | 2003 | J Natl Cancer Inst2003，95，： | 1 |
| 4 | Biodistribution of rhenium-188 Lipiodol infused via the hepatic artery of rats with hepatic tumours显示文摘 | Shyh-Jen Wang Wan-Yu Lin Min-Nan Chen Bor-Tsung Hsieh Lie-Hang Shen Zei-Tsan Tsai Gann Ting Furn F. Knapp | 1996 | European Journal of Nuclear Medicine1996，，1： | 1 |
| 5 | Innovation in project-based, service-enhanced firms: the construction of complex products and systems 显示文摘 | Gann M Salter J | 2002 | Research Policy2002，，29： | 1 |
| 6 | Delayed hypocalcemia after thyroidectomy for Graves disease is prevented by parathyroid autotransplantation显示文摘 | Gann DS Paone JF | 1979 | Ann Surg1979，190，4： | 1 |
| 7 | Growth factors in expressed prostatic fluid form men with prostate cancer,BPH,and clinically normal prostates显示文摘 | Gann PH Klein KG Chatterton RT | 1999 | Prostate1999，40，4： | 1 |
| 8 | Adjuvants designed for veterinary and human vaccimes显示文摘 | Aucouturier J Dupuis L Ganne V | 2001 | Vaccine2001，19，： | 1 |
| 9 | Guidance for advanced fire suppression in aircraft 显示文摘 | Gann R G | 2008 | Fire Technology2008，44，3： | 1 |
| 10 | Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trial显示文摘 | Martin Reck Rolf Kaiser Anders Mellemgaard Jean-Yves Douillard Sergey Orlov Maciej Krzakowski Joachim von Pawel Maya Gottfried Igor Bondarenko Meilin Liao Claudia-Nanette Gann José Barrueco Birgit Gaschler-Markefski Silvia Novello | 2014 | Lancet Oncology2014，，2： | 1 |
| 11 | HBsAg clearance after addition of 48 weeks of PEGIFN in HBeAg negative CHB patients on nucleos (t)ide therapy with undetectable HBV DNA for at least one year: a multicenter randomized controlled phase HI trial ANRS-HB06 PEGAN study: preliminary findings显示文摘 | Bourliere M Rabiega P Ganne Carrie N | 2014 | Hepatology2014，60，1： | 1 |
| 12 | The osmotic rupture hypothesis of intracellular freezing injury显示文摘 | Muldrew K Me Gann L E | 1994 | Biophys J1994，66，6： | 1 |
| 13 | How open is innovation显示文摘 | DAHLANDER L GANN D | 2010 | Re?search Policy2010，39，6： | 1 |
| 14 | Prospective study of screening for hepatocellular carcinoma in Caucasian patients with cirrhosis显示文摘 | Pateron D Ganne N Trinchet JC | 1994 | J Hepatol1994，20，： | 1 |
| 15 | Strategies combining total and percent free prostate specific antigen for detecting prostate cancer:aprospective evaluation显示文摘 | Gann P H Ma J Catalona W J | 2002 | J Urol2002，167，6： | 1 |
| 16 | Fire conditions for smoke toxicity measurement 显示文摘 | Gann R G Babrauskas V Peacock R D | 1994 | Fire Mater1994，18，3： | 1 |
| 17 | Adjuvants designed for veterinary and human vaccines显示文摘 | Dupuis L Ganne V | 2001 | Vaccine2001，19，： | 1 |
| 18 | Defluoridation of groundwater by a hybrid process combining adsorption and Donnan dialysis 显示文摘 | Gannes H Persin F Sandeaux J | 2002 | Desalination2002，145，13： | 1 |
| 19 | EIS investigation of zinc dissolution in aerated sulfate medium, part I: bulk zinc 显示文摘 | Cachet C Ganne F | 2001 | Electrochimica Acta2001，，47： | 1 |
| 20 | The role of technolo- gy in the shift towards open innovation:the ease of procter gamble显示文摘 | DODGSON M GANN D SALTER A | 2006 | R~D Management2006，36，3： | 1 |
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